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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Current and future perspectives on functional molecular imaging in nephro-urology: theranostics on the horizon
Yoshitaka Toyama, Rudolf A. Werner, Camilo A. Ruiz-Bedoya, Alvaro A. Ordonez, Kei Takase, Constantin Lapa, Sanjay K. Jain, Martin G. Pomper, Steven P. Rowe, Takahiro Higuchi
Theranostics 2021; 11(12): 6105-6119. doi:10.7150/thno.58682
[Abstract] [Full text] [PDF]


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Research Paper
Mechanically induced integrin ligation mediates intracellular calcium signaling with single pulsating cavitation bubbles
Fenfang Li, Tae Hyun Park, George Sankin, Christopher Gilchrist, Defei Liao, Chon U Chan, Zheng Mao, Brenton D. Hoffman, Pei Zhong
Theranostics 2021; 11(12): 6090-6104. doi:10.7150/thno.56813
[Abstract] [Full text] [PDF]


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Research Paper
Female mice lacking ERβ display excitatory/inhibitory synaptic imbalance to drive the pathogenesis of temporal lobe epilepsy
Zhongke Wang, Ruxin Xie, Xiaolin Yang, Huachun Yin, Xin Li, Tianyao Liu, Yuanyuan Ma, Junwei Gao, Zhenle Zang, Ruotong Ruan, Yang Li, Kaixuan Huang, Qingbo Chen, Kaifeng Shen, Shengqing Lv, Chunqing Zhang, Hui Yang, Maragret Warner, Jan-Ake Gustafsson, Shiyong Liu, Xiaotang Fan
Theranostics 2021; 11(12): 6074-6089. doi:10.7150/thno.56331
[Abstract] [Full text] [PDF]


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Review
MicroRNAs as theranostic markers in cardiac allograft transplantation: from murine models to clinical practice
Jan Novák, Táňa Macháčková, Jan Krejčí, Julie Bienertová-Vašků, Ondřej Slabý
Theranostics 2021; 11(12): 6058-6073. doi:10.7150/thno.56327
[Abstract] [Full text] [PDF]


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Research Paper
Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy
Gorka Ruiz de Garibay, Elvira García de Jalón, Endre Stigen, Kjetil B Lund, Mihaela Popa, Ben Davidson, Mireia Mayoral Safont, Cecilie B. Rygh, Heidi Espedal, Torill M Barrett, Bengt Erik Haug, Emmet McCormack
Theranostics 2021; 11(12): 6044-6057. doi:10.7150/thno.55092
[Abstract] [Full text] [PDF]


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Research Paper
Genetic engineering cellular vesicles expressing CD64 as checkpoint antibody carrier for cancer immunotherapy
Liyan Li, Qianwei Miao, Fanqiang Meng, Baoqi Li, Tianyuan Xue, Tianliang Fang, Zhirang Zhang, Jinxie Zhang, Xinyu Ye, Yang Kang, Xingding Zhang, Qian Chen, Xin Liang, Hongbo Chen, Xudong Zhang
Theranostics 2021; 11(12): 6033-6043. doi:10.7150/thno.48868
[Abstract] [Full text] [PDF]


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Research Paper
Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy
Shenwu Zhang, Ziyue Wang, Zhiqiang Kong, Yuequan Wang, Xuanbo Zhang, Bingjun Sun, Haotian Zhang, Qiming Kan, Zhonggui He, Cong Luo, Jin Sun
Theranostics 2021; 11(12): 6019-6032. doi:10.7150/thno.59065
[Abstract] [Full text] [PDF]


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Research Paper
The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases
Guifang Gan, Zhaopeng Shi, Chengfang Shangguan, Jieying Zhang, Yuan Yuan, Lei Chen, Weiren Liu, Biao Li, Songshu Meng, Wujun Xiong, Jun Mi
Theranostics 2021; 11(12): 6006-6018. doi:10.7150/thno.59841
[Abstract] [Full text] [PDF]


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Research Paper
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage
Qiang Luo, Panpan Xian, Tian Wang, Shengxi Wu, Tangna Sun, Wenting Wang, Bo Wang, Hao Yang, Yanping Yang, Han Wang, Weiping Liu, Qianfa Long
Theranostics 2021; 11(12): 5986-6005. doi:10.7150/thno.58632
[Abstract] [Full text] [PDF]


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Research Paper
A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABAARs
Jun Li, Lin Zhang, Chu Xu, Ying-Ying Shen, Yu-Hui Lin, Yu Zhang, Hai-Yin Wu, Lei Chang, Ying-Dong Zhang, Rong Chen, Zheng-Ping Zhang, Chun-Xia Luo, Fei Li, Dong-Ya Zhu
Theranostics 2021; 11(12): 5970-5985. doi:10.7150/thno.58364
[Abstract] [Full text] [PDF]


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Research Paper
Enhanced anti-PD-1 therapy in hepatocellular carcinoma by tumor vascular disruption and normalization dependent on combretastatin A4 nanoparticles and DC101
Xin Bao, Na Shen, Yan Lou, Haiyang Yu, Yue Wang, Linlin Liu, Zhaohui Tang, Xuesi Chen
Theranostics 2021; 11(12): 5955-5969. doi:10.7150/thno.58164
[Abstract] [Full text] [PDF]


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Research Paper
Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathy
Jie Ren, Konstantinos Tsilafakis, Liang Chen, Konstantinos Lekkos, Ioanna Kostavasili, Aimilia Varela, Dennis V. Cokkinos, Constantinos H. Davos, Xiaogang Sun, Jiangping Song, Manolis Mavroidis
Theranostics 2021; 11(12): 5939-5954. doi:10.7150/thno.58160
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Research Paper
ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM
Yanming Zhou, Furong Lin, Tao Wan, Ai Chen, Huihui Wang, Bin Jiang, Wentao Zhao, Shan Liao, Shijie Wang, Guannan Li, Zhenzhen Xu, Jinyang Wang, Jia Zhang, Huanhuan Ma, Donghai Lin, Qinxi Li
Theranostics 2021; 11(12): 5926-5938. doi:10.7150/thno.56490
[Abstract] [Full text] [PDF]


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Research Paper
Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg2+/curcumin from injectable self-healing hydrogels
Baojun Chen, Yongping Liang, Jing Zhang, Lang Bai, Meiguang Xu, Qian Han, Xuezhe Han, Jintao Xiu, Meng Li, Xiaoling Zhou, Baolin Guo, Zhanhai Yin
Theranostics 2021; 11(12): 5911-5925. doi:10.7150/thno.56266
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Review
High fat diet, gut microbiome and gastrointestinal cancer
Yao Tong, Huiru Gao, Qiuchen Qi, Xiaoyan Liu, Juan Li, Jie Gao, Peilong Li, Yunshan Wang, Lutao Du, Chuanxin Wang
Theranostics 2021; 11(12): 5889-5910. doi:10.7150/thno.56157
[Abstract] [Full text] [PDF]


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Research Paper
Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm
Jakub Toczek, Parnaz Boodagh, Nowshin Sanzida, Mean Ghim, Mani Salarian, Kiran Gona, Gunjan Kukreja, Saranya Rajendran, Linyan Wei, Jinah Han, Jiasheng Zhang, Jae-Joon Jung, Morven Graham, Xinran Liu, Mehran M. Sadeghi
Theranostics 2021; 11(12): 5876-5888. doi:10.7150/thno.55106
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 8.579

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors
Yulia Svenskaya, Francesca Garello, Ekaterina Lengert, Anastasiia Kozlova, Roman Verkhovskii, Valeria Bitonto, Maria Rosaria Ruggiero, Sergey German, Dmitry Gorin, Enzo Terreno
Nanotheranostics 2021; 5(3): 362-377. doi:10.7150/ntno.59458
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Long circulating tracer tailored for magnetic particle imaging
Sitong Liu, Andreina Chiu-Lam, Angelie Rivera-Rodriguez, Ryan DeGroff, Shehaab Savliwala, Nicole Sarna, Carlos M. Rinaldi-Ramos
Nanotheranostics 2021; 5(3): 348-361. doi:10.7150/ntno.58548
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Nanoparticles exhibiting self-regulating temperature as innovative agents for Magnetic Fluid Hyperthermia
Marco Gerosa, Marco Dal Grande, Alice Busato, Federica Vurro, Barbara Cisterna, Enrico Forlin, Filippo Gherlinzoni, Giovanni Morana, Michele Gottardi, Paolo Matteazzi, Adolfo Speghini, Pasquina Marzola
Nanotheranostics 2021; 5(3): 333-347. doi:10.7150/ntno.55695
[Abstract] [Full text] [PDF] [PubMed] [PMC]

CFP - Special Issue: Osteoarthritis Theranostics. Guest Editors: Dr. WEN, CHUNYI, Dr. Magali Cucchiarini.
CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: https://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues