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Theranostics 2020; 10(25):11656-11672. doi:10.7150/thno.51287 This issue Cite

Research Paper

Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow

Beibei Shan, Haitao Wang, Linhu Li, Guangzhi Zhou, Yu Wen, Mingyang Chen, Ming Li^✉

School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, China.

✉ Corresponding author: E-mails: liming0823edu.cn; liming0823com.

Abstract

NIR-II plasmonic materials offer multiple functionalities for in vivo biomedical applications, such as photothermal tumor ablation, surface-enhanced Raman scattering biosensing, photoacoustic imaging, and drug carriers. However, integration of noble metals and plasmonic semiconductors is greatly challenging because of the large lattice-mismatch. This study reports the regioselective overgrowth of Cu_2-xSe on gold nanorods (GNRs) for preparation of dual-plasmonic GNR@Cu_2-xSe hybrid heterostructures with tunable NIR-II plasmon resonance absorption for in vivo photothermal tumor ablation.

Methods: The regioselective deposition of amorphous Se and its subsequent conversion into Cu_2-xSe on the GNRs are performed by altering capping agents to produce the GNR@Cu_2-xSe heterostructures of various morphologies. Their photothermal performances for NIR-II photothermal tumor ablation are evaluated both in vitro and in vivo.

Results: We find that the lateral one- and two-side deposition, conformal core-shell coating and island growth of Cu_2-xSe on the GNRs can be achieved using different capping agents. The Cu_2-xSe domain size in these hybrids can be effectively adjusted by the SeO₂ concentration, thereby tuning the NIR-II plasmon bands. A photothermal conversion efficiency up to 58-85% and superior photostability of these dual-plasmonic hybrids can be achieved under the NIR-II laser. Results also show that the photothermal conversion efficiency is dependent on the proportion of optical absorption converted into heat; however, the temperature rise is tightly related to the concentration of their constituents. The excellent NIR-II photothermal effect is further verified in the following in vitro and in vivo experiments.

Conclusions: This study achieves one-side or two-side deposition, conformal core-shell coating, and island deposition of Cu_2-xSe on GNRs for GNR@Cu_2-xSe heterostructures with NIR-II plasmonic absorption, and further demonstrates their excellent NIR-II photothermal tumor ablation in vivo. This study provides a promising strategy for the rational design of NIR-II dual-plasmonic heterostructures and highlights their therapeutic in vivo potential.

Keywords: plasmonic materials, in vivo photothermal therapy, NIR-II light, site-selective deposition, metal-semiconductor heterostructures

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