Theranostics 2019; 9(4):1015-1028. doi:10.7150/thno.30853

Review

Design strategies and application progress of therapeutic exosomes

Chunying Liu, Changqing Su

Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center for Liver Cancer, Second Military Medical University, Shanghai 200438, China

Abstract

Exosomes have great potential to be drug delivery vehicles due to their natural material transportation properties, intrinsic long-term circulatory capability, and excellent biocompatibility, which are suitable for delivering a variety of chemicals, proteins, nucleic acids, and gene therapeutic agents. However, an effective method of loading specific protein agents into exosomes for absorption by target cells is still lacking. The application potential of exosome is still limited. In this review, we discussed the methods for loading specific treating molecules (proteins, nucleic acids and small chemicals) into exosomes, the design strategies for cell and tissue targeting, and the factors for exosome formation. This review can be used as a reference for further research as well as for the development of therapeutic exosomes.

Keywords: exosome, drug carrier, therapeutic strategy

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Liu C, Su C. Design strategies and application progress of therapeutic exosomes. Theranostics 2019; 9(4):1015-1028. doi:10.7150/thno.30853. Available from http://www.thno.org/v09p1015.htm