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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Unleashing the potential of adipose organoids: A revolutionary approach to combat obesity-related metabolic diseases
Xingran Liu, Jing Yang, Yuxin Yan, Qingfeng Li, Ru-Lin Huang
Theranostics 2024; 14(5): 2075-2098. doi:10.7150/thno.93919
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Research Paper
NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover
Bei Liu, Duanyi Hua, Linyan Shen, Tingting Li, Zheying Tao, Chenyang Fu, Zhongzheng Tang, Jie Yang, Li Zhang, Aifang Nie, Yiran Jiang, Jiqiu Wang, Yang Li, Yanyun Gu, Guang Ning
Theranostics 2024; 14(5): 2058-2074. doi:10.7150/thno.90946
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Research Paper
Depletion of ApoA5 aggravates spontaneous and diet-induced nonalcoholic fatty liver disease by reducing hepatic NR1D1 in hamsters
Jiabao Guo, Guolin Miao, Wenxi Zhang, Haozhe Shi, Pingping Lai, Yitong Xu, Lianxin Zhang, Gonglie Chen, Yufei Han, Ying Zhao, Geroge Liu, Ling Zhang, Yuhui Wang, Wei Huang, Xunde Xian
Theranostics 2024; 14(5): 2036-2057. doi:10.7150/thno.91084
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Review
Highly oriented hydrogels for tissue regeneration: design strategies, cellular mechanisms, and biomedical applications
Jiuping Wu, Zhihe Yun, Wenlong Song, Tao Yu, Wu Xue, Qinyi Liu, Xinzhi Sun
Theranostics 2024; 14(5): 1982-2035. doi:10.7150/thno.89493
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Review
Cancer diagnosis using label-free SERS-based exosome analysis
Yajuan Liu, Mei Li, Haisha Liu, Chao Kang, Cheng Wang
Theranostics 2024; 14(5): 1966-1981. doi:10.7150/thno.92621
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Research Paper
H-ferritin-nanocaged gadolinium nanoparticles for ultra-sensitive MR molecular imaging
Jianlin Zhang, Chang Yuan, Lingfei Kong, Feiyan Zhu, Wanzhong Yuan, Junying Zhang, Juanji Hong, Fang Deng, Qi Chen, Chen Chen, Tao Wang, Zhentao Zuo, Minmin Liang
Theranostics 2024; 14(5): 1956-1965. doi:10.7150/thno.93856
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Research Paper
Multifunctional Sr/Se co-doped ZIF-8 nanozyme for chemo/chemodynamic synergistic tumor therapy via apoptosis and ferroptosis
Aimin Wu, Ming Han, Zihan Ni, Haoran Li, Yinyin Chen, Zhouping Yang, Yumei Feng, Zufeng He, Hua Zhen, Xianxiang Wang
Theranostics 2024; 14(5): 1939-1955. doi:10.7150/thno.92663
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Research Paper
Neutrophil extracellular trap-mediated impairment of meningeal lymphatic drainage exacerbates secondary hydrocephalus after intraventricular hemorrhage
Qiang Zhang, Yujie Chen, Yingpei Li, Zhou Feng, Liang Liang, Xiaoke Hao, Wenbo Kang, Zhaoqi Zhang, Xuyang Zhang, Rong Hu, Hua Feng, Zhi Chen
Theranostics 2024; 14(5): 1909-1938. doi:10.7150/thno.91653
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile



Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.


CFP: Special issue on mRNA-based vaccine and therapy. Guest Editors: Guocan Yu (Tsinghua University, China), Qiaobing Xu (Tufts University, USA), Wei Tao (Harvard Medical School, USA)


Background: ApoA5 mainly synthesized and secreted by liver is a key modulator of lipoprotein lipase (LPL) activity and triglyceride-rich lipoproteins (TRLs). Although the role of ApoA5 in extrahepatic triglyceride (TG) metabolism in circulation has been well documented, the relationship between ApoA5 and nonalcoholic fatty liver disease (NAFLD) remains incompletely understood and the underlying molecular mechanism still needs to be elucidated. Methods: We used CRISPR/Cas9 gene editing to delete Apoa5 gene from Syrian golden hamster, a small rodent model replicating human metabolic features. Then,....
Rationale: Hydrocephalus is a substantial complication after intracerebral hemorrhage (ICH) or intraventricular hemorrhage (IVH) that leads to impaired cerebrospinal fluid (CSF) circulation. Recently, brain meningeal lymphatic vessels (mLVs) were shown to serve as critical drainage pathways for CSF. Our previous studies indicated that the degradation of neutrophil extracellular traps (NETs) after ICH/IVH alleviates hydrocephalus. However, the mechanisms by which NET degradation exerts beneficial effects in hydrocephalus remain unclear. Methods: A mouse model of hydrocephalus following IVH was established....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Review
Sepsis, Management & Advances in Metabolomics
Swarnima Pandey
Nanotheranostics 2024; 8(3): 270-284. doi:10.7150/ntno.94071
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