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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1
Liang Wu, Ning Zhao, Zili Zhou, Jinhuang Chen, Shengbo Han, Xudan Zhang, Haijun Bao, Wenzheng Yuan, Xiaogang Shu
Theranostics 2021; 11(2): 700-714. doi:10.7150/thno.47800
[Abstract] [Full text] [PDF]


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Research Paper
Expansion of murine and human olfactory epithelium/mucosa colonies and generation of mature olfactory sensory neurons under chemically defined conditions
Wenwen Ren, Li Wang, Xiujuan Zhang, Xiaoyu Feng, Liujing Zhuang, Nan Jiang, Rui Xu, Xuewen Li, Ping Wang, Xicai Sun, Hongmeng Yu, Yiqun Yu
Theranostics 2021; 11(2): 684-699. doi:10.7150/thno.46750
[Abstract] [Full text] [PDF]


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Review
Glioma stem cells and their roles within the hypoxic tumor microenvironment
Nathaniel H. Boyd, Anh Nhat Tran, Joshua D. Bernstock, Tina Etminan, Amber B. Jones, G. Yancey Gillespie, Gregory K. Friedman, Anita B. Hjelmeland
Theranostics 2021; 11(2): 665-683. doi:10.7150/thno.41692
[Abstract] [Full text] [PDF]


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Research Paper
Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein
Lin Wang, Junhu Zhou, Qixue Wang, Yunfei Wang, Chunsheng Kang
Theranostics 2021; 11(2): 649-664. doi:10.7150/thno.51479
[Abstract] [Full text] [PDF]


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Review
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
Song Zhang, Jiangtao Shen, Dali Li, Yiyun Cheng
Theranostics 2021; 11(2): 614-648. doi:10.7150/thno.47007
[Abstract] [Full text] [PDF]


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Research Paper
Cytosolic Ca2+ transients during pulsed focused ultrasound generate reactive oxygen species and cause DNA damage in tumor cells
Robert B. Rosenblatt, Joseph A. Frank, Scott R. Burks
Theranostics 2021; 11(2): 602-613. doi:10.7150/thno.48353
[Abstract] [Full text] [PDF]


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Review
MRI-traceable theranostic nanoparticles for targeted cancer treatment
Tareq Anani, Shiva Rahmati, Nayer Sultana, Allan E. David
Theranostics 2021; 11(2): 579-601. doi:10.7150/thno.48811
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Research Paper
CXCR4 PET imaging of mantle cell lymphoma using [68Ga]Pentixafor: comparison with [18F]FDG-PET
Marius E. Mayerhoefer, Markus Raderer, Wolfgang Lamm, Verena Pichler, Sarah Pfaff, Michael Weber, Barbara Kiesewetter, Markus Hacker, Lukas Kazianka, Philipp B. Staber, Hans-Juergen Wester, Johannes Rohrbeck, Ingrid Simonitsch-Klupp, Alexander Haug
Theranostics 2021; 11(2): 567-578. doi:10.7150/thno.48620
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Research Paper
Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling
Yanli Hou, Bowen Sun, Wenxue Liu, Bo Yu, Qiqi Shi, Fei Luo, Yongrui Bai, Haizhong Feng
Theranostics 2021; 11(2): 555-566. doi:10.7150/thno.49250
[Abstract] [Full text] [PDF]


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Research Paper
Boiling histotripsy and in-situ CD40 stimulation improve the checkpoint blockade therapy of poorly immunogenic tumors
Mohit Pratap Singh, Sri Nandhini Sethuraman, Craig Miller, Jerry Malayer, Ashish Ranjan
Theranostics 2021; 11(2): 540-554. doi:10.7150/thno.49517
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Research Paper
Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats
Weilin Xu, Jun Yan, Umut Ocak, Cameron Lenahan, Anwen Shao, Jiping Tang, Jianmin Zhang, John H. Zhang
Theranostics 2021; 11(2): 522-539. doi:10.7150/thno.49426
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Research Paper
Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles
Wei Tong, Hui Hui, Wenting Shang, Yingqian Zhang, Feng Tian, Qiang Ma, Xin Yang, Jie Tian, Yundai Chen
Theranostics 2021; 11(2): 506-521. doi:10.7150/thno.49812
[Abstract] [Full text] [PDF]


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Research Paper
Inter and intra-tumor somatostatin receptor 2 heterogeneity influences peptide receptor radionuclide therapy response
Danny Feijtel, Gabriela N. Doeswijk, Nicole S. Verkaik, Joost C. Haeck, Daniela Chicco, Carmelina Angotti, Mark W. Konijnenberg, Marion de Jong, Julie Nonnekens
Theranostics 2021; 11(2): 491-505. doi:10.7150/thno.51215
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Research Paper
Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions
Roman Mehling, Johannes Schwenck, Christina Lemberg, Christoph Trautwein, Laimdota Zizmare, Daniela Kramer, Anne Müller, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Katrin Schröder, Ralph P. Brandes, Martin Schaller, Wolfram Ruf, Martin Eichner, Kamran Ghoreschi, Martin Röcken, Bernd J. Pichler, Manfred Kneilling
Theranostics 2021; 11(2): 470-490. doi:10.7150/thno.51462
[Abstract] [Full text] [PDF]


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Review
tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections
Xiuchong Yu, Yaoyao Xie, Shuangshuang Zhang, Xuemei Song, Bingxiu Xiao, Zhilong Yan
Theranostics 2021; 11(1): 461-469. doi:10.7150/thno.51963
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Research Paper
The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential
Rafael Contreras-Lopez, Roberto Elizondo-Vega, Noymar Luque-Campos, María José Torres, Carolina Pradenas, Gautier Tejedor, María José Paredes-Martínez, Ana María Vega-Letter, Mauricio Campos-Mora, Yandi Rigual-Gonzalez, Karina Oyarce, Magdiel Salgado, Christian Jorgensen, Maroun Khoury, María de los Ángeles Garcia-Robles, Claudia Altamirano, Farida Djouad, Patricia Luz-Crawford
Theranostics 2021; 11(1): 445-460. doi:10.7150/thno.51631
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 8.579

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Neural precursors cells expanded in a 3D micro-engineered niche present enhanced therapeutic efficacy in vivo
Stephana Carelli, Toniella Giallongo, Federica Rey, Bianca Barzaghini, Tommaso Zandrini, Andrea Pulcinelli, Riccardo Nardomarino, Giulio Cerullo, Roberto Osellame, Cristina Cereda, Gian Vincenzo Zuccotti, Manuela Teresa Raimondi
Nanotheranostics 2021; 5(1): 8-26. doi:10.7150/ntno.50633
[Abstract] [Full text] [PDF]


Research Paper
Cancer-derived EVs show tropism for tissues at early stage of neoplastic transformation
Mariangela Garofalo, Alessandro Villa, Electra Brunialti, Daniela Crescenti, Giulia Dell'Omo, Lukasz Kuryk, Andrea Vingiani, Vincenzo Mazzaferro, Paolo Ciana
Nanotheranostics 2021; 5(1): 1-7. doi:10.7150/ntno.47226
[Abstract] [Full text] [PDF]


Research Paper
The effect of ultrasound pulse length on microbubble cavitation induced antibody accumulation and distribution in a mouse model of breast cancer
Marie Amate, Joseph Goldgewicht, Balasubramanian Sellamuthu, John Stagg, Francois T.H. Yu
Nanotheranostics 2020; 4(4): 256-269. doi:10.7150/ntno.46892
[Abstract] [Full text] [PDF] [PubMed] [PMC]

CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues