Theranostics 2017; 7(7):1966-1975. doi:10.7150/thno.16866

Research Paper

Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart

Wenshuo Wang1*, Hongyue Tao4*, Yun Zhao1, Xiaotian Sun5*, Jing Tang2, Cordelia Selomulya3, Jia Tang6, Tianchan Chen6, Yang Wang3, Minglei Shu6, Lei Wei6, Guanyu Yi6, Jixue Zhou6, Lai Wei1✉, Chunsheng Wang1, Biao Kong7✉

1. Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China
2. Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
3. Department of Chemical Engineering, Monash University, Clayton, Victoria 3800, Australia
4. Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China
5. Department of Cardiothoracic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China
6. National Supercomputer Research Center of Advanced Materials, Shandong Key Laboratory for High Strength Lightweight Metallic Materials, Advanced Materials Institute, Shandong Academy of Sciences, Jinan 250014, P. R. China
7. Department of Chemistry, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China
* These authors contributed equally to this study

Abstract

The construction, characterization and surgical application of a multilayered iron oxide-based macroporous composite framework were reported in this study. The framework consisted of a highly porous iron oxide core, a gelatin-based hydrogel intermediary layer and a matrigel outer cover, which conferred a multitude of desirable properties including excellent biocompatibility, improved mechanical strength and controlled biodegradability. The large pore sizes and high extent of pore interconnectivity of the framework stimulated robust neovascularization and resulted in substantially better cell viability and proliferation as a result of improved transport efficiency for oxygen and nutrients. In addition, rat models with myocardial infraction showed sustained heart tissue regeneration over the infract region and significant improvement of cardiac functions following the surgical implantation of the framework. These results demonstrated that the current framework might hold great potential for cardiac repair in patients with myocardial infraction.

Keywords: macroporous frameworks, vasculature, stem cell, blood iron pool, cardiac repair.

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How to cite this article:
Wang W, Tao H, Zhao Y, Sun X, Tang J, Selomulya C, Tang J, Chen T, Wang Y, Shu M, Wei L, Yi G, Zhou J, Wei L, Wang C, Kong B. Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart. Theranostics 2017; 7(7):1966-1975. doi:10.7150/thno.16866. Available from http://www.thno.org/v07p1966.htm