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Volume 13 (12); 2023

Research Papers

Senescent melanocytes driven by glycolytic changes are characterized by melanosome transport dysfunction
Young Joon Park, Jin Cheol Kim, Yeongeun Kim, Yul Hee Kim, Soon Sang Park, Charlotte Muther, Agnès Tessier, Gimyung Lee, Gaëlle Gendronneau, Sandra Forestier, Youcef Ben-Khalifa, Tae Jun Park, Hee Young Kang
Theranostics 2023; 13(12): 3914-3924. doi:10.7150/thno.84912
Abstract Full text PDF PubMed PMC

BCR-ABL1-driven exosome-miR130b-3p-mediated gap-junction Cx43 MSC intercellular communications imply therapies of leukemic subclonal evolution
Chengyan Chai, Ke Sui, Jun Tang, Hao Yu, Chao Yang, Hongyang Zhang, Shengwen Calvin Li, Jiang F. Zhong, Zheng Wang, Xi Zhang
Theranostics 2023; 13(12): 3943-3963. doi:10.7150/thno.83178
Abstract Full text PDF PubMed PMC

Outer membrane vesicles derived from gut microbiota mediate tubulointerstitial inflammation: a potential new mechanism for diabetic kidney disease
Pei Pei Chen, Jia Xiu Zhang, Xue Qi Li, Liang Li, Qin Yi Wu, Liang Liu, Gui Hua Wang, Xiong Zhong Ruan, Kun Ling Ma
Theranostics 2023; 13(12): 3988-4003. doi:10.7150/thno.84650
Abstract Full text PDF PubMed PMC

Click-to-Release: Cleavable Radioimmunoimaging with [⁸⁹Zr]Zr-DFO-Trans-Cyclooctene-Trastuzumab Increases Tumor-to-Blood Ratio
Maria Vlastara, Raffaella Rossin, Freek J.M. Hoeben, Kim E. de Roode, Milou Boswinkel, Laurens H.J. Kleijn, James Nagarajah, Mark Rijpkema, Marc S. Robillard
Theranostics 2023; 13(12): 4004-4015. doi:10.7150/thno.84865
Abstract Full text PDF PubMed PMC

OX40L-Armed Oncolytic Virus Boosts T-cell Response and Remodels Tumor Microenvironment for Pancreatic Cancer Treatment
Shiyu Liu, Fan Li, Qiongqiong Ma, Mingjuan Du, Haoran Wang, Yiping Zhu, Li Deng, Wenrui Gao, Chunlei Wang, Yanqin Liu, Zhuoqian Zhao, Huanzhen Liu, Ruikun Wang, Yujie Tian, Manli Hu, Yajuan Wan, Wenyi Lu, Meng Zhang, Mingfeng Zhao, Youjia Cao, Hongkai Zhang, Wei Wang, Hui Wang, Yuan Wang
Theranostics 2023; 13(12): 4016-4029. doi:10.7150/thno.83495
Abstract Full text PDF PubMed PMC

Weak acid-initiated slow release of Dexamethasone from hydrogel to treat orbital inflammation
Jinjing Li, Aichi Zhang, Andi Zhao, Zhaoxia Chen, Gaolin Liang, Hu Liu, Chengfan Wu
Theranostics 2023; 13(12): 4030-4041. doi:10.7150/thno.85627
Abstract Full text PDF PubMed PMC

HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2
Weibo Feng, Jie Chen, Wenjie Huang, Guodong Wang, Xilang Chen, Lili Duan, Yue Yin, Xiaoping Chen, Bixiang Zhang, Mengyu Sun, Xiangyuan Luo, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia
Theranostics 2023; 13(12): 4042-4058. doi:10.7150/thno.84388
Abstract Full text PDF PubMed PMC

Soluble CD93 lectin-like domain sequesters HMGB1 to ameliorate inflammatory diseases
Shang-En Huang, Cheng-Hsiang Kuo, Si-Yu Shiao, Chia-Rui Shen, Fang-Tzu Lee, Bi-Ing Chang, Jong-Hau Hsu, Hua-Lin Wu, Jwu-Lai Yeh, Chao-Han Lai
Theranostics 2023; 13(12): 4059-4078. doi:10.7150/thno.84935
Abstract Full text PDF PubMed PMC

Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients
Maria Eleni Karakatsani, Robin Ji, Maria F. Murillo, Tara Kugelman, Nancy Kwon, Yeh-Hsing Lao, Keyu Liu, Antonios N. Pouliopoulos, Lawrence S. Honig, Karen E. Duff, Elisa E. Konofagou
Theranostics 2023; 13(12): 4102-4120. doi:10.7150/thno.79898
Abstract Full text PDF PubMed PMC

Immunogenic radiation therapy for enhanced anti-tumor immunity via core-shell nanocomposite-mediated multiple strategies
Naihan Huang, Along Qian, Yiming Zou, Miaoli Lin, Weilun Pan, Ming Chen, Wei Meng, Wenhua Zhang, Jinxiang Chen
Theranostics 2023; 13(12): 4121-4137. doi:10.7150/thno.84500
Abstract Full text PDF PubMed PMC

Caveolin-mediated cytosolic delivery of spike nanoparticle enhances antitumor immunity of neoantigen vaccine for hepatocellular carcinoma
Zhiwen Lin, Chenwei Jiang, Peiyuan Wang, Qingjing Chen, Bing Wang, Xinyue Fu, Yuzhi Liang, Da Zhang, Yongyi Zeng, Xiaolong Liu
Theranostics 2023; 13(12): 4166-4181. doi:10.7150/thno.85843
Abstract Full text PDF PubMed PMC

Endothelial TAZ inhibits capillarization of liver sinusoidal endothelium and damage-induced liver fibrosis via nitric oxide production
Jun-Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Theranostics 2023; 13(12): 4182-4196. doi:10.7150/thno.83714
Abstract Full text PDF PubMed PMC

Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation
Wenqiang Xin, Yongli Pan, Wei Wei, Lars Tatenhorst, Irina Graf, Aurel Popa-Wagner, Stefan T Gerner, Sabine Huber, Ertugrul Kilic, Dirk M Hermann, Mathias Bähr, Hagen B Huttner, Thorsten R Doeppner
Theranostics 2023; 13(12): 4197-4216. doi:10.7150/thno.84059
Abstract Full text PDF PubMed PMC

Multimodal assessment of non-alcoholic fatty liver disease with transmission-reflection optoacoustic ultrasound
Berkan Lafci, Anna Hadjihambi, Madita Determann, Christos Konstantinou, Clara Freijo, Joaquin L. Herraiz, Sena Blümel, Luc Pellerin, Neal C. Burton, Xosé Luís Deán-Ben, Daniel Razansky
Theranostics 2023; 13(12): 4217-4228. doi:10.7150/thno.78548
Abstract Full text PDF PubMed PMC

iNOS aggravates pressure overload-induced cardiac dysfunction via activation of the cytosolic-mtDNA-mediated cGAS-STING pathway
Yongzheng Guo, Yuehua You, Fei-Fei Shang, Xiaowen Wang, Bi Huang, Boying Zhao, Dingyi Lv, Shenglan Yang, Ming Xie, Lingwen Kong, Dingyuan Du, Suxin Luo, Xin Tian, Yong Xia
Theranostics 2023; 13(12): 4229-4246. doi:10.7150/thno.84049
Abstract Full text PDF PubMed PMC

Protein phosphatase 2A-B55β mediated mitochondrial p-GPX4 dephosphorylation promoted sorafenib-induced ferroptosis in hepatocellular carcinoma via regulating p53 retrograde signaling
Bo Qian, Lin Che, Ze-Bang Du, Ni-Jun Guo, Xin-Mou Wu, Lei Yang, Zhao-Xuan Zheng, Yun-Lu Gao, Ming-Zhu Wang, Xiao-Xuan Chen, Ling Xu, Zi-Jian Zhou, Yu-Chun Lin, Zhong-Ning Lin
Theranostics 2023; 13(12): 4288-4302. doi:10.7150/thno.82132
Abstract Full text PDF PubMed PMC

Reviews

New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets
Yu-Chun Lin, Ya-Chin Hou, Hao-Chen Wang, Yan-Shen Shan
Theranostics 2023; 13(12): 3925-3942. doi:10.7150/thno.82911
Abstract Full text PDF PubMed PMC

Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair
Jincheng Li, Wenqi Luo, Chunsheng Xiao, Jianhui Zhao, Chunyu Xiang, Wanguo Liu, Rui Gu
Theranostics 2023; 13(12): 3966-3987. doi:10.7150/thno.84133
Abstract Full text PDF PubMed PMC

Theranostics in the vasculature: bioeffects of ultrasound and microbubbles to induce vascular shutdown
Frederic Padilla, Jacqueline Brenner, Francesco Prada, Alexander L Klibanov
Theranostics 2023; 13(12): 4079-4101. doi:10.7150/thno.70372
Abstract Full text PDF PubMed PMC

New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)
Chella Perumal Palanisamy, JinJin Pei, Phaniendra Alugoju, Naga Venkata Anusha Anthikapalli, Selvaraj Jayaraman, Vishnu Priya Veeraraghavan, Sridevi Gopathy, Jeane Rebecca Roy, Coimbatore Sadagopan Janaki, Dwarakesh Thalamati, Monica Mironescu, Qiang Luo, Yu Miao, Yuan Chai, Qianfa Long
Theranostics 2023; 13(12): 4138-4165. doi:10.7150/thno.83066
Abstract Full text PDF PubMed PMC

Regulatory mechanisms and therapeutic implications of insulin-like growth factor 2 mRNA-binding proteins, the emerging crucial m⁶A regulators of tumors
Heng Zhou, Qiang Sun, Mingliang Feng, Ziming Gao, Shiheng Jia, Lanxin Cao, Xue Yu, Shan Gao, Huizhe Wu, Kai Li
Theranostics 2023; 13(12): 4247-4265. doi:10.7150/thno.86528
Abstract Full text PDF PubMed PMC

Engineering strategies and optimized delivery of exosomes for theranostic application in nerve tissue
Qicheng Li, Xiaoyang Fu, Yuhui Kou, Na Han
Theranostics 2023; 13(12): 4266-4286. doi:10.7150/thno.84971
Abstract Full text PDF PubMed PMC

Errata

N6-methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming: Erratum
Zhuojia Chen, Long Wu, Jiawang Zhou, Xinyao Lin, Yanxi Peng, Lichen Ge, Cheng-Ming Chiang, Hui Huang, Hongsheng Wang, Weiling He
Theranostics 2023; 13(12): 3964-3965. doi:10.7150/thno.85930
Abstract Full text PDF PubMed PMC

Autophagy Maintains the Function of Bone Marrow Mesenchymal Stem Cells to Prevent Estrogen Deficiency-Induced Osteoporosis: Erratum
Meng Qi, Liqiang Zhang, Yang Ma, Yi Shuai, Liya Li, Kefu Luo, Wenjia Liu, Yan Jin
Theranostics 2023; 13(12): 4287. doi:10.7150/thno.81713
Abstract Full text PDF PubMed PMC

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