Theranostics 2017; 7(2):425-435. doi:10.7150/thno.17073

Research Paper

Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action

Xiao-yu Ai1*, Hui-juan Liu2*, Cheng Lu1,2*, Cai-li Liang1, 2*, Yan Sun3*, Shuang Chen2, Bo Sun2, Yang Li1, 2, Yan-rong Liu2, Qiang Zhang1, 2*, Xue-qiang Liu1, 2, Ting Xiao1, 2, Xue-shuang Jing2, Tao Sun1,2✉, Hong-gang Zhou1,2✉, Cheng Yang1,2✉

1. State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China;
2. Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China;
3. Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China.
* Contributed equally to this study.

Abstract

Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enrichment in animals. Furthermore, PnAg could upregulate the promoter activity of Jak, Stat3, and Stat3 downstream proteins. Therefore, PnAg may serve as an effective therapeutic compound for wound healing through regulating the gp130/Jak/Stat3 signaling pathway.

Keywords: Nanometer, phenytoin, wound healing, inflammation, Stat3.

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How to cite this article:
Ai Xy, Liu Hj, Lu C, Liang Cl, Sun Y, Chen S, Sun B, Li Y, Liu Yr, Zhang Q, Liu Xq, Xiao T, Jing Xs, Sun T, Zhou Hg, Yang C. Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action. Theranostics 2017; 7(2):425-435. doi:10.7150/thno.17073. Available from http://www.thno.org/v07p0425.htm