Theranostics 2014; 4(4):432-444. doi:10.7150/thno.8074 This issue Cite

Review

Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview

Hao-Li Liu1, Ching-Hsiang Fan2, Chien-Yu Ting2, Chih-Kuang Yeh2, ✉

1. Department of Electrical Engineering, Chang-Gung University, 259 Wen-Hwa 1st Road, Kuei-Shan, Tao-Yuan, Taiwan 33302
2. Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu, Taiwan 30013

Citation:
Liu HL, Fan CH, Ting CY, Yeh CK. Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview. Theranostics 2014; 4(4):432-444. doi:10.7150/thno.8074. https://www.thno.org/v04p0432.htm
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Abstract

Graphic abstract

Malignant glioma is one of the most challenging central nervous system (CNS) diseases, which is typically associated with high rates of recurrence and mortality. Current surgical debulking combined with radiation or chemotherapy has failed to control tumor progression or improve glioma patient survival. Microbubbles (MBs) originally serve as contrast agents in diagnostic ultrasound but have recently attracted considerable attention for therapeutic application in enhancing blood-tissue permeability for drug delivery. MB-facilitated focused ultrasound (FUS) has already been confirmed to enhance CNS-blood permeability by temporally opening the blood-brain barrier (BBB), thus has potential to enhance delivery of various kinds of therapeutic agents into brain tumors. Here we review the current preclinical studies which demonstrate the reports by using FUS with MB-facilitated drug delivery technology in brain tumor treatment. In addition, we review newly developed multifunctional theranostic MBs for FUS-induced BBB opening for brain tumor therapy.

Keywords: Microbubbles, brain tumor, focused ultrasound, blood-brain barrier, chemotherapy


Citation styles

APA
Liu, H.L., Fan, C.H., Ting, C.Y., Yeh, C.K. (2014). Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview. Theranostics, 4(4), 432-444. https://doi.org/10.7150/thno.8074.

ACS
Liu, H.L.; Fan, C.H.; Ting, C.Y.; Yeh, C.K. Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview. Theranostics 2014, 4 (4), 432-444. DOI: 10.7150/thno.8074.

NLM
Liu HL, Fan CH, Ting CY, Yeh CK. Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview. Theranostics 2014; 4(4):432-444. doi:10.7150/thno.8074. https://www.thno.org/v04p0432.htm

CSE
Liu HL, Fan CH, Ting CY, Yeh CK. 2014. Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview. Theranostics. 4(4):432-444.

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