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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Ultrafast three-dimensional microbubble imaging in vivo predicts tissue damage volume distributions during nonthermal brain ablation
Ryan M. Jones, Dallan McMahon, Kullervo Hynynen
Theranostics 2020; 10(16): 7211-7230. doi:10.7150/thno.47281
[Abstract] [Full text] [PDF]


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Research Paper
A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis
Yixin Chen, Yanying Zhou, Fangwei Han, Yingyuan Zhao, Meijuan Tu, Yongtao Wang, Can Huang, Shicheng Fan, Panpan Chen, Xinpeng Yao, Lihuan Guan, Ai-Ming Yu, Frank J. Gonzalez, Min Huang, Huichang Bi
Theranostics 2020; 10(16): 7193-7210. doi:10.7150/thno.44877
[Abstract] [Full text] [PDF]


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Research Paper
Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer
Zhefang Wang, Jie Qin, Jiangang Zhao, Jiahui Li, Dai Li, Marie Popp, Felix Popp, Hakan Alakus, Bo Kong, Qiongzhu Dong, Peter J. Nelson, Yue Zhao, Christiane J. Bruns
Theranostics 2020; 10(16): 7178-7192. doi:10.7150/thno.43093
[Abstract] [Full text] [PDF]


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Research Paper
Kupffer cells promote T-cell hepatitis by producing CXCL10 and limiting liver sinusoidal endothelial cell permeability
Shen Dai, Fengming Liu, Zhongnan Qin, Jinyan Zhang, Jiayi Chen, Wen-Xing Ding, Dechun Feng, Yong Ji, Xuebin Qin
Theranostics 2020; 10(16): 7163-7177. doi:10.7150/thno.44960
[Abstract] [Full text] [PDF]


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Review
Primer design for quantitative real-time PCR for the emerging Coronavirus SARS-CoV-2
Dandan Li, Jiawei Zhang, Jinming Li
Theranostics 2020; 10(16): 7150-7162. doi:10.7150/thno.47649
[Abstract] [Full text] [PDF]


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Research Paper
Bacterial extracellular vesicle-coated multi-antigenic nanovaccines protect against drug-resistant Staphylococcus aureus infection by modulating antigen processing and presentation pathways
Gang Chen, Yanan Bai, Zhenzhen Li, Fei Wang, Xuelian Fan, Xin Zhou
Theranostics 2020; 10(16): 7131-7149. doi:10.7150/thno.44564
[Abstract] [Full text] [PDF]


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Research Paper
Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling
Xianding Sun, Ruobin Zhang, Hangang Chen, Xiaolan Du, Shuai Chen, Junlan Huang, Mi Liu, Meng Xu, Fengtao Luo, Min Jin, Nan Su, Huabing Qi, Jing Yang, Qiaoyan Tan, Dali Zhang, Zhenhong Ni, Sen Liang, Bin Zhang, Di Chen, Xin Zhang, Lingfei Luo, Lin Chen, Yangli Xie
Theranostics 2020; 10(16): 7111-7130. doi:10.7150/thno.45286
[Abstract] [Full text] [PDF]


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Research Paper
NLRP3 inflammasome via IL-1β regulates PCSK9 secretion
Zufeng Ding, Xianwei Wang, Shijie Liu, Sichang Zhou, Rajshekhar A Kore, Shengyu Mu, Xiaoyan Deng, Yubo Fan, Jawahar L Mehta
Theranostics 2020; 10(16): 7100-7110. doi:10.7150/thno.45939
[Abstract] [Full text] [PDF]


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Research Paper
Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis
Chih-Jie Shen, Kwang-Yu Chang, Bo-Wen Lin, Wei-Ting Lin, Che-Min Su, Jhih-Peng Tsai, Yu-Han Liao, Liang-Yi Hung, Wen-Chang Chang, Ben-Kuen Chen
Theranostics 2020; 10(16): 7083-7099. doi:10.7150/thno.44744
[Abstract] [Full text] [PDF]


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Research Paper
Mass spectrometry imaging-based metabolomics to visualize the spatially resolved reprogramming of carnitine metabolism in breast cancer
Chenglong Sun, Fukai Wang, Yang Zhang, Jinqian Yu, Xiao Wang
Theranostics 2020; 10(16): 7070-7082. doi:10.7150/thno.45543
[Abstract] [Full text] [PDF]


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Review
Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells
Huangcan Li, Zhuoying Feng, Ming-Liang He
Theranostics 2020; 10(16): 7053-7069. doi:10.7150/thno.41388
[Abstract] [Full text] [PDF]


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Review
Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19
Manuela Teresa Raimondi, Francesca Donnaloja, Bianca Barzaghini, Alberto Bocconi, Claudio Conci, Valentina Parodi, Emanuela Jacchetti, Stephana Carelli
Theranostics 2020; 10(16): 7034-7052. doi:10.7150/thno.47406
[Abstract] [Full text] [PDF]


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Research Paper
Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation
Yunpeng Zhao, Cheng Qiu, Wenhan Wang, Jiangfan Peng, Xiang Cheng, Yangtao Shangguan, Mingyang Xu, Jiayi Li, Ruize Qu, Xiaomin Chen, Suyi Jia, Dan Luo, Long Liu, Peng Li, Fengjin Guo, Krasimir Vasilev, Liang Liu, John Hayball, Shuli Dong, Xin Pan, Yuhua Li, Linlin Guo, Lei Cheng, Weiwei Li
Theranostics 2020; 10(15): 7015-7033. doi:10.7150/thno.45359
[Abstract] [Full text] [PDF]


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Research Paper
Macrophage correlates with immunophenotype and predicts anti-PD-L1 response of urothelial cancer
Dongqiang Zeng, Zilan Ye, Jiani Wu, Rui Zhou, Xinxiang Fan, Gaofeng Wang, Yiqiang Huang, Jianhua Wu, Huiying Sun, Miaohong Wang, Jianping Bin, Yulin Liao, Nailin Li, Min Shi, Wangjun Liao
Theranostics 2020; 10(15): 7002-7014. doi:10.7150/thno.46176
[Abstract] [Full text] [PDF]


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Research Paper
TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy
Yuanli Luo, Bin Qiao, Ping Zhang, Chao Yang, Jin Cao, Xun Yuan, Haitao Ran, Zhigang Wang, Lan Hao, Yang Cao, Jianli Ren, Zhiyi Zhou
Theranostics 2020; 10(15): 6987-7001. doi:10.7150/thno.44569
[Abstract] [Full text] [PDF]


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Research Paper
An age-independent gene signature for monitoring acute rejection in kidney transplantation
Brian I Shaw, Daniel K. Cheng, Chaitanya R. Acharya, Robert B Ettenger, Herbert Kim Lyerly, Qing Cheng, Allan D Kirk, Eileen T Chambers
Theranostics 2020; 10(15): 6977-6986. doi:10.7150/thno.42110
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque
Rhiannon J. Evans, Begoña Lavin, Alkystis Phinikaridou, Kok Yean Chooi, Zahra Mohri, Eunice Wong, Joseph J. Boyle, Rob Krams, René Botnar, Nicholas J. Long
Nanotheranostics 2020; 4(4): 184-194. doi:10.7150/ntno.44712
[Abstract] [Full text] [PDF]


Research Paper
Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation
Guimiao Lin, Ting Chen, Yongning Pan, Zhiwen Yang, Li Li, Ken-tye Yong, Xiaomei Wang, Jie Wang, Yajing Chen, Wenxiao Jiang, Shuting Weng, Xiaorui Huang, Jiajie Kuang, Gaixia Xu
Nanotheranostics 2020; 4(3): 173-183. doi:10.7150/ntno.42786
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Supramolecular Polysaccharide Nanotheranostics that Inhibit Cancer Cells Growth and Monitor Targeted Therapy Response
Nilesh Deshpande, Anujan Ramesh, Dipika Nandi, Anh Nguyen, Anthony Brouillard, Ashish Kulkarni
Nanotheranostics 2020; 4(3): 156-172. doi:10.7150/ntno.44703
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Preclinical evaluation of cationic DOTA-triarginine-lipid conjugates for theranostic liquid brachytherapy
Wenbo Wang, Frederikke P. Fliedner, Anders E. Hansen, Rasmus Eliasen, Fredrik Melander, Andreas Kjaer, Thomas L. Andresen, Andreas I. Jensen, Jonas R. Henriksen
Nanotheranostics 2020; 4(3): 142-155. doi:10.7150/ntno.44562
[Abstract] [Full text] [PDF] [PubMed] [PMC]

new CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Critical Reviews of Immunotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH), Mingnan Chen (University of Utah)
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue The EPR effect and beyond: Strategies to improve tumor targeting and nanomedicine efficacy. Guest Editors: Yang Shi (RWTH Aachen University), Roy van der Meel (Eindhoven University of Technology), Twan Lammers (RWTH Aachen University), Xiaoyuan (Shawn) Chen (NIBIB/NIH)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues