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Review Frailty and [177Lu]Lu-PSMA-617 therapy: tools and strategies for older men with metastatic castration-resistant prostate cancer Matteo Bauckneht, Nicolò Borsellino, Giuseppe Ferdinando Colloca, Lucia Fratino, Daniele Santini Theranostics 2026; 16(15): 8546-8558. doi:10.7150/thno.131438 Full text PDF


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Research Paper Dual-metallic porphyrinic MOFs with pH/ROS-responsive release for antibacterial and antioxidant therapy of diabetic infected wounds Yipeng Pang, Fructueux Modeste Amona, Hanyuan Liu, Shuming Tang, Jianlong Lao, Xi Chen, Xiaoye Wang Theranostics 2026; 16(15): 8521-8545. doi:10.7150/thno.135365 Full text PDF


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Research Paper A multimodal pipeline for the identification and diagnostic immunoPET validation of hepatocellular carcinoma targets for radiotheranostic development Philip Homan, Joon-Yong Chung, Woonghee Lee, Divya Nambiar, Julia Sheehan-Klenk, Hima Makala, Stanley Fayn, Orit Jacobson, Arthur Paden King, Kyungeun Kim, Jeong Won Kim, Sung Ryol Lee, Maggie Cam, Stephen M. Hewitt, Xin Wei Wang, Mitchell Ho, Freddy E. Escorcia Theranostics 2026; 16(15): 8501-8520. doi:10.7150/thno.136906 Full text PDF


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Research Paper An αvβ6/αvβ8-targeting peptibody inhibits integrin-dependent TGFβ activation, enables tumor-selective cytotoxic delivery, and synergizes with PD-L1 immune checkpoint blockade Angelo Corti, Anna Maria Gasparri, Barbara Colombo, Giulia Taiè, Elisa Sangiovanni, Leopoldo Sitia, Valeria Barreca, Alice Schirru, Alessandro Gori, Luc Garrigues, Sophie Chabot, Annapaola Andolfo, Maurilio Ponzoni, Anna Mondino, Arianna Pocaterra, Claudio Doglioni, Flavio Curnis Theranostics 2026; 16(15): 8478-8500. doi:10.7150/thno.131237 Full text PDF


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Research Paper Radiocopper in BCMA-targeted immunotheranostics of myeloma Martin Ullrich, Kristof Zarschler, Manja Kubeil, Markus Laube, Jens Pietzsch, Birgit Belter Theranostics 2026; 16(15): 8461-8477. doi:10.7150/thno.134397 Full text PDF


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Research Paper Novel nastorazepide-based radioligands demonstrate effective cholecystokinin-2 receptor targeting with potential for theranostic applications Lennart Bohrmann, Doroteja Novak, Marko Kroselj, Raghuvir H. Gaonkar, Francesca Porto, Melpomeni Fani, Petra Kolenc, Marko Anderluh, Rosalba Mansi Theranostics 2026; 16(15): 8447-8460. doi:10.7150/thno.129327 Full text PDF

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Issue 12; 2026

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Founding Editor-in-Chief:
Prof. Xiaoyuan (Shawn) Chen, PhD
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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.



An αvβ6/αvβ8-targeting peptibody inhibits integrin-dependent TGFβ activation, enables tumor-selective cytotoxic delivery, and synergizes with PD-L1 immune checkpoint blockade

Background: The αvβ6 and αvβ8 integrins are upregulated in many solid-tumors and drive local activation of transforming growth factor-β (TGFβ), promoting immune evasion and resistance to immune checkpoint blockade. The chromogranin A-derived peptide 4Δ targets the RGD-binding site of αvβ6/αvβ8 and inhibits integrin-dependent TGFβ-activation. We investigated whether 4Δ-derived peptibodies ...

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