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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Role of the gut microbiota in tumorigenesis and treatment
Qingya Liu, Yun Yang, Meng Pan, Fan Yang, Yan Yu, Zhiyong Qian
Theranostics 2024; 14(6): 2304-2328. doi:10.7150/thno.91700
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Research Paper
Programming peptide-oligonucleotide nano-assembly for engineering of neoantigen vaccine with potent immunogenicity
Zhichu Xiang, Jianhua Lu, Shangrui Rao, Chenxing Fu, Yuying Yao, Yongdong Yi, Yang Ming, Weijian Sun, Weisheng Guo, Xiaoyuan Chen
Theranostics 2024; 14(6): 2290-2303. doi:10.7150/thno.93395
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Review
Extracellular vesicles as carriers of mRNA: Opportunities and challenges in diagnosis and treatment
Robert D. Kirian, Darby Steinman, Christopher M. Jewell, Hannah C. Zierden
Theranostics 2024; 14(5): 2265-2289. doi:10.7150/thno.93115
Abstract Full text PDF PMC


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Research Paper
Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H+-ATPase V0d1 subunit
Wenlin Yuan, Hui Lin, Yuan Sun, Lihuan Liu, Meijuan Yan, Yujuan Song, Xiaofan Zhang, Xiangling Lu, Yipei Xu, Qiyue He, Kunfu Ouyang, Chenglin Zhang, Yong Pan, Yu Huang, Ying Li, Xifeng Lu, Jie Liu
Theranostics 2024; 14(5): 2246-2264. doi:10.7150/thno.93192
Abstract Full text PDF PMC


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Research Paper
Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophages
Yunsheng Liang, Yongfei Hu, Jun Zhang, Haosen Song, Xiaoqian Zhang, Yishan Chen, Yu Peng, Lihua Sun, Yuzhe Sun, Ruzeng Xue, Suyun Ji, Chuanwei Li, Zhili Rong, Bin Yang, Yingping Xu
Theranostics 2024; 14(5): 2232-2245. doi:10.7150/thno.94121
Abstract Full text PDF PMC


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Research Paper
Intravital imaging of splenic classical monocytes modifying the hepatic CX3CR1+ cells motility to exacerbate liver fibrosis via spleen-liver axis
Chenlu Han, Yujie Zhai, Yuke Wang, Xuwen Peng, Xian Zhang, Bolei Dai, Yuehong Leng, Zhihong Zhang, Shuhong Qi
Theranostics 2024; 14(5): 2210-2231. doi:10.7150/thno.87791
Abstract Full text PDF PMC


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Research Paper
G protein subunit alpha i2's pivotal role in angiogenesis
Chao-wen Bai, Lu Lu, Jia-nan Zhang, Chengyu Zhou, Yi-chao Ni, Ke-ran Li, Jin Yao, Xiao-zhong Zhou, Chang-gong Lan, Cong Cao
Theranostics 2024; 14(5): 2190-2209. doi:10.7150/thno.92909
Abstract Full text PDF PMC


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Research Paper
Immunotherapeutic IL-6R and targeting the MCT-1/IL-6/CXCL7/PD-L1 circuit prevent relapse and metastasis of triple-negative breast cancer
Aushia Tanzih Al Haq, Pao-Pao Yang, Christopher Jin, Jou-Ho Shih, Li-Mei Chen, Hong-Yu Tseng, Yen-An Chen, Yueh-Shan Weng, Lu-Hai Wang, Michael P. Snyder, Hsin-Ling Hsu
Theranostics 2024; 14(5): 2167-2189. doi:10.7150/thno.92922
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile



Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.


CFP: Special issue on mRNA-based vaccine and therapy. Guest Editors: Guocan Yu (Tsinghua University, China), Qiaobing Xu (Tufts University, USA), Wei Tao (Harvard Medical School, USA)


The gut microbiota is a crucial component of the intricate microecosystem within the human body that engages in interactions with the host and influences various physiological processes and pathological conditions. In recent years, the association between dysbiosis of the gut microbiota and tumorigenesis has garnered increasing attention, as it is recognized as a hallmark of cancer within the scientific community. However, only a few microorganisms have been identified as potential drivers of tumorigenesis, and enhancing the molecular understanding of this process has substantial scientific importance....
Rationale: Systemic sclerosis (SSc) is a chronic and incurable autoimmune disease with high mortality rates, and skin fibrosis is one of distinguishing hallmarks in the pathogenesis. However, macrophage heterogeneity regulating skin fibrosis remain largely unknown. Methods: We established mouse disease model and performed single-cell RNA-sequencing (scRNA-seq) to resolve the dynamic and heterogenous characteristics of macrophages in skin fibrosis, and the role of TREM2-dependent macrophages in the pathological process was investigated using knockout mice and intraperitoneal transferring TREM2+....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Biogenic Zinc Oxide Nanoparticles synthesized from Tinospora Cordifolia induce oxidative stress, mitochondrial damage and apoptosis in Colorectal Cancer
Hadgu Mendefro Berehu, Srinivas Patnaik
Nanotheranostics 2024; 8(3): 312-329. doi:10.7150/ntno.84995
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