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Volume 14 (2); 2024

Research Papers

Long-term Nephrotoxicity after PRRT: Myth or Reality
Richard P. Baum, Xin Fan, Vivianne Jakobsson, Fei Yu, Christiane Schuchardt, Xiaoyuan Chen, Jingjing Zhang
Theranostics 2024; 14(2): 451-459. doi:10.7150/thno.92487
Abstract Full text PDF PubMed PMC

Differential effect of cancer-associated fibroblast-derived extracellular vesicles on cisplatin resistance in oral squamous cell carcinoma via miR-876-3p
Soo Hyun Kang, Su Young Oh, Kah-Young Lee, Heon-Jin Lee, Mee-Seon Kim, Tae-Geon Kwon, Jin-Wook Kim, Sung-Tak Lee, So-Young Choi, Su-Hyung Hong
Theranostics 2024; 14(2): 460-479. doi:10.7150/thno.87329
Abstract Full text PDF PubMed PMC

Cerebellar Purkinje cell firing promotes conscious recovery from anesthesia state through coordinating neuronal communications with motor cortex
Jinpiao Zhu, Chang Chen, Xiaodong Liu, Mengying He, Yuanyuan Fang, Li Wang, Junke Jia, Juan Guo, Ziyue Zhao, Chenyi Gao, Jingang He, Chengshi Xu, Fuqiang Xu, Daqing Ma, Jie Wang, Zongze Zhang
Theranostics 2024; 14(2): 480-495. doi:10.7150/thno.89592
Abstract Full text PDF PubMed PMC

Generic design principles for antibody-based tumour necrosis factor (TNF) receptor 2 (TNFR2) agonists with FcγR-independent agonism
Mohamed A. Anany, Stefanie Haack, Isabell Lang, Julia Dahlhoff, Juan Gamboa Vargas, Tim Steinfatt, Lea Päckert, Daniela Weisenberger, Olena Zaitseva, Juliane Medler, Kirstin Kucka, Tengyu Zhang, Tom Van Belle, Luc van Rompaey, Andreas Beilhack, Harald Wajant
Theranostics 2024; 14(2): 496-509. doi:10.7150/thno.84404
Abstract Full text PDF PubMed PMC

Exosomes derived from CD271⁺CD56⁺ bone marrow mesenchymal stem cell subpopoulation identified by single-cell RNA sequencing promote axon regeneration after spinal cord injury
Yi Sun, Quanbo Liu, Yiming Qin, Yan Xu, Jinyun Zhao, Yong Xie, Chengjun Li, Tian Qin, Yuxin Jin, Liyuan Jiang, Yong Cao, Hongbin Lu, Jianzhong Hu
Theranostics 2024; 14(2): 510-527. doi:10.7150/thno.89008
Abstract Full text PDF PubMed PMC

Targeted modulation of intestinal epithelial regeneration and immune response in ulcerative colitis using dual-targeting bilirubin nanoparticles
Zewei Zhuo, Kehang Guo, Yujun Luo, Qi Yang, Huihuan Wu, Ruijie Zeng, Rui Jiang, Jingwei Li, Rui Wei, Qizhou Lian, Weihong Sha, Yuliang Feng, Hao Chen
Theranostics 2024; 14(2): 528-546. doi:10.7150/thno.87739
Abstract Full text PDF PubMed PMC

Combined BET and MEK Inhibition synergistically suppresses melanoma by targeting YAP1
Rui Hu, Huihui Hou, Yao Li, Minghui Zhang, Xin Li, Yanzhong Chen, Ying Guo, Hongyin Sun, Shuang Zhao, Mengting Liao, Dongsheng Cao, Qin Yan, Xiang Chen, Mingzhu Yin
Theranostics 2024; 14(2): 593-607. doi:10.7150/thno.85437
Abstract Full text PDF PubMed PMC

Inactivation of the NLRP3 inflammasome mediates exosome-based prevention of atrial fibrillation
Sandrine Parent, Ramana Vaka, Jennifer St Amant, Saad Kahn, Sophie Van Remortel, Christina Bi, David Courtman, Duncan John Stewart, Darryl Raymond Davis
Theranostics 2024; 14(2): 608-621. doi:10.7150/thno.89520
Abstract Full text PDF PubMed PMC

Pharmacological inhibition of MYC to mitigate chemoresistance in preclinical models of squamous cell carcinoma
Shuo Liu, Zhen Qin, Yaqing Mao, Ning Wang, Wenbo Zhang, Yujia Wang, Yiwen Chen, Lingfei Jia, Xin Peng
Theranostics 2024; 14(2): 622-639. doi:10.7150/thno.88759
Abstract Full text PDF PubMed PMC

Microenvironment-induced CREPT expression by cancer-derived small extracellular vesicles primes field cancerization
Yuting Lin, Hanguo Jiang, Jun Li, Fangli Ren, Yinyin Wang, Ying Qiu, Jianghua Li, Mengdi Li, Ying Wang, Liu Yang, Yunhao Song, Huihui Jia, Wanli Zhai, Yanshen Kuang, Hanyang Yu, Wenyuan Zhu, Suling Liu, Eiichi Morii, Christian Ensinger, Charles David, Hanqiu Zheng, Jianguo Ji, Hongxia Wang, Zhijie Chang
Theranostics 2024; 14(2): 662-680. doi:10.7150/thno.87344
Abstract Full text PDF PubMed PMC

NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway
Xiaohui Sun, Mingxin Dong, Jiale Li, Yuxiao Sun, Yu Gao, Yan Wang, Liqing Du, Yang Liu, Kaihua Ji, Ningning He, Jinhan Wang, Manman Zhang, Huijuan Song, Chang Xu, Qiang Liu
Theranostics 2024; 14(2): 681-698. doi:10.7150/thno.88899
Abstract Full text PDF PubMed PMC

Annotation of CD8⁺ T-cell function via ICAM-1 imaging identifies FAK inhibition as an adjuvant to augment the antitumor immunity of radiotherapy
Ting Zhang, Yining Zhang, Yang Zhao, Rui Song, Yanpu Wang, Kui Li, Haoyi Zhou, Feng Wang, Shixin Zhou, Meixin Zhao, Hua Zhu, Weifang Zhang, Zhi Yang, Zhaofei Liu
Theranostics 2024; 14(2): 699-713. doi:10.7150/thno.90709
Abstract Full text PDF PubMed PMC

ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription
Ielizaveta Gorodetska, Anne Offermann, Jakob Püschel, Vasyl Lukiyanchuk, Diana Gaete, Anastasia Kurzyukova, Vera Freytag, Marie-Therese Haider, Christina S Fjeldbo, Simona Di Gaetano, Franziska Maria Schwarz, Shivaprasad Patil, Angelika Borkowetz, Holger H. H. Erb, Aria Baniahmad, Jovan Mircetic, Heidi Lyng, Steffen Löck, Annett Linge, Tobias Lange, Franziska Knopf, Ben Wielockx, Mechthild Krause, Sven Perner, Anna Dubrovska
Theranostics 2024; 14(2): 714-737. doi:10.7150/thno.88057
Abstract Full text PDF PubMed PMC

Lower-grade gliomas surgery guided by GRPR-targeting PET/NIR dual-modality image probe: a prospective and single-arm clinical trial
Liangpeng Chen, Jingjing Zhang, Chongwei Chi, Wenqiang Che, Gehong Dong, Junmei Wang, Yanru Du, Rongxi Wang, Zhaohui Zhu, Jie Tian, Nan Ji, Xiaoyuan Chen, Deling Li
Theranostics 2024; 14(2): 819-829. doi:10.7150/thno.91554
Abstract Full text PDF PubMed PMC

Quaternization drives spleen-to-lung tropism conversion for mRNA-loaded lipid-like nanoassemblies
Yixuan Huang, Jiacai Wu, Sanpeng Li, Zhen Liu, Zhenghua Li, Boping Zhou, Bin Li
Theranostics 2024; 14(2): 830-842. doi:10.7150/thno.90071
Abstract Full text PDF PubMed PMC

Comprehensive characterization of early-programmed tumor microenvironment by tumor-associated macrophages reveals galectin-1 as an immune modulatory target in breast cancer
Hyewon Chung, Park Gyu-mi, Yi Rang Na, Yun-Sang Lee, Hongyoon Choi, Seung Hyeok Seok
Theranostics 2024; 14(2): 843-860. doi:10.7150/thno.88917
Abstract Full text PDF PubMed PMC

SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease
Qing-Qing Dong, Yu-Chi Tu, Pan Gao, Qian-Qian Liao, Peng Zhou, Hui Zhang, Hua-Pan Shu, Lu-Lu Sun, Li Feng, Li-Jun Yao
Theranostics 2024; 14(2): 861-878. doi:10.7150/thno.87317
Abstract Full text PDF PubMed PMC

Initial IL-10 production dominates the therapy of mesenchymal stem cell scaffold in spinal cord injury
Lijun Yang, Jian Cao, Yiwen Du, Xunqi Zhang, Wenxiang Hong, Bowen Peng, Jiahe Wu, Qinjie Weng, Jiajia Wang, Jianqing Gao
Theranostics 2024; 14(2): 879-891. doi:10.7150/thno.87843
Abstract Full text PDF PubMed PMC

Reciprocal interactions between malignant cells and macrophages enhance cancer stemness and M2 polarization in HBV-associated hepatocellular carcinoma
Qingyang Zhang, Yu-Man Tsui, Vanilla Xin Zhang, Anna Jingyi Lu, Joyce Man-Fong Lee, Eva Lee, Gary Cheuk-Hang Cheung, Po-Man Li, Elaine Tin-Yan Cheung, Nam-Hung Chia, Irene Lai-Oi Lo, Albert Chi-Yan Chan, Tan-To Cheung, Irene Oi-Lin Ng, Daniel Wai-Hung Ho
Theranostics 2024; 14(2): 892-910. doi:10.7150/thno.87962
Abstract Full text PDF PubMed PMC

Reviews

Copper incorporated biomaterial-based technologies for multifunctional wound repair
Zhenhe Zhang, Hang Xue, Yuan Xiong, Yongtao Geng, Adriana C. Panayi, Samuel Knoedler, Guandong Dai, Mohammad-Ali Shahbazi, Bobin Mi, Gouhui Liu
Theranostics 2024; 14(2): 547-570. doi:10.7150/thno.87193
Abstract Full text PDF PubMed PMC

Tumor-tropic Trojan horses: Using mesenchymal stem cells as cellular nanotheranostics
Ana Rosu, Behnaz Ghaemi, Jeff W.M. Bulte, Ali Shakeri-Zadeh
Theranostics 2024; 14(2): 571-592. doi:10.7150/thno.90187
Abstract Full text PDF PubMed PMC

Current evidence and therapeutic implication of PANoptosis in cancer
Dickson Kofi Wiredu Ocansey, Fei Qian, Peipei Cai, Stephen Ocansey, Samuel Amoah, Yingchen Qian, Fei Mao
Theranostics 2024; 14(2): 640-661. doi:10.7150/thno.91814
Abstract Full text PDF PubMed PMC

Nanoparticle technology for mRNA: Delivery strategy, clinical application and developmental landscape
Xiang Li, Jing Qi, Juan Wang, Weiwei Hu, Weichang Zhou, Yi Wang, Tao Li
Theranostics 2024; 14(2): 738-760. doi:10.7150/thno.84291
Abstract Full text PDF PubMed PMC

Engineered bacterial outer membrane vesicles: a versatile bacteria-based weapon against gastrointestinal tumors
Keshuang Zheng, Yongpu Feng, Lei Li, Fanyang Kong, Jie Gao, Xiangyu Kong
Theranostics 2024; 14(2): 761-787. doi:10.7150/thno.85917
Abstract Full text PDF PubMed PMC

Human organoids-on-chips for biomedical research and applications
Hui Wang, Xiufan Ning, Feng Zhao, Hui Zhao, Dong Li
Theranostics 2024; 14(2): 788-818. doi:10.7150/thno.90492
Abstract Full text PDF PubMed PMC

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