◂ Last issue Archive
Volume 16 (13); 2026
Research Papers
Ultrasound targeted fatty acid nitroalkene-containing lipid nanoparticles attenuate inflammation and reverse myocardial fibrosis Muhammad W. Amjad, Soheb A. Mohammed, Marco Fazzari, Xucai Chen, Bruce A. Freeman, Terry O. Matsunaga, Yijen L. Wu, Sean Hartwick, Thomas Becker-Szurszewski, Devin R. E. Cortes, John J. Pacella
Theranostics 2026; 16(13): 7088-7107. doi:10.7150/thno.126503
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Porphyrin-lipid nanotheranostics for multimodal imaging of nodal disease in preclinical oral cancers Michael S. Valic, Esmat Najjar, Mark Zheng, Jason L. Townson, Harley H. L. Chan, Sharon Tzelnick, Alessandra Ruaro, Abdullah El-Sayes, Michael Halim, Pamela Schimmer, Chris J. Zhang, Tina Ye, Wenlei Jiang, Juan Chen, Jonathan C. Irish, Gang Zheng
Theranostics 2026; 16(13): 7108-7123. doi:10.7150/thno.129853
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DKK3–CKAP4 signaling drives fibroimmune remodeling and hair follicle miniaturization in androgenetic alopecia Seungchan An, Hyunju Kim, Mei Zheng, In Guk Park, Leegu Song, Jino Kim, Minsoo Noh, Jong-Hyuk Sung
Theranostics 2026; 16(13): 7124-7138. doi:10.7150/thno.135412
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A clinically translatable, irreversibly attenuated Salmonella strain as a next-generation adjuvant for checkpoint immunotherapy Dinh-Huy Nguyen, Sung-Hwan You, Khuynh Van Nguyen, Phuong Thi-Minh Nguyen, Hien Thi-Thu Ngo, Khang Vuong Tran, Thanh Quang Tran, Miryoung Song, Yeongjin Hong, Jung-Joon Min
Theranostics 2026; 16(13): 7139-7159. doi:10.7150/thno.129698
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Intermittent hypoxia ameliorates behavioral deficits and exerts neurorestoration in a mouse photothrombotic stroke model Tao Wu, Shu Feng, Mengjie Chen, Xin Wang, Emily Parker, Li Gong, Luodan Yang, Rui Duan
Theranostics 2026; 16(13): 7160-7177. doi:10.7150/thno.126126
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c-Met-targeted NIR-II imaging for precision management of oral squamous cell carcinoma and premalignant lesions Zhipeng Xia, Aiyan Ji, Qifan Ma, Yonghao Li, Hongyue Lou, Kun Qian, Jie Tian, Ying Yuan, Zhen Cheng, Xiaofeng Tao
Theranostics 2026; 16(13): 7178-7195. doi:10.7150/thno.132350
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NOD1 is a key mediator of atrial myopathy in heart failure Marta Gil-Fernández, Almudena Val-Blasco, Andrea Bueno-Sen, Paula Cantolla-Pablo, Carlos Galán-Arriola, Ali Ayaon, Teresa López-Fernández, Yuriana Aguilar-Sanchez, Satadru K Lahiri, José Alberto Navarro-García, Rafael Peinado, Angel Aroca, Miguel Ángel Rubio, José Antonio Blázquez, María Tamayo, Eduardo López-Collazo, Gema Ruiz-Hurtado, Inmaculada Jorge, Jesús Vázquez, Patricia Prieto, Tarik Smani, Antonio Ordoñez, David Filgueiras-Dama, Raúl Moreno, Borja Rivero-Santana, Jorge Nuche, José Jalife, Borja Ibáñez, Carmen Delgado, Lisardo Boscá, Xander H.T. Wehrens, María Fernández-Velasco
Theranostics 2026; 16(13): 7244-7258. doi:10.7150/thno.134756
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P-glycoprotein 1 as a shared target for resensitizing drug-resistant tumor cells and preventing fibronectin-driven metastasis Li-Tzu Huang, Li-Hsin Cheng, Chin-Ho Kuo, Chin-Yun Cheng, Shane-Rong Sheu, Cheng-Han Yang, Pei-Chu Shih, Yi-Syuan Li, Lin Tseng, Wei-Ting Hsueh, Lyh-Jyh Hao, Hung-Chi Cheng
Theranostics 2026; 16(13): 7288-7307. doi:10.7150/thno.131375
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Targeted RNA Therapy Reprograms Fibrotic Macrophages to Reverse Pulmonary Fibrosis Zhimin Song, Jingjing Chen, Jiaying Fan, Tinghong Zhang, Xing Peng, Yao Pan, Yun Zhang, Yaofeng Wang, Jinling Qin, Shu Meng
Theranostics 2026; 16(13): 7308-7323. doi:10.7150/thno.132296
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Ion-Responsive Microneedles Delivering Subtype-Specific Mitochondrial Extracellular Vesicles from HEY1⁺ Cardiomyocytes for Cardiac Repair in Bama Minipigs with Myocardial Ischemia–Reperfusion Injury Peng Qu, Jiao Shi, Xue Li, Yao Gu, Jun Liu, Hongyan Zhang, MingZhi Zhou, Cui Ma, Xinghui Li, Wenjie Tian, Qi Liang, Gang Li, Panke Cheng
Theranostics 2026; 16(13): 7367-7387. doi:10.7150/thno.123209
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Engineered CCR2 positive macrophages coordinate immunoregulation with neural regeneration and matrix remodeling after spinal cord injury Yuqi Zhao, Tao Xie, Yanming Ma, Yuhao Wang, Shenghang Liu, Hui Li, Youjun Liu, Renfeng Liu, Hailiang Xu, Cheng Ju, Weidong Wu, Yifan Wang, Siyuan He, Rongjin Luo, Dageng Huang, Shuaijun Jia, Chunping Hu, Liang Yan, Zhiyuan Wang, Lei Zhu
Theranostics 2026; 16(13): 7388-7418. doi:10.7150/thno.134560
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Honeysuckle-derived nanovesicles alleviate inflammatory bowel disease-associated neuropsychiatric disorders via the gut–brain axis Ailin Wu, Qin Chu, Le Ding, Yan Zeng, Liqiang Shao, Yuanyuan Wang, Yuanhao Zhou, Weijiao Fan, Xin Zhang, Jianwei Wang, Jie Wang, Shunyuan Guo, Ketao Jin, Xiaoru Chang, Xiaozhou Mou
Theranostics 2026; 16(13): 7419-7441. doi:10.7150/thno.132241
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Self-synergizing mutual prodrug liposomes for targeted cancer therapy via redox-amplified Pin1 inhibition Nuri Kim, Ilseob Kim, Hanui Jo, Nanhee Song, Sangmin Jo, Suyeon Lee, Hoechang Kim, Changjin Lim, Dongwon Lee
Theranostics 2026; 16(13): 7442-7465. doi:10.7150/thno.131597
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CDK9 degrader induces BRCAness and sensitizes castration-resistant prostate cancer to PARP inhibitor Jiaxuan Li, Jingya Sun, Weisong Tan, Guoqi Li, Wenjie Xiao, Jiajun Wu, Wei Yang, Changqing Chen, Yang Li, Jiakuan Liu, Yuanyu Liu, Dong Liu, Xiao-hua Chen, Rujian Zhu, Ruimin Huang, Jun Yan
Theranostics 2026; 16(13): 7495-7513. doi:10.7150/thno.131907
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Bone-Targeting Microspheres Enable Sustained Release of CD301b+ Macrophage-Derived Small Extracellular Vesicles to Promote Bone Repair Xiang Gao, Shanshan Ma, Yeying Dong, Fengkai Yang, Rui Huang, Xiudan Zheng, Zhijun Liu, Hong Zheng, Fatai Lu, Thomas Groth, Mingyan Zhao
Theranostics 2026; 16(13): 7514-7536. doi:10.7150/thno.132666
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Multimodal imaging-guided NIR-II photo-gas nanoplatform amplifies PD-1 blockade for synergistic TNBC therapy Linlin Song, Meixu Chen, Huiling Wang, Xin Wang, Tianyue Xu, Heqing Zhang, Shuwen Ran, Liwen Huang, Yingying Ma, Zhihui Liu, Zihan Xu, Yujie Zhao, Zichang Liu, Yong Luo, Xiujun Yu, Yulan Peng, Hubing Shi, Jing Jing, Xiujing He
Theranostics 2026; 16(13): 7571-7593. doi:10.7150/thno.133453
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Cardiomyocyte-derived USP20 mitigates myocardial ischemia/reperfusion injury through deubiquitinating GRP78 Zhenfeng Cheng, Lingfeng Zhong, Miaomiao Ying, Ziyi Huang, Zexin Yang, Wenli Zhang, Zhouqing Huang, Naijin Zhang, Xudong Chen, Xiaoxi Fan, Yucong Zhang, Ruihan Zheng, Keke Ye, Shuang Lin, Weijian Huang, Guangju Zhao, Shanshan Dai
Theranostics 2026; 16(13): 7594-7612. doi:10.7150/thno.132067
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Programmable pH-responsive DNA inter-strand matching (PRISM) for precision molecular band-pass actuation Xiaole Han, Hongyan Yu, Xiaomei Lin, Li Zhang, Weitao Wang, Yaoyi Zhang, Jianbo Jiang, Xingyu Liu, Ke Lv, Guoming Xie
Theranostics 2026; 16(13): 7613-7625. doi:10.7150/thno.136316
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Peripheral blood immune profiling reveals key signatures in newly diagnosed NK/T cell lymphoma patients Dahui Li, Hongyuan Zou, Mingyu Wang, Na Tian, Chuanxu Liu, Wenhao Zhang, Shiyu Jiang, Ruiliang Zhu, Xiangyu Yang, Fangxia Li, Ying Gao, Wendi Wei, Ran Jia, Zihan Jiang, Yuanhua Liu, Rong Tao, Xiaozhen Liang
Theranostics 2026; 16(13): 7626-7640. doi:10.7150/thno.132582
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A robust asymmetric bioadhesive patch for sutureless intestinal repair to prevent anastomotic leakage and postoperative adhesion Ruiqi Gao, Fangfang Su, Xiaohua Li, Zhongjie He, Yanglin Pan, Yaping Zheng, Mingzhong Wang, Lijun Yuan, Jiahe Liang, Xiaoqian Li
Theranostics 2026; 16(13): 7641-7659. doi:10.7150/thno.135611
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Ultra-high-field magnetic resonance imaging reveals sex-specific recovery after ischemic stroke following treatment with three-dimensional human mesenchymal stem cell–derived extracellular vesicles Jamini Bhagu, Arshia Arbabian, Thurston Da Vitoria Lobo, Katherine Martinez, Dayna L. Richter, Hannah Bryant, Malathy Elumalai, Yan Li, Samuel C. Grant
Theranostics 2026; 16(13): 7698-7714. doi:10.7150/thno.129188
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Reviews
GRP78 in human diseases: From molecular chaperone to therapeutic target Yang Li, Dan Mu, Jiajie Feng, Zhijia Li, Lan Zhang, Lei Wang
Theranostics 2026; 16(13): 7196-7243. doi:10.7150/thno.136060
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Molecular design of MRI probes for targeting amyloid-β species: from in vitro binding to in vivo imaging Yupeng Shi, Ruiyang Zhang, Miaoqing Li, Yaning Xia, Mengyang Zhou, Rui Cao, Qing Zhou, Yong Zhang
Theranostics 2026; 16(13): 7259-7287. doi:10.7150/thno.131311
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Biomechanical signaling of cytoskeleton and membrane reorganization in tumor immune chemotactic migration Qijie Zhao, Keliang Chen, Minglu Zhou, Jing Jin
Theranostics 2026; 16(13): 7324-7344. doi:10.7150/thno.134995
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Sonogenetics for precision medicine: from molecular toolkit to clinical translation Xinrui Yu, Min Pu, Ruoli Wang, Haitao Ran
Theranostics 2026; 16(13): 7345-7366. doi:10.7150/thno.134803
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Engineering spherical nucleic acids for precision cancer therapy: design strategies and medical applications Yilin Wang, Wenbing Wu, Fuli Yao
Theranostics 2026; 16(13): 7466-7494. doi:10.7150/thno.132738
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TAM-targeted nanomedicine in cancer: biological basis, therapeutic strategies, and translational perspectives Lili Zhou, Fang Yuan, Yangyang Wu, Xin Li, Debiao Xiang
Theranostics 2026; 16(13): 7537-7570. doi:10.7150/thno.132714
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Cellular senescence in musculoskeletal diseases: biological mechanisms and clinical implications Bingfei Li, Wanwan Qi, Bin Zhang, Shuo Ma, Wei Zhang, Caihua Zhang, Wei Xiang, Ran Chen, Chuanqing Bai, Jun Fei, Changyue Gao, Zhenhong Ni, Siru Zhou
Theranostics 2026; 16(13): 7660-7697. doi:10.7150/thno.130018
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Understanding immune checkpoint inhibitors-related myocarditis: Mechanisms and targeted therapeutic pathways Wenxiao Xia, Huan Zhang, Libo Liu, Chenchen Tu, Xiantao Song
Theranostics 2026; 16(13): 7715-7734. doi:10.7150/thno.127500
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Mechano-immune interactions in musculoskeletal aging: Mechanisms and translational perspectives Fulin Zhou, Xianglong Zhou, Jiheng Xiao, Jianhui Xiang, Yang Liu, Weicheng Chen, Hanhong Fang, Haoran Zhou, Xiao Lv, Liming Xiong
Theranostics 2026; 16(13): 7735-7764. doi:10.7150/thno.131071
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