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Theranostics 2017; 7(3):614-623. doi:10.7150/thno.17381 This issue Cite

Research Paper

Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer

Longlong Tian1,2‡, Qian Chen2‡, Xuan Yi1, Guanglin Wang1, Jie Chen1, Ping Ning1, Kai Yang1✉, Zhuang Liu2✉

1. School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu, 215123, China
2. Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China
‡These authors contributed equally to this work

✉ Corresponding author: kyangedu.cn, zliuedu.cn

Citation:
Tian L, Chen Q, Yi X, Wang G, Chen J, Ning P, Yang K, Liu Z. Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer. Theranostics 2017; 7(3):614-623. doi:10.7150/thno.17381. https://www.thno.org/v07p0614.htm
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Abstract

Graphic abstract

Development of biocompatible/biodegradable materials with multiple functionalities via simple methods for cancer combination therapy has attracted great attention in recent years. Herein, paclitaxel (PTX), a popular anti-tumor chemotherapeutic drug, is used to induce the self-assembly of human serum albumin (HSA) pre-labeled with radionuclide I-131, obtaining 131I-HSA-PTX nanoparticles for combined chemotherapy and radioisotope therapy (RIT) of cancer. Such 131I-HSA-PTX nanoparticles show prolonged blood circulation time, high tumor specific uptake and excellent intra-tumor penetration ability. Interestingly, as revealed by in vivo photoacoustic imaging and ex vivo immunofluorescence staining, PTX delivered into the tumor by HSA-nanoparticle transportation can remarkably enhance the tumor local oxygen level and suppress the expression of HIF-1α, leading to greatly relieved tumor hypoxia. As the results, the combined in vivo chemotherapy & RIT with 131I-HSA-PTX nanoparticles in the animal tumor model offers excellent synergistic therapeutic efficacy, likely owing to the greatly modulated tumor microenvironment associated with PTX-based chemotherapy. Therefore, in this work, a simple yet effective therapeutic agent is developed for synergistic chemo-RIT of cancer, promising for future clinic translations in cancer treatment.

Keywords: albumin, paclitaxel, radioisotope therapy, chemotherapy, hypoxia

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APA
Tian, L., Chen, Q., Yi, X., Wang, G., Chen, J., Ning, P., Yang, K., Liu, Z. (2017). Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer. Theranostics, 7(3), 614-623. https://doi.org/10.7150/thno.17381.

ACS
Tian, L.; Chen, Q.; Yi, X.; Wang, G.; Chen, J.; Ning, P.; Yang, K.; Liu, Z. Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer. Theranostics 2017, 7 (3), 614-623. DOI: 10.7150/thno.17381.

NLM
Tian L, Chen Q, Yi X, Wang G, Chen J, Ning P, Yang K, Liu Z. Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer. Theranostics 2017; 7(3):614-623. doi:10.7150/thno.17381. https://www.thno.org/v07p0614.htm

CSE
Tian L, Chen Q, Yi X, Wang G, Chen J, Ning P, Yang K, Liu Z. 2017. Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer. Theranostics. 7(3):614-623.

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