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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
UBE2C, Directly Targeted by miR-548e-5p, Increases the Cellular Growth and Invasive Abilities of Cancer Cells Interacting with the EMT Marker Protein Zinc Finger E-box Binding Homeobox 1/2 in NSCLC
Dan Jin, Jiwei Guo, Yan Wu, Jing Du, Xiaohong Wang, Jiajia An, Baoguang Hu, Lingqun Kong, Weihua Di, Wansheng Wang
Theranostics 2019; 9(7): 2036-2055. doi:10.7150/thno.32738
[Abstract] [Full text] [PDF]


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Research Paper
Mitochondrial Transfer from Bone Marrow Mesenchymal Stem Cells to Motor Neurons in Spinal Cord Injury Rats via Gap Junction
Heyangzi Li, Chao Wang, Teng He, Tengfei Zhao, Ying-ying Chen, Yue-liang Shen, Xiaoming Zhang, Lin-lin Wang
Theranostics 2019; 9(7): 2017-2035. doi:10.7150/thno.29400
[Abstract] [Full text] [PDF]


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Research Paper
Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis
Andreas von Knethen, Anne Schäfer, Laura Kuchler, Tilo Knape, Urs Christen, Edith Hintermann, Beate Fißlthaler, Katrin Schröder, Ralf P. Brandes, Berit Genz, Kerstin Abshagen, Brigitte M. Pützer, Lisa K. Sha, Andreas Weigert, Shahzad N. Syed, Martin Schulz, Ajay M. Shah, Andreas Ernst, Mateusz Putyrski, Fabian Finkelmeier, Marina Pesic, Florian Greten, Michael Hogardt, Volkhard A. J. Kempf, Sandra Gunne, Michael J. Parnham, Bernhard Brüne
Theranostics 2019; 9(7): 2003-2016. doi:10.7150/thno.28057
[Abstract] [Full text] [PDF]


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Research Paper
DNAzyme Catalyzed Tyramide Depositing Reaction for In Situ Imaging of Protein Status on the Cell Surface
Lulu Xu, Shengchun Liu, Tiantian Yang, Yifan Shen, Yuhong Zhang, Lizhen Huang, Lutan Zhang, Shijia Ding, Fangzhou Song, Wei Cheng
Theranostics 2019; 9(7): 1993-2002. doi:10.7150/thno.31943
[Abstract] [Full text] [PDF]


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Research Paper
Hyaluronic Acid Oligosaccharides Improve Myocardial Function Reconstruction and Angiogenesis against Myocardial Infarction by Regulation of Macrophages
Ning Wang, Chao Liu, Xinxin Wang, Tao He, Lu Li, Xiuqi Liang, Li Wang, Linjiang Song, Yuquan Wei, Qinjie Wu, Changyang Gong
Theranostics 2019; 9(7): 1980-1992. doi:10.7150/thno.31073
[Abstract] [Full text] [PDF]


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Research Paper
Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis
Xiao-Peng Tian, Chen-Yuan Wang, Xiao-Han Jin, Mei Li, Feng-Wei Wang, Wei-Juan Huang, Jing-Ping Yun, Rui-Hua Xu, Qing-Qing Cai, Dan Xie
Theranostics 2019; 9(7): 1965-1979. doi:10.7150/thno.30958
[Abstract] [Full text] [PDF]


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Research Paper
Repurposing Ponatinib as a Potent Agent against KIT Mutant Melanomas
Yong Han, Ziyue Gu, Jing Wu, Xiaojuan Huang, Rong Zhou, Chaoji Shi, Wenjie Tao, Lizhen Wang, Yanan Wang, Guoyu Zhou, Jiang Li, Zhiyuan Zhang, Shuyang Sun
Theranostics 2019; 9(7): 1952-1964. doi:10.7150/thno.30890
[Abstract] [Full text] [PDF]


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Review
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Xiaojun Feng, Antoni Sureda, Samineh Jafari, Zahra Memariani, Devesh Tewari, Giuseppe Annunziata, Luigi Barrea, Sherif T.S. Hassan, Karel Šmejkal, Milan Malaník, Alice Sychrová, Davide Barreca, Lovro Ziberna, Mohamad Fawzi Mahomoodally, Gokhan Zengin, Suowen Xu, Seyed Mohammad Nabavi, Ai-Zong Shen
Theranostics 2019; 9(7): 1923-1951. doi:10.7150/thno.30787
[Abstract] [Full text] [PDF]


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Research Paper
HMGB1-Induced p62 Overexpression Promotes Snail-Mediated Epithelial-Mesenchymal Transition in Glioblastoma Cells via the Degradation of GSK-3β
Hong Li, Junjie Li, Guozhong Zhang, Qian Da, Lei Chen, Shishi Yu, Qiang Zhou, Zhijian Weng, Zong Xin, Linyong Shi, Liyi Ma, Annie Huang, Songtao Qi, Yuntao Lu
Theranostics 2019; 9(7): 1909-1922. doi:10.7150/thno.30578
[Abstract] [Full text] [PDF]


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Research Paper
Tumor Chemo-Radiotherapy with Rod-Shaped and Spherical Gold Nano Probes: Shape and Active Targeting Both Matter
Lu Zhang, Huilan Su, Haolu Wang, Qian Li, Xiao Li, Chuanqing Zhou, Jia Xu, Yimin Chai, Xiaowen Liang, Liqin Xiong, Chunfu Zhang
Theranostics 2019; 9(7): 1893-1908. doi:10.7150/thno.30523
[Abstract] [Full text] [PDF]


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Research Paper
Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy
Sitong Du, Chao Li, Yiping Lu, Xue Lei, Yiting Zhang, Siyi Li, Fangwei Liu, Ying Chen, Dong Weng, Jie Chen
Theranostics 2019; 9(7): 1878-1892. doi:10.7150/thno.29682
[Abstract] [Full text] [PDF]


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Research Paper
miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease
Bin Wang, Aiqing Zhang, Haidong Wang, Janet D. Klein, Lin Tan, Ze-Mu Wang, Jie Du, Nawazish Naqvi, Bi-Cheng Liu, Xiaonan H. Wang
Theranostics 2019; 9(7): 1864-1877. doi:10.7150/thno.29579
[Abstract] [Full text] [PDF]


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Research Paper
Fully Automated, Label-Free Isolation of Extracellular Vesicles from Whole Blood for Cancer Diagnosis and Monitoring
Vijaya Sunkara, Chi-Ju Kim, Juhee Park, Hyun-Kyung Woo, Dongyoung Kim, Hong Koo Ha, Mi-Hyun Kim, Youlim Son, Jae-Ryong Kim, Yoon-Kyoung Cho
Theranostics 2019; 9(7): 1851-1863. doi:10.7150/thno.32438
[Abstract] [Full text] [PDF]


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Research Paper
An Optogenetic Controllable T Cell System for Hepatocellular Carcinoma Immunotherapy
Bixing Zhao, Yingchao Wang, Xionghong Tan, Xiaoyuan Zheng, Fei Wang, Kun Ke, Cuilin Zhang, Naishun Liao, Yuan Dang, Yingjun Shi, Youshi Zheng, Yunzhen Gao, Qin Li, Xiaolong Liu, Jingfeng Liu
Theranostics 2019; 9(7): 1837-1850. doi:10.7150/thno.27051
[Abstract] [Full text] [PDF]


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Research Paper
Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-κB Pathway
Qing Yuan, Fuping Gao, Yawen Yao, Pengju Cai, Xiangchun Zhang, Jinling Yuan, Kaixiao Hou, Liang Gao, Xiaojun Ren, Xueyun Gao
Theranostics 2019; 9(7): 1825-1836. doi:10.7150/thno.31893
[Abstract] [Full text] [PDF]


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Research Paper
Water-Mediated Nanostructures for Enhanced MRI: Impact of Water Dynamics on Relaxometric Properties of Gd-DTPA
Franca De Sarno, Alfonso Maria Ponsiglione, Maria Russo, Anna Maria Grimaldi, Ernesto Forte, Paolo Antonio Netti, Enza Torino
Theranostics 2019; 9(6): 1809-1824. doi:10.7150/thno.27313
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

newNanotheranostics is indexed in MEDLINE and PubMed Central. Submit manuscript now... Congratulations to Dr. Moritz F. Kircher who has been appointed Chair of the Department of Imaging and Radiology, Dana-Farber Cancer Institute, Harvard Medical School.

new CFP - Special Issue Progress in Critical Reviews of Immunotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH), Mingnan Chen (University of Utah)
new CFP - Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
new CFP - Special Issue The EPR effect and beyond: Strategies to improve tumor targeting and nanomedicine efficacy. Guest Editors: Yang Shi (RWTH Aachen University), Roy van der Meel (Eindhoven University of Technology), Twan Lammers (RWTH Aachen University), Xiaoyuan (Shawn) Chen (NIBIB/NIH)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues