Theranostics 2018; 8(16):4279-4294. doi:10.7150/thno.26345

Review

Imaging and therapy of ovarian cancer: clinical application of nanoparticles and future perspectives

Giovanni Di Lorenzo, Giuseppe Ricci, Giovanni Maria Severini, Federico Romano, Stefania Biffi

Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy

Abstract

Despite significant advances in cancer diagnostics and treatment, ovarian cancers (OC) continue to kill more than 150,000 women every year worldwide. Due to the relatively asymptomatic nature and the advanced stage of the disease at the time of diagnosis, OC is the most lethal gynecologic malignancy. The current treatment for advanced OC relies on the synergistic effect of combining surgical cytoreduction and chemotherapy; however, beside the fact that chemotherapy resistance is a major challenge in OC management, new imaging strategies are needed to target microscopic lesions and improve both cytoreductive surgery and patient outcomes. In this context, nanostructured probes are emerging as a new class of medical tool that can simultaneously provide imaging contrast, target tumor cells, and carry a wide range of medicines resulting in better diagnosis and therapeutic precision. Herein we summarize several exemplary efforts in nanomedicine for addressing unmet clinical needs.

Keywords: ovarian cancer, imaging, therapy, nanoparticles, surgery

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How to cite this article:
Di Lorenzo G, Ricci G, Severini GM, Romano F, Biffi S. Imaging and therapy of ovarian cancer: clinical application of nanoparticles and future perspectives. Theranostics 2018; 8(16):4279-4294. doi:10.7150/thno.26345. Available from http://www.thno.org/v08p4279.htm