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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

Latest articles:


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Research Paper
HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery
Lingling Geng, Zihua Wang, Xiangqian Jia, Qiuju Han, Zhichu Xiang, Dan Li, Xiaoliang Yang, Di Zhang, Xiangli Bu, Weizhi Wang, Zhiyuan Hu, Qiaojun Fang
Theranostics 2016; 6(8): 1261-1273. doi:10.7150/thno.14302
[Abstract] [Full text] [PDF]


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Research Paper
Mitochondrial Transplantation Attenuates Airway Hyperresponsiveness by Inhibition of Cholinergic Hyperactivity
Yuan Su, Liping Zhu, Xiangyuan Yu, Lei Cai, Yankai Lu, Jiwei Zhang, Tongfei Li, Jiansha Li, Jingyan Xia, Feng Xu, Qinghua Hu
Theranostics 2016; 6(8): 1244-1260. doi:10.7150/thno.13804
[Abstract] [Full text] [PDF]


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Research Paper
Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway
Pengfei Ma, Yujie Fu, Minjiang Chen, Ying Jing, Jie Wu, Ke Li, Ying Shen, Jian-Xin Gao, Mengzhao Wang, Xiaojing Zhao, Guanglei Zhuang
Theranostics 2016; 6(8): 1232-1243. doi:10.7150/thno.14409
[Abstract] [Full text] [PDF]


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Research Paper
18F-DPA-714 PET Imaging for Detecting Neuroinflammation in Rats with Chronic Hepatic Encephalopathy
Xiang Kong, Song Luo, Jin Rong Wu, Shawn Wu, Carlo N. De Cecco, U. Joseph Schoepf, Adam J. Spandorfer, Chun Yan Wang, Ying Tian, Hui Juan Chen, Guang Ming Lu, Gui Fen Yang, Long Jiang Zhang
Theranostics 2016; 6(8): 1220-1231. doi:10.7150/thno.15362
[Abstract] [Full text] [PDF]


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Research Paper
Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling
Cun Wang, Haojie Jin, Ning Wang, Shaohua Fan, Yanyan Wang, Yurong Zhang, Lin Wei, Xuemei Tao, Dishui Gu, Fangyu Zhao, Jingyuan Fang, Ming Yao, Wenxin Qin
Theranostics 2016; 6(8): 1205-1219. doi:10.7150/thno.15083
[Abstract] [Full text] [PDF]


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Research Paper
Improvement of Prostate Cancer Diagnosis by Detecting PSA Glycosylation-Specific Changes
Esther Llop, Montserrat Ferrer-Batallé, Sílvia Barrabés, Pedro Enrique Guerrero, Manel Ramírez, Radka Saldova, Pauline M. Rudd, Rosa N. Aleixandre, Josep Comet, Rafael de Llorens, Rosa Peracaula
Theranostics 2016; 6(8): 1190-1204. doi:10.7150/thno.15226
[Abstract] [Full text] [PDF]


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Research Paper
Polymer-DNA Nanoparticle-Induced CXCR4 Overexpression Improves Stem Cell Engraftment and Tissue Regeneration in a Mouse Hindlimb Ischemia Model
Lorenzo Deveza, Jeffrey Choi, Jerry Lee, Ngan Huang, John Cooke, Fan Yang
Theranostics 2016; 6(8): 1176-1189. doi:10.7150/thno.12866
[Abstract] [Full text] [PDF]


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Research Paper
Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications
Huai-Qiang Ju, Yun-Xin Lu, Dong-Liang Chen, Tian Tian, Hai-Yu Mo, Xiao-Li Wei, Jian-Wei Liao, Feng Wang, Zhao-Lei Zeng, Helene Pelicano, Mitzi Aguilar, Wei-Hua Jia, Rui-Hua Xu
Theranostics 2016; 6(8): 1160-1175. doi:10.7150/thno.14848
[Abstract] [Full text] [PDF]


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Research Paper
Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase
Lu Wang, Wakana Mori, Ran Cheng, Joji Yui, Akiko Hatori, Longle Ma, Yiding Zhang, Benjamin H. Rotstein, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Yuji Nagai, Takafumi Minamimoto, Makoto Higuchi, Neil Vasdev, Ming-Rong Zhang, Steven H. Liang
Theranostics 2016; 6(8): 1145-1159. doi:10.7150/thno.15257
[Abstract] [Full text] [PDF]


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Research Paper
Photodynamic Therapy Induced Enhancement of Tumor Vasculature Permeability Using an Upconversion Nanoconstruct for Improved Intratumoral Nanoparticle Delivery in Deep Tissues
Weidong Gao, Zhaohui Wang, Liwei Lv, Deyan Yin, Dan Chen, Zhihao Han, Yi Ma, Min Zhang, Man Yang, Yueqing Gu
Theranostics 2016; 6(8): 1131-1144. doi:10.7150/thno.15262
[Abstract] [Full text] [PDF]


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Research Paper
Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model
Aranzazu Villasante, Alessandro Marturano-Kruik, Srikanth R. Ambati, Zen Liu, Amandine Godier-Furnemont, Hesam Parsa, Benjamin W. Lee, Malcolm A.S. Moore, Gordana Vunjak-Novakovic
Theranostics 2016; 6(8): 1119-1130. doi:10.7150/thno.13944
[Abstract] [Full text] [PDF]


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Research Paper
MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma
Alessia Lo Dico, Viviana Costa, Cristina Martelli, Cecilia Diceglie, Francesca Rajata, Aroldo Rizzo, Carmine Mancone, Marco Tripodi, Luisa Ottobrini, Riccardo Alessandro, Alice Conigliaro
Theranostics 2016; 6(8): 1105-1118. doi:10.7150/thno.14700
[Abstract] [Full text] [PDF]


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Research Paper
Fabrication of Graphene and AuNP Core Polyaniline Shell Nanocomposites as Multifunctional Theranostic Platforms for SERS Real-time Monitoring and Chemo-photothermal Therapy
Haolin Chen, Zhiming Liu, Songyang Li, Chengkang Su, Xuejun Qiu, Huiqing Zhong, Zhouyi Guo
Theranostics 2016; 6(8): 1096-1104. doi:10.7150/thno.14361
[Abstract] [Full text] [PDF]


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Research Paper
Design of Internalizing PSMA-specific Glu-ureido-based Radiotherapeuticals
Till Wüstemann, Ulrike Bauder-Wüst, Martin Schäfer, Matthias Eder, Martina Benesova, Karin Leotta, Clemens Kratochwil, Uwe Haberkorn, Klaus Kopka, Walter Mier
Theranostics 2016; 6(8): 1085-1095. doi:10.7150/thno.13448
[Abstract] [Full text] [PDF]


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Research Paper
High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe
Ruimin Huang, Stefan Harmsen, Jason M. Samii, Hazem Karabeber, Kenneth L. Pitter, Eric C. Holland, Moritz F. Kircher
Theranostics 2016; 6(8): 1075-1084. doi:10.7150/thno.13842
[Abstract] [Full text] [PDF]


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Research Paper
Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells
Hao Su, Pengcheng Zhang, Andrew G Cheetham, Jin Mo Koo, Ran Lin, Asad Masood, Paula Schiapparelli, Alfredo Quiñones-Hinojosa, Honggang Cui
Theranostics 2016; 6(7): 1065-1074. doi:10.7150/thno.15420
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile
new Impact factor is 8.022, according to 2015 release of Journal Citation Reports®. Congratulations!

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Most Cited Paper Award: Winners of this year are Mi Kyung Yu, Jinho Park, Sangyong Jon. A certificate and $US 1000 have been issued. Details ...
Theme Issue on “Light-Mediated Deep-Tissue Theranostics. Guest Editors: Dr. Gang Han, University of Massachusetts Medical School, and Dr. Jin Xie, University of Georgia
new Congratulations to Dr. Chen for receiving the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.
NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues