New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

Palanisamy, Chella Perumal; Pei, JinJin; Alugoju, Phaniendra; Anthikapalli, Naga Venkata Anusha; Jayaraman, Selvaraj; Veeraraghavan, Vishnu Priya; Gopathy, Sridevi; Roy, Jeane Rebecca; Janaki, Coimbatore Sadagopan; Thalamati, Dwarakesh; Mironescu, Monica; Luo, Qiang; Miao, Yu; Chai, Yuan; Long, Qianfa

doi:10.7150/thno.83066

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Nanotheranostics 2024; 8(4): 442-457. [Abstract] [Full text] [PDF]

Nanotheranostics 2024; 8(4): 427-441. [Abstract] [Full text] [PDF]

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Theranostics 2023; 13(12):4138-4165. doi:10.7150/thno.83066 This issue Cite

Review

New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

Chella Perumal Palanisamy^1,2†, JinJin Pei^3†, Phaniendra Alugoju⁴, Naga Venkata Anusha Anthikapalli⁵, Selvaraj Jayaraman², Vishnu Priya Veeraraghavan², Sridevi Gopathy⁶, Jeane Rebecca Roy⁷, Coimbatore Sadagopan Janaki⁷, Dwarakesh Thalamati⁸, Monica Mironescu⁹, Qiang Luo¹, Yu Miao¹, Yuan Chai¹, Qianfa Long^1✉

1. Mini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University, No. 161, West 5th Road, Xincheng District, Xi'an, 710003, PR China.
2. Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai 600077, India.
3. Qinba State Key Laboratory of Biological Resources and Ecological Environment, 2011 QinLing-Bashan Mountains Bioresources Comprehensive Development C. I. C, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Shaanxi University of Technology, Hanzhong 723001, China.
4. Department of Clinical Chemistry, Chulalongkorn University, Bangkok 10330, Thailand.
5. Department of Chemistry, A.N.R College, Bethavolu, Gudivada, Andhra Pradesh 521301, India.
6. Department of Physiology, SRM Dental College, Ramapuram campus, Chennai, Tamil Nadu 600089, India.
7. Department of Anatomy, Bhaarath Medical College and hospital, Bharath Institute of Higher Education and Research (BIHER), Chennai, Tamil Nadu 600073, India.
8. Department of Anaesthesia, Hull Royal Infirmary, NHS, England.
9. Faculty of Agricultural Sciences Food Industry and Environmental Protection, Lucian Blaga University of Sibiu, Bv. Victoriei 10, 550024 Sibiu, Romania.
†Authors are contributed equally and shared first authorship in this work

Citation:

Palanisamy CP, Pei J, Alugoju P, Anthikapalli NVA, Jayaraman S, Veeraraghavan VP, Gopathy S, Roy JR, Janaki CS, Thalamati D, Mironescu M, Luo Q, Miao Y, Chai Y, Long Q. New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs). Theranostics 2023; 13(12):4138-4165. doi:10.7150/thno.83066. https://www.thno.org/v13p4138.htm

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Abstract

Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within the affected regions. Reliable biomarkers that can accurately reflect disease activity, diagnose, and monitor the progression of neurodegenerative diseases are crucial for the development of effective therapies. However, identifying suitable biomarkers has been challenging due to the heterogeneous nature of these diseases, affecting specific subsets of neurons in different brain regions. One promising approach for promoting brain regeneration and recovery involves the transplantation of mesenchymal stem cells (MSCs). MSCs have demonstrated the ability to modulate the immune system, promote neurite outgrowth, stimulate angiogenesis, and repair damaged tissues, partially through the release of their extracellular vesicles (EVs). MSC-derived EVs retain some of the therapeutic characteristics of their parent MSCs, including their ability to regulate neurite outgrowth, promote angiogenesis, and facilitate tissue repair. This review aims to explore the potential of MSC-derived EVs as an emerging therapeutic strategy for neurodegenerative diseases, highlighting their role in modulating disease progression and promoting neuronal recovery. By elucidating the mechanisms by which MSC-derived EVs exert their therapeutic effects, we can advance our understanding and leverage their potential for the development of novel treatment approaches in the field of neurodegenerative diseases.

Keywords: MSC-EVs, Neurodegenerative diseases, Mechanisms, Therapeutic strategies

Citation styles

APA

Palanisamy, C.P., Pei, J., Alugoju, P., Anthikapalli, N.V.A., Jayaraman, S., Veeraraghavan, V.P., Gopathy, S., Roy, J.R., Janaki, C.S., Thalamati, D., Mironescu, M., Luo, Q., Miao, Y., Chai, Y., Long, Q. (2023). New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs). Theranostics, 13(12), 4138-4165. https://doi.org/10.7150/thno.83066.

ACS

Palanisamy, C.P.; Pei, J.; Alugoju, P.; Anthikapalli, N.V.A.; Jayaraman, S.; Veeraraghavan, V.P.; Gopathy, S.; Roy, J.R.; Janaki, C.S.; Thalamati, D.; Mironescu, M.; Luo, Q.; Miao, Y.; Chai, Y.; Long, Q. New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs). Theranostics 2023, 13 (12), 4138-4165. DOI: 10.7150/thno.83066.

NLM

CSE

Palanisamy CP, Pei J, Alugoju P, Anthikapalli NVA, Jayaraman S, Veeraraghavan VP, Gopathy S, Roy JR, Janaki CS, Thalamati D, Mironescu M, Luo Q, Miao Y, Chai Y, Long Q. 2023. New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs). Theranostics. 13(12):4138-4165.

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