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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Tumor-derived extracellular vesicles convey solute transporters to induce bioenergetic dependence shift contributing to treatment resistance
Jayshree Hirpara, Win Lwin Thuya, Sok-Hwee Cheow, Kanishka Fernando, Jie Qing Eu, Lingzhi Wang, Andrea Li-Ann Wong, Eliza Li Shan Fong, Azhar Bin Ali, Ling-wen Ding, Wu Zhuoran, Yaw-Chyn Lim, Shazib Pervaiz, Boon-Cher Goh
Theranostics 2024; 14(16): 6350-6369. doi:10.7150/thno.100374
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Research Paper
PET imaging of CXCR4 expression using [18F]AlF-NOTA-QHY-04 for hematologic malignancy and solid tumors
Kai Cheng, Shijie Wang, Tianxin Liu, Jinli Pei, Shasha Wang, Jingru Liu, Kunlong Zhao, Yuxi Luo, Shengnan Xu, Jinming Yu, Jie Liu
Theranostics 2024; 14(16): 6337-6349. doi:10.7150/thno.99025
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Research Paper
PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies
Monireh Shojaei, Rebecca Schaefer, Kai Schlepckow, Lea H. Kunze, Felix L. Struebing, Bettina Brunner, Michael Willem, Laura M. Bartos, Astrid Feiten, Giovanna Palumbo, Thomas Arzberger, Peter Bartenstein, Gian Carlo Parico, Dan Xia, Kathryn M. Monroe, Christian Haass, Matthias Brendel, Simon Lindner
Theranostics 2024; 14(16): 6319-6336. doi:10.7150/thno.97149
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Research Paper
Preclinical pharmacology of patient-derived extracellular vesicles for the intraoperative imaging of tumors
Alessandro Villa, Daniela Crescenti, Zemira De Mitri, Elisabetta Crippa, Silvia Rosa, Nicoletta Rizzi, Fereshteh Shojaei-Ghahrizjani, Monica Rebecchi, Simona Vincenti, Francesca Selmin, Electra Brunialti, Nicolò Simonotti, Marianna Maspero, Michele Dei Cas, Camilla Recordati, Saverio Paltrinieri, Alessia Giordano, Rita Paroni, Margherita Galassi, Vito Ladisa, Flavio Arienti, Francesco Cilurzo, Vincenzo Mazzaferro, Paolo Ciana
Theranostics 2024; 14(16): 6301-6318. doi:10.7150/thno.98671
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Review
Targeted radiopharmaceuticals: an underexplored strategy for ovarian cancer
Melissa Crabbé, Tomas Opsomer, Koen Vermeulen, Maarten Ooms, Charlotte Segers
Theranostics 2024; 14(16): 6281-6300. doi:10.7150/thno.99782
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Research Paper
Preoperative PET imaging and fluorescence-guided surgery of human glioblastoma using dual-labeled antibody targeting ETA receptors in a preclinical mouse model: A theranostic approach
Marie Hautiere, Delphine Vivier, Paul Dorval, Donovan Pineau, Dimitri Kereselidze, Caroline Denis, Amaury Herbet, Narciso Costa, Claire Bernhard, Victor Goncalves, Erwan Selingue, Benoit Larrat, Pierre Alix Dancer, Jean-Philippe Hugnot, Didier Boquet, Charles Truillet, Franck Denat
Theranostics 2024; 14(16): 6268-6280. doi:10.7150/thno.98163
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

Rationale: Growing evidence points to the tumor microenvironment's role in developing drug resistance. A key element of this microenvironment is inter-cellular communication, which includes the release of membrane-encapsulated vesicles containing various cargo, known as extracellular vesicles (EVs). Understanding how EVs contribute to acquired resistance holds significant clinical implications. Methods: Differential centrifugation-based methods were used to isolate EVs from established cell lines and human plasma. TMT labeling proteomics analysis of EVs revealed an abundance of metabolic transporter....
C-X-C motif chemokine receptor 4 (CXCR4) is an attractive target for the diagnosis and treatment of cancers. Here, we aimed to develop a new CXCR4-targeted PET tracer, and to investigate the translational potential for noninvasive imaging of CXCR4 expression in various cancer entities through preclinical and pilot clinical studies. Methods [18F]AlF-NOTA-QHY-04 was synthesized and evaluated by cellular uptake, blocking and biolayer interferometry studies in vitro. The pharmacokinetics, biodistribution, and imaging specificity were researched in tumor-bearing mice. [18F]AlF-NOTA-QHY-04 PET/CT imaging....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Unraveling In vivo Potential of Curcumin-loaded Graphene Quantum Dots on Drug Delivery and Release Kinetics Aspects of Cancer Treatment
Mochamad Z. Fahmi, Siti F. A. Sugito, Aswandi Wibrianto, Siska Novania, Shinta Widyastuti, Musbahu Adam Ahmad, Satya C. W. Sakti, Lee H. Voon
Nanotheranostics 2024; 8(4): 521-534.
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