Cover image

Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


toc.jpg

Research Paper
Silk Fibroin-Coated Nanoagents for Acidic Lysosome Targeting by a Functional Preservation Strategy in Cancer Chemotherapy
Mixiao Tan, Weiwei Liu, Fengqiu Liu, Wei Zhang, Hui Gao, Juan Cheng, Yu Chen, Zhigang Wang, Yang Cao, Haitao Ran
Theranostics 2019; 9(4): 961-973. doi:10.7150/thno.30765
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways
Meng Ma, Jie Dai, Huan Tang, Tianxiao Xu, Sifan Yu, Lu Si, Chuanliang Cui, Xinan Sheng, Zhihong Chi, Lili Mao, Xiaowen Wu, Lu Yang, Huan Yu, Siming Li, Bin Lian, Bixiang Tang, Xuan Wang, Xieqiao Yan, Xue Bai, Li Zhou, Yan Kong, Jun Guo
Theranostics 2019; 9(4): 945-960. doi:10.7150/thno.30516
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Quantitative MALDI Imaging of Spatial Distributions and Dynamic Changes of Tetrandrine in Multiple Organs of Rats
Weiwei Tang, Jun Chen, Jie Zhou, Junyue Ge, Ying Zhang, Ping Li, Bin Li
Theranostics 2019; 9(4): 932-944. doi:10.7150/thno.30408
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Serum miR-626 and miR-5100 are Promising Prognosis Predictors for Oral Squamous Cell Carcinoma
Jianbo Shi, Xin Bao, Zengying Liu, Zhiyuan Zhang, Wantao Chen, Qin Xu
Theranostics 2019; 9(4): 920-931. doi:10.7150/thno.30339
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
CircHMGCS1 Promotes Hepatoblastoma Cell Proliferation by Regulating the IGF Signaling Pathway and Glutaminolysis
Ni Zhen, Song Gu, Ji Ma, Jiabei Zhu, Minzhi Yin, Min Xu, Jing Wang, Nan Huang, Zhongqi Cui, Zhixuan Bian, Fenyong Sun, Qiuhui Pan
Theranostics 2019; 9(3): 900-919. doi:10.7150/thno.29515
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Nanoparticle Binding to Urokinase Receptor on Cancer Cell Surface Triggers Nanoparticle Disintegration and Cargo Release
Shijie Li, Cai Yuan, Jincan Chen, Dan Chen, Zhuo Chen, Wenlie Chen, Shufeng Yan, Ping Hu, Jinping Xue, Rui Li, Ke Zheng, Mingdong Huang
Theranostics 2019; 9(3): 884-899. doi:10.7150/thno.29445
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Radioembolization of Hepatocellular Carcinoma with Built-In Dosimetry: First in vivo Results with Uniformly-Sized, Biodegradable Microspheres Labeled with 188Re
José Carlos De La Vega, Pedro Luis Esquinas, Cristina Rodríguez-Rodríguez, Mehrdad Bokharaei, Igor Moskalev, David Liu, Katayoun Saatchi, Urs O. Häfeli
Theranostics 2019; 9(3): 868-883. doi:10.7150/thno.29381
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Monoclonal Antibody against CXCL1 (HL2401) as a Novel Agent in Suppressing IL6 Expression and Tumoral Growth
Makito Miyake, Hideki Furuya, Sayuri Onishi, Kanani Hokutan, Satoshi Anai, Owen Chan, Sixiang Shi, Kiyohide Fujimoto, Steve Goodison, Weibo Cai, Charles J. Rosser
Theranostics 2019; 9(3): 853-867. doi:10.7150/thno.29553
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Anti-EGF Receptor Aptamer-Guided Co-Delivery of Anti-Cancer siRNAs and Quantum Dots for Theranostics of Triple-Negative Breast Cancer
Min Woo Kim, Hwa Yeon Jeong, Seong Jae Kang, In Ho Jeong, Moon Jung Choi, Young Myoung You, Chan Su Im, In Ho Song, Tae Sup Lee, Jin Suk Lee, Aeju Lee, Yong Serk Park
Theranostics 2019; 9(3): 837-852. doi:10.7150/thno.30228
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
On the Lipophilic Nature of Autoreactive IgE in Chronic Spontaneous Urticaria
Elisa Lakin, Martin K. Church, Marcus Maurer, Oliver Schmetzer
Theranostics 2019; 9(3): 829-836. doi:10.7150/thno.29902
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog
Junxia Cao, Min Zhao, Jian Liu, Xueying Zhang, Yujun Pei, Jingyang Wang, Xiao Yang, Beifen Shen, Jiyan Zhang
Theranostics 2019; 9(3): 811-828. doi:10.7150/thno.29271
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway
Yin-Li Zheng, Lei Li, Yong-Xun Jia, Bao-Zhu Zhang, Jiang-Chao Li, Ying-Hui Zhu, Meng-Qing Li, Jiao-Zi He, Ting-Ting Zeng, Xiao-Jiao Ban, Yun-Fei Yuan, Yan Li, Xin-Yuan Guan
Theranostics 2019; 9(3): 796-810. doi:10.7150/thno.28992
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Targeted Drug Delivery and Image-Guided Therapy of Heterogeneous Ovarian Cancer Using HER2-Targeted Theranostic Nanoparticles
Minati Satpathy, Liya Wang, Rafal J. Zielinski, Weiping Qian, Y. Andrew Wang, Aaron M. Mohs, Brad A. Kairdolf, Xin Ji, Jacek Capala, Malgorzata Lipowska, Shuming Nie, Hui Mao, Lily Yang
Theranostics 2019; 9(3): 778-795. doi:10.7150/thno.29964
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer
Yong Yu, Jingjing Qi, Jieyi Xiong, Liping Jiang, Di Cui, Junlin He, Ping Chen, Lianjie Li, Chenjie Wu, Tonghui Ma, Su Shao, Jianjun Wang, Dansong Yu, Bing Zhou, Dongsheng Huang, Clemens A. Schmitt, Ran Tao
Theranostics 2019; 9(3): 761-777. doi:10.7150/thno.29520
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Lectin-Mediated pH-Sensitive Doxorubicin Prodrug for Pre-Targeted Chemotherapy of Colorectal Cancer with Enhanced Efficacy and Reduced Side Effects
Meinan Yao, Xiaotu Ma, Xin Zhang, Linqing Shi, Tianyu Liu, Xiaolong Liang, Huiyun Zhao, Xiaoda Li, Liqiang Li, Hannan Gao, Bing Jia, Fan Wang
Theranostics 2019; 9(3): 747-760. doi:10.7150/thno.29989
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Spatial Distribution of Motor Endplates and its Adaptive Change in Skeletal Muscle
Xiaofeng Yin, Tingting Yu, Bo Chen, Jianyi Xu, Wentao Chen, Yisong Qi, Peixun Zhang, Yusha Li, Yuhui Kou, Yilin Ma, Na Han, Peng Wan, Qingming Luo, Dan Zhu, Baoguo Jiang
Theranostics 2019; 9(3): 734-746. doi:10.7150/thno.28729
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD, Chief, Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH*
* Dr. Chen is serving in his personal capacity.
Editor-in-chief profile

newNanotheranostics is indexed in MEDLINE and PubMed Central. Submit manuscript now... Congratulations to Dr. Moritz F. Kircher who has been appointed Chair of the Department of Imaging and Radiology, Dana-Farber Cancer Institute, Harvard Medical School.

new CFP - Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues