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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Concurrent imaging of vascularization and metabolism in a mouse model of paraganglioma under anti-angiogenic treatment
Caterina Facchin, Mailyn Perez-Liva, Anikitos Garofalakis, Thomas Viel, Anais Certain, Daniel Balvay, Thulaciga Yoganathan, Justine Woszczyk, Kelly De Sousa, Joevin Sourdon, Jean Provost, Mickael Tanter, Charlotte Lussey-Lepoutre, Judith Favier, Bertrand Tavitian
Theranostics 2020; 10(8): 3518-3532. doi:10.7150/thno.40687
[Abstract] [Full text] [PDF]


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Review
Circular RNA-protein interactions: functions, mechanisms, and identification
Anqing Huang, Haoxiao Zheng, Zhiye Wu, Minsheng Chen, Yuli Huang
Theranostics 2020; 10(8): 3503-3517. doi:10.7150/thno.42174
[Abstract] [Full text] [PDF]


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Research Paper
Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma
Jiahui Chu, Xiangjie Niu, Jiang Chang, Mingming Shao, Linna Peng, Yiyi Xi, Ai Lin, Chengcheng Wang, Qionghua Cui, Yingying Luo, Wenyi Fan, Yamei Chen, Yanxia Sun, Wenjia Guo, Wen Tan, Dongxin Lin, Chen Wu
Theranostics 2020; 10(8): 3488-3502. doi:10.7150/thno.41427
[Abstract] [Full text] [PDF]


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Research Paper
Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs
Li Qiao, Shiqi Hu, Ke Huang, Teng Su, Zhenhua Li, Adam Vandergriff, Jhon Cores, Phuong-Uyen Dinh, Tyler Allen, Deliang Shen, Hongxia Liang, Yongjun Li, Ke Cheng
Theranostics 2020; 10(8): 3474-3487. doi:10.7150/thno.39434
[Abstract] [Full text] [PDF]


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Research Paper
A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor α-dependent transcriptional activation and breast carcinogenesis
Bing-ling Peng, Wen-juan Li, Jian-cheng Ding, Yao-hui He, Ting Ran, Bing-lan Xie, Zi-rui Wang, Hai-feng Shen, Rong-quan Xiao, Wei-wei Gao, Tian-yi Ye, Xiang Gao, Wen Liu
Theranostics 2020; 10(8): 3451-3473. doi:10.7150/thno.39241
[Abstract] [Full text] [PDF]


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Research Paper
Smart Sorting of Tumor Phenotype with Versatile Fluorescent Ag Nanoclusters by Sensing Specific Reactive Oxygen Species
Xin Chen, Tiegong Wang, Wenjun Le, Xin Huang, Minghui Gao, Qian Chen, Shuogui Xu, Detao Yin, Qingge Fu, Chengwei Shao, Bingdi Chen, Donglu Shi
Theranostics 2020; 10(8): 3430-3450. doi:10.7150/thno.38422
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Research Paper
Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging
Bowen Qi, Ayrianne J. Crawford, Nicholas E. Wojtynek, Geoffrey A. Talmon, Michael A. Hollingsworth, Quan P. Ly, Aaron M. Mohs
Theranostics 2020; 10(8): 3413-3429. doi:10.7150/thno.40688
[Abstract] [Full text] [PDF]


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Research Paper
Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity
Sri Nandhini Sethuraman, Mohit Pratap Singh, Girish Patil, Shitao Li, Steven Fiering, P. Jack Hoopes, Chandan Guha, Jerry Malayer, Ashish Ranjan
Theranostics 2020; 10(8): 3397-3412. doi:10.7150/thno.42243
[Abstract] [Full text] [PDF]


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Research Paper
N6-methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming
Zhuojia Chen, Long Wu, Jiawang Zhou, Xinyao Lin, Yanxi Peng, Lichen Ge, Cheng-Ming Chiang, Hui Huang, Hongsheng Wang, Weiling He
Theranostics 2020; 10(8): 3382-3396. doi:10.7150/thno.40144
[Abstract] [Full text] [PDF]


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Research Paper
Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy
Yuning Liao, Yuan Liu, Xiaohong Xia, Zhenlong Shao, Chuyi Huang, Jinchan He, Lili Jiang, Daolin Tang, Jinbao Liu, Hongbiao Huang
Theranostics 2020; 10(8): 3366-3381. doi:10.7150/thno.41849
[Abstract] [Full text] [PDF]


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Research Paper
ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma
Bo Han, Xiangqi Meng, Pengfei Wu, Ziwei Li, Siyi Li, Yangong Zhang, Caijun Zha, Qile Ye, Chuanlu Jiang, Jinquan Cai, Tao Jiang
Theranostics 2020; 10(7): 3351-3365. doi:10.7150/thno.41219
[Abstract] [Full text] [PDF]


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Research Paper
Detection of Lymph Node Metastases by Ultra-pH-Sensitive Polymeric Nanoparticles
Zachary T. Bennett, Qiang Feng, Justin A. Bishop, Gang Huang, Baran D. Sumer, Jinming Gao
Theranostics 2020; 10(7): 3340-3350. doi:10.7150/thno.41239
[Abstract] [Full text] [PDF]


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Research Paper
Bioinspired tumor-homing nanoplatform for co-delivery of paclitaxel and siRNA-E7 to HPV-related cervical malignancies for synergistic therapy
Cong Xu, Wan Liu, Yuan Hu, Weiping Li, Wen Di
Theranostics 2020; 10(7): 3325-3339. doi:10.7150/thno.41228
[Abstract] [Full text] [PDF]


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Research Paper
Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis
Yong Zhao, Pengfei Zhang, Wei Ge, Yanni Feng, Lan Li, Zhongyi Sun, Hongfu Zhang, Wei Shen
Theranostics 2020; 10(7): 3308-3324. doi:10.7150/thno.43189
[Abstract] [Full text] [PDF]


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Research Paper
Circular RNA-ZBTB44 regulates the development of choroidal neovascularization
Rong-mei Zhou, Lian-jun Shi, Kun Shan, Ya-nan Sun, Shan-shan Wang, Shu-jie Zhang, Xiu-miao Li, Qin Jiang, Biao Yan, Chen Zhao
Theranostics 2020; 10(7): 3293-3307. doi:10.7150/thno.39488
[Abstract] [Full text] [PDF]


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Research Paper
EDTA-Modified 17β-Estradiol-Laden Upconversion Nanocomposite for Bone-Targeted Hormone Replacement Therapy for Osteoporosis
Xiaoting Chen, Xingjun Zhu, Yan Hu, Wei Yuan, Xiaochen Qiu, Tianyuan Jiang, Chao Xia, Liqin Xiong, Fuyou Li, Yanhong Gao
Theranostics 2020; 10(7): 3281-3292. doi:10.7150/thno.37599
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

newNanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Organ Biodistribution of Radiolabelled δγ T Cells Following Liposomal Alendronate Administration in Different Mice Tumour Models
Julie T-W. Wang, Naomi O. Hodgins, Wafa' T. Al-Jamal, John Maher, Jane K. Sosabowski, Khuloud T. Al-Jamal
Nanotheranostics 2020; 4(2): 71-82. doi:10.7150/ntno.32876
[Abstract] [Full text] [PDF]


Research Paper
Effects of molecular weight and structural conformation of multivalent-based elastin-like polypeptides on tumor accumulation and tissue biodistribution
Vijaya Sarangthem, Bo-Yeon Seo, Aena Yi, Young-Jin Lee, Sun-Ha Cheon, Sang Kyoon Kim, Thoudam Debraj Singh, Byung-Heon Lee, Rang-Woon Park
Nanotheranostics 2020; 4(2): 57-70. doi:10.7150/ntno.39804
[Abstract] [Full text] [PDF]


Research Paper
Phospholipid prodrug conjugates of insoluble chemotherapeutic agents for ultrasound targeted drug delivery
Mendi G. Márquez, Rachel Dotson, Sally Pias, Liliya V. Frolova, Michaelann S. Tartis
Nanotheranostics 2020; 4(1): 40-56. doi:10.7150/ntno.37738
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
FGF2 engineered SPIONs attenuate tumor stroma and potentiate the effect of chemotherapy in 3D heterospheroidal model of pancreatic tumor
Deby Fajar Mardhian, Aggelos Vrynas, Gert Storm, Ruchi Bansal, Jai Prakash
Nanotheranostics 2020; 4(1): 26-39. doi:10.7150/ntno.38092
[Abstract] [Full text] [PDF] [PubMed] [PMC]

new CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Critical Reviews of Immunotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH), Mingnan Chen (University of Utah)
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue The EPR effect and beyond: Strategies to improve tumor targeting and nanomedicine efficacy. Guest Editors: Yang Shi (RWTH Aachen University), Roy van der Meel (Eindhoven University of Technology), Twan Lammers (RWTH Aachen University), Xiaoyuan (Shawn) Chen (NIBIB/NIH)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues