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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins
Jiayi Lin, Jinmei Jin, Yiwen Shen, Lijun Zhang, Gang Gong, Huiting Bian, Hongzhuan Chen, Dale G. Nagle, Ye Wu, Weidong Zhang, Xin Luan
Theranostics 2021; 11(17): 8337-8349. doi:10.7150/thno.62686
[Abstract] [Full text] [PDF]


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Review
Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming
Zhenzhen Li, Chanjun Sun, Zhihai Qin
Theranostics 2021; 11(17): 8322-8336. doi:10.7150/thno.62378
[Abstract] [Full text] [PDF]


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Research Paper
Microenvironment Activatable Nanoprodrug Based on Gripper-like Cyclic Phenylboronic Acid to Precisely and Effectively Alleviate Drug-induced Hepatitis
Qixiong Zhang, Shanshan Li, Lulu Cai, Yuxuan Zhu, Xingmei Duan, Peidu Jiang, Lei Zhong, Kun Guo, Rongsheng Tong
Theranostics 2021; 11(17): 8301-8321. doi:10.7150/thno.61214
[Abstract] [Full text] [PDF]


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Research Paper
Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4
Jinxin Liu, Chenzhipeng Nie, Lamei Xue, Ying Yan, Shengnan Liu, Juan Sun, Mingcong Fan, Haifeng Qian, Hao Ying, Li Wang, Yan Li
Theranostics 2021; 11(17): 8283-8300. doi:10.7150/thno.61192
[Abstract] [Full text] [PDF]


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Research Paper
Cell membrane inspired nano-shell enabling long-acting Glucose Oxidase for Melanoma starvation therapy via microneedles-based percutaneous delivery
Yang Zeng, Haiyan Zhou, Jinsong Ding, Wenhu Zhou
Theranostics 2021; 11(17): 8270-8282. doi:10.7150/thno.60758
[Abstract] [Full text] [PDF]


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Research Paper
Iron Oxide Nanoparticles Promote Cx43-Overexpression of Mesenchymal Stem Cells for Efficient Suicide Gene Therapy during Glioma Treatment
Ai Li, Tianyuan Zhang, Ting Huang, Ruyi Lin, Jiafu Mu, Yuanqin Su, Hao Sun, Xinchi Jiang, Honghui Wu, Donghang Xu, Hongcui Cao, Xiaoyi Sun, Daishun Ling, Jianqing Gao
Theranostics 2021; 11(17): 8254-8269. doi:10.7150/thno.60160
[Abstract] [Full text] [PDF]


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Review
Obesity and severe coronavirus disease 2019: molecular mechanisms, paths forward, and therapeutic opportunities
Tiantian Yan, Rong Xiao, Nannan Wang, Ruoyu Shang, Guoan Lin
Theranostics 2021; 11(17): 8234-8253. doi:10.7150/thno.59293
[Abstract] [Full text] [PDF]


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Research Paper
GATA3 functions downstream of BRCA1 to suppress EMT in breast cancer
Feng Bai, Li-Han Zhang, Xiong Liu, Chuying Wang, Chenglong Zheng, Jianping Sun, Min Li, Wei-Guo Zhu, Xin-Hai Pei
Theranostics 2021; 11(17): 8218-8233. doi:10.7150/thno.59280
[Abstract] [Full text] [PDF]


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Research Paper
Early administration of MPC-n(IVIg) selectively accumulates in ischemic areas to protect inflammation-induced brain damage from ischemic stroke
Weili Jin, Ye Wu, Ning Chen, Qixue Wang, Yunfei Wang, Yansheng Li, Sidi Li, Xing Han, Eryan Yang, Fei Tong, Jialing Wu, Xubo Yuan, Chunsheng Kang
Theranostics 2021; 11(17): 8197-8217. doi:10.7150/thno.58947
[Abstract] [Full text] [PDF]


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Research Paper
Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy
Jianbing Du, Zhuo Wan, Cong Wang, Fan Lu, Mengying Wei, Desheng Wang, Qiang Hao
Theranostics 2021; 11(17): 8185-8196. doi:10.7150/thno.59121
[Abstract] [Full text] [PDF]


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Research Paper
Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth
Fangrui Wu, Shenyou Nie, Yuan Yao, Tong Huo, Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qianxing Mo, Yongcheng Song
Theranostics 2021; 11(17): 8172-8184. doi:10.7150/thno.56737
[Abstract] [Full text] [PDF]


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Research Paper
Fructose-coated Ångstrom silver prevents sepsis by killing bacteria and attenuating bacterial toxin-induced injuries
Hao Yin, Mao Zhou, Xia Chen, Teng-Fei Wan, Ling Jin, Shan-Shan Rao, Yi-Juan Tan, Ran Duan, Yu Zhang, Zhen-Xing Wang, Yi-Yi Wang, Ze-Hui He, Ming-Jie Luo, Xiong-Ke Hu, Yang Wang, Wei-Yi Situ, Si-Yuan Tang, Wen-En Liu, Chun-Yuan Chen, Hui Xie
Theranostics 2021; 11(17): 8152-8171. doi:10.7150/thno.55334
[Abstract] [Full text] [PDF]


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Research Paper
Total tumor volume reduction and low PSMA expression in patients receiving Lu-PSMA therapy
Robert Seifert, Katharina Kessel, Katrin Schlack, Matthias Weckesser, David Kersting, Konstantin E. Seitzer, Manuel Weber, Martin Bögemann, Kambiz Rahbar
Theranostics 2021; 11(17): 8143-8151. doi:10.7150/thno.60222
[Abstract] [Full text] [PDF]


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Research Paper
Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model
Allaura S. Cone, Xuegang Yuan, Li Sun, Leanne C. Duke, Michael P. Vreones, Allison N. Carrier, Stephanie M. Kenyon, Spencer R. Carver, Sarah D. Benthem, Alina C. Stimmell, Shawn C. Moseley, David Hike, Samuel C. Grant, Aaron A. Wilber, James M. Olcese, David G. Meckes
Theranostics 2021; 11(17): 8129-8142. doi:10.7150/thno.62069
[Abstract] [Full text] [PDF]


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Research Paper
CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer
Tongyuan Deng, Peng Shen, Aimin Li, Ziyan Zhang, Huiling Yang, Xiaojie Deng, Xuemei Peng, Zhe Hu, Zibo Tang, Jiahao Liu, Rentao Hou, Zhen Liu, Weiyi Fang
Theranostics 2021; 11(16): 8112-8128. doi:10.7150/thno.54961
[Abstract] [Full text] [PDF]


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Research Paper
N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application
Haeng Eun Song, Yoonji Lee, Eunmi Kim, Chang Yun Cho, Oisun Jung, Doohyung Lee, Eun Goo Lee, Seo Hee Nam, Minkyung Kang, Stephani Joy Y. Macalino, Ji Eon Kim, Jae Woo Jung, Sung Won Kwon, Sun Choi, Jung Weon Lee
Theranostics 2021; 11(16): 8092-8111. doi:10.7150/thno.58739
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 11.556. Congratulations!

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Novel Protocols for Scalable Production of High Quality Purified Small Extracellular Vesicles from Bovine Milk
Spencer R. Marsh, Kevin J. Pridham, Jane Jourdan, Robert G. Gourdie
Nanotheranostics 2021; 5(4): 488-498. doi:10.7150/ntno.62213
[Abstract] [Full text] [PDF]


Research Paper
Photoactive Silver Nanoagents for Backgroundless Monitoring and Precision Killing of Multidrug-Resistant Bacteria
Zhiwen Xu, Cai Zhang, Yunjian Yu, Wenshuai Li, Zhuang Ma, Jingjing Wang, Xinge Zhang, Hongmei Gao, Dingbin Liu
Nanotheranostics 2021; 5(4): 472-487. doi:10.7150/ntno.62364
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Review
Nanotheranostic Application of Fluorescent Protein-Gold Nanocluster Hybrid Materials: A Mini-review
Han Ding, Zhijun Chen
Nanotheranostics 2021; 5(4): 461-471. doi:10.7150/ntno.58060
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.
Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: https://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues