Cover image

Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


Graphic abstract

Research Paper
Estimating dynamic vascular perfusion based on Er-based lanthanide nanoprobes with enhanced down-conversion emission beyond 1500 nm
Qian Jia, Zheng Li, Mingli Bai, Haohao Yan, Ruili Zhang, Yu Ji, Yanbin Feng, Zuo Yang, Zhongliang Wang, Jianxiong Li
Theranostics 2021; 11(20): 9859-9872. doi:10.7150/thno.65771
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
Multiple regression analysis of a comprehensive transcriptomic data assembly elucidates mechanically- and biochemically-driven responses to focused ultrasound blood-brain barrier disruption
Alexander S. Mathew, Catherine M. Gorick, Richard J. Price
Theranostics 2021; 11(20): 9847-9858. doi:10.7150/thno.65064
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
A programmable hierarchical-responsive nanoCRISPR elicits robust activation of endogenous target to treat cancer
Chao Liu, Ning Wang, Rui Luo, Lu Li, Wen Yang, Xiye Wang, Meiling Shen, Qinjie Wu, Changyang Gong
Theranostics 2021; 11(20): 9833-9846. doi:10.7150/thno.62449
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis
Xiaoxun Li, Yajun Liang, Cheng Lian, Fangli Peng, Yansen Xiao, Yunfei He, Chengxin Ma, Yuan Wang, Peiyuan Zhang, Yuhan Deng, Yunpeng Su, Cheng Luo, Xiangyin Kong, Qingcheng Yang, Tong Liu, Guohong Hu
Theranostics 2021; 11(20): 9821-9832. doi:10.7150/thno.62187
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury
Jesus Amo-Aparicio, Joana Garcia-Garcia, Isaac Francos-Quijorna, Andrea Urpi, Anna Esteve-Codina, Marta Gut, Albert Quintana, Ruben Lopez-Vales
Theranostics 2021; 11(20): 9805-9820. doi:10.7150/thno.65203
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice
Chaojun Tang, Lei Wang, Yulan Sheng, Zhong Zheng, Zhanli Xie, Fan Wu, Tao You, Lijie Ren, Lijun Xia, Changgeng Ruan, Li Zhu
Theranostics 2021; 11(20): 9791-9804. doi:10.7150/thno.64601
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
Identification of three tumor antigens and immune subtypes for mRNA vaccine development in diffuse glioma
Quanwei Zhou, Xuejun Yan, Hecheng Zhu, Zhaoqi Xin, Jin Zhao, Wenyue Shen, Wen Yin, Youwei Guo, Hongjuan Xu, Ming Zhao, Weidong Liu, Xingjun Jiang, Caiping Ren
Theranostics 2021; 11(20): 9775-9790. doi:10.7150/thno.61677
[Abstract] [Full text] [PDF]


Erratum
Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy: Erratum
Meng-Lu Chen, Chun-Gu Hong, Tao Yue, Hong-Ming Li, Ran Duan, Wen-Bao Hu, Jia Cao, Zhen-Xing Wang, Chun-Yuan Chen, Xiong-Ke Hu, Ben Wu, Hao-Ming Liu, Yi-Juan Tan, Jiang-Hua Liu, Zhong-Wei Luo, Yan Zhang, Shan-Shan Rao, Ming-Jie Luo, Hao Yin, Yi-Yi Wang, Kun Xia, Si-Yuan Tang, Hui Xie, Zheng-Zhao Liu
Theranostics 2021; 11(20): 9774. doi:10.7150/thno.67227
[Abstract] [Full text] [PDF]


Erratum
Nanosonosensitizers for Highly Efficient Sonodynamic Cancer Theranostics: Erratum
Ju Huang, Fengqiu Liu, Xiaoxia Han, Liang Zhang, Zhongqian Hu, Qinqin Jiang, Zhigang Wang, Haitao Ran, Dong Wang, Pan Li
Theranostics 2021; 11(20): 9772-9773. doi:10.7150/thno.67168
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2
Arun Pandian Chandrasekaran, Kamini Kaushal, Chang-Hwan Park, Kye-Seong Kim, Suresh Ramakrishna
Theranostics 2021; 11(20): 9752-9771. doi:10.7150/thno.63806
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
Osteoblast-derived EGFL6 couples angiogenesis to osteogenesis during bone repair
Kai Chen, Shijie Liao, Yicheng Li, Haibo Jiang, Yun Liu, Chao Wang, Vincent Kuek, Jacob Kenny, Boxiang Li, Qian Huang, Jianxin Hong, Yan Huang, Shek Man Chim, Jennifer Tickner, Nathan J. Pavlos, Jinmin Zhao, Qian Liu, An Qin, Jiake Xu
Theranostics 2021; 11(20): 9738-9751. doi:10.7150/thno.60902
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
Practical considerations for quantitative clinical SPECT/CT imaging of alpha particle emitting radioisotopes
Nadia Benabdallah, William Scheve, Nicholas Dunn, Delynn Silvestros, Paul Schelker, Diane Abou, Uday Jammalamadaka, Richard Laforest, Zekun Li, Jonathan Liu, David H. Ballard, Nichole M. Maughan, Hiram Gay, Brian C. Baumann, Robert F. Hobbs, Buck Rogers, Amir Iravani, Abhinav K. Jha, Farrokh Dehdashti, Daniel L. J. Thorek
Theranostics 2021; 11(20): 9721-9737. doi:10.7150/thno.63860
[Abstract] [Full text] [PDF]


Graphic abstract

Research Paper
Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis
Lin Mao, Jin Chen, Xue Lu, Canlin Yang, Yi Ding, Mingming Wang, Yunpeng Zhang, Yuying Tian, Xing Li, Yunyun Fu, Yueying Yang, Yunyun Gu, Fei Gao, Junxing Huang, Lujian Liao
Theranostics 2021; 11(19): 9705-9720. doi:10.7150/thno.61731
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Research Paper
Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment
Soohyun Hong, Jae Young You, Kyurim Paek, Jubin Park, Su Jin Kang, Eun Hee Han, Nakwon Choi, Seok Chung, Won Jong Rhee, Jeong Ah Kim
Theranostics 2021; 11(19): 9687-9704. doi:10.7150/thno.60851
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Research Paper
Tumor microenvironment-based screening repurposes drugs targeting cancer stem cells and cancer-associated fibroblasts
Pei-Jung Lee, Chao-Chi Ho, Hao Ho, Wan-Jiun Chen, Chiu-Hua Lin, Yi-Hua Lai, Yi-Chen Juan, Wen-Chung Chu, Jia-Hua Lee, Sheng-Fang Su, Hsuan-Yu Chen, Jeremy J. W. Chen, Gee-Chen Chang, Ker-Chau Li, Pan-Chyr Yang, Huei-Wen Chen
Theranostics 2021; 11(19): 9667-9686. doi:10.7150/thno.62676
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Graphic abstract

Research Paper
Polyamino acid calcified nanohybrids induce immunogenic cell death for augmented chemotherapy and chemo-photodynamic synergistic therapy
Wei Qiu, Mengyun Liang, Yuan Gao, Xuelian Yang, Xingyao Zhang, Xiaoli Zhang, Peng Xue, Yuejun Kang, Zhigang Xu
Theranostics 2021; 11(19): 9652-9666. doi:10.7150/thno.64354
[Abstract] [Full text] [PDF] [PubMed] [PMC]

More ...

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 11.556.

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Flavin Adenine Dinucleotide (FAD) Pegylated (PEG)-Complexes: Proof of Concept (PoC) of theranostic tool on a Murine Breast Cancer Model
Celia Arib, Hui Liu, Qiqian Liu, Anne-Marie Cieutat, Didier Paleni, Xiaowu Li, Jolanda Spadavecchia
Nanotheranostics 2022; 6(2): 175-183. doi:10.7150/ntno.63496
[Abstract] [Full text] [PDF]


Research Paper
Development of CD44E/s dual-targeting DNA aptamer as nanoprobe to deliver treatment in hepatocellular carcinoma
Cario Wing-Sze Lo, Cecilia Ka Wing Chan, Jianqing Yu, Mian He, Chung Hang Jonathan Choi, James Yun Wong Lau, Nathalie Wong
Nanotheranostics 2022; 6(2): 161-174. doi:10.7150/ntno.62639
[Abstract] [Full text] [PDF]


Research Paper
Metal-Organic Frameworks for Bioimaging: Strategies and Challenges
Yanfei Liu, Ting Jiang, Zhenbao Liu
Nanotheranostics 2022; 6(2): 143-160. doi:10.7150/ntno.63458
[Abstract] [Full text] [PDF]

Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.
Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: https://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues