Cover image

Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


toc.jpg

Research Paper
CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2
Panyang Shen, Yute Yang, Gang Liu, Weijie Chen, Junxing Chen, Qingxin Wang, Hongliang Gao, Shunwu Fan, Shuying Shen, Xing Zhao
Theranostics 2020; 10(20): 9113-9131. doi:10.7150/thno.45993
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration
Yuyao Wang, Yan Li, Jie Feng, Weijing Liu, Yandong Li, Jun Liu, Qianqian Yin, Hong Lian, Lihui Liu, Yu Nie
Theranostics 2020; 10(20): 9100-9112. doi:10.7150/thno.44281
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway
Hui-Juan Liu, Yuan Qin, Zi-Han Zhao, Yang Zhang, Jia-Huan Yang, Deng-Hui Zhai, Fang Cui, Ce Luo, Man-Xi Lu, Piao-Piao Liu, Heng-Wei Xu, Kun Li, Bo Sun, Shuang Chen, Hong-Gang Zhou, Cheng Yang, Tao Sun
Theranostics 2020; 10(20): 9083-9099. doi:10.7150/thno.46467
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Super-enhancer-driven AJUBA is activated by TCF4 and involved in epithelial-mesenchymal transition in the progression of Hepatocellular Carcinoma
Chi Zhang, Shi Wei, Wei-Peng Sun, Kai Teng, Miao-Miao Dai, Feng-Wei Wang, Jie-Wei Chen, Han Ling, Xiao-Dan Ma, Zi-Hao Feng, Jin-Ling Duan, Mu-Yan Cai, Dan Xie
Theranostics 2020; 10(20): 9066-9082. doi:10.7150/thno.45349
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic and Benzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property and Tumorigenesis
Ping Yang, Jie Xie, Yunfei Li, Hsuan-Pei Lin, William Fenske, Marco Clementino, Yiguo Jiang, Chengfeng Yang, Zhishan Wang
Theranostics 2020; 10(20): 9050-9065. doi:10.7150/thno.47897
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced Corticosterone
Wen Li, Zhuo Luo, Chang-Yu Yan, Xiao-Hua Wang, Zheng-Jie He, Shu-Hua Ouyang, Chang Yan, Li-Fang Liu, Qing-Qing Zhou, Han-Lu Mu, Hai-Biao Gong, Wen-Jun Duan, Lei Liang, Hiroshi Kurihara, Du Feng, Yi-Fang Li, Rong-Rong He
Theranostics 2020; 10(20): 9032-9049. doi:10.7150/thno.46921
[Abstract] [Full text] [PDF]


toc.jpg

Review
Silver nanoparticles: Synthesis, medical applications and biosafety
Li Xu, Yi-Yi Wang, Jie Huang, Chun-Yuan Chen, Zhen-Xing Wang, Hui Xie
Theranostics 2020; 10(20): 8996-9031. doi:10.7150/thno.45413
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p
Bing Xia, Jianbo Gao, Shengyou Li, Liangliang Huang, Lei Zhu, Teng Ma, Laihe Zhao, Yujie Yang, Kai Luo, Xiaowei, Shi, Liangwei Mei, Hao Zhang, Yi Zheng, Lei Lu, Zhuojing Luo, Jinghui Huang
Theranostics 2020; 10(20): 8974-8995. doi:10.7150/thno.44912
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Oxygen carrier in core-shell fibers synthesized by coaxial electrospinning enhances Schwann cell survival and nerve regeneration
Teng Ma, Yafeng Yang, Xin Quan, Lei Lu, Bing Xia, Jianbo Gao, Fengyu Qi, Shengyou Li, Laihe Zhao, Liangwei Mei, Yi Zheng, Yanbing Shen, Zhuojing Luo, Yan Jin, Jinghui Huang
Theranostics 2020; 10(20): 8957-8973. doi:10.7150/thno.45035
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications
Dongdong Jian, Ying Wang, Liguo Jian, Hao Tang, Lixin Rao, Ke Chen, Zhen Jia, Wanjun Zhang, Yiran Liu, Xu Chen, Xiwen Shen, Chuanyu Gao, Shuai Wang, Muwei Li
Theranostics 2020; 10(20): 8939-8956. doi:10.7150/thno.45178
[Abstract] [Full text] [PDF]


toc.jpg

Review
An emerging role of regulatory T-cells in cardiovascular repair and regeneration
Tiffany H.W. Fung, Kevin Y. Yang, Kathy O. Lui
Theranostics 2020; 10(20): 8924-8938. doi:10.7150/thno.47118
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
DNA methylation maintains the CLDN1-EPHB6-SLUG axis to enhance chemotherapeutic efficacy and inhibit lung cancer progression
Jia-En Wu, Yi-Ying Wu, Chia-Hao Tung, Yao-Tsung Tsai, Hsuan-Yu Chen, Yuh-Ling Chen, Tse-Ming Hong
Theranostics 2020; 10(19): 8903-8923. doi:10.7150/thno.45785
[Abstract] [Full text] [PDF]


toc.jpg

Review
Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications
Huidan Tan, Shouyue Zhang, Jin Zhang, Lingjuan Zhu, Yanmei Chen, Hongmei Yang, Yi Chen, Yang An, Bo Liu
Theranostics 2020; 10(19): 8880-8902. doi:10.7150/thno.47548
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression
Ming Li, Yuan Deng, Minghui Zhuo, Hui Zhou, Xu Kong, Xiaogang Xia, Zhaojie Su, Qiang Chen, Peng Guo, Pingli Mo, Chundong Yu, Wengang Li
Theranostics 2020; 10(19): 8863-8879. doi:10.7150/thno.45581
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Single-cell analysis reveals immune landscape in kidneys of patients with chronic transplant rejection
Yongguang Liu, Jianmin Hu, Ding Liu, Song Zhou, Jun Liao, Guorong Liao, Siqiang Yang, Zefeng Guo, Yuzhu Li, Shichao Li, Hua Chen, Ying Guo, Ming Li, Lipei Fan, Liuyang Li, Anqi Lin, Ming Zhao
Theranostics 2020; 10(19): 8851-8862. doi:10.7150/thno.48201
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
LXR activation potentiates sorafenib sensitivity in HCC by activating microRNA-378a transcription
Zhongjie Lin, Shunjie Xia, Yuelong Liang, Lin Ji, Yu Pan, Shi Jiang, Zhe Wan, Liye Tao, Jiang Chen, Chengping Lin, Xiao Liang, Junjie Xu, Xiujun Cai
Theranostics 2020; 10(19): 8834-8850. doi:10.7150/thno.45158
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 8.579

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
A Gold Nanoparticle Bouquet held on plasma membrane: An ultrasensitive dark-field imaging approach for Cancer Cell Analysis
Yue Cao, Jie Wang, Qiao-Yan Jiang, Li Hu, You-Jia Yu, Yan-Fang Yu, Feng Chen
Nanotheranostics 2020; 4(4): 201-209. doi:10.7150/ntno.41639
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Brain iron deposition after Ferumoxytol-enhanced MRI: A study of Porcine Brains
Ashok Joseph Theruvath, Maryam Aghighi, Michael Iv, Hossein Nejadnik, Jonathan Lavezo, Laura Jean Pisani, Heike Elisabeth Daldrup-Link
Nanotheranostics 2020; 4(4): 195-200. doi:10.7150/ntno.46356
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque
Rhiannon J. Evans, Begoña Lavin, Alkystis Phinikaridou, Kok Yean Chooi, Zahra Mohri, Eunice Wong, Joseph J. Boyle, Rob Krams, René Botnar, Nicholas J. Long
Nanotheranostics 2020; 4(4): 184-194. doi:10.7150/ntno.44712
[Abstract] [Full text] [PDF] [PubMed] [PMC]

CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues