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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19
Manuela Teresa Raimondi, Francesca Donnaloja, Bianca Barzaghini, Alberto Bocconi, Claudio Conci, Valentina Parodi, Emanuela Jacchetti, Stephana Carelli
Theranostics 2020; 10(16): 7034-7052. doi:10.7150/thno.47406
[Abstract] [Full text] [PDF]


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Research Paper
Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation
Yunpeng Zhao, Cheng Qiu, Wenhan Wang, Jiangfan Peng, Xiang Cheng, Yangtao Shangguan, Mingyang Xu, Jiayi Li, Ruize Qu, Xiaomin Chen, Suyi Jia, Dan Luo, Long Liu, Peng Li, Fengjin Guo, Krasimir Vasilev, Liang Liu, John Hayball, Shuli Dong, Xin Pan, Yuhua Li, Linlin Guo, Lei Cheng, Weiwei Li
Theranostics 2020; 10(15): 7015-7033. doi:10.7150/thno.45359
[Abstract] [Full text] [PDF]


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Research Paper
Macrophage correlates with immunophenotype and predicts anti-PD-L1 response of urothelial cancer
Dongqiang Zeng, Zilan Ye, Jiani Wu, Rui Zhou, Xinxiang Fan, Gaofeng Wang, Yiqiang Huang, Jianhua Wu, Huiying Sun, Miaohong Wang, Jianping Bin, Yulin Liao, Nailin Li, Min Shi, Wangjun Liao
Theranostics 2020; 10(15): 7002-7014. doi:10.7150/thno.46176
[Abstract] [Full text] [PDF]


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Research Paper
TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy
Yuanli Luo, Bin Qiao, Ping Zhang, Chao Yang, Jin Cao, Xun Yuan, Haitao Ran, Zhigang Wang, Lan Hao, Yang Cao, Jianli Ren, Zhiyi Zhou
Theranostics 2020; 10(15): 6987-7001. doi:10.7150/thno.44569
[Abstract] [Full text] [PDF]


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Research Paper
An age-independent gene signature for monitoring acute rejection in kidney transplantation
Brian I Shaw, Daniel K. Cheng, Chaitanya R. Acharya, Robert B Ettenger, Herbert Kim Lyerly, Qing Cheng, Allan D Kirk, Eileen T Chambers
Theranostics 2020; 10(15): 6977-6986. doi:10.7150/thno.42110
[Abstract] [Full text] [PDF]


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Research Paper
Up-regulation of hypoxia-inducible factor antisense as a novel approach to treat ovarian cancer
Tiangong Lu, Jianming Tang, Binita Shrestha, Blake R. Heath, Li Hong, Yu L. Lei, Mats Ljungman, Nouri Neamati
Theranostics 2020; 10(15): 6959-6976. doi:10.7150/thno.41792
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Research Paper
Preclinical evaluation of an 111In/225Ac theranostic targeting transformed MUC1 for triple negative breast cancer
Vanessa J Kelly, Shu-ta Wu, Vijay Gottumukkala, Richard Coelho, Keryn Palmer, Surabhi Nair, Timothy Erick, Rahul Puri, Ohad Ilovich, Pinku Mukherjee
Theranostics 2020; 10(15): 6946-6958. doi:10.7150/thno.38236
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Research Paper
Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells
Huizhen Sun, Husheng Wang, Xue Wang, Yoichi Aoki, Xinjing Wang, Yufei Yang, Xi Cheng, Ziliang Wang, Xipeng Wang
Theranostics 2020; 10(15): 6928-6945. doi:10.7150/thno.43811
[Abstract] [Full text] [PDF]


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Research Paper
RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells
Shuai Zhang, Md Rana Hamid, Ting Wang, Jinqi Liao, Liru Wen, Yan Zhou, Pengfei Wei, Xuenong Zou, Gang Chen, Junhui Chen, Guangqian Zhou
Theranostics 2020; 10(15): 6915-6927. doi:10.7150/thno.44875
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Research Paper
Homozygous MESP1 knock-in reporter hESCs facilitated cardiovascular cell differentiation and myocardial infarction repair
Lin Wang, Fengzhi Zhang, Fuyu Duan, Rujin Huang, Xi Chen, Jia Ming, Jie Na
Theranostics 2020; 10(15): 6898-6914. doi:10.7150/thno.42347
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Research Paper
Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs
Wang Jia, Mingming Zhen, Lei Li, Chen Zhou, Zihao Sun, Shuai Liu, Zhongpu Zhao, Jie Li, Chunru Wang, Chunli Bai
Theranostics 2020; 10(15): 6886-6897. doi:10.7150/thno.46794
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Research Paper
808 nm light triggered lanthanide nanoprobes with enhanced down-shifting emission beyond 1500 nm for imaging-guided resection surgery of tumor and vascular visualization
Youbin L i, Mingyang Jiang, Zhenluan Xue, Songjun Zeng
Theranostics 2020; 10(15): 6875-6885. doi:10.7150/thno.41967
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Research Paper
Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease
Shudan Wang, Hongyang Yao, Yihua Xu, Rui Hao, Wen Zhang, Hang Liu, Ying Huang, Wei Guo, Bai Lu
Theranostics 2020; 10(15): 6854-6874. doi:10.7150/thno.44165
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Research Paper
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription
Gengyi Zou, Xiaotong Zhang, Lun Wang, Xiyang Li, Tianyu Xie, Jin Zhao, Jie Yan, Longlong Wang, Haoyu Ye, Shunchang Jiao, Rong Xiang, Yi Shi
Theranostics 2020; 10(15): 6839-6853. doi:10.7150/thno.43622
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Research Paper
Osteoclast-derived apoptotic bodies show extended biological effects of parental cell in promoting bone defect healing
Qinyu Ma, Mengmeng Liang, Nathachit Limjunyawong, Yang Dan, Junchao Xing, Jianmei Li, Jianzhong Xu, Ce Dou
Theranostics 2020; 10(15): 6825-6838. doi:10.7150/thno.45170
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Research Paper
Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction
Chunmei Xu, Xiaojun Zhou, Tianyue Xie, Yuan Zhou, Qian Zhang, Shan Jiang, Rui Zhang, Lin Liao, Jianjun Dong
Theranostics 2020; 10(15): 6806-6824. doi:10.7150/thno.43145
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation
Guimiao Lin, Ting Chen, Yongning Pan, Zhiwen Yang, Li Li, Ken-tye Yong, Xiaomei Wang, Jie Wang, Yajing Chen, Wenxiao Jiang, Shuting Weng, Xiaorui Huang, Jiajie Kuang, Gaixia Xu
Nanotheranostics 2020; 4(3): 173-183. doi:10.7150/ntno.42786
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Research Paper
Supramolecular Polysaccharide Nanotheranostics that Inhibit Cancer Cells Growth and Monitor Targeted Therapy Response
Nilesh Deshpande, Anujan Ramesh, Dipika Nandi, Anh Nguyen, Anthony Brouillard, Ashish Kulkarni
Nanotheranostics 2020; 4(3): 156-172. doi:10.7150/ntno.44703
[Abstract] [Full text] [PDF]


Research Paper
Preclinical evaluation of cationic DOTA-triarginine-lipid conjugates for theranostic liquid brachytherapy
Wenbo Wang, Frederikke P. Fliedner, Anders E. Hansen, Rasmus Eliasen, Fredrik Melander, Andreas Kjaer, Thomas L. Andresen, Andreas I. Jensen, Jonas R. Henriksen
Nanotheranostics 2020; 4(3): 142-155. doi:10.7150/ntno.44562
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Research Paper
Multicolor spectral photon counting CT monitors and quantifies therapeutic cells and their encapsulating scaffold in a model of brain damage
Elisa Cuccione, Peter Chhour, Salim Si-Mohamed, Chloé Dumot, Johoon Kim, Violaine Hubert, Claire Crola Da Silva, Marc Vandamme, Emmanuel Chereul, Joëlle Balegamire, Yves Chevalier, Yves Berthezène, Loïc Boussel, Philippe Douek, David P. Cormode, Marlène Wiart
Nanotheranostics 2020; 4(3): 129-141. doi:10.7150/ntno.45354
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new CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Critical Reviews of Immunotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH), Mingnan Chen (University of Utah)
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue The EPR effect and beyond: Strategies to improve tumor targeting and nanomedicine efficacy. Guest Editors: Yang Shi (RWTH Aachen University), Roy van der Meel (Eindhoven University of Technology), Twan Lammers (RWTH Aachen University), Xiaoyuan (Shawn) Chen (NIBIB/NIH)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues