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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function
Yu Ding, Yongwen Zhou, Ping Ling, Xiaojun Feng, Sihui Luo, Xueying Zheng, Peter J. Little, Suowen Xu, Jianping Weng
Theranostics 2021; 11(19): 9376-9396. doi:10.7150/thno.64706
[Abstract] [Full text] [PDF]


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Research Paper
IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1+/- mice display increases atherosclerotic plaque stability
Shaohong Fang, Song Sun, Hengxuan Cai, Xiaoyi Zou, Shanjie Wang, Xinran Hao, Xin Wan, Jiangtian Tian, Zhaoying Li, Zhongze He, Wei Huang, Chenchen Liang, Zhenming Zhang, Liming Yang, Jinwei Tian, Bo Yu, Bo Sun
Theranostics 2021; 11(19): 9358-9375. doi:10.7150/thno.62797
[Abstract] [Full text] [PDF]


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Research Paper
Neuromedin B receptor stimulation of Cav3.2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity
Yuan Zhang, Zhiyuan Qian, Dongsheng Jiang, Yufang Sun, Shangshang Gao, Xinghong Jiang, Hua Wang, Jin Tao
Theranostics 2021; 11(19): 9342-9357. doi:10.7150/thno.62255
[Abstract] [Full text] [PDF]


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Research Paper
Pyruvate kinase M2 regulates fibrosis development and progression by controlling glycine auxotrophy in myofibroblasts
Ganesh Satyanarayana, Ravi Chakra Turaga, Malvika Sharma, Siming Wang, Falguni Mishra, Guangda Peng, Xiaonan Deng, Jenny Yang, Zhi-Ren Liu
Theranostics 2021; 11(19): 9331-9341. doi:10.7150/thno.60385
[Abstract] [Full text] [PDF]


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Research Paper
Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases
Baolong Liu, Xingzhi Li, Han Yu, Xuan Shi, You Zhou, Sophie Alvarez, Michael J. Naldrett, Stephen D. Kachman, Seung-Hyun Ro, Xinghui Sun, Soonkyu Chung, Lili Jing, Jiujiu Yu
Theranostics 2021; 11(19): 9311-9330. doi:10.7150/thno.60265
[Abstract] [Full text] [PDF]


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Research Paper
Upregulated NMDAR-enhanced GABAergic transmission underlies autistic-like deficits in Htr3a knockout mice
Lang Huang, Jing Wang, Guanmei Liang, Yue Gao, Shi-Yang Jin, Jian Hu, Xiaoxue Yang, Jianpei Lao, Jinfa Chen, Zhou-Cai Luo, Cuixia Fan, Li Xiong, Xinhong Zhu, Tian-Ming Gao, Mei Zhong, Xinping Yang
Theranostics 2021; 11(19): 9296-9310. doi:10.7150/thno.60531
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Review
Shining light on chiral inorganic nanomaterials for biological issues
Yining Shao, Guilin Yang, Jiaying Lin, Xiaofeng Fan, Yue Guo, Wentao Zhu, Ying Cai, Huiyu Huang, Die Hu, Wei Pang, Yanjun Liu, Yiwen Li, Jiaji Cheng, Xiaoqian Xu
Theranostics 2021; 11(19): 9262-9295. doi:10.7150/thno.64511
[Abstract] [Full text] [PDF]


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Research Paper
Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis
Suet Yen Chong, Olga Zharkova, Siti Maryam J.M. Yatim, Xiaoyuan Wang, Xiong Chang Lim, Chenyuan Huang, Chia Yee Tan, Jianming Jiang, Lei Ye, Michelle Siying Tan, Veronique Angeli, Henri H. Versteeg, Mieke Dewerchin, Peter Carmeliet, Carolyn S.P. Lam, Mark Y. Chan, Dominique P.V. de Kleijn, Jiong-Wei Wang
Theranostics 2021; 11(19): 9243-9261. doi:10.7150/thno.63354
[Abstract] [Full text] [PDF]


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Research Paper
Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy
Lina Sun, Xianwen Wang, Fei Gong, Kui Yin, Wenxiang Zhu, Nailin Yang, Shang Bai, Fan Liao, Mingwang Shao, Liang Cheng
Theranostics 2021; 11(19): 9234-9242. doi:10.7150/thno.58755
[Abstract] [Full text] [PDF]


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Research Paper
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma
Verena Panitz, Saša Končarević, Ahmed Sadik, Dennis Friedel, Tobias Bausbacher, Saskia Trump, Vadim Farztdinov, Sandra Schulz, Philipp Sievers, Stefan Schmidt, Ina Jürgenson, Stephan Jung, Karsten Kuhn, Irada Pflüger, Suraj Sharma, Antje Wick, Pauline Pfänder, Stefan Selzer, Philipp Vollmuth, Felix Sahm, Andreas von Deimling, Ines Heiland, Carsten Hopf, Peter Schulz-Knappe, Ian Pike, Michael Platten, Wolfgang Wick, Christiane A. Opitz
Theranostics 2021; 11(19): 9217-9233. doi:10.7150/thno.60679
[Abstract] [Full text] [PDF]


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Research Paper
LOXL2-enriched small extracellular vesicles mediate hypoxia-induced premetastatic niche and indicates poor outcome of head and neck cancer
Guiquan Zhu, Linlin Wang, Wanrong Meng, Shun Lu, Bangrong Cao, Xinhua Liang, Chuanshi He, Yaying Hao, Xueyu Du, Xiaoyi Wang, Longjiang Li, Ling Li
Theranostics 2021; 11(19): 9198-9216. doi:10.7150/thno.62455
[Abstract] [Full text] [PDF]


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Research Paper
BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators
Olivier Castellanet, Fahmida Ahmad, Yaron Vinik, Gordon B. Mills, Bianca Habermann, Jean-Paul Borg, Sima Lev, Fabienne Lamballe, Flavio Maina
Theranostics 2021; 11(19): 9180-9197. doi:10.7150/thno.60503
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Editorial
High-performance renal imaging with a radiolabeled, non-excretable chimeric fusion protein
Dawei Jiang, Muhsin H. Younis, Xiaoli Lan, Weibo Cai
Theranostics 2021; 11(18): 9177-9179. doi:10.7150/thno.66417
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression
Yongshuai Jiang, Yuanyang Yuan, Ming Chen, Shengzhe Li, Jun Bai, Yuanteng Zhang, Ying Sun, Guojue Wang, Haiyan Xu, Ziyu Wang, Yingxia Zheng, Hong Nie
Theranostics 2021; 11(18): 9162-9176. doi:10.7150/thno.59605
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Oligonucleotide aptamers for pathogen detection and infectious disease control
Quanyuan Wan, Xiaohui Liu, Youli Zu
Theranostics 2021; 11(18): 9133-9161. doi:10.7150/thno.61804
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Targeted design of a recombinant tracer for SPECT renal imaging
Pan Liu, Steven E. Johnson, Xinfang Xie, Li Gao, Chad R. Haney, Ming Zhao, Jing Jin
Theranostics 2021; 11(18): 9118-9132. doi:10.7150/thno.60132
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 11.556.

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Metal-Organic Frameworks for Bioimaging: Strategies and Challenges
Yanfei Liu, Ting Jiang, Zhenbao Liu
Nanotheranostics 2022; 6(2): 143-160. doi:10.7150/ntno.63458
[Abstract] [Full text] [PDF]


Research Paper
Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis
Kristen R. Hollinger, Anjali Sharma, Carolyn Tallon, Lyndah Lovell, Ajit G. Thomas, Xiaolei Zhu, Robyn Wiseman, Ying Wu, Siva P. Kambhampati, Kevin Liaw, Rishi Sharma, Camilo Rojas, Rana Rais, Sujatha Kannan, Rangaramanujam M. Kannan, Barbara S. Slusher
Nanotheranostics 2022; 6(2): 126-142. doi:10.7150/ntno.63158
[Abstract] [Full text] [PDF]


In Memory
The brightest stars - a tribute to Moritz Kircher
Chrysafis Andreou
Nanotheranostics 2022; 6(1): 121-122. doi:10.7150/ntno.63531
[Abstract] [Full text] [PDF]

Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.
Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: https://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues