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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Research Paper
RGD-expressed bacterial membrane-derived nanovesicles enhance cancer therapy via multiple tumorous targeting
Jin Gao, Sihan Wang, Xinyue Dong, Zhenjia Wang
Theranostics 2021; 11(7): 3301-3316. doi:10.7150/thno.51988
[Abstract] [Full text] [PDF]


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Review
Recent advances in innovative strategies for enhanced cancer photodynamic therapy
Tingting Hu, Zhengdi Wang, Weicheng Shen, Ruizheng Liang, Dan Yan, Min Wei
Theranostics 2021; 11(7): 3278-3300. doi:10.7150/thno.54227
[Abstract] [Full text] [PDF]


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Review
Semaphorins as emerging clinical biomarkers and therapeutic targets in cancer
Roberta Mastrantonio, Hua You, Luca Tamagnone
Theranostics 2021; 11(7): 3262-3277. doi:10.7150/thno.54023
[Abstract] [Full text] [PDF]


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Research Paper
Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy
Jiwei Hou, Qijian Ji, Jie Ji, Shenghong Ju, Chun Xu, Xueqing Yong, Xiaoxuan Xu, Mohd. Muddassir, Xiang Chen, Jinbing Xie, Xiaodong Han
Theranostics 2021; 11(7): 3244-3261. doi:10.7150/thno.54217
[Abstract] [Full text] [PDF]


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Research Paper
Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients
Gangqin Xi, Wenhui Guo, Deyong Kang, Jianli Ma, Fangmeng Fu, Lida Qiu, Liqin Zheng, Jiajia He, Na Fang, Jianhua Chen, Jingtong Li, Shuangmu Zhuo, Xiaoxia Liao, Haohua Tu, Lianhuang Li, Qingyuan Zhang, Chuan Wang, Stephen A. Boppart, Jianxin Chen
Theranostics 2021; 11(7): 3229-3243. doi:10.7150/thno.55921
[Abstract] [Full text] [PDF]


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Research Paper
Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway
Xue Xie, Jiulong Zhao, Wei Gao, Jie Chen, Bing Hu, Xiaojun Cai, Yuanyi Zheng
Theranostics 2021; 11(7): 3213-3228. doi:10.7150/thno.52010
[Abstract] [Full text] [PDF]


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Research Paper
Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF-κB inhibition
Kai Li, Zhicheng Zhang, Yu Mei, Qingzhu Yang, Shupei Qiao, Cheng Ni, Yao Yao, Xinyuan Li, Mengmeng Li, Dongdong Wei, Wangjun Fu, Xuefei Guo, Xuemei Huang, Huanjie Yang
Theranostics 2021; 11(7): 3196-3212. doi:10.7150/thno.51976
[Abstract] [Full text] [PDF]


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Review
Engineering exosomes for targeted drug delivery
Yujie Liang, Li Duan, Jianping Lu, Jiang Xia
Theranostics 2021; 11(7): 3183-3195. doi:10.7150/thno.52570
[Abstract] [Full text] [PDF]


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Research Paper
Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer
Zheng Zhang, Menglan Lu, Cailong Chen, Xing Tong, Yunhong Li, Kai Yang, Haitao Lv, Jiaying Xu, Liqiang Qin
Theranostics 2021; 11(7): 3167-3182. doi:10.7150/thno.52028
[Abstract] [Full text] [PDF]


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Research Paper
PHB2 promotes tumorigenesis via RACK1 in non-small cell lung cancer
Bin Wu, Ning Chang, Hangtian Xi, Jie Xiong, Ying Zhou, Yingtong Wu, Shuo Wu, Ning Wang, Hongyu Yi, Yun Song, Lihua Chen, Jian Zhang
Theranostics 2021; 11(7): 3150-3166. doi:10.7150/thno.52848
[Abstract] [Full text] [PDF]


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Research Paper
Conditioned medium from adipose-derived stem cells attenuates ischemia/reperfusion-induced cardiac injury through the microRNA-221/222/PUMA/ETS-1 pathway
Tzu-Lin Lee, Tsai-Chun Lai, Shu-Rung Lin, Shu-Wha Lin, Yu-Chen Chen, Chi-Ming Pu, I-Ta Lee, Jaw-Shiun Tsai, Chiang-Wen Lee, Yuh-Lien Chen
Theranostics 2021; 11(7): 3131-3149. doi:10.7150/thno.52677
[Abstract] [Full text] [PDF]


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Research Paper
Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits
Jenolyn F. Alexander, Alexandre V. Seua, Luis D. Arroyo, Pradipta R. Ray, Andi Wangzhou, Laura Heiβ-Lückemann, Manfred Schedlowski, Theodore J. Price, Annemieke Kavelaars, Cobi J. Heijnen
Theranostics 2021; 11(7): 3109-3130. doi:10.7150/thno.53474
[Abstract] [Full text] [PDF]


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Research Paper
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer
Jiao Hu, Anze Yu, Belaydi Othmane, Dongxu Qiu, Huihuang Li, Chao Li, Peihua Liu, Wenbiao Ren, Minfeng Chen, Guanghui Gong, Xi Guo, Huihui Zhang, Jinbo Chen, Xiongbing Zu
Theranostics 2021; 11(7): 3089-3108. doi:10.7150/thno.53649
[Abstract] [Full text] [PDF]


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Research Paper
Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering
Bohan Zhang, Hanlin Xu, Jun Chen, Xiaoxia Zhu, Yu Xue, Yifan Yang, Jianpeng Ao, Yinghui Hua, Minbiao Ji
Theranostics 2021; 11(7): 3074-3088. doi:10.7150/thno.53755
[Abstract] [Full text] [PDF]


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Research Paper
Systematic analysis of enhancer regulatory circuit perturbation driven by copy number variations in malignant glioma
Jun Xiao, Xiaoyan Jin, Chunlong Zhang, Haozhe Zou, Zhenghong Chang, Nan Han, Xia Li, Yunpeng Zhang, Yongsheng Li
Theranostics 2021; 11(7): 3060-3073. doi:10.7150/thno.54150
[Abstract] [Full text] [PDF]


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Review
Ferroptosis as a novel therapeutic target for cardiovascular disease
Xiaoguang Wu, Yi Li, Shuchen Zhang, Xiang Zhou
Theranostics 2021; 11(7): 3052-3059. doi:10.7150/thno.54113
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Latest Impact Factor 8.579

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Resveratrol and its Nanoparticle suppress Doxorubicin/Docetaxel-resistant anaplastic Thyroid Cancer Cells in vitro and in vivo
Le Xiong, Xiao-Min Lin, Jun-Hua Nie, Hai-Shan Ye, Jia Liu
Nanotheranostics 2021; 5(2): 143-154. doi:10.7150/ntno.53844
[Abstract] [Full text] [PDF] [PMC]


Research Paper
MR-labelled liposomes and focused ultrasound for spatiotemporally controlled drug release in triple negative breast cancers in mice
Maral Amrahli, Miguel Centelles, Paul Cressey, Martynas Prusevicius, Wladyslaw Gedroyc, Xiao Yun Xu, Po-Wah So, Michael Wright, Maya Thanou
Nanotheranostics 2021; 5(2): 125-142. doi:10.7150/ntno.52168
[Abstract] [Full text] [PDF] [PMC]


Research Paper
Resveratrol loaded polymeric micelles for theranostic targeting of breast cancer cells
Yiota Gregoriou, Gregoria Gregoriou, Vural Yilmaz, Konstantinos Kapnisis, Marianna Prokopi, Andreas Anayiotos, Katerina Strati, Nikolas Dietis, Andreas I. Constantinou, Chrysafis Andreou
Nanotheranostics 2021; 5(1): 113-124. doi:10.7150/ntno.51955
[Abstract] [Full text] [PDF] [PubMed] [PMC]

CFP - Special Issue: Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases. Guest Editor: Ming-Lin Liu, Perelman School of Medicine, University of Pennsylvania.
Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: https://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues