Online advance articles

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A transcriptional biosensor to monitor single cancer cell therapeutic responses by bioluminescence microscopy
Audrey Champagne, Pallavi Jain, Lauriane Vélot, Julie Riopel, Véronique Lefebvre, Bertrand Neveu, Frédéric Pouliot
Theranostics 2021; doi:10.7150/thno.63744; accepted
[Author manuscript]

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2
Kuan-Ying A. Huan, Daming Zhou, Tiong Kit Tan, Charles Chen, Helen M. E. Duyvesteyn, Yuguang Zhao, Helen M. Ginn, Ling Qin, Pramila Rijal, Lisa Schimanski, Robert Donat, Adam Harding, Javier Gilbert-Jaramillo, William James, Julia A. Tree, Karen Buttigieg, Miles Carroll, Sue Charlton, Chia-En Lien, Meei-Yun Lin, Cheng-Pin Chen, Shu-Hsing Cheng, Tzou-Yien Lin, Elizabeth E. Fry, Jingshan Ren, Che Ma, Alain R. Townsend, David I. Stuart
Theranostics 2021; doi:10.7150/thno.65563; in press
[Author manuscript]

CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism
Juliane Medler, Kirstin Kucka, Vinicio Melo, Tengyu Zhang, Stefan von Rotenhan, Jakob Ulrich, Edwin Bremer, Michael Hudecek, Andreas Beilhack and Harald Wajant
Theranostics 2021; doi:10.7150/thno.66119; accepted
[Author manuscript]

A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects
Ho Jin Lee, Hye-Young Min, Young-Sik Yong, Jihyae Ann, Cong Truong Nguyen, Minh Thanh La, Seung Yeob Hyun, Huong Thuy Le, Hyewon Kim, Hyukjin Kwon, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Ho-Young Lee
Theranostics 2021; doi:10.7150/thno.63788; in press
[Author manuscript]

BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus
Huai-Chia Chuang, Ming-Han Chen, Yi-Ming Chen, Huang-Yu Yang, Yi-Ru Ciou, Chia-Hsin Hsueh, Ching-Yi Tsai, Tse-Hua Tan
Theranostics 2021; doi:10.7150/thno.63743; in press
[Author manuscript]

hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9
Yujiao Wen, Xixiang Ma, Xiaoli Wang, Fengli Wang, Juan Dong, Yanqing Wu, Chunyu lv, Kuan Liu, Yan Zhang, Zhibing Zhang, Shuiqiao Yuan
Theranostics 2021; doi:10.7150/thno.66819; in press
[Author manuscript]

Single-stranded circular DNA theranostics
Tingting Shen, Yu Zhang, Lei Mei, Xiao-Bing Zhang, Guizhi Zhu
Theranostics 2021; doi:10.7150/thno.66466; accepted
[Author manuscript]

Peptide ligands targeting FGF receptors promote recovery from dorsal root crush injury via AKT/mTOR signaling
Ying Zhao Qiang Wang Cheng Xie Yuling Cai Xue Chen Yuhui Hou Liu He Jianping Li Min Yao Shuangxi Chen Wutian Wu Xiaojia Chen An Hong
Theranostics 2021; doi:10.7150/thno.62525; in press
[Author manuscript]

A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy
Qinqin Jiang, Bin Qiao, Xiaohong Lin, Jin Cao, Nan Zhang, Huanling Guo, Weiwei Liu, Lingyu Zhu, Xue Xie, Li Wan, Rui Tang, Bing Liang, Dong Wang,Zhigang WangYang Zhou, HaiTao Ran, Pan Li
Theranostics 2021; doi:10.7150/thno.64862; in press
[Author manuscript]

Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing
Heng Sun, Jianming Zeng, Zengqiang Miao, Kuan Cheok Lei, Chen Huang, Lingling Hu, Sek Man Su, Un In Chan, Kai Miao, Xu Zhang, Aiping Zhang, Sen Guo, Si Chen, Ya Meng, Min Deng, Wenhui Hao, Haipeng Lei, Ying Lin, Zhonglin Yang, Dongjiang Tang, Koon Ho Wong, Xiaohua Douglas Zhang, Xiaoling Xu, Chu-Xia Deng
Theranostics 2021; doi:10.7150/thno.63995; in press
[Author manuscript]

Sonobiopsy for noninvasive, spatiotemporally-controlled, and sensitive detection of glioblastoma-derived circulating tumor DNA
Christopher P. Pacia, Jinyun Yuan, Yimei Yue, Lu Xu, Arash Nazeri, Rupen Desai, H. Michael Gach, Xiaowei Wang, Michael R. Talcott, Aadel A. Chaudhuri, Gavin P. Dunn, Eric C. Leuthardt, and Hong Chen
Theranostics 2021; doi:10.7150/thno.65597; accepted
[Author manuscript]

Establishment of tumor inflammasome clusters with distinct immunogenomic landscape aids immunotherapy
Qingyu Liang,Jianqi Wu,Xin Zhao,Shuai Shen,Chen Zhu,Tianqi Liu,Xiao Cui,Ling Chen,Chunmi Wei,Peng Cheng,Wen Cheng, and Anhua Wu
Theranostics 2021; doi:10.7150/thno.63202; in press
[Author manuscript]

Rational design of non-toxic GOx-based biocatalytic nanoreactor for multimodal synergistic therapy and tumor metastasis suppression
Lifeng Hang, Tao Zhang, Hua Wen, Meng Li, Lianbao Liang, Xinfeng Tang, Chunze Zhou, JunZhang Tian, Xiaofen Ma, Guihua Jiang
Theranostics 2021; doi:10.7150/thno.65399; in press
[Author manuscript]

CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders
Hanju Yoo, Ha-Ri Lee, Ki-Hyun Kim, Min-Ah Kim, Seunghyun Bang, Young-Ho Kang, Woo-hyung Kim, Youngsup Song, Sung Eun Chang
Theranostics 2021; doi:10.7150/thno.66378; in press
[Author manuscript]

Non-invasive longitudinal imaging of VEGF-induced microvascular alterations in skin wounds
Yu-Hang Liu, Lorenz M. Brunner, Johannes Rebling, Maya Ben-Yehuda Greenwald, Sabine Werner, Michael Detmar, Daniel Razansky
Theranostics 2021; doi:10.7150/thno.65287; accepted
[Author manuscript]

Microneedle arrays integrated with living organisms for smart biomedical applications
Bo Cai, Yusheng Gong, Zheng Wang, Lin Wang, Wei Chen
Theranostics 2021; doi:10.7150/thno.66478; in press
[Author manuscript]

Tumor-infiltrating lymphocytes are functionally inactivated by CD90+ stromal cells and reactivated by combined Ibrutinib and Rapamycin in human pleural mesothelioma
Haitang Yang, Sabina Berezowska, Patrick Dorn, Philipp Zens, Peiru Chen, Ren-Wang Peng, Thomas M. Marti, Ralph A. Schmid, and Sean R.R. Hall
Theranostics 2021; doi:10.7150/thno.61209; accepted
[Author manuscript]

Clinically Translatable Gold Nanozymes with Broad Spectrum Antioxidant and Anti-inflammatory Activity for Alleviating Acute Kidney Injury
Dong-Yang Zhang, Tianhui Tu, Muhammad Rizwan Younis, Kathy S. Zhu, Hengke Liu, Shan Lei, Junle Qu, Jing Lin and Peng Huang
Theranostics 2021; doi:10.7150/thno.66518; in press
[Author manuscript]

Exosome-mediated delivery of inflammation–responsive Il-10 mRNA for controlled atherosclerosis treatment
Te Bu, Zhelong Li, Ying Hou, Wenqi Sun, Rongxin Zhang, Lianbi Zhao, Mengying Wei, Guodong Yang, Lijun Yuan
Theranostics 2021; doi:10.7150/thno.64229; in press
[Author manuscript]

Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics
Bohan Yin, Junguo Ni, Claire E. Witherel, Mo Yang, Jason A. Burdick, Chunyi Wen and Siu Hong Dexter Wong
Theranostics 2021; doi:10.7150/thno.62708; accepted
[Author manuscript]

Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance
Anil Kumar, Kumaran Sundaram, Yun Teng, Jingyao Mu, Mukesh K Sriwastva, Lifeng Zhang, Joshua L. Hood, Jun Yan, Xiang Zhang, Juw Won Park, Michael L Merchant, and Huang-Ge Zhang
Theranostics 2021; doi:10.7150/thno.62514; accepted
[Author manuscript]

Integrated analysis of circulating immune cellular and soluble mediators reveals specific COVID19 signatures at hospital admission with utility for prediction of clinical outcomes
Iratxe Uranga-Murillo, Elena Morte, Sandra Hidalgo, Cecilia Pesini, Sandra García-Mulero, Jose L. Sierra, Llipsy Santiago, Maykel Arias, Diego De Miguel, Maria del Mar Encabo-Berzosa, Borja Gracia-Tello, Rebeca Sanz-Pamplona, Luis M. Martinez-Lostao, Eva M. Galvez, Jose R. Paño-Pardo, Ariel Ramirez-Labrada, and Julian Pardo
Theranostics 2021; doi:10.7150/thno.63463; accepted
[Author manuscript]

An MMP-Degradable and Conductive Hydrogel to Stabilize HIF-1α for Recovering Cardiac Functions
Xiaojuan Wei, Si Chen, Tian Xie, Hongchi Chen, Xin Jin, Jumin Yang, Shafaq Sahar, Huanlei Huang, Shuoji Zhu, Nanbo Liu, Changjiang Yu, Ping Zhu, Wei Wang, Wei Zhang
Theranostics 2021; doi:10.7150/thno.63481; in press
[Author manuscript]

Driver mutations of intrahepatic cholangiocarcinoma shape clinically relevant genomic clusters with distinct molecular features and targetable vulnerabilities
Xiang-Yu Wang, Wen-Wei Zhu, Zheng Wang, Jian-Bo Huang, Sheng-Hao Wang, Fu-Mao Bai, Tian-En Li, Ying Zhu, Jing Zhao, Xin Yang, Lu Lu, Ju-Bo Zhang, Hu-Liang Jia, Qiong-Zhu Dong, Jin-Hong Chen, Jesper B. Andersen, Dan Ye and Lun-Xiu Qin
Theranostics 2021; doi:10.7150/thno.63417; accepted
[Author manuscript]

Modulation of H4K16Ac Levels Reduces Pro-Fibrotic Gene Expression and Mitigates Lung Fibrosis in Aged Mice
Xiangyu Zhang, Hui Liu, Jennifer Q Zhou, Stefanie Krick, Jarrod W Barnes, Victor J Thannickal, Yan Y Sanders
Theranostics 2021; doi:10.7150/thno.62760; accepted
[Author manuscript]

Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage
Jiawei Huang, Kin Pong U, Fuyuan Yang, Zeyuan Ji, Jiacheng Lin, Zhihui Weng, Lai Ling Tsang, Tobias D Merson, Ye Chun Ruan, Chao Wan, Gang Li, Xiaohua Jiang
Theranostics 2021; doi:10.7150/thno.57234; accepted
[Author manuscript]

Biological relevance of Granzymes A and K during E. coli sepsis
Iratxe Uranga-Murillo, Elena Tapia, Marcela Garzón-Tituaña, Ariel Ramirez-Labrada, Llipsy Santiago, Eva M Galvez, Phillip I Bird, Julián Pardo and Maykel A Arias
Theranostics 2021; doi:10.7150/thno.59418; in press
[Author manuscript]

Note: This page contains manuscripts that have been accepted by this journal. They haven't been copyedited by the journal and the content may change before final publication.