Theranostics
2012; 2(2):148-155.
doi:10.7150/thno.4077 This issueCite
Review
Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
Howard H. Chen1,2, Hushan Yuan3, Lee Josephson1,3, David E. Sosnovik1,2✉
1. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA 2. Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston MA 3. Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA
✉ Corresponding author: David E. Sosnovik. 149 13th Street, Charlestown MA 02129 617 724-3407; sosnovikmgh.harvard.edu
Citation:
Chen HH, Yuan H, Josephson L, Sosnovik DE. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics 2012; 2(2):148-155. doi:10.7150/thno.4077. https://www.thno.org/v02p0148.htm
Several signaling cascades are involved in cell death, with a significant amount of crosstalk between them. Despite the complexity of these cascades several key pro-survival and pro-death players have been identified. These include PI3-kinase, AKT and caspase-3. Here we review the approaches used to date to perform molecular imaging of these important targets. We focus in particular on approaches that include the possibility of modulating the activity of these kinases and proteases in a theranostic approach.
Chen, H.H., Yuan, H., Josephson, L., Sosnovik, D.E. (2012). Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics, 2(2), 148-155. https://doi.org/10.7150/thno.4077.
ACS
Chen, H.H.; Yuan, H.; Josephson, L.; Sosnovik, D.E. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics 2012, 2 (2), 148-155. DOI: 10.7150/thno.4077.
NLM
Chen HH, Yuan H, Josephson L, Sosnovik DE. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics 2012; 2(2):148-155. doi:10.7150/thno.4077. https://www.thno.org/v02p0148.htm
CSE
Chen HH, Yuan H, Josephson L, Sosnovik DE. 2012. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics. 2(2):148-155.