Theranostics 2016; 6(6):875-886. doi:10.7150/thno.14694 This issue Cite

Research Paper

KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway

Yanjie Kong1, 2*, Fubin Li1, 2*, Yin Nian1,3*, Zhongmei Zhou1, Runxiang Yang4✉, Ming-Hua Qiu3✉, Ceshi Chen1✉

1. Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China;
2. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204 Yunnan, China;
3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204 Yunnan, China;
4. Department of the second medical oncology, the 3rd affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China.
* These authors contributed equally to this work.

Citation:
Kong Y, Li F, Nian Y, Zhou Z, Yang R, Qiu MH, Chen C. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway. Theranostics 2016; 6(6):875-886. doi:10.7150/thno.14694. https://www.thno.org/v06p0875.htm
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Abstract

Graphic abstract

Triterpenoids extracted from Cimicifuga foetida have been reported to inhibit cancer by inducing cell cycle arrest and apoptosis. In this study, KHF16 (24-acetylisodahurinol-3-O-β-D-xylopyranoside), a cycloartane triterpenoid isolated from the rhizomes of C. foetida, showed potent anti-cancer activity in multiple ERα/PR/HER2 triple-negative breast cancer (TNBC) cell lines. KHF16 significantly induces cell cycle G2/M phase arrest and apoptosis in both MDA-MB-468 and SW527 TNBC cell lines. KHF16 reduces the expression levels of XIAP, Mcl-1, Survivin and Cyclin B1/D1 proteins. Importantly, KHF16 inhibits TNFα-induced IKKα/β phosphorylation, IKBα phosphorylation, p65 nuclear translocation and NF-κB downstream target gene expression, including XIAP, Mcl-1 and Survivin, in TNBC cells. These results suggest that KHF16 may inhibit TNBC by blocking the NF-κB signaling pathway in part.

Keywords: KHF16, Cycloartane triterpenoid, Triple negative breast cancer, Cell cycle, Apoptosis, NF-κB.


Citation styles

APA
Kong, Y., Li, F., Nian, Y., Zhou, Z., Yang, R., Qiu, M.H., Chen, C. (2016). KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway. Theranostics, 6(6), 875-886. https://doi.org/10.7150/thno.14694.

ACS
Kong, Y.; Li, F.; Nian, Y.; Zhou, Z.; Yang, R.; Qiu, M.H.; Chen, C. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway. Theranostics 2016, 6 (6), 875-886. DOI: 10.7150/thno.14694.

NLM
Kong Y, Li F, Nian Y, Zhou Z, Yang R, Qiu MH, Chen C. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway. Theranostics 2016; 6(6):875-886. doi:10.7150/thno.14694. https://www.thno.org/v06p0875.htm

CSE
Kong Y, Li F, Nian Y, Zhou Z, Yang R, Qiu MH, Chen C. 2016. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway. Theranostics. 6(6):875-886.

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