Theranostics 2013; 3(6):395-408. doi:10.7150/thno.5935 This issue Cite

Review

Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid

Qi Wang2, Lei Chen1, Yitao Long1, He Tian1, Junchen Wu1,

1. Key Lab for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, China.
2. College of Public Health, Nantong University, China.

Citation:
Wang Q, Chen L, Long Y, Tian H, Wu J. Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid. Theranostics 2013; 3(6):395-408. doi:10.7150/thno.5935. https://www.thno.org/v03p0395.htm
Other styles

File import instruction

Abstract

Molecular beacons (MBs) of DNA and RNA have aroused increasing interest because they allow a continuous readout, excellent spatial and temporal resolution to observe in real time. This kind of dual-labeled oligonucleotide probes can differentiate between bound and unbound DNA/RNA in homogenous hybridization with a high signal-to-background ratio in living cells. This review briefly summarizes the different unnatural sugar backbones of oligonucleotides combined with fluorophores that have been employed to sense DNA/RNA. With different probes, we epitomize the fundamental understanding of driving forces and these recognition processes. Moreover, we will introduce a few novel and attractive emerging applications and discuss their advantages and disadvantages. We also highlight several perspective probes in the application of cancer therapeutics.

Keywords: Xeno-nucleic acid, Nucleic acid, Molecular beacon, Diagnostics.


Citation styles

APA
Wang, Q., Chen, L., Long, Y., Tian, H., Wu, J. (2013). Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid. Theranostics, 3(6), 395-408. https://doi.org/10.7150/thno.5935.

ACS
Wang, Q.; Chen, L.; Long, Y.; Tian, H.; Wu, J. Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid. Theranostics 2013, 3 (6), 395-408. DOI: 10.7150/thno.5935.

NLM
Wang Q, Chen L, Long Y, Tian H, Wu J. Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid. Theranostics 2013; 3(6):395-408. doi:10.7150/thno.5935. https://www.thno.org/v03p0395.htm

CSE
Wang Q, Chen L, Long Y, Tian H, Wu J. 2013. Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid. Theranostics. 3(6):395-408.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image