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Volume 15 (12); 2025
Research Papers
Pilot first-in-human CCR2 PET/CT to detect abdominal aortic aneurysm wall instability Santiago Elizondo-Benedetto, Deborah Sultan, Ryan Wahidi, Mahdjoub Hamdi, Mohamed S. Zaghloul, Shahab Hafezi, Batool Arif, Laura K. McDonald, Kitty Harrison, Dakkota Thies, Gyu Seong Heo, Hannah Luehmann, Lisa Detering, J. Westley Ohman, Zachary J. Wanken, Luis A. Sanchez, Joseph E. Ippolito, Jie Zheng, Robert J. Gropler, Richard Laforest, Yongjian Liu, Mohamed A. Zayed
Theranostics 2025; 15(12): 5518-5528. doi:10.7150/thno.108656
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Bispecific Siglec-15/T cell antibody (STAB) activates T cells and suppresses pancreatic ductal adenocarcinoma and non-small cell lung tumors in vivo Limei Shen, Alison Schaefer, Justin Huckaby, Whitney Wolf, Samuel K. Lai
Theranostics 2025; 15(12): 5529-5542. doi:10.7150/thno.103372
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Shh agonist enhances maturation in homotypic Lgr5-positive inner ear organoids Nathaniel T Carpena, So-Young Chang, Seyoung Mun, Kyung Wook Kim, Hyun C Yoon, Phil-Sang Chung, Ji-Hun Mo, Jin-Chul Ahn, Ji On Park, Kyudong Han, Ji Eun Choi, Jae Yun Jung, Min Young Lee
Theranostics 2025; 15(12): 5543-5565. doi:10.7150/thno.107345
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Apolipoprotein E promotes primary resistance to AR-targeted therapy via inducing TRIM25-mediated AR ubiquitination and sensitizes immunotherapy in prostate cancer Chaofan Liu, Xi Wang, Qinyu Li, Xintao Gao, Kai Zeng, Beining Li, Jianping Miao, Bolong Zheng, Jihong Liu, Zhihua Wang, Xianglin Yuan, Bo Liu
Theranostics 2025; 15(12): 5572-5591. doi:10.7150/thno.109994
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Integrated cascade antioxidant nanozymes-Cu5.4O@CNDs combat acute liver injury by regulating retinol metabolism Jiayu Chen, Yujie Zhang, Zhichao Deng, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Wenlong Wang, Jie Xiao, Zhengtao Xiao, Mingzhen Zhang, Kangsheng Tu
Theranostics 2025; 15(12): 5592-5615. doi:10.7150/thno.106811
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Optimizing theranostics chatbots with context-augmented large language models Pia Koller, Christoph Clement, Albert van Eijk, Robert Seifert, Jingjing Zhang, George Prenosil, Mike M. Sathekge, Ken Herrmann, Richard Baum, Wolfgang A. Weber, Axel Rominger, Kuangyu Shi
Theranostics 2025; 15(12): 5693-5704. doi:10.7150/thno.107757
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Development of a robust BH3 drug toolkit for precision medicine in hematologic malignancies Valentin Jacquier, Andréa Romero, Caroline Molinaro, Ritu Somayaji, Matthieu Abouladze, Ouissem Karmous Gadacha, Sara Ovejero, Hugues de Boussac, Ludovic Gabellier, Matthew S. Davids, Jérôme Moreaux, Charles Herbaux
Theranostics 2025; 15(12): 5705-5718. doi:10.7150/thno.107852
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A bifunctional fusion membrane-based biocompatible nanovaccine to potentiate cancer immunotherapy Wei Fu, Xing Cai, Jinru Yang, Lian Yang, Yaoyu Pan, Zhan Tuo
Theranostics 2025; 15(12): 5719-5737. doi:10.7150/thno.106376
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Investigating post-infection anxiety- and depression-like behaviors in a SARS-CoV-2 mouse model Qian Ge, Shan Zhou, Jose Porras, Panfeng Fu, Ting Wang, Jianyang Du, Kun Li
Theranostics 2025; 15(12): 5738-5755. doi:10.7150/thno.102752
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Polyphenol and metal ion-reinforced supermolecular hydrogels incorporating nanofiber drug and peptide for annulus fibrosus regeneration Long Xin, Xiaolin Li, Yang Yang, Pan Chen, Yi Li, Jianhua Liu, Kangbo Chen, Peipei Su, Shuaishuai Feng, Shiping He, Xinwei Xu, Wei Wang, Weixing Xu
Theranostics 2025; 15(12): 5756-5771. doi:10.7150/thno.106913
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AHCYL1 mediates the tumor-promoting effect of PREX2 in non-small cell lung carcinoma Mingjuan Lei, Yiu To Yeung, Wenna Nie, Ran Yang, Jian Li, Hanyong Chen, Ran Zhao, Kangdong Liu, Zigang Dong
Theranostics 2025; 15(12): 5772-5789. doi:10.7150/thno.108654
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Comparative study of [18F]AlF-NOTA-FAPI-RGD and [18F]FDG/[18F]AlF-NOTA-FAPI-04 PET/CT in renal cell carcinoma Haiyan Gao, Zhiwei Ma, Ziyang Zhu, Zhichuan Yang, Bo Chen, Xiaoming Wu, Vivianne Jakobsson, Yujiao Deng, Hao Wang, Wei Zhang, Jingjing Zhang
Theranostics 2025; 15(12): 5790-5800. doi:10.7150/thno.113070
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Promotion of Cx26 mutants located in TM4 region for membrane translocation successfully rescued hearing loss Yan-Jun Zong, Xiao-Zhou Liu, Xin-Yu Shi, Zheng-Dong Zhao, Yu Sun
Theranostics 2025; 15(12): 5801-5825. doi:10.7150/thno.112225
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GPX4 knockdown suppresses M2 macrophage polarization in gastric cancer by modulating kynurenine metabolism Jingli Xu, Chunyan Weng, Yanqiang Zhang, Qianyu Zhao, Jiahui Chen, Siwei Pan, Yan Wang, Ruolan Zhang, Yuqi Wang, Weiwei Zhu, Mengxuan Cao, Dan Zu, Shengjie Zhang, Zhiyuan Xu, Can Hu, Xiangdong Cheng
Theranostics 2025; 15(12): 5826-5845. doi:10.7150/thno.108817
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Sulfated chitosan directs the recovery of ischemic stroke by attenuating the inflammatory cascade Zehua Gao, Xuanlin Wang, Qiyong Mei, Tong Shen, Jing Wang, Changsheng Liu
Theranostics 2025; 15(12): 5870-5889. doi:10.7150/thno.111681
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Dual prophylactic and therapeutic potential of iPSC-based vaccines and neoantigen discovery in colorectal cancer Si-Han Jwo, Shang-Kok Ng, Chin-Tzu Li, Shao-Peng Chen, Li-Yu Chen, Pin-Jung Liu, Huai-Jie Wang, Jr-Shiuan Lin, Chun-Jung Ko, Cheng-Fan Lee, Chun-Hao Wang, Xiaoming Ouyang, Lin Wang, Tzu-Tang Wei
Theranostics 2025; 15(12): 5890-5908. doi:10.7150/thno.111400
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A small molecule esculetin accelerates postprandial lipid clearance involving activation of C/EBPβ and CD36-mediated phagocytosis by adipose tissue macrophages Gang Wang, Zhaokai Li, Wei Ni, Heng Ye, Yang Liu, Linjian Chen, Lin Wang, Changjiang Liu, Jingyu Chen, Xuchao Wang, Xue Ding, Longshan Zhao, Xiaofeng Ge, Yan Wang, Yuanchao Ye, Toshihiko Kiwa, Linghe Zang, Jin Wang, Cuilian Dai, Binbin Liu
Theranostics 2025; 15(12): 5910-5930. doi:10.7150/thno.110207
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Short-term starvation inhibits CD36 N-glycosylation and downregulates USP7 UFMylation to alleviate RBPJ-maintained T cell exhaustion in liver cancer Banglun Pan, Siyan Chen, Hao Wu, Xiaoxia Zhang, Zhu Zhang, Dongjie Ye, Yuxin Yao, Yue Luo, Xinyu Zhang, Xiaoqian Wang, Nanhong Tang
Theranostics 2025; 15(12): 5931-5952. doi:10.7150/thno.110567
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A self-assembled and H2O2-activatable hybrid nanoprodrug for lung infection and wound healing therapy Rui Zhang, Danhua Mao, Yiyong Fu, Rong Ju, Guoqing Wei
Theranostics 2025; 15(12): 5953-5968. doi:10.7150/thno.114344
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Lipopolysaccharide-induced DNA damage response activates DNA-PKcs to drive actin cytoskeleton disruption and cardiac microvascular dysfunction in endotoxemia Ying Tan, Yue Ouyang, Lushan Xiao, Jianming Huang, Fuye Li, Zisheng Ma, Chuhong Tan, Weibin Feng, Erica Davis, Yaoping Tang, Xing Chang, Haixia Li
Theranostics 2025; 15(12): 5969-5997. doi:10.7150/thno.111266
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Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathy Qingyong He, Xing Chang, Hui Zhang, Qianying Hao, Jianguo Zhi, Hongshuo Shi, Yingjie Tian, Hao Zhou, Ying Tan, Junmeng Zheng, Junxiong Qiu, Jun Tao
Theranostics 2025; 15(12): 5998-6021. doi:10.7150/thno.112247
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pH-responsive nano-vaccine combined with anti-PD-1 antibodies for enhanced immunotherapy of breast cancer Ning Wang, Hong Yu, Jianqiao Yin, Xiaopeng Yu
Theranostics 2025; 15(12): 6022-6043. doi:10.7150/thno.107200
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Reviews
Inorganic and hybrid nanomaterials for NIR-II fluorescence imaging-guided therapy of Glioblastoma and perspectives Zhigang Li, Lixin Du, Binghua Du, Zia Ullah, Yinghe Zhang, Yanyang Tu, Ying Zhou, Bing Guo
Theranostics 2025; 15(12): 5616-5665. doi:10.7150/thno.112204
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Fish-derived biomaterials for tissue engineering: advances in scaffold fabrication and applications in regenerative medicine and cancer therapy Seoyul Jo, Hanjun Hwangbo, Nacionales Francis, JaeYoon Lee, Mohan Pei, GeunHyung Kim
Theranostics 2025; 15(12): 5666-5692. doi:10.7150/thno.109186
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Targeting neutrophil extracellular traps in cancer progression and metastasis Ji Zhang, Changhong Miao, Hao Zhang
Theranostics 2025; 15(12): 5846-5869. doi:10.7150/thno.111096
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Errata
Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells: Erratum Lei Miao, Jingjing Qi, Qi Zhao, Qi-Nian Wu, Da-Liang Wei, Xiao-Li Wei, Jia Liu, Jun Chen, Zhao-Lei Zeng, Huai-Qiang Ju, Hui-yan Luo, Rui-Hua Xu
Theranostics 2025; 15(12): 5566-5567. doi:10.7150/thno.114260
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Pharmacological Ascorbate Suppresses Growth of Gastric Cancer Cells with GLUT1 Overexpression and Enhances the Efficacy of Oxaliplatin Through Redox Modulation: Erratum Yun-Xin Lu, Qi-Nian Wu, Dong-liang Chen, Le-Zong Chen, Zi-Xian Wang, Chao Ren, Hai-yu Mo, Ya Chen, Hui Sheng, Ying-Nan Wang, Yun Wang, Jia-Huan Lu, De-shen Wang, Zhao-lei Zeng, Feng Wang, Feng-Hua Wang, Yu-Hong Li, Huai-Qiang Ju, Rui-Hua Xu
Theranostics 2025; 15(12): 5568-5569. doi:10.7150/thno.114259
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Image-guided Pro-angiogenic Therapy in Diabetic Stroke Mouse Models Using a Multi-modal Nanoprobe: Erratum Ying-Ying Bai, Xihui Gao, Yuan-Cheng Wang, Xin-Gui Peng, Di Chang, Shuyan Zheng, Cong Li, Shenghong Ju
Theranostics 2025; 15(12): 5570-5571. doi:10.7150/thno.114285
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