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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Targeting cathepsin C ameliorates murine acetaminophen-induced liver injury
Jessica Raith, Malte Bachmann, Sina Gonther, Hendrik Stülb, Ali A. Aghdassi, Christine T. N. Pham, Heiko Mühl
Theranostics 2024; 14(8): 3029-3042. doi:10.7150/thno.96092
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Research Paper
Cancer-associated fibroblast-derived periostin promotes papillary thyroid tumor growth through integrin-FAK-STAT3 signaling
Xiaorui Jin, Qianmei Deng, Shuting Ye, Shuting Liu, Yilong Fu, Yingfu Liu, Guoyang Wu, Gaoliang Ouyang, Tiantian Wu
Theranostics 2024; 14(7): 3014-3028. doi:10.7150/thno.94207
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Review
Mitochondrial Sirtuins in Cancer: A Revisited Review from Molecular Mechanisms to Therapeutic Strategies
Hui Shen, Wei Ma, Yue Hu, Yuan Liu, Yaowen Song, Leilei Fu, Zheng Qin
Theranostics 2024; 14(7): 2993-3013. doi:10.7150/thno.97320
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Review
Actinium-225 targeted alpha particle therapy for prostate cancer
Anil P. Bidkar, Luann Zerefa, Surekha Yadav, Henry F. VanBrocklin, Robert R. Flavell
Theranostics 2024; 14(7): 2969-2992. doi:10.7150/thno.96403
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Review
Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery
Junxian Cao, Caifeng Li, Zhao Cui, Shiwen Deng, Tong Lei, Wei Liu, Hongjun Yang, Peng Chen
Theranostics 2024; 14(7): 2946-2968. doi:10.7150/thno.95908
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Research Paper
A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation
Hyung Shik Kim, Elias A. Halabi, Noah Enbergs, Rainer H. Kohler, Fan Fei, Christopher S. Garris, Ralph Weissleder
Theranostics 2024; 14(7): 2934-2945. doi:10.7150/thno.95267
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Research Paper
Comprehensive multi-omics analysis of pyroptosis for optimizing neoadjuvant immunotherapy in patients with gastric cancer
Jia-Bin Wang, You-Xin Gao, Yin-Hua Ye, Qiao-Ling Zheng, Hua-You Luo, Shuan-Hu Wang, Tao Zhang, Qin-Wen Jin, Chao-Hui Zheng, Ping Li, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Ying-Hong Yang, Chang-Ming Huang, Jian-Wei Xie
Theranostics 2024; 14(7): 2915-2933. doi:10.7150/thno.93124
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Research Paper
Adaptive plasticity of natural interleukin-35-induced regulatory T cells (Tr35) that are required for T-cell immune regulation
Xundong Wei, Jianhua Zhang, Jian Cui, Wei Xu, Gang Zhao, Chang Guo, Wei Yuan, Xuyu Zhou, Jie Ma
Theranostics 2024; 14(7): 2897-2914. doi:10.7150/thno.90608
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

CFP - Special issue on Molecular Imaging and Theranostics. Guest Editors: Dr. Jianhua Zou, Dr. Jingjing Zhang and Dr. Mengyao Zhao.

Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.

Acetaminophen (APAP) overdosing is a major cause of acute liver failure worldwide and an established model for drug-induced acute liver injury (ALI). While studying gene expression during murine APAP-induced ALI by 3'mRNA sequencing (massive analysis of cDNA ends, MACE), we observed splenic mRNA accumulation encoding for the neutrophil serine proteases cathepsin G, neutrophil elastase, and proteinase-3 - all are hierarchically activated by cathepsin C (CtsC). This, along with increased serum levels of these proteases in diseased mice, concurs with the established phenomenon of myeloid cell mobilization....
Background: IL-35 potently inhibits immune responses both in vivo and in vitro. However, the specific characteristics of IL-35-producing cells, including their developmental origin, cellular phenotype, and function, are unknown. Methods: By using a novel IL-35 reporter mouse (Ebi3-Dre-Thy1.1) and double transgenic fate-mapping reporter mice (35EbiT-Rosa26-rox-tdTomato reporter mice or Foxp3 fate-mapping system), we tracked and analyzed the differentiation and developmental trajectories of Tr35 cells in vivo. And then we investigated the therapeutic effects of OVA-specific Tr35 cells in an OVA-induced....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Dual Functional Magnetic Nanoparticles Conjugated with Carbon Quantum Dots for Hyperthermia and Photodynamic Therapy for Cancer
Mounika Choppadandi, Kondi Soumya, Sumanta Ghosh, Aishwarya Balu, Tanvi Shingote, Srivalliputtur Sarath Babu, Vani Sai Prasanna, Somasundaram Arumugam, Ravichandiran Velyutham, Murali M. Yallapu, Govinda Kapusetti
Nanotheranostics 2024; 8(4): 442-457. doi:10.7150/ntno.91871
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