Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

Review
Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies
Lai Jiang, Yiru Shen, Yajing Liu, Lei Zhang, Wei Jiang
Theranostics 2022; 12(4): 1537-1556. doi:10.7150/thno.66670
[Abstract] [Full text] [PDF]

Research Paper
GKRP-dependent modulation of feeding behavior by tanycyte-released monocarboxylates
Magdiel Salgado, Roberto Elizondo-Vega, Pablo S Villar, Macarena Konar, Scarlet Gallegos, Estefanía Tarifeño-Saldivia, Patricia Luz-Crawford, Luis G. Aguayo, Ricardo C. Araneda, Elena Uribe, María Ángeles García-Robles
Theranostics 2022; 12(4): 1518-1536. doi:10.7150/thno.66634
[Abstract] [Full text] [PDF]

Research Paper
KDM1A promotes thyroid cancer progression and maintains stemness through the Wnt/β-catenin signaling pathway
Wei Zhang, Xianhui Ruan, Yaoshuang Li, Jingtai Zhi, Linfei Hu, Xiukun Hou, Xianle Shi, Xin Wang, Jinpeng Wang, Weike Ma, Pengfei Gu, Xiangqian Zheng, Ming Gao
Theranostics 2022; 12(4): 1500-1517. doi:10.7150/thno.66142
[Abstract] [Full text] [PDF]

Research Paper
CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism
Juliane Medler, Kirstin Kucka, Vinicio Melo, Tengyu Zhang, Stefan von Rotenhan, Jakob Ulrich, Edwin Bremer, Michael Hudecek, Andreas Beilhack, Harald Wajant
Theranostics 2022; 12(4): 1486-1499. doi:10.7150/thno.66119
[Abstract] [Full text] [PDF]

Review
Activated molecular probes for enzyme recognition and detection
Meng Yuan, Ying Wu, Caiyan Zhao, Zhongxiang Chen, Lichao Su, Huanghao Yang, Jibin Song
Theranostics 2022; 12(3): 1459-1485. doi:10.7150/thno.66676
[Abstract] [Full text] [PDF]

Research Paper
Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids
Laurent Vachon, Ali Smaani, Nolwenn Tessier, Gabriel Jean, Annie Demers, Andreea Milasan, Nadine Ardo, Stéphanie Jarry, Louis Villeneuve, Azadeh Alikashani, Vincent Finherty, Matthieu Ruiz, Mary G. Sorci-Thomas, Gaétan Mayer, Catherine Martel
Theranostics 2022; 12(3): 1440-1458. doi:10.7150/thno.58780
[Abstract] [Full text] [PDF]

Review
Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies
Guanyu Chen, Weirong Kang, Wanqiong Li, Shaomeng Chen, Yanfeng Gao
Theranostics 2022; 12(3): 1419-1439. doi:10.7150/thno.61747
[Abstract] [Full text] [PDF]

Research Paper
Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer's disease
Sangjoon Lee, Tae Kyoo Kim, Ji Eun Choi, Yunjung Choi, Minsu You, Jeewon Ryu, Yoo Lim Chun, Suji Ham, Seung Jae Hyeon, Hoon Ryu, Hye-Sun Kim, Heh-In Im
Theranostics 2022; 12(3): 1404-1418. doi:10.7150/thno.68439
[Abstract] [Full text] [PDF]

Research Paper
Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance
Anil Kumar, Kumaran Sundaram, Yun Teng, Jingyao Mu, Mukesh K Sriwastva, Lifeng Zhang, Joshua L. Hood, Jun Yan, Xiang Zhang, Juw Won Park, Michael L Merchant, Huang-Ge Zhang
Theranostics 2022; 12(3): 1388-1403. doi:10.7150/thno.62514
[Abstract] [Full text] [PDF]

Research Paper
Three-dimensional colon cancer organoids model the response to CEA-CD3 T-cell engagers
Alvaro Teijeira, Itziar Migueliz, Saray Garasa, Vaios Karanikas, Carlos Luri, Asunta Cirella, Irene Olivera, Marta Cañamero, Maite Alvarez, Maria C. Ochoa, Ana Rouzaut, Maria E. Rodriguez-Ruiz, Miguel F. Sanmamed, Christian Klein, Pablo Umaña, Mariano Ponz, Marina Bacac, Ignacio Melero
Theranostics 2022; 12(3): 1373-1387. doi:10.7150/thno.63359
[Abstract] [Full text] [PDF]

Review
Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications
Jing Liu, Yanyan Zhang, Yan Tian, Wei Huang, Nanwei Tong, Xianghui Fu
Theranostics 2022; 12(3): 1342-1372. doi:10.7150/thno.65778
[Abstract] [Full text] [PDF]

Erratum
Focused ultrasound activates voltage-gated calcium channels through depolarizing TRPC1 sodium currents in kidney and skeletal muscle
Scott R. Burks, Rebecca M. Lorsung, Matthew E. Nagle, Tsang-Wei Tu, Joseph A. Frank
Theranostics 2022; 12(3): 1341. doi:10.7150/thno.69908
[Abstract] [Full text] [PDF]

Erratum
Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress: Erratum
Siqi Ying, Minmin Tan, Ge Feng, Yunchun Kuang, Duanjing Chen, Jie Li, Jinlin Song
Theranostics 2022; 12(3): 1337-1340. doi:10.7150/thno.69529
[Abstract] [Full text] [PDF]

Erratum
circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis: Erratum
Huan Liu, Guanghui Hu, Zaoyu Wang, Qunlong Liu, Jin Zhang, Yonghui Chen, Yiran Huang, Wei Xue, Yunfei Xu, Wei Zhai
Theranostics 2022; 12(3): 1335-1336. doi:10.7150/thno.69378
[Abstract] [Full text] [PDF]

Erratum
Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression: Erratum
Yongyu Chen, Yan Chen, Jixiang Zhang, Pan Cao, Wenhao Su, Yunchao Deng, Na Zhan, Xiangsheng Fu, Yun Huang, Weiguo Dong
Theranostics 2022; 12(3): 1333-1334. doi:10.7150/thno.69114
[Abstract] [Full text] [PDF]

Review
Exploiting macropinocytosis for drug delivery into KRAS mutant cancer
Huiqin Liu, Feng Qian
Theranostics 2022; 12(3): 1321-1332. doi:10.7150/thno.67889
[Abstract] [Full text] [PDF]

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