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Volume 7 (5); 2017

Editorial

The NETPET Score: Combining FDG and Somatostatin Receptor Imaging for Optimal Management of Patients with Metastatic Well-Differentiated Neuroendocrine Tumors
Elif Hindié
Theranostics 2017; 7(5): 1159-1163. doi:10.7150/thno.19588
Abstract Full text PDF PubMed PMC

Research Papers

A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology
Bock Lim, Yu Yao, Alex Lin-i Huang, May Lin Yap, Ulrike Flierl, Jathushan Palasubramaniam, Maria T.K. Zaldivia, Xiaowei Wang, Karlheinz Peter
Theranostics 2017; 7(5): 1047-1061. doi:10.7150/thno.18099
Abstract Full text PDF PubMed PMC

Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis
Yinlong Zhang, Jingyan Wei, Shaoli Liu, Jing Wang, Xuexiang Han, Hao Qin, Jiayan Lang, Keman Cheng, Yiye Li, Yingqiu Qi, Greg J Anderson, Saraswati Sukumar, Suping Li, Guangjun Nie
Theranostics 2017; 7(5): 1062-1071. doi:10.7150/thno.17908
Abstract Full text PDF PubMed PMC

Zero-order controlled release of BMP2-derived peptide P24 from the chitosan scaffold by chemical grafting modification technique for promotion of osteogenesis in vitro and enhancement of bone repair in vivo
Yan Chen, Xujie Liu, Rui Liu, Yong Gong, Mingbo Wang, Qianli Huang, Qingling Feng, Bo Yu
Theranostics 2017; 7(5): 1072-1087. doi:10.7150/thno.18193
Abstract Full text PDF PubMed PMC

Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities
Shih-Chi Su, Chiao-Wen Lin, Yu-Fan Liu, Wen-Lang Fan, Mu-Kuan Chen, Chun-Ping Yu, Wei-En Yang, Chun-Wen Su, Chun-Yi Chuang, Wen-Hsiung Li, Wen-Hung Chung, Shun-Fa Yang
Theranostics 2017; 7(5): 1088-1099. doi:10.7150/thno.18551
Abstract Full text PDF PubMed PMC

AHNAK2 is a Novel Prognostic Marker and Oncogenic Protein for Clear Cell Renal Cell Carcinoma
Minglei Wang, Xuefeng Li, Jin Zhang, Qiong Yang, Wenqi Chen, Weilin Jin, Yi-Ran Huang, Ru Yang, Wei-Qiang Gao
Theranostics 2017; 7(5): 1100-1113. doi:10.7150/thno.18198
Abstract Full text PDF PubMed PMC

The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer
De-Wei Wu, Po-Lin Lin, Lee Wang, Chi-Chou Huang, Huei Lee
Theranostics 2017; 7(5): 1114-1132. doi:10.7150/thno.18175
Abstract Full text PDF PubMed PMC

SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer
Feng Yin, Kuan Hu, Yangzi Chen, Mengying Yu, Dongyuan Wang, Qianqian Wang, Ken-Tye Yong, Fei Lu, Yongye Liang, Zigang Li
Theranostics 2017; 7(5): 1133-1148. doi:10.7150/thno.17841
Abstract Full text PDF PubMed PMC

Dual Somatostatin Receptor/FDG PET/CT Imaging in Metastatic Neuroendocrine Tumours: Proposal for a Novel Grading Scheme with Prognostic Significance
David LH Chan, Nick Pavlakis, Geoffrey P Schembri, Elizabeth J Bernard, Edward Hsiao, Aimee Hayes, Tristan Barnes, Connie Diakos, Mustafa Khasraw, Jaswinder Samra, Enid Eslick, Paul J Roach, Alexander Engel, Stephen J Clarke, Dale L Bailey
Theranostics 2017; 7(5): 1149-1158. doi:10.7150/thno.18068
Abstract Full text PDF PubMed PMC

Physiological Effects of Ac4ManNAz and Optimization of Metabolic Labeling for Cell Tracking
Sang-Soo Han, Dong-Eun Lee, Hye-Eun Shim, Sangmin Lee, Taekhee Jung, Jung-Hwa Oh, Hyang-Ae Lee, Sung-Hwan Moon, Jongho Jeon, Seokjoo Yoon, Kwangmeyung Kim, Sun-Woong Kang
Theranostics 2017; 7(5): 1164-1176. doi:10.7150/thno.17711
Abstract Full text PDF PubMed PMC

Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression
Yu-Jung Lin, Woei-Cherng Shyu, Chi-Wei Chang, Chi-Chung Wang, Chung-Pu Wu, Hsu-Tung Lee, Liang-Jwu Chen, Chia-Hung Hsieh
Theranostics 2017; 7(5): 1177-1191. doi:10.7150/thno.17895
Abstract Full text PDF PubMed PMC

Phosphorylcholine-based stealthy nanocapsules enabling tumor microenvironment-responsive doxorubicin release for tumor suppression
Gan Liu, Hsiang-i Tsai, Xiaowei Zeng, Yixiong Zuo, Wei Tao, Jun Han, Lin Mei
Theranostics 2017; 7(5): 1192-1203. doi:10.7150/thno.17881
Abstract Full text PDF PubMed PMC

Aptamer Internalization via Endocytosis Inducing S-Phase Arrest and Priming Maver-1 Lymphoma Cells for Cytarabine Chemotherapy
Huan Li, Shuanghui Yang, Ge Yu, Liangfang Shen, Jia Fan, Ling Xu, Hedong Zhang, Nianxi Zhao, Zihua Zeng, Tony Hu, Jianguo Wen, Youli Zu
Theranostics 2017; 7(5): 1204-1213. doi:10.7150/thno.17069
Abstract Full text PDF PubMed PMC

Size-dependent Effects of Gold Nanoparticles on Osteogenic Differentiation of Human Periodontal Ligament Progenitor Cells
Yangheng Zhang, Na Kong, Yuanchao Zhang, Wenrong Yang, Fuhua Yan
Theranostics 2017; 7(5): 1214-1224. doi:10.7150/thno.17252
Abstract Full text PDF PubMed PMC

Recipient Glycemic Micro-environments Govern Therapeutic Effects of Mesenchymal Stem Cell Infusion on Osteopenia
Bing-Dong Sui, Cheng-Hu Hu, Chen-Xi Zheng, Yi Shuai, Xiao-Ning He, Ping-Ping Gao, Pan Zhao, Meng Li, Xin-Yi Zhang, Tao He, Kun Xuan, Yan Jin
Theranostics 2017; 7(5): 1225-1244. doi:10.7150/thno.18181
Abstract Full text PDF PubMed PMC

A Programmed Nanoparticle with Self-Adapting for Accurate Cancer Cell Eradication and Therapeutic Self-Reporting
Yingping Luo, Liwei Huang, Ye Yang, Xianfei Zhuang, Siyao Hu, Huangxian Ju, Bo-Yang Yu, Jiangwei Tian
Theranostics 2017; 7(5): 1245-1256. doi:10.7150/thno.18187
Abstract Full text PDF PubMed PMC

Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging
Hannes Mikula, Shawn Stapleton, Rainer H. Kohler, Claudio Vinegoni, Ralph Weissleder
Theranostics 2017; 7(5): 1257-1265. doi:10.7150/thno.18238
Abstract Full text PDF PubMed PMC

Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin
Martin Metz, Petra Staubach, Andrea Bauer, Randolf Brehler, Janine Gericke, Michael Kangas, Joanna Ashton-Chess, Philip Jarvis, Panayiotis Georgiou, Janice Canvin, Rainer Hillenbrand, Veit J. Erpenbeck, Marcus Maurer
Theranostics 2017; 7(5): 1266-1276. doi:10.7150/thno.18304
Abstract Full text PDF PubMed PMC

Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice
Maximilian Wiesmann, Valerio Zerbi, Diane Jansen, Dieter Lütjohann, Andor Veltien, Arend Heerschap, Amanda J Kiliaan
Theranostics 2017; 7(5): 1277-1289. doi:10.7150/thno.18509
Abstract Full text PDF PubMed PMC

Design of Tumor Acidity-Responsive Sheddable Nanoparticles for Fluorescence/Magnetic Resonance Imaging-Guided Photodynamic Therapy
Feng Fan, Yue Yu, Fei Zhong, Meng Gao, Tianmeng Sun, Jiaxin Liu, Huimao Zhang, Haisheng Qian, Wei Tao, Xianzhu Yang
Theranostics 2017; 7(5): 1290-1302. doi:10.7150/thno.18557
Abstract Full text PDF PubMed PMC

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth
Daniele Bellavia, Stefania Raimondo, Giovanna Calabrese, Stefano Forte, Marta Cristaldi, Agostina Patinella, Lorenzo Memeo, Mauro Manno, Samuele Raccosta, Patrizia Diana, Girolamo Cirrincione, Gianluca Giavaresi, Francesca Monteleone, Simona Fontana, Giacomo De Leo, Riccardo Alessandro
Theranostics 2017; 7(5): 1333-1345. doi:10.7150/thno.17092
Abstract Full text PDF PubMed PMC

Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer
Ming Tang, Xiaopeng Lu, Chaohua Zhang, Changzheng Du, Linlin Cao, Tianyun Hou, Zhiming Li, Bo Tu, Ziyang Cao, Yinglu Li, Yongcan Chen, Lu Jiang, Hui Wang, Lina Wang, Baohua Liu, Xingzhi Xu, Jianyuan Luo, Jiadong Wang, Jin Gu, Haiying Wang, Wei-Guo Zhu
Theranostics 2017; 7(5): 1346-1359. doi:10.7150/thno.18804
Abstract Full text PDF PubMed PMC

Nucleolin-targeted Extracellular Vesicles as a Versatile Platform for Biologics Delivery to Breast Cancer
Yayu Wang, Xiaojia Chen, Baoqing Tian, Jiafan Liu, Li Yang, Lilan Zeng, Tianfen Chen, An Hong, Xiaogang Wang
Theranostics 2017; 7(5): 1360-1372. doi:10.7150/thno.16532
Abstract Full text PDF PubMed PMC

Simultaneous targeting of CD44 and EpCAM with a bispecific aptamer effectively inhibits intraperitoneal ovarian cancer growth
Jingying Zheng, Shuhua Zhao, Xiaolin Yu, Shuang Huang, Hong Yan Liu
Theranostics 2017; 7(5): 1373-1388. doi:10.7150/thno.17826
Abstract Full text PDF PubMed PMC

Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related-protein 1
Teng-Jian Zhou, Shi-Li Zhang, Cheng-Yong He, Qun-Ying Zhuang, Pei-Yu Han, Sheng-Wei Jiang, Huan Yao, Yi-Jun Huang, Wen-Hua Ling, Yu-Chun Lin, Zhong-Ning Lin
Theranostics 2017; 7(5): 1389-1406. doi:10.7150/thno.17647
Abstract Full text PDF PubMed PMC

Review

Ultrasound Elastography: Review of Techniques and Clinical Applications
Rosa M.S. Sigrist, Joy Liau, Ahmed El Kaffas, Maria Cristina Chammas, Juergen K. Willmann
Theranostics 2017; 7(5): 1303-1329. doi:10.7150/thno.18650
Abstract Full text PDF PubMed PMC

Commentary

Does H₂ Alter Mitochondrial Bioenergetics via GHS-R1α Activation?
Sergej M. Ostojic
Theranostics 2017; 7(5): 1330-1332. doi:10.7150/thno.18745
Abstract Full text PDF PubMed PMC

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