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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition
Qi Wang, Juan Liu, Yinan Hu, Ting Pan, Yongjian Xu, Jun Yu, Weining Xiong, Qing Zhou, Yi Wang
Theranostics 2021; 11(14): 7110-7125. doi:10.7150/thno.61085
[Abstract] [Full text] [PDF]


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Research Paper
Genomic and transcriptional alterations in first-line chemotherapy exert a potentially unfavorable influence on subsequent immunotherapy in NSCLC
Yayi He, Linsong Chen, Lishu Zhao, Shiying Dang, Guifeng Liu, Shinji Sasada, Patrick C. Ma, Nico van Zandwijk, Rafael Rosell, Helmut H. Popper, Hao Wang, Minlin Jiang, Haoyue Guo, Xinyi Liu, Shifu Chen, Xiaoni Zhang, Mingyan Xu, Bo Zhu, Ming Liu, Caicun Zhou
Theranostics 2021; 11(14): 7092-7109. doi:10.7150/thno.58039
[Abstract] [Full text] [PDF]


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Research Paper
An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment
Chih-Hsiung Hsieh, Hung-Chia Hsieh, Fu-Shiuan Shih, Pei-Wen Wang, Li-Xing Yang, Dar-Bin Shieh, Yi-Ching Wang
Theranostics 2021; 11(14): 7072-7091. doi:10.7150/thno.57803
[Abstract] [Full text] [PDF]


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Research Paper
Macrophage-mediated tumor homing of hyaluronic acid nanogels loaded with polypyrrole and anticancer drug for targeted combinational photothermo-chemotherapy
Tingting Xiao, Wei Hu, Yu Fan, Mingwu Shen, Xiangyang Shi
Theranostics 2021; 11(14): 7057-7071. doi:10.7150/thno.60427
[Abstract] [Full text] [PDF]


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Research Paper
γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy
Fangyuan Zhou, Shikui Yang, Chao Zhao, Wangwang Liu, Xufeng Yao, Hui Yu, Xiaolian Sun, Yi Liu
Theranostics 2021; 11(14): 7045-7056. doi:10.7150/thno.60586
[Abstract] [Full text] [PDF]


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Research Paper
Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment
I-Ying Kuo, You-En Yang, Pei-Shan Yang, Yu-Jou Tsai, Hong-Tai Tzeng, Hung-Chi Cheng, Wan-Ting Kuo, Wu-Chou Su, Chih-Peng Chang, Yi-Ching Wang
Theranostics 2021; 11(14): 7029-7044. doi:10.7150/thno.60040
[Abstract] [Full text] [PDF]


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Research Paper
Dynamic monitoring of circulating tumor DNA to predict prognosis and efficacy of adjuvant chemotherapy after resection of colorectal liver metastases
De-Shen Wang, Hui Yang, Xiao-Yun Liu, Zhi-Gang Chen, Yun Wang, William Pat Fong, Ming-Tao Hu, Yuan-Chao Zheng, Yun Zheng, Bin-Kui Li, Yun-Fei Yuan, Gong Chen, Zhi-Zhong Pan, Lele Song, Yu-Hong Li, Rui-Hua Xu
Theranostics 2021; 11(14): 7018-7028. doi:10.7150/thno.59644
[Abstract] [Full text] [PDF]


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Research Paper
Nanoparticle encapsulation of non-genotoxic p53 activator Inauhzin-C for improved therapeutic efficacy
Nimisha Bhattarai, Jieqiong Wang, Daniel Nguyen, Xiaoxiao Yang, Linh Helmers, Jennifer Paruch, Li Li, Yiwei Zhang, Kun Meng, Alun Wang, Janarthanan Jayawickramarajah, Binghe Wang, Shelya Zeng, Hua Lu
Theranostics 2021; 11(14): 7005-7017. doi:10.7150/thno.57404
[Abstract] [Full text] [PDF]


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Research Paper
The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity
Petra I. Lorenzo, Eugenia Martin Vazquez, Livia López-Noriega, Esther Fuente-Martín, José M. Mellado-Gil, Jaime M. Franco, Nadia Cobo-Vuilleumier, José A. Guerrero Martínez, Silvana Y. Romero-Zerbo, Jesús A. Perez-Cabello, Sabrina Rivero Canalejo, Antonio Campos-Caro, Christian Claude Lachaud, Alejandra Crespo Barreda, Manuel Aguilar-Diosdado, Eduardo García Fuentes, Alejandro Martin-Montalvo, Manuel Álvarez Dolado, Franz Martin, Gemma Rojo-Martinez, David Pozo, Francisco J. Bérmudez-Silva, Valentine Comaills, José C. Reyes, Benoit R. Gauthier
Theranostics 2021; 11(14): 6983-7004. doi:10.7150/thno.57237
[Abstract] [Full text] [PDF]


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Research Paper
Improving the sensitivity of T1 contrast-enhanced MRI and sensitive diagnosing tumors with ultralow doses of MnO octahedrons
Lijiao Yang, Lili Wang, Guoming Huang, Xuan Zhang, Lanlan Chen, Ao Li, Jinhao Gao, Zijian Zhou, Lichao Su, Huanghao Yang, Jibin Song
Theranostics 2021; 11(14): 6966-6982. doi:10.7150/thno.59096
[Abstract] [Full text] [PDF]


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Research Paper
Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer
Xuan Qin, Jia Li, Shiqing Wang, Jianying Lv, Fangkun Luan, Yanhua Liu, Yanan Chen, Xiaosu Chen, Yujia Zhao, Jingjin Zhu, Yongjun Piao, Wenwen Zhang, Yi Shi, Rong Xiang, Pengpeng Qu, Longlong Wang
Theranostics 2021; 11(14): 6950-6965. doi:10.7150/thno.58956
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Research Paper
A spontaneous multifunctional hydrogel vaccine amplifies the innate immune response to launch a powerful antitumor adaptive immune response
Xiuqi Liang, Lu Li, Xinchao Li, Tao He, Songlin Gong, Shunyao Zhu, Miaomiao Zhang, Qinjie Wu, Changyang Gong
Theranostics 2021; 11(14): 6936-6949. doi:10.7150/thno.58173
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Research Paper
Molecular ultrasound imaging of neutrophil membrane-derived biomimetic microbubbles for quantitative evaluation of hepatic ischemia-reperfusion injury
Zheng Zhang, Xiaoyan Miao, Weifeng Yao, Jie Ren, Chaojin Chen, Xiang Li, Jing Yang, Yujia You, Yuejun Lin, Tinghui Yin, Ziqing Hei
Theranostics 2021; 11(14): 6922-6935. doi:10.7150/thno.57794
[Abstract] [Full text] [PDF]


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Research Paper
Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT
Li Jia, Jun Li, Pengfei Li, Didi Liu, Jing Li, Jiechen Shen, Bojing Zhu, Chen Ma, Ting Zhao, Rongxia Lan, Liuyi Dang, Wang Li, Shisheng Sun
Theranostics 2021; 11(14): 6905-6921. doi:10.7150/thno.56882
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Research Paper
Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2
Ying Huang, Shan-He Yu, Wen-Xuan Zhen, Tao Cheng, Dan Wang, Jie-Bo Lin, Yu-Han Wu, Yi-Fan Wang, Yi Chen, Li-Ping Shu, Yi Wang, Xiao-Jian Sun, Yi Zhou, Fan Yang, Chih-Hung Hsu, Peng-Fei Xu
Theranostics 2021; 11(14): 6891-6904. doi:10.7150/thno.53170
[Abstract] [Full text] [PDF]


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Research Paper
Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer
Xin Li, Lajos Gera, Shumin Zhang, Yanhua Chen, Lei Lou, Lauren Marie Wilson, Zhong-Ru Xie, Giuseppe Sautto, Degang Liu, Alira Danaher, Kenza Mamouni, Yang Yang, Yuhong Du, Haian Fu, Omer Kucuk, Adeboye O. Osunkoya, Jia Zhou, Daqing Wu
Theranostics 2021; 11(14): 6873-6890. doi:10.7150/thno.49235
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 8.579

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Letter
Pentraxin 3: a powerful orchestrator in urinary tract infection
Cheng Qiu, Tianyi Liu, Dan Luo, Zhaoxiang Xie
Nanotheranostics 2021; 5(4): 445-447. doi:10.7150/ntno.60901
[Abstract] [Full text] [PDF]


Research Paper
Tracking adoptive T cell immunotherapy using magnetic particle imaging
Angelie Rivera-Rodriguez, Lan B. Hoang-Minh, Andreina Chiu-Lam, Nicole Sarna, Leyda Marrero-Morales, Duane A. Mitchell, Carlos M. Rinaldi-Ramos
Nanotheranostics 2021; 5(4): 431-444. doi:10.7150/ntno.55165
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Europium sulfide nanoprobes predict antiretroviral drug delivery into HIV-1 cell and tissue reservoirs
Jonathan Herskovitz, Mahmudul Hasan, Jatin Machhi, Insiya Mukadam, Brendan M. Ottemann, James R. Hilaire, Christopher Woldstad, JoEllyn McMillan, Yutong Liu, Javier Seravalli, Anandakumar Sarella, Howard E. Gendelman, Bhavesh D. Kevadiya
Nanotheranostics 2021; 5(4): 417-430. doi:10.7150/ntno.59568
[Abstract] [Full text] [PDF] [PubMed] [PMC]

CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: https://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues