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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer
Ying Wu, Yuexiao Tang, Shangzhi Xie, Xiaoxiao Zheng, Shufen Zhang, Jiayan Mao, Baoming Wang, Yuerou Hou, Liqiang Hu, Kequn Chai, Wei Chen
Theranostics 2020; 10(3): 1151-1165. doi:10.7150/thno.38327
[Abstract] [Full text] [PDF]


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Research Paper
High Loading of Hydrophobic and Hydrophilic Agents via Small Immunostimulatory Carrier for Enhanced Tumor Penetration and Combinational Therapy
Jingjing Sun, Yichao Chen, Jieni Xu, Xiangping Song, Zhuoya Wan, Yuqian Du, Weina Ma, Xizhen Li, Lin Zhang, Song Li
Theranostics 2020; 10(3): 1136-1150. doi:10.7150/thno.38287
[Abstract] [Full text] [PDF]


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Research Paper
Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
Maria Tsioumpekou, Sara I. Cunha, Haisha Ma, Aive Åhgren, Jessica Cedervall, Anna-Karin Olsson, Carl-Henrik Heldin, Johan Lennartsson
Theranostics 2020; 10(3): 1122-1135. doi:10.7150/thno.37851
[Abstract] [Full text] [PDF]


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Research Paper
The combination of bevacizumab/Avastin and erlotinib/Tarceva is relevant for the treatment of metastatic renal cell carcinoma: the role of a synonymous mutation of the EGFR receptor
Renaud Grépin, Mélanie Guyot, Aurore Dumond, Jérôme Durivault, Damien Ambrosetti, Jean-François Roussel, Florence Dupré, Hervé Quintens, Gilles Pagès
Theranostics 2020; 10(3): 1107-1121. doi:10.7150/thno.38346
[Abstract] [Full text] [PDF]


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Research Paper
Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice
Chuanrui Ma, Ronglin Xia, Shu Yang, Lipei Liu, Jing Zhang, Ke Feng, Yuna Shang, Jingtian Qu, Lingwei Li, Ning Chen, Shixin Xu, Wenwen Zhang, Jingyuan Mao, Jihong Han, Yuanli Chen, Xiaoxiao Yang, Yajun Duan, Guanwei Fan
Theranostics 2020; 10(3): 1090-1106. doi:10.7150/thno.38115
[Abstract] [Full text] [PDF]


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Research Paper
Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications
Guanqi Liu, Xiaoshuang Wang, Xuan Zhou, Linjun Zhang, Jiaomei Mi, Zhengjie Shan, Baoxin Huang, Zhuofan Chen, Zetao Chen
Theranostics 2020; 10(3): 1074-1089. doi:10.7150/thno.37931
[Abstract] [Full text] [PDF]


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Research Paper
Cardio-renal Exosomes in Myocardial Infarction Serum Regulate Proangiogenic Paracrine Signaling in Adipose Mesenchymal Stem Cells
Lei Gao, Shuya Mei, Shuning Zhang, Qing Qin, Hao Li, Yiteng Liao, Huimin Fan, Zhongmin Liu, Hongming Zhu
Theranostics 2020; 10(3): 1060-1073. doi:10.7150/thno.37678
[Abstract] [Full text] [PDF]


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Research Paper
Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells
Heng Zhang, He Huang, Xing Feng, Huiwen Song, Zhiyong Zhang, Aizong Shen, Xingfeng Qiu
Theranostics 2020; 10(3): 1046-1059. doi:10.7150/thno.36503
[Abstract] [Full text] [PDF]


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Research Paper
Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity
Bo Wang, Yingke Zhou, Jun Zhang, Xin Jin, Heshui Wu, Haojie Huang
Theranostics 2020; 10(3): 1033-1045. doi:10.7150/thno.38137
[Abstract] [Full text] [PDF]


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Research Paper
PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness
Mohamed Hamyeh, Florence Bernex, Romain M. Larive, Aurélien Naldi, Serge Urbach, Joelle Simony-Lafontaine, Carole Puech, William Bakhache, Jérome Solassol, Peter J. Coopman, Wiljan J.A.J Hendriks, Gilles Freiss
Theranostics 2020; 10(3): 1016-1032. doi:10.7150/thno.38537
[Abstract] [Full text] [PDF]


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Research Paper
Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression
Xueran Chen, Aijun Hao, Xian Li, Kaiqin Ye, Chenggang Zhao, Haoran Yang, Huihui Ma, Lei Hu, Zhiyang Zhao, Lizhu Hu, Fang Ye, Qiuyan Sun, Huaman Zhang, Hongzhi Wang, Xuebiao Yao, Zhiyou Fang
Theranostics 2020; 10(3): 998-1015. doi:10.7150/thno.40076
[Abstract] [Full text] [PDF]


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Review
Improving nanotherapy delivery and action through image-guided systems pharmacology
Thomas S.C. Ng, Michelle A. Garlin, Ralph Weissleder, Miles A. Miller
Theranostics 2020; 10(3): 968-997. doi:10.7150/thno.37215
[Abstract] [Full text] [PDF]


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Review
Imaging-assisted anticancer nanotherapy
Anshuman Dasgupta, Ilaria Biancacci, Fabian Kiessling, Twan Lammers
Theranostics 2020; 10(3): 956-967. doi:10.7150/thno.38288
[Abstract] [Full text] [PDF]


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Review
Monoclonal antibody-based molecular imaging strategies and theranostic opportunities
Niels Dammes, Dan Peer
Theranostics 2020; 10(2): 938-955. doi:10.7150/thno.37443
[Abstract] [Full text] [PDF]


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Research Paper
Cancer immunotherapy is accompanied by distinct metabolic patterns in primary and secondary lymphoid organs observed by non-invasive in vivo 18F-FDG-PET
Johannes Schwenck, Barbara Schörg, Francesco Fiz, Dominik Sonanini, Andrea Forschner, Thomas Eigentler, Benjamin Weide, Manuela Martella, Irene Gonzalez-Menendez, Cristina Campi, Gianmario Sambuceti, Ferdinand Seith, Leticia Quintanilla-Martinez, Claus Garbe, Christina Pfannenberg, Martin Röcken, Christian la Fougere, Bernd J Pichler, Manfred Kneilling
Theranostics 2020; 10(2): 925-937. doi:10.7150/thno.35989
[Abstract] [Full text] [PDF]


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Research Paper
Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation
Oriana Lo Re, Tommaso Mazza, Sebastiano Giallongo, Paola Sanna, Francesca Rappa, Tu Vinh Luong, Giovanni Li Volti, Adela Drovakova, Tania Roskams, Matthias Van Haele, Emmanuel Tsochatzis, Manlio Vinciguerra
Theranostics 2020; 10(2): 910-924. doi:10.7150/thno.35045
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

newNanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy
Stefan J. Roobol, Thomas A. Hartjes, Johan A. Slotman, Robin M. de Kruijff, Guzman Torrelo, T.E. Abraham, Frank Bruchertseifer, Alfred Morgenstern, Roland Kanaar, Dik C. van Gent, Adriaan B. Houtsmuller, Antonia G. Denkova, Martin E. van Royen, Jeroen Essers
Nanotheranostics 2020; 4(1): 14-25. doi:10.7150/ntno.37080
[Abstract] [Full text] [PDF]


Research Paper
Thermo-responsive Fluorescent Nanoparticles for Multimodal Imaging and Treatment of Cancers
Nikhil Pandey, Jyothi U. Menon, Masaya Takahashi, Jer-Tsong Hsieh, Jian Yang, Kytai T. Nguyen, Aniket S. Wadajkar
Nanotheranostics 2020; 4(1): 1-13. doi:10.7150/ntno.39810
[Abstract] [Full text] [PDF]


Research Paper
Nano-Antagonist Alleviates Inflammation and Allows for MRI of Atherosclerosis
Brian Mog, Courteney Asase, Alice Chaplin, Huiyun Gao, Sanjay Rajagopalan, Andrei Maiseyeu
Nanotheranostics 2019; 3(4): 342-355. doi:10.7150/ntno.37391
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Microbubble enhanced ultrasound for the antivascular treatment and monitoring of hepatocellular carcinoma
Julia C. D'Souza, Laith R. Sultan, Stephen J. Hunt, Terence P. Gade, Mrigendra B. Karmacharya, Susan M. Schultz, Angela K. Brice, Andrew K. W. Wood, Chandra M. Sehgal
Nanotheranostics 2019; 3(4): 331-341. doi:10.7150/ntno.39514
[Abstract] [Full text] [PDF] [PubMed] [PMC]

new CFP - Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Critical Reviews of Immunotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH), Mingnan Chen (University of Utah)
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue The EPR effect and beyond: Strategies to improve tumor targeting and nanomedicine efficacy. Guest Editors: Yang Shi (RWTH Aachen University), Roy van der Meel (Eindhoven University of Technology), Twan Lammers (RWTH Aachen University), Xiaoyuan (Shawn) Chen (NIBIB/NIH)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues