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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Photosensitizer-based multimodal PSMA-targeting ligands for intraoperative detection of prostate cancer
Yvonne H.W. Derks, Mark Rijpkema, Helene I.V. Amatdjais-Groenen, Annemarie Kip, Gerben M. Franssen, J. P. Michiel Sedelaar, Diederik M. Somford, Michiel Simons, Peter Laverman, Martin Gotthardt, Dennis W. P. M. Löwik, Susanne Lütje, Sandra Heskamp
Theranostics 2021; 11(4): 1527-1541. doi:10.7150/thno.52166
[Abstract] [Full text] [PDF]


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Review
Recent advances in supramolecular antidotes
Hang Yin, Xiangjun Zhang, Jianwen Wei, Siyu Lu, David Bardelang, Ruibing Wang
Theranostics 2021; 11(3): 1513-1526. doi:10.7150/thno.53459
[Abstract] [Full text] [PDF]


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Review
The Current Landscape of Antibody-based Therapies in Solid Malignancies
Ashu Shah, Sanchita Rauth, Abhijit Aithal, Sukhwinder Kaur, Koelina Ganguly, Catherine Orzechowski, Grish C Varshney, Maneesh Jain, Surinder K Batra
Theranostics 2021; 11(3): 1493-1512. doi:10.7150/thno.52614
[Abstract] [Full text] [PDF]


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Research Paper
H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts
Ying Zhang, Zhaoyong Liu, Xia Yang, Weiqing Lu, Yelong Chen, Youbin Lin, Jin Wang, Suxia Lin, Jing-Ping Yun
Theranostics 2021; 11(3): 1473-1492. doi:10.7150/thno.51245
[Abstract] [Full text] [PDF]


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Research Paper
Proteasome activator PA200 maintains stability of histone marks during transcription and aging
Tian-Xia Jiang, Shuang Ma, Xia Han, Zi-Yu Luo, Qian-Qian Zhu, Tomoki Chiba, Wei Xie, Kui Lin, Xiao-Bo Qiu
Theranostics 2021; 11(3): 1458-1472. doi:10.7150/thno.48744
[Abstract] [Full text] [PDF]


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Research Paper
Tofacitinib restores the balance of γδTreg/γδT17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome
Xinyu Yang, Ning Zhan, Yang Jin, Hanzhi Ling, Chipeng Xiao, Zhen Xie, Hao Zhong, Xinxin Yu, Runhua Tang, Jinglan Ma, Jubo Guan, Guoyu Yin, Gan Wu, Liangjing Lu, Jianguang Wang
Theranostics 2021; 11(3): 1446-1457. doi:10.7150/thno.47860
[Abstract] [Full text] [PDF]


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Research Paper
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells
Xinxin Yuan, Niansong Qian, Shukuan Ling, Yuheng Li, Weijia Sun, Jianwei Li, Ruikai Du, Guohui Zhong, Caizhi Liu, Guotao Yu, Dengchao Cao, Zizhong Liu, Yinbo Wang, Zhihong Qi, Yingpeng Yao, Fang Wang, Jingjing Liu, Shanshan Hao, Xiaoyan Jin, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Xingcheng Gao, Shuai Liang, Youyou Li, Jinping Song, Shuyang Yu, Yingxian Li
Theranostics 2021; 11(3): 1429-1445. doi:10.7150/thno.45351
[Abstract] [Full text] [PDF]


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Research Paper
Network- and systems-based re-engineering of dendritic cells with non-coding RNAs for cancer immunotherapy
Xin Lai, Florian S. Dreyer, Martina Cantone, Martin Eberhardt, Kerstin F. Gerer, Tanushree Jaitly, Steffen Uebe, Christopher Lischer, Arif Ekici, Jürgen Wittmann, Hans-Martin Jäck, Niels Schaft, Jan Dörrie, Julio Vera
Theranostics 2021; 11(3): 1412-1428. doi:10.7150/thno.53092
[Abstract] [Full text] [PDF]


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Research Paper
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR
Hailing Liu, Tian Lan, Hui Li, Lin Xu, Xing Chen, Haotian Liao, Xiangzheng Chen, Jinpeng Du, Yunshi Cai, Jinju Wang, Xuefeng Li, Jiwei Huang, Kefei Yuan, Yong Zeng
Theranostics 2021; 11(3): 1396-1411. doi:10.7150/thno.53227
[Abstract] [Full text] [PDF]


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Research Paper
Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer
Raimund Dietze, Mohamad K. Hammoud, María Gómez-Serrano, Annika Unger, Tim Bieringer, Florian Finkernagel, Anna M. Sokol, Andrea Nist, Thorsten Stiewe, Silke Reinartz, Viviane Ponath, Christian Preußer, Elke Pogge von Strandmann, Sabine Müller-Brüsselbach, Johannes Graumann, Rolf Müller
Theranostics 2021; 11(3): 1377-1395. doi:10.7150/thno.52442
[Abstract] [Full text] [PDF]


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Research Paper
Molecular stratification by BCL2A1 and AIM2 provides additional prognostic value in penile squamous cell carcinoma
Xingliang Tan, Dong Chen, Shengjie Guo, Yanjun Wang, Yuantao Zou, Zhiming Wu, Fangjian Zhou, Zike Qin, Zhuowei Liu, Yun Cao, Chunhua Lin, Gangjun Yuan, Kai Yao
Theranostics 2021; 11(3): 1364-1376. doi:10.7150/thno.51725
[Abstract] [Full text] [PDF]


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Review
Targeting transforming growth factor-β signaling for enhanced cancer chemotherapy
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Theranostics 2021; 11(3): 1345-1363. doi:10.7150/thno.51383
[Abstract] [Full text] [PDF]


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Research Paper
Identification of novel CD44v6-binding peptides that block CD44v6 and deliver a pro-apoptotic peptide to tumors to inhibit tumor growth and metastasis in mice
Fatima Khan, Smriti Gurung, Gowri Rangaswamy Gunassekaran, Sri Murugan Poongkavithai Vadevoo, Lianhua Chi, Uttapol Permpoon, Md. Enamul Haque, Yun-Ki Lee, Soo-Woong Lee, Soyoun Kim, Byungheon Lee
Theranostics 2021; 11(3): 1326-1344. doi:10.7150/thno.50564
[Abstract] [Full text] [PDF]


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Review
From biomarkers to therapeutic targets: the promise of PD-L1 in thyroid autoimmunity and cancer
Grégoire D'Andréa, Sandra Lassalle, Nicolas Guevara, Baharia Mograbi, Paul Hofman
Theranostics 2021; 11(3): 1310-1325. doi:10.7150/thno.50333
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Research Paper
Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells
Md Nabiul Hasan, Lanxin Luo, Dawei Ding, Shanshan Song, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Lesley M. Foley, Xiudong Guan, Gary Kohanbash, T. Kevin Hitchens, Maria G. Castro, Zhongling Zhang, Dandan Sun
Theranostics 2021; 11(3): 1295-1309. doi:10.7150/thno.50150
[Abstract] [Full text] [PDF]


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Research Paper
Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring
Luodan Yang, Yan Dong, Chongyun Wu, Hannah Youngblood, Yong Li, Xuemei Zong, Lei Li, Tongda Xu, Quanguang Zhang
Theranostics 2021; 11(3): 1269-1294. doi:10.7150/thno.49672
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 8.579

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Review
Noninvasive Imaging of Cancer Immunotherapy
Omar Abousaway, Taha Rakhshandehroo, Annick D. Van den Abbeele, Moritz F. Kircher, Mohammad Rashidian
Nanotheranostics 2021; 5(1): 90-112. doi:10.7150/ntno.50860
[Abstract] [Full text] [PDF]


Review
Multifunctional microfluidic chip for cancer diagnosis and treatment
Qiao-ru Guo, Ling-ling Zhang, Ji-fang Liu, Zhen Li, Jia-jun Li, Wen-min Zhou, Hui Wang, Jing-quan Li, Da-yu Liu, Xi-yong Yu, Jian-ye Zhang
Nanotheranostics 2021; 5(1): 73-89. doi:10.7150/ntno.49614
[Abstract] [Full text] [PDF]


Research Paper
Intraoperative assessment and postsurgical treatment of prostate cancer tumors using tumor-targeted nanoprobes
James Teh, Manisha Tripathi, Derek Reichel, Bien Sagong, Ricardo Montoya, Yi Zhang, Shawn Wagner, Rola Saouaf, Leland W. K. Chung, J. Manuel Perez
Nanotheranostics 2021; 5(1): 57-72. doi:10.7150/ntno.50095
[Abstract] [Full text] [PDF]

CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: https://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues