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Theranostics 2017; 7(10):2649-2651. doi:10.7150/thno.19866 This issue Cite

Editorial

S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis

Masakiyo Sakaguchi✉

Department of Cell Biology, Okayama University Graduate School of Medicine and Dentistry, Okayama-shi 700-8558, Japan

✉ Corresponding author: Masakiyo Sakaguchi, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama 700-8558, Japan; E-mail: masa-sokayama-u.ac.jp, Phone number: +81-8 More

Citation:
Sakaguchi M. S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis. Theranostics 2017; 7(10):2649-2651. doi:10.7150/thno.19866. https://www.thno.org/v07p2649.htm
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Abstract

Graphic abstract

Great progress has been made in in vivo imaging for cancer metastasis. Eisenblaetter et al. developed an innovative S100A8/A9-specific single photon emission computed tomography (SPECT) probe for imaging and succeeded in detecting the metastatic organ favored by the cancer before the cancer arrival. By utilizing this advanced method, researchers have also found that cancer-derived monocytes are the main source of the abundant production of S100A8/A9 in the pre-metastatic area. The CCL2-CCR2 axis is associated with S100A8/A9 production. Clinical establishment of this technique is expected to enable accurate prediction and monitoring of cancer metastasis during therapy.

Keywords: In vivo imaging, S100A8/A9, organ-specific metastasis, pre-metastatic niche, monocytes, inflammation, CCR2, CCL2

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APA
Sakaguchi, M. (2017). S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis. Theranostics, 7(10), 2649-2651. https://doi.org/10.7150/thno.19866.

ACS
Sakaguchi, M. S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis. Theranostics 2017, 7 (10), 2649-2651. DOI: 10.7150/thno.19866.

NLM
Sakaguchi M. S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis. Theranostics 2017; 7(10):2649-2651. doi:10.7150/thno.19866. https://www.thno.org/v07p2649.htm

CSE
Sakaguchi M. 2017. S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis. Theranostics. 7(10):2649-2651.

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