Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

Van Laere, Camille; Koole, Michel; Deroose, Christophe M.; de Voorde, Michiel Van; Baete, Kristof; Cocolios, Thomas E.; Duchemin, Charlotte; Ooms, Maarten; Cleeren, Frederik

doi:10.7150/thno.92775

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Nanotheranostics 2024; 8(4): 442-457. [Abstract] [Full text] [PDF]

Nanotheranostics 2024; 8(4): 427-441. [Abstract] [Full text] [PDF]

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Theranostics 2024; 14(4):1720-1743. doi:10.7150/thno.92775 This issue Cite

Review

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

Camille Van Laere^1,2, Michel Koole^3,4, Christophe M. Deroose^3,4, Michiel Van de Voorde¹, Kristof Baete^3,4, Thomas E. Cocolios⁵, Charlotte Duchemin⁶, Maarten Ooms¹, Frederik Cleeren^2✉

1. Belgian Nuclear Research Centre (SCK CEN), Institute for Nuclear Medical Applications, Mol, Belgium.
2. Radiopharmaceutical Research, Department of Pharmacy and Pharmacology, KU Leuven, Leuven, Belgium.
3. Nuclear Medicine, University Hospitals Leuven, Belgium.
4. Nuclear Medicine & Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
5. KU Leuven, Institute for Nuclear and Radiation Physics, Department of Physics and Astronomy, Leuven, Belgium.
6. CERN, Geneva, Switzerland.

Citation:

Van Laere C, Koole M, Deroose CM, de Voorde MV, Baete K, Cocolios TE, Duchemin C, Ooms M, Cleeren F. Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside. Theranostics 2024; 14(4):1720-1743. doi:10.7150/thno.92775. https://www.thno.org/v14p1720.htm

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Abstract

Terbium features four clinically interesting radionuclides for application in nuclear medicine: terbium-149, terbium-152, terbium-155, and terbium-161. Their identical chemical properties enable the synthesis of radiopharmaceuticals with the same pharmacokinetic character, while their distinctive decay characteristics make them valuable for both imaging and therapeutic applications. In particular, terbium-152 and terbium-155 are useful candidates for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging, respectively; whereas terbium-149 and terbium-161 find application in α- and β^--/Auger electron therapy, respectively. This unique characteristic makes the terbium family ideal for the “matched-pair” principle of theranostics. In this review, the advantages and challenges of terbium-based radiopharmaceuticals are discussed, covering the entire chain from radionuclide production to bedside administration. It elaborates on the fundamental properties of terbium, the production routes of the four interesting radionuclides and gives an overview of the available bifunctional chelators. Finally, we discuss the preclinical and clinical studies as well as the prospects of this promising development in nuclear medicine.

Keywords: Terbium radionuclides, Theranostics, Nuclear Medicine, Radionuclide Therapy, Molecular Imaging

Citation styles

APA

Van Laere, C., Koole, M., Deroose, C.M., de Voorde, M.V., Baete, K., Cocolios, T.E., Duchemin, C., Ooms, M., Cleeren, F. (2024). Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside. Theranostics, 14(4), 1720-1743. https://doi.org/10.7150/thno.92775.

ACS

Van Laere, C.; Koole, M.; Deroose, C.M.; de Voorde, M.V.; Baete, K.; Cocolios, T.E.; Duchemin, C.; Ooms, M.; Cleeren, F. Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside. Theranostics 2024, 14 (4), 1720-1743. DOI: 10.7150/thno.92775.

NLM

CSE

Van Laere C, Koole M, Deroose CM, de Voorde MV, Baete K, Cocolios TE, Duchemin C, Ooms M, Cleeren F. 2024. Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside. Theranostics. 14(4):1720-1743.

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