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Theranostics 2023; 13(12):3966-3987. doi:10.7150/thno.84133 This issue Cite

Review

Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair

Jincheng Li1, Wenqi Luo1, Chunsheng Xiao2, Jianhui Zhao1, Chunyu Xiang1, Wanguo Liu1✉, Rui Gu1✉

1. Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, People's Republic of China.
2. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.

✉ Corresponding authors: Rui Gu, guruiedu.cn; Wanguo Liu, liuwanguo6016edu.cn

Citation:
Li J, Luo W, Xiao C, Zhao J, Xiang C, Liu W, Gu R. Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair. Theranostics 2023; 13(12):3966-3987. doi:10.7150/thno.84133. https://www.thno.org/v13p3966.htm
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Abstract

Graphic abstract

Traumatic spinal cord injury (SCI) can cause severe neurological impairments. Clinically available treatments are quite limited, with unsatisfactory remediation effects. Residing endogenous neural stem/progenitor cells (eNSPCs) tend to differentiate towards astrocytes, leaving only a small fraction towards oligodendrocytes and even fewer towards neurons; this has been suggested as one of the reasons for the failure of autonomous neuronal regeneration. Thus, finding ways to recruit and facilitate the differentiation of eNSPCs towards neurons has been considered a promising strategy for the noninvasive and immune-compatible treatment of SCI. The present manuscript first introduces the responses of eNSPCs after exogenous interventions to boost endogenous neurogenesis in various SCI models. Then, we focus on state-of-art manipulation approaches that enhance the intrinsic neurogenesis capacity and reconstruct the hostile microenvironment, mainly consisting of pharmacological treatments, stem cell-derived exosome administration, gene therapy, functional scaffold implantation, inflammation regulation, and inhibitory element delineation. Facing the extremely complex situation of SCI, combined treatments are also highlighted to provide more clues for future relevant investigations.

Keywords: Endogenous neural stem/progenitor cells, neurogenesis, spinal cord injury repair, combined treatment

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APA
Li, J., Luo, W., Xiao, C., Zhao, J., Xiang, C., Liu, W., Gu, R. (2023). Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair. Theranostics, 13(12), 3966-3987. https://doi.org/10.7150/thno.84133.

ACS
Li, J.; Luo, W.; Xiao, C.; Zhao, J.; Xiang, C.; Liu, W.; Gu, R. Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair. Theranostics 2023, 13 (12), 3966-3987. DOI: 10.7150/thno.84133.

NLM
Li J, Luo W, Xiao C, Zhao J, Xiang C, Liu W, Gu R. Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair. Theranostics 2023; 13(12):3966-3987. doi:10.7150/thno.84133. https://www.thno.org/v13p3966.htm

CSE
Li J, Luo W, Xiao C, Zhao J, Xiang C, Liu W, Gu R. 2023. Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair. Theranostics. 13(12):3966-3987.

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