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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


Commentary
Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story
Alessandro Corti, Eugenia Belcastro, Alfonso Pompella
Theranostics 2018; 8(21): 6035-6037. doi:10.7150/thno.29864
[Abstract] [Full text] [PDF]


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Research Paper
Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy
Xiaoqing Meng, Jiali Zhang, Zhihong Sun, Lihua Zhou, Guanjun Deng, Sanpeng Li, Wenjun Li, Ping Gong, Lintao Cai
Theranostics 2018; 8(21): 6025-6034. doi:10.7150/thno.26607
[Abstract] [Full text] [PDF]


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Research Paper
Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery
Mikyung Yu, Carleena A. Ortega, Kevin Si, Roberto Molinaro, Frederick J. Schoen, Renata F. C. Leitao, Xiaoding Xu, Morteza Mahmoudi, Suyeon Ahn, Jerry Liu, Phei Er Saw, In-Hyun Lee, Mirna M. B. Brayner, Azita Lotfi, Jinjun Shi, Peter Libby, Sangyong Jon, Omid C. Farokhzad
Theranostics 2018; 8(21): 6008-6024. doi:10.7150/thno.24365
[Abstract] [Full text] [PDF]


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Research Paper
CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy
Yun-Peng Xie, Song Lai, Qiu-Yue Lin, Xin Xie, Jia-Wei Liao, Hong-Xia Wang, Cui Tian, Hui-Hua Li
Theranostics 2018; 8(21): 5995-6007. doi:10.7150/thno.27706
[Abstract] [Full text] [PDF]


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Research Paper
Chemoresistance Transmission via Exosome-Mediated EphA2 Transfer in Pancreatic Cancer
Jia Fan, Qian Wei, Eugene J Koay, Yang Liu, Bo Ning, Paul W Bernard, Ning Zhang, Haiyong Han, Matthew H Katz, Zhen Zhao, Ye Hu
Theranostics 2018; 8(21): 5986-5994. doi:10.7150/thno.26650
[Abstract] [Full text] [PDF]


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Research Paper
Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis
Meryem Ammari, Jessy Presumey, Clara Ponsolles, Gautier Roussignol, Christine Roubert, Virginie Escriou, Karine Toupet, Anne-Laure Mausset-Bonnefont, Maïlys Cren, Maxime Robin, Philippe Georgel, Ramzi Nehmar, Leonie Taams, Joachim Grün, Andrea Grützkau, Thomas Häupl, Yves-Marie Pers, Christian Jorgensen, Isabelle Duroux-Richard, Gabriel Courties, Florence Apparailly
Theranostics 2018; 8(21): 5972-5985. doi:10.7150/thno.29313
[Abstract] [Full text] [PDF]


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Research Paper
Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice
Xinzhi Li, Linna Jia, Xiaoyue Chen, Ying Dong, Xiaomeng Ren, Yuefan Dong, Ying Chen, Liwei Xie, Ming Liu, Chiyo Shiota, George K. Gittes, Liangyou Rui, Zheng Chen
Theranostics 2018; 8(21): 5960-5971. doi:10.7150/thno.28960
[Abstract] [Full text] [PDF]


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Research Paper
Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin
Zhen-Xiong Zhao, Jie Fu, Shu-Rong Ma, Ran Peng, Jin-Bo Yu, Lin Cong, Li-Bin Pan, Zuo-Guang Zhang, Hui Tian, Chun-Tao Che, Yan Wang, Jian-Dong Jiang
Theranostics 2018; 8(21): 5945-5959. doi:10.7150/thno.28068
[Abstract] [Full text] [PDF]


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Research Paper
Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated blood-brain barrier preservation
Yinong Huang, Jiancheng Wang, Jianye Cai, Yuan Qiu, Haiqing Zheng, Xiaofan Lai, Xin Sui, Yi Wang, Qiying Lu, Yanan Zhang, Meng Yuan, Jin Gong, Wei Cai, Xin Liu, Yilong Shan, Zhezhi Deng, Yue Shi, Yaqing Shu, Lei Zhang, Wei Qiu, Lisheng Peng, Jie Ren, Zhengqi Lu, Andy Peng Xiang
Theranostics 2018; 8(21): 5929-5944. doi:10.7150/thno.28029
[Abstract] [Full text] [PDF]


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Research Paper
Radiomic signature of 18F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits
Yuming Jiang, Qingyu Yuan, Wenbing Lv, Sujuan Xi, Weicai Huang, Zepang Sun, Hao Chen, Liying Zhao, Wei Liu, Yanfeng Hu, Lijun Lu, Jianhua Ma, Tuanjie Li, Jiang Yu, Quanshi Wang, Guoxin Li
Theranostics 2018; 8(21): 5915-5928. doi:10.7150/thno.28018
[Abstract] [Full text] [PDF]


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Research Paper
Dual-Modality ImmunoPET/Fluorescence Imaging of Prostate Cancer with an Anti-PSCA Cys-Minibody
Wenting K Tsai, Kirstin A Zettlitz, Richard Tavaré, Naoko Kobayashi, Robert E Reiter, Anna M Wu
Theranostics 2018; 8(21): 5903-5914. doi:10.7150/thno.27679
[Abstract] [Full text] [PDF]


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Research Paper
BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1
Panpan Zhang, Shaolei Li, Chao Lv, Jiahui Si, Ying Xiong, Lieming Ding, Yuanyuan Ma, Yue Yang
Theranostics 2018; 8(21): 5890-5902. doi:10.7150/thno.27667
[Abstract] [Full text] [PDF]


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Research Paper
Radiation-responsive scintillating nanotheranostics for reduced hypoxic radioresistance under ROS/NO-mediated tumor microenvironment regulation
Yan Dou, Yajuan Liu, Fangshi Zhao, Yanyan Guo, Xue Li, Menglin Wu, Jin Chang, Chunshui Yu
Theranostics 2018; 8(21): 5870-5889. doi:10.7150/thno.27351
[Abstract] [Full text] [PDF]


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Research Paper
A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p
Mengyang Li, Wei Ding, Muhammad Akram Tariq, Wenguang Chang, Xuejuan Zhang, Wenhua Xu, Lin Hou, Yifei Wang, Jianxun Wang
Theranostics 2018; 8(21): 5855-5869. doi:10.7150/thno.27285
[Abstract] [Full text] [PDF]


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Research Paper
Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
Sean P. Arlauckas, Seth B. Garren, Chris S. Garris, Rainer H. Kohler, Juhyun Oh, Mikael J. Pittet, Ralph Weissleder
Theranostics 2018; 8(21): 5842-5854. doi:10.7150/thno.26888
[Abstract] [Full text] [PDF]


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Research Paper
Remote loading of liposomes with a 124I-radioiodinated compound and their in vivo evaluation by PET/CT in a murine tumor model
Gokce Engudar, Henrik Schaarup-Jensen, Frederikke P. Fliedner, Anders E. Hansen, Paul Kempen, Rasmus I. Jølck, Andreas Kjæer, Thomas L. Andresen, Mads H. Clausen, Andreas I. Jensen, Jonas R. Henriksen
Theranostics 2018; 8(21): 5828-5841. doi:10.7150/thno.26706
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

Managing Editor position available in Theranostics.

Nanotheranostics in PubMed Central. Submit manuscript now...

Cover image
Most Cited Paper Award for year 2016: Winners of this year are Lian Jin, Xin Zeng, Ming Liu, Yan Deng, Nongyue He, for the paper "Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers". Details ...

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
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