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Volume 7 (6); 2017

Research Paper

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Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs
Jiaqi Wang, Huamao Ye, Dandan Zhang, Kai Cheng, Yijun Hu, Xiya Yu, Lei Lu, Jingjing Hu, Changjing Zuo, Baohua Qian, Yongwei Yu, Shupeng Liu, Geng Liu, Chuanbin Mao, Shanrong Liu
Theranostics 2017; 7(6): 1407-1421. doi:10.7150/thno.18262
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease
Michelle L. James, Nadia P. Belichenko, Adam J. Shuhendler, Aileen Hoehne, Lauren E. Andrews, Christina Condon, Thuy-Vi V. Nguyen, Vladimer Reiser, Paul Jones, William Trigg, Jianghong Rao, Sanjiv S. Gambhir, Frank M. Longo
Theranostics 2017; 7(6): 1422-1436. doi:10.7150/thno.17666
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cross-Platform Comparison of Four Leading Technologies for Detecting EGFR Mutations in Circulating Tumor DNA from Non-Small Cell Lung Carcinoma Patient Plasma
Ting Xu, Xiaozheng Kang, Xiaofang You, Liang Dai, Dequan Tian, Wanpu Yan, Yongbo Yang, Hongchao Xiong, Zhen Liang, Grace Q. Zhao, Shengrong Lin, Ke-Neng Chen, Guobing Xu
Theranostics 2017; 7(6): 1437-1446. doi:10.7150/thno.16558
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The antihelminthic drug niclosamide effectively inhibits the malignant phenotypes of uveal melanoma in vitro and in vivo
Jingfeng Zhou, Bei Jin, Yanli Jin, Yizhi Liu, Jingxuan Pan
Theranostics 2017; 7(6): 1447-1462. doi:10.7150/thno.17451
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Spectroscopic Photoacoustic Molecular Imaging of Breast Cancer using a B7-H3-targeted ICG Contrast Agent
Katheryne E. Wilson, Sunitha V. Bachawal, Lotfi Abou-Elkacem, Kristen Jensen, Steven Machtaler, Lu Tian, Jürgen K. Willmann
Theranostics 2017; 7(6): 1463-1476. doi:10.7150/thno.18217
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Theranostic Performance of Acoustic Nanodroplet Vaporization-Generated Bubbles in Tumor Intertissue
Yi-Ju Ho, Chih-Kuang Yeh
Theranostics 2017; 7(6): 1477-1488. doi:10.7150/thno.19099
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors - a Triple Tracer Comparative Approach
Rudolf A. Werner, Alexander Weich, Takahiro Higuchi, Jan S. Schmid, Andreas Schirbel, Michael Lassmann, Vanessa Wild, Martina Rudelius, Theodor Kudlich, Ken Herrmann, Michael Scheurlen, Andreas K. Buck, Saskia Kropf, Hans-Jürgen Wester, Constantin Lapa
Theranostics 2017; 7(6): 1489-1498. doi:10.7150/thno.18754
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Noninvasive Assessment of Elimination and Retention using CT-FMT and Kinetic Whole-body Modeling
Wa'el Al Rawashdeh, Simin Zuo, Andrea Melle, Lia Appold, Susanne Koletnik, Yoanna Tsvetkova, Nataliia Beztsinna, Andrij Pich, Twan Lammers, Fabian Kiessling, Felix Gremse
Theranostics 2017; 7(6): 1499-1510. doi:10.7150/thno.17263
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Novel Linear Peptides with High Affinity to αvβ3 Integrin for Precise Tumor Identification
Yi Ma, Guanhua Ai, Congying Zhang, Menglu Zhao, Xue Dong, Zhihao Han, Zhaohui Wang, Min Zhang, Yuxi Liu, Weidong Gao, Siwen Li, Yueqing Gu
Theranostics 2017; 7(6): 1511-1523. doi:10.7150/thno.18401
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy
Juan Mou, Tianquan Lin, Fuqiang Huang, Jianlin Shi, Hangrong Chen
Theranostics 2017; 7(6): 1531-1542. doi:10.7150/thno.17247
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CXCR4-directed endoradiotherapy induces high response rates in extramedullary relapsed Multiple Myeloma
Constantin Lapa, Ken Herrmann, Andreas Schirbel, Heribert Hänscheid, Katharina Lückerath, Margret Schottelius, Malte Kircher, Rudolf A. Werner, Martin Schreder, Samuel Samnick, Saskia Kropf, Stefan Knop, Andreas K. Buck, Hermann Einsele, Hans-Juergen Wester, K. Martin Kortüm
Theranostics 2017; 7(6): 1589-1597. doi:10.7150/thno.19050
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Overexpression of Insulin-Like Growth Factor 1 Enhanced the Osteogenic Capability of Aging Bone Marrow Mesenchymal Stem Cells
Ching-Yun Chen, Kuo-Yun Tseng, Yen-Liang Lai, Yo-Shen Chen, Feng-Huei Lin, Shankung Lin
Theranostics 2017; 7(6): 1598-1611. doi:10.7150/thno.16637
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Lung Cancer-Targeting Peptides with Multi-subtype Indication for Combinational Drug Delivery and Molecular Imaging
Yi-Hsuan Chi, Jong-Kai Hsiao, Ming-Huang Lin, Chen Chang, Chun-Hsin Lan, Han-Chung Wu
Theranostics 2017; 7(6): 1612-1632. doi:10.7150/thno.17573
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Multifunctional Nucleus-targeting Nanoparticles with Ultra-high Gene Transfection Efficiency for In Vivo Gene Therapy
Ling Li, Xia Li, Yuzhe Wu, Linjiang Song, Xi Yang, Tao He, Ning Wang, Suleixin Yang, Yan Zeng, Qinjie Wu, Zhiyong Qian, Yuquan Wei, Changyang Gong
Theranostics 2017; 7(6): 1633-1649. doi:10.7150/thno.17588
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor-triggered drug release from calcium carbonate-encapsulated gold nanostars for near-infrared photodynamic/photothermal combination antitumor therapy
Yanlei Liu, Xiao Zhi, Meng Yang, Jingpu Zhang, Lingnan Lin, Xin Zhao, Wenxiu Hou, Chunlei Zhang, Qian Zhang, Fei Pan, Gabriel Alfranca, Yuming Yang, Jesús M. de la Fuente, Jian Ni, Daxiang Cui
Theranostics 2017; 7(6): 1650-1662. doi:10.7150/thno.17602
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MiR-200c Inhibits the Tumor Progression of Glioma via Targeting Moesin
Yuanyuan Qin, Weilong Chen, Bingjie Liu, Lei Zhou, Lu Deng, Wanxiang Niu, Dejun Bao, Chuandong Cheng, Dongxue Li, Suling Liu, Chaoshi Niu
Theranostics 2017; 7(6): 1663-1673. doi:10.7150/thno.17886
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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3,3′-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing
Hui Shi, Xiao Xu, Bin Zhang, Jiahao Xu, Zhaoji Pan, Aihua Gong, Xu Zhang, Rong Li, Yaoxiang Sun, Yongmin Yan, Fei Mao, Hui Qian, Wenrong Xu
Theranostics 2017; 7(6): 1674-1688. doi:10.7150/thno.18082
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor Penetrating Theranostic Nanoparticles for Enhancement of Targeted and Image-guided Drug Delivery into Peritoneal Tumors following Intraperitoneal Delivery
Ning Gao, Erica N. Bozeman, Weiping Qian, Liya Wang, Hongyu Chen, Malgorzata Lipowska, Charles A Staley, Y. Andrew Wang, Hui Mao, Lily Yang
Theranostics 2017; 7(6): 1689-1704. doi:10.7150/thno.18125
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Peptide vaccination in the presence of adjuvants in patients after hematopoietic stem cell transplantation with CD4+ T cell reconstitution elicits consistent CD8+ T cell responses
Michael Schmitt, Anita Schmitt, Markus Wiesneth, Angela Hückelhoven, Zeguang Wu, Jürgen Kuball, Lei Wang, Peter Schauwecker, Susanne Hofmann, Marlies Götz, Birgit Michels, Birgit Maccari, Patrick Wuchter, Volker Eckstein, Thomas Mertens, Paul Schnitzler, Hartmut Döhner, Anthony D. Ho, Donald W. Bunjes, Peter Dreger, Hubert Schrezenmeier, Jochen Greiner
Theranostics 2017; 7(6): 1705-1718. doi:10.7150/thno.18301
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Redox Responsive Hyaluronic Acid Nanogels for Treating RHAMM (CD168) Over-expressive Cancer, both Primary and Metastatic Tumors
Chenchen Yang, Cheng Li, Peng Zhang, Wei Wu, Xiqun Jiang
Theranostics 2017; 7(6): 1719-1734. doi:10.7150/thno.18340
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field
Yajing Shen, Congyu Wu, Taro Q. P. Uyeda, Gustavo R. Plaza, Bin Liu, Yu Han, Maciej S. Lesniak, Yu Cheng
Theranostics 2017; 7(6): 1735-1748. doi:10.7150/thno.18352
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SAK-HV Triggered a Short-period Lipid-lowering Biotherapy Based on the Energy Model of Liver Proliferation via a Novel Pathway
Chao Zhang, Zhiguang Huang, Haoran Jing, Wenliang Fu, Min Yuan, Wenrong Xia, Ling Cai, Xiangdong Gan, Yao Chen, Minji Zou, Minhui Long, Jiaxi Wang, Min Wang, Donggang Xu
Theranostics 2017; 7(6): 1749-1769. doi:10.7150/thno.18415
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Diagnostic Accuracy of Ga-68-HBED-CC-PSMA-Ligand-PET/CT before Salvage Lymph Node Dissection for Recurrent Prostate Cancer
Cordula A. Jilg, Vanessa Drendel, H. Christian Rischke, Teresa Beck, Werner Vach, Kathrin Schaal, Ulrich Wetterauer, Wolfgang Schultze-Seemann, Philipp T. Meyer
Theranostics 2017; 7(6): 1770-1780. doi:10.7150/thno.18421
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication

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Synthesis of 5-[18F]Fluoro-α-methyl Tryptophan: New Trp Based PET Agents
Benjamin C. Giglio, Haiyang Fei, Mengzhe Wang, Hui Wang, Liu He, Huijuan Feng, Zhanhong Wu, Hongjian Lu, Zibo Li
Theranostics 2017; 7(6): 1524-1530. doi:10.7150/thno.19371
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
Helen Ha, Bikash Debnath, Nouri Neamati
Theranostics 2017; 7(6): 1543-1588. doi:10.7150/thno.15625
[Abstract] [Full text] [PDF] [PubMed] [PMC]