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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Intelligent gold nanostars for in vivo CT imaging and catalase-enhanced synergistic photodynamic & photothermal tumor therapy
Lin Zhang, Xiao-Quan Yang, Jian-Shuang Wei, Xing Li, Huan Wang, Yuan-Di Zhao
Theranostics 2019; 9(19): 5424-5442. doi:10.7150/thno.33015
[Abstract] [Full text] [PDF]


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Research Paper
A novel anti-DR5 antibody-drug conjugate possesses a high-potential therapeutic efficacy for leukemia and solid tumors
Shuyong Zhang, Chao Zheng, Wan Zhu, Peng Xiong, Dongdong Zhou, Changjiang Huang, Dexian Zheng
Theranostics 2019; 9(18): 5412-5423. doi:10.7150/thno.33598
[Abstract] [Full text] [PDF]


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Research Paper
Unilateral Focused Ultrasound-Induced Blood-Brain Barrier Opening Reduces Phosphorylated Tau from The rTg4510 Mouse Model
Maria Eleni Karakatsani, Tara Kugelman, Robin Ji, Maria Murillo, Shutao Wang, Yusuke Niimi, Scott A. Small, Karen E. Duff, Elisa E. Konofagou
Theranostics 2019; 9(18): 5396-5411. doi:10.7150/thno.28717
[Abstract] [Full text] [PDF]


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Research Paper
RNA-silencing nanoprobes for effective activation and dynamic imaging of neural stem cell differentiation
Ruili Zhang, Zhe Wang, Zuo Yang, Linlin Wang, Zhongdi Wang, Baihang Chen, Zhongliang Wang, Jie Tian
Theranostics 2019; 9(18): 5386-5395. doi:10.7150/thno.35032
[Abstract] [Full text] [PDF]


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Research Paper
A radiomics approach based on support vector machine using MR images for preoperative lymph node status evaluation in intrahepatic cholangiocarcinoma
Lei Xu, Pengfei Yang, Wenjie Liang, Weihai Liu, Weigen Wang, Chen Luo, Jing Wang, Zhiyi Peng, Lei Xing, Mi Huang, Shusen Zheng, Tianye Niu
Theranostics 2019; 9(18): 5374-5385. doi:10.7150/thno.34149
[Abstract] [Full text] [PDF]


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Research Paper
Fatty acid-induced CD36 expression via O-GlcNAcylation drives gastric cancer metastasis
Mingzuo Jiang, Nan Wu, Bing Xu, Yi Chu, Xiaowei Li, Song Su, Di Chen, Wenjiao Li, Yanting Shi, Xiaoliang Gao, Haohao Zhang, Zhao Zhang, Wei Du, Yongzhan Nie, Jie Liang, Daiming Fan
Theranostics 2019; 9(18): 5359-5373. doi:10.7150/thno.34024
[Abstract] [Full text] [PDF]


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Research Paper
Evaluation of serum extracellular vesicles as noninvasive diagnostic markers of glioma
Huayi Wang, Dengzhi Jiang, Wenzhe Li, Xiang Xiang, Jun Zhao, Bin Yu, Chen Wang, Zhaohui He, Ling Zhu, Yanlian Yang
Theranostics 2019; 9(18): 5347-5358. doi:10.7150/thno.33114
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Review
New CXCR1/CXCR2 inhibitors represent an effective treatment for kidney or head and neck cancers sensitive or refractory to reference treatments
Maeva Dufies, Oleksandr Grytsai, Cyril Ronco, Oumar Camara, Damien Ambrosetti, Anaïs Hagege, Julien Parola, Lou Mateo, Marion Ayrault, Sandy Giuliano, Renaud Grépin, Nathalie Lagarde, Matthieu Montes, Patrick Auberger, Luc Demange, Rachid Benhida, Gilles Pagès
Theranostics 2019; 9(18): 5332-5346. doi:10.7150/thno.34681
[Abstract] [Full text] [PDF]


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Research Paper
Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics
Duyang Gao, Boyu Zhang, Yubin Liu, Dehong Hu, Zonghai Sheng, Xuanjun Zhang, Zhen Yuan
Theranostics 2019; 9(18): 5315-5331. doi:10.7150/thno.34418
[Abstract] [Full text] [PDF]


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Research Paper
LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α
Zhu Zeng, Feng-yu Xu, Hai Zheng, Ping Cheng, Qing-yong Chen, Zeng Ye, Jian-xin Zhong, Shi-jiang Deng, Ming-liang Liu, Kang Huang, Qiang Li, Wei Li, Yu-hang Hu, Fan Wang, Chun-you Wang, Gang Zhao
Theranostics 2019; 9(18): 5298-5314. doi:10.7150/thno.34559
[Abstract] [Full text] [PDF]


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Research Paper
Hybrid micelles containing methotrexate-conjugated polymer and co-loaded with microRNA-124 for rheumatoid arthritis therapy
Fei Hao, Robert J Lee, Lihuang Zhong, Shiyan Dong, Chunmiao Yang, Lirong Teng, Qingfan Meng, Jiahui Lu, Jing Xie, Lesheng Teng
Theranostics 2019; 9(18): 5282-5297. doi:10.7150/thno.32268
[Abstract] [Full text] [PDF]


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Research Paper
Focused ultrasound-augmented targeting delivery of nanosonosensitizers from homogenous exosomes for enhanced sonodynamic cancer therapy
Yichen Liu, Lianmei Bai, Kaili Guo, Yali Jia, Kun Zhang, Quanhong Liu, Pan Wang, Xiaobing Wang
Theranostics 2019; 9(18): 5261-5281. doi:10.7150/thno.33183
[Abstract] [Full text] [PDF]


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Research Paper
APLN promotes hepatocellular carcinoma through activating PI3K/Akt pathway and is a druggable target
Huarong Chen, Chi-Chun Wong, Dabin Liu, Minnie Y.Y. Go, Bin Wu, Sui Peng, Ming Kuang, Nathalie Wong, Jun Yu
Theranostics 2019; 9(18): 5246-5260. doi:10.7150/thno.34713
[Abstract] [Full text] [PDF]


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Research Paper
LncRNA PCNAP1 modulates hepatitis B virus replication and enhances tumor growth of liver cancer
Jinyan Feng, Guang Yang, Yunxia Liu, Yuen Gao, Man Zhao, Yanan Bu, Hongfeng Yuan, Ying Yuan, Haolin Yun, Mingming Sun, Hongwei Gao, Shuqin Zhang, Zixian Liu, Ming Yin, Xijun Song, Zhenchuan Miao, Zhongqing Lin, Xiaodong Zhang
Theranostics 2019; 9(18): 5227-5245. doi:10.7150/thno.34273
[Abstract] [Full text] [PDF]


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Research Paper
W-doped TiO2 nanoparticles with strong absorption in the NIR-II window for photoacoustic/CT dual-modal imaging and synergistic thermoradiotherapy of tumors
Ke Gao, Wenzhi Tu, Xujiang Yu, Farooq Ahmad, Xiannan Zhang, Weijie Wu, Xiao An, Xiaoyuan Chen, Wanwan Li
Theranostics 2019; 9(18): 5214-5226. doi:10.7150/thno.33574
[Abstract] [Full text] [PDF]


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Research Paper
Spontaneous evolution of human skin fibroblasts into wound-healing keratinocyte-like cells
Fang Zhang, Dandan Zhang, Kai Cheng, Zaixin Zhou, Shupeng Liu, Liang Chen, Yijun Hu, Chuanbin Mao, Shanrong Liu
Theranostics 2019; 9(18): 5200-5213. doi:10.7150/thno.31526
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

newNanotheranostics is indexed in MEDLINE and PubMed Central. Submit manuscript now...

new CFP - Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Critical Reviews of Immunotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH), Mingnan Chen (University of Utah)
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue The EPR effect and beyond: Strategies to improve tumor targeting and nanomedicine efficacy. Guest Editors: Yang Shi (RWTH Aachen University), Roy van der Meel (Eindhoven University of Technology), Twan Lammers (RWTH Aachen University), Xiaoyuan (Shawn) Chen (NIBIB/NIH)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues