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Theranostics 2023; 13(12):4121-4137. doi:10.7150/thno.84500 This issue Cite

Research Paper

Immunogenic radiation therapy for enhanced anti-tumor immunity via core-shell nanocomposite-mediated multiple strategies

Naihan Huang1, Along Qian1, Yiming Zou1, Miaoli Lin1, Weilun Pan1, Ming Chen1, Wei Meng1, Wenhua Zhang2, Jinxiang Chen1✉

1. Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
2. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

✉ Corresponding author: E-mails addresses: jxchenedu.cn (J. Chen).

Citation:
Huang N, Qian A, Zou Y, Lin M, Pan W, Chen M, Meng W, Zhang W, Chen J. Immunogenic radiation therapy for enhanced anti-tumor immunity via core-shell nanocomposite-mediated multiple strategies. Theranostics 2023; 13(12):4121-4137. doi:10.7150/thno.84500. https://www.thno.org/v13p4121.htm
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Abstract

Graphic abstract

Background: Due to the immunosuppressive tumor microenvironment (TME), radiation therapy (RT)-mediated immune response is far from satisfactory. How to improve the efficacy of immunogenic RT by priming strong immunogenic cell death (ICD) is an interesting and urgent challenge.

Methods: A polyacrylic acid-coated core-shell UiO@Mn3O4 (denoted as UMP) nanocomposite is constructed for immunogenic RT via multiple strategies.

Results: Reshaping the TME via Mn3O4-mediated integration of O2 production, GSH depletion, ROS generation and cell cycle arrest, accompanied by Hf-based UiO-mediated radiation absorption, eventually amplifies UMP-mediated RT to induce intense ICD. With the potent ICD induction and reprogrammed tumor-associated macrophages, this synergetic strategy can promote dendritic cells maturation and CD8+ T cells infiltration, and potentiate anti-tumor immunity against primary, distant, and metastatic tumors.

Conclusion: This work is expected to shed light on the immunosuppressive TME-reshaping via multiple strategies to reinforce the immunogenic RT outcome and facilitate the development of effective cancer nanomedicine.

Keywords: radiation therapy, tumor microenvironment, anti-tumor immunity, immunogenic cell death

Citation styles

APA
Huang, N., Qian, A., Zou, Y., Lin, M., Pan, W., Chen, M., Meng, W., Zhang, W., Chen, J. (2023). Immunogenic radiation therapy for enhanced anti-tumor immunity via core-shell nanocomposite-mediated multiple strategies. Theranostics, 13(12), 4121-4137. https://doi.org/10.7150/thno.84500.

ACS
Huang, N.; Qian, A.; Zou, Y.; Lin, M.; Pan, W.; Chen, M.; Meng, W.; Zhang, W.; Chen, J. Immunogenic radiation therapy for enhanced anti-tumor immunity via core-shell nanocomposite-mediated multiple strategies. Theranostics 2023, 13 (12), 4121-4137. DOI: 10.7150/thno.84500.

NLM
Huang N, Qian A, Zou Y, Lin M, Pan W, Chen M, Meng W, Zhang W, Chen J. Immunogenic radiation therapy for enhanced anti-tumor immunity via core-shell nanocomposite-mediated multiple strategies. Theranostics 2023; 13(12):4121-4137. doi:10.7150/thno.84500. https://www.thno.org/v13p4121.htm

CSE
Huang N, Qian A, Zou Y, Lin M, Pan W, Chen M, Meng W, Zhang W, Chen J. 2023. Immunogenic radiation therapy for enhanced anti-tumor immunity via core-shell nanocomposite-mediated multiple strategies. Theranostics. 13(12):4121-4137.

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