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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow
Beibei Shan, Haitao Wang, Linhu Li, Guangzhi Zhou, Yu Wen, Mingyang Chen, Ming Li
Theranostics 2020; 10(25): 11656-11672. doi:10.7150/thno.51287
[Abstract] [Full text] [PDF]


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Research Paper
ROS production and mitochondrial dysfunction driven by PU.1-regulated NOX4-p22phox activation in Aβ-induced retinal pigment epithelial cell injury
Junran Sun, Jieqiong Chen, Tong Li, Peirong Huang, Jie Li, Mengxi Shen, Min Gao, Yang Sun, Jian Liang, Xiaomeng Li, Yimin Wang, Yushu Xiao, Xiang Shi, Yifan Hu, Jingyang Feng, Huixun Jia, Te Liu, Xiaodong Sun
Theranostics 2020; 10(25): 11637-11655. doi:10.7150/thno.48064
[Abstract] [Full text] [PDF]


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Research Paper
Targeting BCL10 by small peptides for the treatment of B cell lymphoma
Wei Bao, Chenxia Sun, Xiaochen Sun, Miaoxia He, Haolan Yu, Wenfen Yan, Fuping Wen, Liang Zhang, Chenghua Yang
Theranostics 2020; 10(25): 11622-11636. doi:10.7150/thno.47533
[Abstract] [Full text] [PDF]


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Research Paper
Hemoglobin-mediated biomimetic synthesis of paramagnetic O2-evolving theranostic nanoprobes for MR imaging-guided enhanced photodynamic therapy of tumor
Xiudong Shi, Weitao Yang, Qiong Ma, Yang Lu, Yan Xu, Kexin Bian, Fengjun Liu, Chunzi Shi, Han Wang, Yuxin Shi, Bingbo Zhang
Theranostics 2020; 10(25): 11607-11621. doi:10.7150/thno.46228
[Abstract] [Full text] [PDF]


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Research Paper
Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer
Sheng Zhang, Cheng Kong, Yongzhi Yang, Sanjun Cai, Xinxiang Li, Guoxiang Cai, Yanlei Ma
Theranostics 2020; 10(25): 11595-11606. doi:10.7150/thno.49515
[Abstract] [Full text] [PDF]


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Research Paper
A snake toxin as a theranostic agent for the type 2 vasopressin receptor
Laura Droctové, Manon Lancien, Vu Long Tran, Michaël Susset, Benoit Jego, Frederic Theodoro, Pascal Kessler, Gilles Mourier, Philippe Robin, Sékou Siramakan Diarra, Stefano Palea, Adrien Flahault, Amélia Chorfa, Maithé Corbani, Catherine Llorens-Cortes, Bernard Mouillac, Christiane Mendre, Alain Pruvost, Denis Servent, Charles Truillet, Nicolas Gilles
Theranostics 2020; 10(25): 11580-11594. doi:10.7150/thno.47485
[Abstract] [Full text] [PDF]


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Research Paper
Extracellular vesicles derived from Krüppel-Like Factor 2-overexpressing endothelial cells attenuate myocardial ischemia-reperfusion injury by preventing Ly6Chigh monocyte recruitment
Shuaihua Qiao, Wenfeng Zhang, Yong Yin, Zhonghai Wei, Fu Chen, Jinxuan Zhao, Xuan Sun, Dan Mu, Jun Xie, Biao Xu
Theranostics 2020; 10(25): 11562-11579. doi:10.7150/thno.45459
[Abstract] [Full text] [PDF]


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Research Paper
CXCR4 induces cell autophagy and maintains EBV latent infection in EBVaGC
Weiwen Wang, Yan Zhang, Wen Liu, Xiangyan Zhang, Hua Xiao, Menghe Zhao, Bing Luo
Theranostics 2020; 10(25): 11549-11561. doi:10.7150/thno.44251
[Abstract] [Full text] [PDF]


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Research Paper
FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma
Ying Wang, Zhaojie Lyu, Yanru Qin, Xia Wang, Liangzhan Sun, Yu Zhang, Lanqi Gong, Shayi Wu, Shuo Han, Ying Tang, Yongxu Jia, Dora Lai-Wan Kwong, NgarWoon Kam, Xin-Yuan Guan
Theranostics 2020; 10(25): 11535-11548. doi:10.7150/thno.45261
[Abstract] [Full text] [PDF]


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Research Paper
Inactivation of tumor suppressor gene Clusterin leads to hyperactivation of TAK1-NF-κB signaling axis in lung cancer cells and denotes a therapeutic opportunity
Zhipeng Chen, Zhenzhen Fan, Xiaowei Dou, Qian Zhou, Guandi Zeng, Lu Liu, Wensheng Chen, Ruirui Lan, Wanting Liu, Guoqing Ru, Lei Yu, Qing-Yu He, Liang Chen
Theranostics 2020; 10(25): 11520-11534. doi:10.7150/thno.44829
[Abstract] [Full text] [PDF]


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Research Paper
Precise and efficient silencing of mutant KrasG12D by CRISPR-CasRx controls pancreatic cancer progression
Wang Jiang, Hao Li, Xiyu Liu, Jianping Zhang, Wuhu zhang, Tianjiao Li, Liang Liu, Xianjun Yu
Theranostics 2020; 10(25): 11507-11519. doi:10.7150/thno.46642
[Abstract] [Full text] [PDF]


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Research Paper
PPARα mediates night neon light-induced weight gain: role of lipid homeostasis
Yishuang Luo, Julin Yang, Jinyu Kang, Kuihao Chen, Xiaofeng Jin, Frank J Gonzalez, Aiming Liu
Theranostics 2020; 10(25): 11497-11506. doi:10.7150/thno.50953
[Abstract] [Full text] [PDF]


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Research Paper
Redox DAPK1 destabilizes Pellino1 to govern inflammation-coupling tubular damage during septic AKI
Bang-Chuan Hu, Guo-Hua Wu, Zi-Qiang Shao, Yang Zheng, Jin-Quan Liu, Run Zhang, Jun Hong, Xiang-Hong Yang, Ren-Hua Sun, Shi-Jing Mo
Theranostics 2020; 10(25): 11479-11496. doi:10.7150/thno.49870
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Review
Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies
Jia-Wei He, Xu-Jie Zhou, Ji-Cheng Lv, Hong Zhang
Theranostics 2020; 10(25): 11462-11478. doi:10.7150/thno.49778
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Research Paper
Restoring the epigenetically silenced PCK2 suppresses renal cell carcinoma progression and increases sensitivity to sunitinib by promoting endoplasmic reticulum stress
Zhiyong Xiong, Changfei Yuan, Jian shi, Wei Xiong, Yu Huang, Wen Xiao, Hongmei Yang, Ke Chen, Xiaoping Zhang
Theranostics 2020; 10(25): 11444-11461. doi:10.7150/thno.48469
[Abstract] [Full text] [PDF]


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Research Paper
BET inhibitor suppresses melanoma progression via the noncanonical NF-κB/SPP1 pathway
Guangtong Deng, Furong Zeng, Juan Su, Shuang Zhao, Rui Hu, Wu Zhu, Shuo Hu, Xiang Chen, Mingzhu Yin
Theranostics 2020; 10(25): 11428-11443. doi:10.7150/thno.47432
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 8.579

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
The effect of ultrasound pulse length on microbubble cavitation induced antibody accumulation and distribution in a mouse model of breast cancer
Marie Amate, Joseph Goldgewicht, Balasubramanian Sellamuthu, John Stagg, Francois T.H. Yu
Nanotheranostics 2020; 4(4): 256-269. doi:10.7150/ntno.46892
[Abstract] [Full text] [PDF]


Review
Local delivery of insulin/IGF-1 for bone regeneration: carriers, strategies, and effects
Xiaoxuan Zhang, Helin Xing, Feng Qi, Hongchen Liu, Lizeng Gao, Xing Wang
Nanotheranostics 2020; 4(4): 242-255. doi:10.7150/ntno.46408
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Electrostatic reaction for the detection of circulating tumor cells as a potential diagnostic biomarker for metastasis in solid tumor
Zhiming Li, Xingping Liu, Weidong Zhang, Xuan Zhuang
Nanotheranostics 2020; 4(4): 233-241. doi:10.7150/ntno.46928
[Abstract] [Full text] [PDF] [PubMed] [PMC]

CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues