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Theranostics 2023; 13(12):3925-3942. doi:10.7150/thno.82911 This issue Cite

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New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets

Yu-Chun Lin1, Ya-Chin Hou1,2,3, Hao-Chen Wang1,4, Yan-Shen Shan1,3,✉

1. Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
2. Department of Clinical Medicine Research Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
3. Division of General Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
4. Medical Imaging Center, Innovation Headquarter, National Cheng Kung University; Tainan 704, Taiwan.

✉ Corresponding author: ysshanncku.edu.tw, Tel.: +886-6-2353535 (ext. 3105); Fax: +886-6-2766676

Citation:
Lin YC, Hou YC, Wang HC, Shan YS. New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets. Theranostics 2023; 13(12):3925-3942. doi:10.7150/thno.82911. https://www.thno.org/v13p3925.htm
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Abstract

Graphic abstract

Pancreatic cancer (PC) remains one of the most lethal malignancies across the world, which is due to delayed diagnosis and resistance to current therapies. The interactions between pancreatic tumor cells and their tumor microenvironment (TME) allow cancer cells to escape from anti-cancer therapies, leading to difficulties in treating PC. With endocrine function and lipid storage capacity, adipose tissue can maintain energy homeostasis. Direct or indirect interaction between adipocytes and PC cells leads to adipocyte dysfunction characterized by morphological change, fat loss, abnormal adipokine secretion, and fibroblast-like transformation. Various adipokines released from dysfunctional adipocytes have been reported to promote proliferation, invasion, metastasis, stemness, and chemoresistance of PC cells via different mechanisms. Additional lipid outflow from adipocytes can be taken into the TME and thus alter the metabolism in PC cells and surrounding stromal cells. Besides, the trans-differentiation potential enables adipocytes to turn into various cell types, which may give rise to an inflammatory response as well as extracellular matrix reorganization to modulate tumor burden. Understanding the molecular basis behind the protumor functions of adipocytes in PC may offer new therapeutic targets.

Keywords: pancreatic cancer, tumor microenvironment, adipocyte dysfunction, fat loss, adipokines, trans-differentiation

Citation styles

APA
Lin, Y.C., Hou, Y.C., Wang, H.C., Shan, Y.S. (2023). New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets. Theranostics, 13(12), 3925-3942. https://doi.org/10.7150/thno.82911.

ACS
Lin, Y.C.; Hou, Y.C.; Wang, H.C.; Shan, Y.S. New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets. Theranostics 2023, 13 (12), 3925-3942. DOI: 10.7150/thno.82911.

NLM
Lin YC, Hou YC, Wang HC, Shan YS. New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets. Theranostics 2023; 13(12):3925-3942. doi:10.7150/thno.82911. https://www.thno.org/v13p3925.htm

CSE
Lin YC, Hou YC, Wang HC, Shan YS. 2023. New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets. Theranostics. 13(12):3925-3942.

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