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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation
Na Cui, Chengyu Liu, Xiang Tang, Liangliang Song, Zixuan Xiao, Chen Wang, Yancai Wu, Yihao Zhou, Chentai Peng, Yuxia Liu, Ling Zheng, Xinran Liu, Kun Huang, Hong Chen
Theranostics 2024; 14(11): 4536-4553. doi:10.7150/thno.95796
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Research Paper
Transcranial blood-brain barrier opening in Alzheimer's disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping
Sua Bae, Keyu Liu, Antonios N. Pouliopoulos, Robin Ji, Sergio Jiménez-Gambín, Omid Yousefian, Alina R. Kline-Schoder, Alec J. Batts, Fotios N. Tsitsos, Danae Kokossis, Akiva Mintz, Lawrence S. Honig, Elisa E. Konofagou
Theranostics 2024; 14(11): 4519-4535. doi:10.7150/thno.94206
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Research Paper
Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction
Ke Wang, Xing-Yang Liu, Sui-Feng Liu, Xiao-Xia Wang, Yi-Hua Wei, Jun-Rong Zhu, Jing Liu, Xiu Qin Xu, Lei Wen
Theranostics 2024; 14(11): 4499-4518. doi:10.7150/thno.96045
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Research Paper
Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy
Kunjian Lei, Jingying Li, Zewei Tu, Chuandong Gong, Junzhe Liu, Min Luo, Wenqian Ai, Lei Wu, Yishuang Li, Zhihong Zhou, Zhihao Chen, Shigang Lv, Minhua Ye, Miaojing Wu, Xiaoyan Long, Xingen Zhu, Kai Huang
Theranostics 2024; 14(11): 4481-4498. doi:10.7150/thno.98574
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Research Paper
Cypher/ZASP drives cardiomyocyte maturation via actin-mediated MRTFA-SRF signalling
Jialan Lyu, Zhicheng Pan, Ruobing Li, Hailong Yu, Yuesheng Zhang, Dongfei Wang, Xiang Yin, Yan He, Liding Zhao, Siyuan Chen, Shan Zhang, Hongqiang Cheng, Xiaogang Guo
Theranostics 2024; 14(11): 4462-4480. doi:10.7150/thno.98734
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Review
Remote actuation and on-demand activation of biomaterials pre-incorporated with physical cues for bone repair
Xueping Kong, Tianyi Zheng, Zhaoyi Wang, Tong Zhou, Jiezhong Shi, Ying Wang, Ben Zhang
Theranostics 2024; 14(11): 4438-4461. doi:10.7150/thno.97610
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Review
Nucleic acid-based nanotherapeutics for treating sepsis and associated organ injuries
Huang-Ping Yu, Fu-Chao Liu, Yu-Kuo Chung, Ahmed Alalaiwe, Calvin T. Sung, Jia-You Fang
Theranostics 2024; 14(11): 4411-4437. doi:10.7150/thno.98487
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Research Paper
Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis
Yajie Cai, Shuo Li, Yang Yang, Shuni Duan, Guifang Fan, Jinzhao Bai, Qi Zheng, Yiqing Gu, Xiaojiaoyang Li, Runping Liu
Theranostics 2024; 14(11): 4393-4410. doi:10.7150/thno.96184
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

CFP - Special issue on Molecular Imaging and Theranostics. Guest Editors: Dr. Jianhua Zou, Dr. Jingjing Zhang and Dr. Mengyao Zhao.

Background: Focused ultrasound (FUS) in combination with microbubbles has recently shown great promise in facilitating blood-brain barrier (BBB) opening for drug delivery and immunotherapy in Alzheimer's disease (AD). However, it is currently limited to systems integrated within the MRI suites or requiring post-surgical implants, thus restricting its widespread clinical adoption. In this pilot study, we investigate the clinical safety and feasibility of a portable, non-invasive neuronavigation-guided FUS (NgFUS) system with integrated real-time 2-D microbubble cavitation mapping. Methods: A phase....
Rationale: Since oncogene expression products often exhibit upregulation or abnormally activated activity, developing a technique to regulate abnormal protein levels represent a viable approach for treating tumors and protein abnormality-related diseases. Methods: We first screened out eMIATAC components with high targeted degradation efficiency and explored the mechanism by which eMIATAC induced target protein degradation, and verified the degradation efficiency of the target protein by protein imprinting and flow cytometry. Next, we recombined eMIATAC with some controllable elements to verify....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Neuroprotective Effects of Zinc Oxide Nanoparticles in a Rotenone-Induced Mouse Model of Parkinson's Disease
Yasmeen Khafajah, Mariam Shaheen, Dania El Natour, Maxime Merheb, Rachel Matar, Jamilah Borjac
Nanotheranostics 2024; 8(4): 497-505.
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