Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Theranostics 2014; 4(1):36-46. doi:10.7150/thno.7143 This issue Cite

Research Paper

Intravascular Photoacoustics for Image-Guidance and Temperature Monitoring During Plasmonic Photothermal Therapy of Atherosclerotic Plaques: A Feasibility Study

Doug Yeager1, Yun-Sheng Chen1, 2, Silvio Litovsky3, Stanislav Emelianov1, 2✉

1. Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA 78712;
2. Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX, USA 78712;
3. Department of Pathology, University of Alabama Birmingham, Birmingham, AL, USA 35249.

✉ Corresponding author: emelianutexas.edu.

Citation:
Yeager D, Chen YS, Litovsky S, Emelianov S. Intravascular Photoacoustics for Image-Guidance and Temperature Monitoring During Plasmonic Photothermal Therapy of Atherosclerotic Plaques: A Feasibility Study. Theranostics 2014; 4(1):36-46. doi:10.7150/thno.7143. https://www.thno.org/v04p0036.htm
Other styles

File import instruction

Abstract

Recently, combined intravascular ultrasound and photoacoustic (IVUS/IVPA) imaging has been demonstrated as a novel imaging modality capable of visualizing both morphology (via IVUS) and cellular/molecular composition (via IVPA) of atherosclerotic plaques, using both endogenous tissue absorbers and exogenous contrast agents. Plasmonic gold nanoparticles were previously utilized as IVPA contrast agents which co-localize with atherosclerotic plaques, particularly phagocytically active macrophages. The present work demonstrates the use of IVUS/IVPA imaging as a tool for localized temperature monitoring during laser heating. The temperature dependent change in IVPA signal intensity of silica-coated gold nanorod contrast agents absorbing within the near-infrared optical wavelength range is evaluated and shown to have a linear relationship, with a slope greater than that of endogenous tissue. A continuous wave laser was subsequently incorporated into the IVUS/IVPA integrated catheter and utilized to selectively heat the nanoparticles with simultaneous IVPA temperature monitoring. IVUS/IVPA, therefore, provides a platform for detection and temperature monitoring of atherosclerotic plaques through the selective heating of plasmonic gold nanoparticle contrast agents.

Keywords: photoacoustic, atherosclerosis, gold nanorods, photothermal, temperature monitoring, intravascular.

Citation styles

APA
Yeager, D., Chen, Y.S., Litovsky, S., Emelianov, S. (2014). Intravascular Photoacoustics for Image-Guidance and Temperature Monitoring During Plasmonic Photothermal Therapy of Atherosclerotic Plaques: A Feasibility Study. Theranostics, 4(1), 36-46. https://doi.org/10.7150/thno.7143.

ACS
Yeager, D.; Chen, Y.S.; Litovsky, S.; Emelianov, S. Intravascular Photoacoustics for Image-Guidance and Temperature Monitoring During Plasmonic Photothermal Therapy of Atherosclerotic Plaques: A Feasibility Study. Theranostics 2014, 4 (1), 36-46. DOI: 10.7150/thno.7143.

NLM
Yeager D, Chen YS, Litovsky S, Emelianov S. Intravascular Photoacoustics for Image-Guidance and Temperature Monitoring During Plasmonic Photothermal Therapy of Atherosclerotic Plaques: A Feasibility Study. Theranostics 2014; 4(1):36-46. doi:10.7150/thno.7143. https://www.thno.org/v04p0036.htm

CSE
Yeager D, Chen YS, Litovsky S, Emelianov S. 2014. Intravascular Photoacoustics for Image-Guidance and Temperature Monitoring During Plasmonic Photothermal Therapy of Atherosclerotic Plaques: A Feasibility Study. Theranostics. 4(1):36-46.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use