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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
FN1 mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the FN1 3'-UTR-let-7i-5p-THBS1 axis
Siwei Pan, Jiaming Zhu, Pengfei Liu, Qiaochu Wei, Siyu Zhang, Wen An, Yuxin Tong, Zhenguo Cheng, Funan Liu
Theranostics 2023; 13(14): 5130-5150. doi:10.7150/thno.82492
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Research Paper
Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE-/- mice with minimal side effects
Liang Zhang, Chen Wang, Wei Hu, Te Bu, Wenqi Sun, Tian Zhou, Shuo Qiu, Mengying Wei, Helin Xing, Zhelong Li, Guodong Yang, Lijun Yuan
Theranostics 2023; 13(14): 5114-5129. doi:10.7150/thno.87484
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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Research Paper
A dendritic/tumor fusion cell vaccine enhances efficacy of nanobody-based CAR-T cells against solid tumor
Shuyang Sun, Ziqiang Ding, Li Gao, Bruce D. Hammock, Xianing Huang, Zhi Ping Xu, Xuan Wang, Qihong Cheng, Fengzhen Mo, Wei Shi, Shenxia Xie, Aiqun Liu, Haixia Li, Xiaomei Yang, Xiaoling Lu
Theranostics 2023; 13(14): 5099-5113. doi:10.7150/thno.84946
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Research Paper
Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy
Minjee Kim, Hyeyoung Kim, Bu-Gyeong Kang, Jooyoung Lee, Taegun Kim, Hwanho Lee, Jane Jung, Myung Joon Oh, Seungyoon Seo, Myung-Jeom Ryu, Yeojin Sung, Yunji Lee, Jeonghun Yeom, Gyoonhee Han, Sun-Shin Cha, Hosung Jung, Hyun Seok Kim
Theranostics 2023; 13(14): 5075-5098. doi:10.7150/thno.85356
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Research Paper
Exosomal transfer leads to chemoresistance through oxidative phosphorylation-mediated stemness phenotype in colorectal cancer
Jinhai Deng, Teng Pan, Chunxin Lv, Lulu Cao, Lifeng Li, Xingang Zhou, Gang Li, Huanxin Li, Jose M Vicencio, Yihan Xu, Fengxiang Wei, Yazhou Wang, Zaoqu Liu, Guanglin Zhou, Mingzhu Yin
Theranostics 2023; 13(14): 5057-5074. doi:10.7150/thno.84937
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Review
Targeting cullin neddylation for cancer and fibrotic diseases
Zhang-Xu He, Wei-guang Yang, Dan Zengyangzong, Ge Gao, Qian Zhang, Hong-Min Liu, Wen Zhao, Li-Ying Ma
Theranostics 2023; 13(14): 5017-5056. doi:10.7150/thno.78876
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Research Paper
Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE-/-mice
Peng Xiang, Qingqiu Chen, Le Chen, Jin Lei, Zhiyi Yuan, Hui Hu, Yining Lu, Xianmin Wang, Tingting Wang, Ruihong Yu, Wanping Zhang, Jun Zhang, Chao Yu, Limei Ma
Theranostics 2023; 13(14): 4993-5016. doi:10.7150/thno.87968
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Research Paper
Application of Lung-Targeted Lipid Nanoparticle-delivered mRNA of soluble PD-L1 via SORT Technology in Acute Respiratory Distress Syndrome
Han Sun, Yu Zhang, Jiahui Wang, Juncheng Su, Dejian Zhou, Xiang Yu, Yingjie Xu, Wen Yang
Theranostics 2023; 13(14): 4974-4992. doi:10.7150/thno.86466
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.

CFP: Special issue on mRNA-based vaccine and therapy. Guest Editors: Guocan Yu (Tsinghua University, China), Qiaobing Xu (Tufts University, USA), Wei Tao (Harvard Medical School, USA)

Senescent cells in plaques emerge as a detrimental factor for atherosclerosis (AS), for which targeted senolysis might be a promising therapeutic strategy. The development of safe and efficient senolytics for senescent cell eradication by targeted delivery is greatly needed. Methods: Pro-apoptotic intelligent Bax (iBax)-overexpressing plasmid was constructed by molecular cloning, in which Bax CDS was fused to miR-122 recognition sites. Extracellular vesicle-based senolytics (EViTx) were developed to be conjugated with magnetic nanoparticles on the surface, iBax mRNA encapsulated inside, and BAX....
Background: Exploiting synthetic lethality (SL) relationships between protein pairs has emerged as an important avenue for the development of anti-cancer drugs. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme of the NAD+ salvage pathway, having an SL relationship with nicotinic acid phosphoribosyltransferase (NAPRT), the key enzyme in the NAD+ Preiss-Handler pathway. NAMPT inhibitor holds clinical potential not only as a promising cancer treatment but also as a means of protection against chemotherapy-induced-peripheral-neuropathy (CIPN). However, as NAD+ is essential....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Review
Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine
Mahbuba Rahman
Nanotheranostics 2023; 7(4): 424-449. doi:10.7150/ntno.86467
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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