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Theranostics 2017; 7(10):2555-2564. doi:10.7150/thno.19851 This issue Cite

Research Paper

Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest

Yvan Devaux1✉, Antonio Salgado-Somoza1, Josef Dankiewicz2, Adeline Boileau1, Pascal Stammet3, Anna Schritz4, Lu Zhang1, Mélanie Vausort1, Patrik Gilje2, David Erlinge2, Christian Hassager5, Matthew P. Wise6, Michael Kuiper7, Hans Friberg8, Niklas Nielsen9, the TTM-trial investigators On behalf of the Cardiolinc™ network

1. Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg;
2. Department of Cardiology, Clinical Sciences, Lund University and Skane University Hospital, Lund, Sweden;
3. Department of Anaesthesia and Intensive Care Medicine, Centre Hospitalier de Luxembourg, Luxembourg;
4. Competence Centre for Methodology and Statistics, Luxembourg Institute of Health, Luxembourg;
5. Department of Cardiology B, The Heart Centre, Rigshospitalet University Hospital, Copenhagen, Denmark;
6. Department of Intensive Care, University Hospital of Wales, Cardiff, United Kingdom;
7. Department of Intensive Care, Leeuwarden Medical Centrum, Leeuwarden, The Netherlands;
8. Department of Anesthesia and Intensive Care, Clinical Sciences, Lund University and Skane University Hospital, Lund, Sweden;
9. Department of Anesthesia and Intensive Care, Clinical Sciences, Lund University and Helsingborg Hospital, Helsingborg, Sweden.

✉ Corresponding author: Yvan Devaux, Cardiovascular Research Unit, Luxembourg Institute of Health (L.I.H.), L1526 Luxembourg. Tel: +352 26970300. Fax: +352 26970396. Email: yvan.devauxlu

Citation:
Devaux Y, Salgado-Somoza A, Dankiewicz J, Boileau A, Stammet P, Schritz A, Zhang L, Vausort M, Gilje P, Erlinge D, Hassager C, Wise MP, Kuiper M, Friberg H, Nielsen N, the TTM-trial investigators. Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest. Theranostics 2017; 7(10):2555-2564. doi:10.7150/thno.19851. https://www.thno.org/v07p2555.htm
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Abstract

Graphic abstract

Rationale. The value of microRNAs (miRNAs) as biomarkers has been addressed in various clinical contexts. Initial studies suggested that miRNAs, such as the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest. The aim of this study is to determine the prognostic value of miR-122-5p in a large cohort of comatose survivors of out-of-hospital cardiac arrest.

Methods. We analyzed 590 patients from the Targeted Temperature Management trial (TTM-trial). Circulating levels of miR-122-5p were measured in serum samples obtained 48 hours after return of spontaneous circulation. The primary end-point was poor neurological outcome at 6 months evaluated by the cerebral performance category score. The secondary end-point was survival at the end of the trial.

Results. Forty-eight percent of patients had a poor neurological outcome at 6 months and 43% were dead at the end of the trial. Levels of miR-122-5p were lower in patients with poor neurological outcome compared to patients with good neurological outcome (p<0.001), independently of targeted temperature management regimen. Levels of miR-122-5p were significant univariate predictors of neurological outcome (odds ratios (OR), 95% confidence intervals (CI): 0.71 [0.57-0.88]). In multivariable analyses, miR-122-5p was an independent predictor of neurological outcome and improved the predictive value of a clinical model including miR-124-3p (integrated discrimination improvement of 0.03 [0.02-0.04]). In Cox proportional hazards models, miR-122-5p was a significant predictor of survival at the end of the trial.

Conclusion. Circulating levels of miR-122-5p improve the prediction of outcome after out-of-hospital cardiac arrest.

Keywords: microRNAs, biomarker, prognostic, cardiac arrest, neurological function.

Citation styles

APA
Devaux, Y., Salgado-Somoza, A., Dankiewicz, J., Boileau, A., Stammet, P., Schritz, A., Zhang, L., Vausort, M., Gilje, P., Erlinge, D., Hassager, C., Wise, M.P., Kuiper, M., Friberg, H., Nielsen, N., the TTM-trial investigators (2017). Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest. Theranostics, 7(10), 2555-2564. https://doi.org/10.7150/thno.19851.

ACS
Devaux, Y.; Salgado-Somoza, A.; Dankiewicz, J.; Boileau, A.; Stammet, P.; Schritz, A.; Zhang, L.; Vausort, M.; Gilje, P.; Erlinge, D.; Hassager, C.; Wise, M.P.; Kuiper, M.; Friberg, H.; Nielsen, N.; the TTM-trial investigators Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest. Theranostics 2017, 7 (10), 2555-2564. DOI: 10.7150/thno.19851.

NLM
Devaux Y, Salgado-Somoza A, Dankiewicz J, Boileau A, Stammet P, Schritz A, Zhang L, Vausort M, Gilje P, Erlinge D, Hassager C, Wise MP, Kuiper M, Friberg H, Nielsen N, the TTM-trial investigators. Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest. Theranostics 2017; 7(10):2555-2564. doi:10.7150/thno.19851. https://www.thno.org/v07p2555.htm

CSE
Devaux Y, Salgado-Somoza A, Dankiewicz J, Boileau A, Stammet P, Schritz A, Zhang L, Vausort M, Gilje P, Erlinge D, Hassager C, Wise MP, Kuiper M, Friberg H, Nielsen N, the TTM-trial investigators. 2017. Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest. Theranostics. 7(10):2555-2564.

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