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Review GRP78 in human diseases: From molecular chaperone to therapeutic target Full text PDF
Research Paper c-Met-targeted NIR-II imaging for precision management of oral squamous cell carcinoma and premalignant lesions Full text PDF
Research Paper Intermittent hypoxia ameliorates behavioral deficits and exerts neurorestoration in a mouse photothrombotic stroke model Full text PDF
Research Paper A clinically translatable, irreversibly attenuated Salmonella strain as a next-generation adjuvant for checkpoint immunotherapy Full text PDF
Research Paper DKK3–CKAP4 signaling drives fibroimmune remodeling and hair follicle miniaturization in androgenetic alopecia Full text PDF
Research Paper Porphyrin-lipid nanotheranostics for multimodal imaging of nodal disease in preclinical oral cancers Full text PDF
Issue 10; 2026
Founding Editor-in-Chief:
Prof. Xiaoyuan (Shawn) Chen, PhD
Profile
Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.
- Theranostics is indexed by Science Citation Index (SCI) and MEDLINE. (Full index information)
- Full texts of articles in PubMed Central and Europe PMC. Abstracts in PubMed.
- (For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.
GRP78 in human diseases: From molecular chaperone to therapeutic target
Glucose-regulated Protein 78 (GRP78, also known as BiP/HSPA5) is a central member of the Hsp70 family. As a key molecular chaperone in the endoplasmic reticulum (ER), it plays an important role in cell survival and biological function by maintaining protein folding homeostasis and regulating endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR). Its function is precisely regulated by various post-translational modifications (PTMs), ...