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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


Erratum
Dual target gene therapy to EML4-ALK NSCLC by a gold nanoshell-based system: Erratum
Siwen Li, Yuxi Liu, Yalan Rui, Liping Tang, Samuel Achilefu, Yueqing Gu
Theranostics 2020; 10(5): 2402-2404. doi:10.7150/thno.43075
[Abstract] [Full text] [PDF]


Erratum
Enhanced Blood Suspensibility and Laser-Activated Tumor-specific Drug Release of Theranostic Mesoporous Silica Nanoparticles by Functionalizing with Erythrocyte Membranes: Erratum
Jinghan Su, Huiping Sun, Qingshuo Meng, Pengcheng Zhang, Qi Yin, Yaping Li
Theranostics 2020; 10(5): 2401. doi:10.7150/thno.42848
[Abstract] [Full text] [PDF]


Erratum
pH-Sensitive Nano-Complexes Overcome Drug Resistance and Inhibit Metastasis of Breast Cancer by Silencing Akt Expression: Erratum
Jieying Yin, Tianqun Lang, Dongmei Cun, Zhong Zheng, Yan Huang, Qi Yin, Haijun Yu, Yaping Li
Theranostics 2020; 10(5): 2399-2400. doi:10.7150/thno.42847
[Abstract] [Full text] [PDF]


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Research Paper
Cooperation therapy between anti-growth by photodynamic-AIEgens and anti-metastasis by small molecule inhibitors in ovarian cancer
Jun Dai, Min Xu, Quan Wang, Juliang Yang, Jinjin Zhang, Pengfei Cui, Wenwen Wang, Xiaoding Lou, Fan Xia, Shixuan Wang
Theranostics 2020; 10(5): 2385-2398. doi:10.7150/thno.41708
[Abstract] [Full text] [PDF]


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Review
Refining Cancer Management Using Integrated Liquid Biopsy
Juhui Qiu, Jianxiong Xu, Kang Zhang, Wei Gu, Liming Nie, Guixue Wang, Yang Luo
Theranostics 2020; 10(5): 2374-2384. doi:10.7150/thno.40677
[Abstract] [Full text] [PDF]


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Research Paper
IKKε phosphorylates kindlin-2 to induce invadopodia formation and promote colorectal cancer metastasis
Ge Liu, Yantao Bao, Chaohua Liu, Qinchang Zhu, Lin Zhao, Xiaopeng Lu, Qian Zhu, Yafei Lv, Feng Bai, He Wen, Yujie Sun, Wei-Guo Zhu
Theranostics 2020; 10(5): 2358-2373. doi:10.7150/thno.40397
[Abstract] [Full text] [PDF]


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Research Paper
ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury
Hui Yu, Feiyang Jin, Di Liu, Gaofeng Shu, Xiaojuan Wang, Jing Qi, Mingchen Sun, Ping Yang, Saiping Jiang, Xiaoying Ying, Yongzhong Du
Theranostics 2020; 10(5): 2342-2357. doi:10.7150/thno.40395
[Abstract] [Full text] [PDF]


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Research Paper
CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer
Jinglue Song, Wei Chen, Xuewei Cui, Zhenyu Huang, Dongpeng Wen, Yili Yang, Wei Yu, Long Cui, Chen-Ying Liu
Theranostics 2020; 10(5): 2327-2341. doi:10.7150/thno.39740
[Abstract] [Full text] [PDF]


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Review
Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis
Bairen Pang, Ying Zhu, Jie Ni, James Thompson, David Malouf, Joseph Bucci, Peter Graham, Yong Li
Theranostics 2020; 10(5): 2309-2326. doi:10.7150/thno.39486
[Abstract] [Full text] [PDF]


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Research Paper
Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism
Yin Hu, Yan Zhang, Chu-Yu Ni, Chun-Yuan Chen, Shan-Shan Rao, Hao Yin, Jie Huang, Yi-Juan Tan, Zhen-Xing Wang, Jia Cao, Zheng-Zhao Liu, Ping-Li Xie, Ben Wu, Juan Luo, Hui Xie
Theranostics 2020; 10(5): 2293-2308. doi:10.7150/thno.39238
[Abstract] [Full text] [PDF]


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Research Paper
Association of MRI-derived radiomic biomarker with disease-free survival in patients with early-stage cervical cancer
Jin Fang, Bin Zhang, Shuo Wang, Yan Jin, Fei Wang, Yingying Ding, Qiuying Chen, Liting Chen, Yueyue Li, Minmin Li, Zhuozhi Chen, Lizhi Liu, Zhenyu Liu, Jie Tian, Shuixing Zhang
Theranostics 2020; 10(5): 2284-2292. doi:10.7150/thno.37429
[Abstract] [Full text] [PDF]


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Research Paper
68Ga-PSMA-HBED-CC PET/CT imaging for adenoid cystic carcinoma and salivary duct carcinoma: a phase 2 imaging study
Wim van Boxtel, Susanne Lütje, Ilse C.H. van Engen-van Grunsven, Gerald W. Verhaegh, Jack A. Schalken, Marianne A. Jonker, James Nagarajah, Martin Gotthardt, Carla M.L. van Herpen
Theranostics 2020; 10(5): 2273-2283. doi:10.7150/thno.38501
[Abstract] [Full text] [PDF]


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Research Paper
Nanococktail Based on AIEgens and Semiconducting Polymers: A Single Laser Excited Image-Guided Dual Photothermal Therapy
Zi Long, Jun Dai, Qinyu Hu, Quan Wang, Shijie Zhen, Zujin Zhao, Zitong Liu, Jing-Jing Hu, Xiaoding Lou, Fan Xia
Theranostics 2020; 10(5): 2260-2272. doi:10.7150/thno.41317
[Abstract] [Full text] [PDF]


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Research Paper
19q13 KRAB zinc-finger protein ZNF471 activates MAPK10/JNK3 signaling but is frequently silenced by promoter CpG methylation in esophageal cancer
Ran Sun, Tingxiu Xiang, Jun Tang, Weiyan Peng, Jie Luo, Lili Li, Zhu Qiu, Yiqing Tan, Lin Ye, Min Zhang, Guosheng Ren, Qian Tao
Theranostics 2020; 10(5): 2243-2259. doi:10.7150/thno.35861
[Abstract] [Full text] [PDF]


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Research Paper
Megakaryocytes promote bone formation through coupling osteogenesis with angiogenesis by secreting TGF-β1
Yong Tang, Mengjia Hu, Yang Xu, Fang Chen, Shilei Chen, Mo Chen, Yan Qi, Mingqiang Shen, Cheng Wang, Yukai Lu, Zihao Zhang, Hao Zeng, Yong Quan, Fengchao Wang, Yongping Su, Dongfeng Zeng, Song Wang, Junping Wang
Theranostics 2020; 10(5): 2229-2242. doi:10.7150/thno.40559
[Abstract] [Full text] [PDF]


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Research Paper
CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T
Xiongqi Han, Jianpan Huang, Anthea K.W. To, Joseph H.C. Lai, Peng Xiao, Ed X. Wu, Jiadi Xu, Kannie W.Y. Chan
Theranostics 2020; 10(5): 2215-2228. doi:10.7150/thno.40146
[Abstract] [Full text] [PDF]

Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

newNanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Effects of molecular weight and structural conformation of multivalent-based elastin-like polypeptides on tumor accumulation and tissue biodistribution
Vijaya Sarangthem, Bo-Yeon Seo, Aena Yi, Young-Jin Lee, Sun-Ha Cheon, Sang Kyoon Kim, Thoudam Debraj Singh, Byung-Heon Lee, Rang-Woon Park
Nanotheranostics 2020; 4(2): 57-70. doi:10.7150/ntno.39804
[Abstract] [Full text] [PDF]


Research Paper
Phospholipid prodrug conjugates of insoluble chemotherapeutic agents for ultrasound targeted drug delivery
Mendi G. Márquez, Rachel Dotson, Sally Pias, Liliya V. Frolova, Michaelann S. Tartis
Nanotheranostics 2020; 4(1): 40-56. doi:10.7150/ntno.37738
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
FGF2 engineered SPIONs attenuate tumor stroma and potentiate the effect of chemotherapy in 3D heterospheroidal model of pancreatic tumor
Deby Fajar Mardhian, Aggelos Vrynas, Gert Storm, Ruchi Bansal, Jai Prakash
Nanotheranostics 2020; 4(1): 26-39. doi:10.7150/ntno.38092
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy
Stefan J. Roobol, Thomas A. Hartjes, Johan A. Slotman, Robin M. de Kruijff, Guzman Torrelo, T.E. Abraham, Frank Bruchertseifer, Alfred Morgenstern, Roland Kanaar, Dik C. van Gent, Adriaan B. Houtsmuller, Antonia G. Denkova, Martin E. van Royen, Jeroen Essers
Nanotheranostics 2020; 4(1): 14-25. doi:10.7150/ntno.37080
[Abstract] [Full text] [PDF] [PubMed] [PMC]

new CFP - Special Issue: Noble-metal Nanostructures for Theranostics. Guest Editors: Xiaohu Xia, University of Central Florida and Hui Wei, Nanjing University
Special Issue Targeting the Cancer Stem Cells. Guest Editor: Fei Chen, PhD, Professor, Wayne State University
Special Issue Progress in Critical Reviews of Immunotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH), Mingnan Chen (University of Utah)
Special Issue Progress in Gene Editing Nanotheranostics. Guest Editors: Gang Han (University of Massachusetts Medical School), Wen Xue (University of Massachusetts Medical School), Qiaobing Xu (Tufts University)
Special Issue The EPR effect and beyond: Strategies to improve tumor targeting and nanomedicine efficacy. Guest Editors: Yang Shi (RWTH Aachen University), Roy van der Meel (Eindhoven University of Technology), Twan Lammers (RWTH Aachen University), Xiaoyuan (Shawn) Chen (NIBIB/NIH)
Special Issue Progress in Supramolecular Nanotheranostics. Guest Editors: Xiaoyuan (Shawn) Chen (NIBIB/NIH); Gang Zheng (University of Toronto); Jianjun Cheng (University of Illinois Urbana-Champaign); Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, Singapore)

Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/

Dr. Chen was recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/

Dr. Chen received the 2016 Bioconjugate Chemistry Lectureship Award for his extensive contributions at the interface between chemistry, biology, and medicine that have helped define the field of nanomedicine.

NCI provides a data repository for characterized cancer nanomaterials, the cancer Nanotechnology Laboratory (caNanoLab). Authors and readers of Theranostics are invited to learn more about the information deposited and how they can add their characterized nanomaterials data.
Office of Cancer Nanotechnology Research in NCI has publicly launched a Dialogue on Nanotechnology in Cancer public discussion forum. Readers of Theranostics are invited to participate in this dialog.
Media coverage: Dr. Chen and Theranostics journal have been featured in an article of Laser Focus World magazine, and in C&EN (Chemical and Engineering News).
Published Special Issues