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Volume 16 (12); 2026
Editorial
Beyond catalysis: Spatial topology of GPX4 in ferroptosis and its theranostic implications Fantian Zeng, Feida Li, Huifen Guo, Guoao Dong, Zijian Zhou, Xiaoyuan Chen
Theranostics 2026; 16(12): 7084-7087. doi:10.7150/thno.134666
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Research Papers
Scalable differentiation of human cardiac organoids from iPSCs generates cardiac tissues for cardiac cell therapy Sarkawt Hamad, Ebru Aksoy, Maria Kalil, Daina Martínez-Falguera, Christian Jüngst, Katharina Zahn, Felix Gaedke, Gabriel Peinkofer, Bastiaan J Boukens, Rezwan Firuzi, Rebecca Prause, Julia Aranyo, Felipe Bisbal, Oriol Iborra-Egea, Esther Jorge, Georgina Iraola-Picornell, Albert Teis, Martina de Raffele, Victoria Delgado, Frank Nitsche, Agapios Sachinidis, Markus Khalil, Fatma Alhashimi, Astrid Schauss, Antoni Bayes-Genis, Carolina Gálvez-Montón, Kurt P Pfannkuche
Theranostics 2026; 16(12): 6437-6462. doi:10.7150/thno.127654
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Development and in vivo evaluation of 18F-labeled PET tracers covalently targeting KRAS-G12C for noninvasive cancer diagnosis and therapy monitoring Michael Willmann, Jens P. Bankstahl, Frank M. Bengel, Christine Drechsler, Christina Esdar, Kathrin Gläser, Andrea U. Lopez, Tatjana Ross, Hanno Schieferstein, Tobias L. Ross
Theranostics 2026; 16(12): 6485-6496. doi:10.7150/thno.123741
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Localized and sustained release of Botulinum Toxin A from supramolecular peptide hydrogel for strabismus treatment Wei Guo, Hui Zhu, Yuchen Yao, Dan Huang, Tiantian Zhou, Xiaoqi Zhu, Jiaying Zhang, Gaolin Liang, Wenjun Zhan, Hu Liu
Theranostics 2026; 16(12): 6497-6508. doi:10.7150/thno.128115
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On-demand sIPN microneedles promote infected burn wound healing via microenvironment remodeling and activation of the Wnt–KLF5 regenerative axis Xiang Fang, Boquan Qin, Aaron Qi Zhang, Zhiyuan Zhang, Tingli Wang, Shizhou Wu, Hui Zhang, Hong Duan
Theranostics 2026; 16(12): 6509-6528. doi:10.7150/thno.130253
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A dual functional theranostic microneedle patch for immunomodulation and real time monitoring in diabetic wound therapy Shuai Fan, Junlong Zhong, Yeke Chen, Kang Chen, Zhiming Liu, Xinmin Yang, Wen Tan, Wenlong Tang, Wanhui Zhou, Degui Wu, Jiachao Xiong, Zhenhai Zhou, Fanrong Ai, Kai Cao
Theranostics 2026; 16(12): 6529-6553. doi:10.7150/thno.133451
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Mitochondria-targeting organoselenium theranostic radioprotectors for simultaneous treatment and imaging of radiation-induced liver injury Zifei Wu, Xie Huang, Mingquan Gao, Liting Wang, Zaizhi Du, Ziqian Shang, Xudong Yu, Xiaojiao Wang, Shuyue Deng, Xinrui Yang, Binghui Lu, Jing Liu, Weidong Wang, Rong Li, Shenglin Luo
Theranostics 2026; 16(12): 6554-6575. doi:10.7150/thno.133714
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Submicron-sized ultrasound contrast agents as therapeutic peptide delivery vehicles in type 1 diabetes Mark Ciccaglione, Eric Abenojar, Theresa Kosmides, James E. DiLisio, Kristen A. McDaniel, Kathryn Hartmoore, Anne Gresch, Dillon K. Jarrell, David G. Ramirez, Maura Sticco-Ivins, Aaron W. Michels, Kathryn Haskins, Agata A. Exner, Richard K.P. Benninger
Theranostics 2026; 16(12): 6692-6712. doi:10.7150/thno.126925
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Extracellular vesicles from glycolytic mesenchymal stromal cells restrain arthritis progression via IL-10–Producing T and B cells Eliana Lara-Barba, Raúl Lagos, Yesenia Flores-Elías, Yeimi Herrera-Luna, Noymar Luque-Campos, María Jesús Araya-Sapag, Constanza Aros-Valdivia, Felipe A. Bustamante-Barrientos, Liliana Yantén-Fuentes, Consuelo Covarruvias-Segovia, Consuelo Contreras, María Ignacia Cádiz, César Merino-Flores, Grégory Collin, Yessia Hidalgo-Fadic, Aliosha I Figueroa-Valdés, Hugo Tobar, Francisca Alcayaga-Miranda, María Paz Hernandez, Gino Nardocci, Estefanía Nova-Lamperti, Karine Toupet, Carolina Pradenas-Fuenzalida, Claudia Terraza, Francisca Uribe, Andrés Villarroel, Jasna V. Campos, Marcela Mondaca, Pablo Cruz, Andrea Matamoros, Alvaro A. Elorza, Claudio Carril, Carlos Farkas, Karina Oyarce, Andy J Pérez, Ana María Vega-Letter, Roberto Elizondo-Vega, Farida Djouad, Patricia Luz-Crawford
Theranostics 2026; 16(12): 6713-6731. doi:10.7150/thno.123898
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Exosomal immune decoy integrates cfDNA scavenging and mTOR inhibition for synergistic lupus nephritis therapy Mingxin Zhu, Qinyao Xu, Zhicheng Tang, Zexin Wang, Haofang Zhu, Lingyun Sun
Theranostics 2026; 16(12): 6763-6782. doi:10.7150/thno.130906
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Glutathione depletion under hypoxia via a birnessite-type manganese oxide nanozyme inducing immunogenic ferroptosis for magnetic resonance imaging guided cancer therapy Huilin Sun, Bo Li, Lin Qiu, Yufeng Zhao, Xin Wang, Chenxian Zhu, Haonan Zhang, Xiang Wang, Yang Bai, Jianhao Wang
Theranostics 2026; 16(12): 6783-6802. doi:10.7150/thno.129808
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Therapeutic pressure drives the evolution of a protective ecotype characterized by AR-loss-induced senescence in prostate cancer Limin He, Jun Jiang, Shaojie Liu, Hongtao Song, Tong Lu, Zhihao Hu, Yu Li, Hai Zhu, Yike Zhou, Zhengxuan Li, Fa Yang, Keying Zhang, Rui Zhang, Tao Wu, Kai Gan, Bin Zhao, Jingliang Zhang, Dailing Si, Rui Zhang, Changhong Shi, Weihong Wen, Donghui Han, Chao Xu, Weijun Qin
Theranostics 2026; 16(12): 6803-6826. doi:10.7150/thno.134940
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Reversing Bladder Cancer Chemo-resistance through Blocking Cell Senescence by a Combination Therapy Yirui He, Zaixiang Fang, Jiapeng Zhang, Qiang Wei, Yunkun Li, Zhenyu Duan, Gang Xu, Tianhai Lin, Qiao Xiong, Qiyong Gong, Pin Tan, Kui Luo
Theranostics 2026; 16(12): 6827-6842. doi:10.7150/thno.133484
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A PSMA-targeted dextran-based conjugate eradicates PSMA-overexpressing prostate tumors while abolishing cabazitaxel toxicity Li Yang, Tingchao Liu, Meng Huo, Weiping Jia, Yu Chen, Maoxu Ge, Yan Pan, Jianfei Shi, Xiaohai Li, Si Wang, Yikang Shi
Theranostics 2026; 16(12): 6843-6860. doi:10.7150/thno.124663
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Primary Cilium Forces Neuroendocrine Shift in Prostate Cancer through YAP1 Repression and Reduced Mitochondrial Activity Yingbo Guo, Siyong Peng, Thibaud Jamet, Virginie Firlej, Marie Irondelle, Constance Nau, Christophe A. Girard, Kaushal Asrani, Tamara L. Lotan, Romain Huc, Pascale Soyeux, Matthieu Rouleau, Sandra Lacas-Gervais, Amandine Rovini, Samantha Luciano, Olivier Humbert, Renaud Schiappa, Marc Pujalte-Martin, Mathieu Vigneau, Pascal Peraldi, Frédéric Bost, Gwendal Lazennec, Francis Vacherot, Nathalie M. Mazure
Theranostics 2026; 16(12): 6861-6891. doi:10.7150/thno.126688
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Epigenetic subtypes of high-grade T1 bladder cancer reveal intra-tumor heterogeneity and distinct interactions with tumor microenvironment Joaquim Bellmunt, Yingtian Xie, Nuria Juanpere, Miguel Gomez Munoz, Shweta Kukreja, Sonsoles Liria Veiga, Rong Li, Xintao Qiu, Yijia Jiang, Alba Font-Tello, Marie Nunez Duarte, Ilana Epstein, Silvia Hernández-Llodrà, Marta Lorenzo, Silvia Menendez, Toni Choueiri, Myles Brown, Henry W Long, Paloma Cejas
Theranostics 2026; 16(12): 6892-6910. doi:10.7150/thno.129729
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Conditional knockout of Dkk3 drives Lgr5+ progenitor reprogramming into hair cells in the mouse cochlea Hairong Xiao, Xinlin Wang, Zixuan Ye, Xin Tan, Ying Ma, Xiangyu Ma, Wei Tong, Luying Zhang, Yanqin Lin, Xujun Tang, Huiling Zhang, Jinxian Wan, Qiuyue Zhang, Renjie Chai, Shasha Zhang
Theranostics 2026; 16(12): 6911-6927. doi:10.7150/thno.131808
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Inhibition of SRC prevents bone metastasis of breast cancer by blocking metastatic cell motility and bone directionality Yong June Choi, Minju Kwon, Myung Jun Kim, Munkyung Choi, Phuong Thao Tran, Yujeong Lee, Wan Seob Shim, Minjae Kang, Seungseok Oh, Sung-Chul Lim, Yong-Chul Kim, Keon Wook Kang
Theranostics 2026; 16(12): 6928-6947. doi:10.7150/thno.130647
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First-in-human ex-vivo validation of carbonic anhydrase IX-PET for high-risk renal cancer (CAT-VHL - PNRR-POC-2023-12377493) Alessandro Larcher, Fabrizia Gelardi, Lidija Antunovic, Annarita Savi, Michela Olivieri, Paolo Rainone, Martina Sollini, Rosa Maria Moresco, Chiara Re, Francesco Cei, Federico Belladelli, Giacomo Musso, Lucia Salerno, Francesco De Cobelli, Nazario Tenace, Maurilio Ponzoni, Antonio Cigliola, Paolo Verze, Roberto Bertini, Alberto Briganti, Francesco Montorsi, Umberto Capitanio, Andrea Salonia, Arturo Chiti
Theranostics 2026; 16(12): 6980-6987. doi:10.7150/thno.122256
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BMAL1 regulates tubular epithelial-derived exosomal miR-27a-3p to inhibit macrophage–myofibroblast transition and alleviate ischemia/reperfusion-induced renal fibrosis Wu Chen, Sheng Zhao, Songyuan Yang, Weimin Yu, Ting Rao, Xiangjun Zhou, Yuan Ruan, Fan Zou, Fan Cheng, Wei Li
Theranostics 2026; 16(12): 6988-7006. doi:10.7150/thno.127538
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Converting focused ultrasound–based boiling histotripsy into a systemic cancer vaccine using antigen-capturing microparticles Akansha Singh, Sri Vidhya Chandrasekar, Faraz Chamani, Harshini Ashar, Steve Hartson, Steve Fiering, Ashish Ranjan
Theranostics 2026; 16(12): 7007-7028. doi:10.7150/thno.132091
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ecPICK: A deep learning-enabled spatial diagnostic platform for direct ecDNA identification and clinical prognosis across pan-cancer histopathology Xue-Ting Zhen, Zhen Yang, Lu-Ning Qin, Yun-Long Zhao, Lu Chen, Ming Gao, Tao Sun, Heng Zhang
Theranostics 2026; 16(12): 7067-7083. doi:10.7150/thno.134316
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Reviews
Human Multi-Organ-on-a-Chip Platforms for Next-Generation Drug Delivery Strategies Cosmo S. Mitchell, Hong-Il Yoo, Carolina Gracia Diaz, Jordan J. Green, Deok-Ho Kim
Theranostics 2026; 16(12): 6463-6484. doi:10.7150/thno.130030
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The CXCR4-targeted theranostics era: a comprehensive review of a decade of progress (2015–2025) Biao Yang, Wenzhu Hu, Xiao Zhang, Yongkang Gai, Rui An, Chunxia Qin, Mengting Li, Xiaoli Lan
Theranostics 2026; 16(12): 6576-6599. doi:10.7150/thno.130266
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Bacterial extracellular vesicles as multifaceted regulators of human diseases and emerging therapeutic platforms Jing Wang, Shuwen Wang, Yanzheng Wang, Ting Zhang, Xu Zhang
Theranostics 2026; 16(12): 6600-6633. doi:10.7150/thno.132287
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Functionalized metallic nanomaterials, nanozymes and nanomotors for emerging tumor diagnosis and treatment: from design to theranostics strategies Ze Wang, Dongzhou Wang, Bingya Zhang, Tong Sha, Di You, Mikhail I. Voevoda, Guokun Zhang, Bai Yang, Wenlai Guo, Quan Lin, Wenrui Qu
Theranostics 2026; 16(12): 6634-6670. doi:10.7150/thno.131873
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Efferocytosis in heart failure: Mechanisms, dysregulation and therapeutic potential Otega Oviri, Shijie Liu, Hongye Huang, Xiaoyuan Bai, Jingke Yao, Zufeng Ding
Theranostics 2026; 16(12): 6671-6690. doi:10.7150/thno.132477
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Converging chemistry and clinical orthopedics in the emerging role of MOFs in advanced bone defect repair Yangmengfan Chen, Xiaoyang Liu, Xuming Chen, Hao Du, Zongke Zhou
Theranostics 2026; 16(12): 6732-6762. doi:10.7150/thno.129987
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Integrating the hallmarks of cancer into autophagy: a perspective from underlying mechanisms to therapeutic strategies Huidi Liu, Wei Liu, Xiaochun Zhang, Yufeng Jiang, Heng Xu, Ningning Wang, Bo Liu, Na Lin
Theranostics 2026; 16(12): 6948-6979. doi:10.7150/thno.135134
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Stimuli-responsive nanomaterials for wound healing: advances and emerging directions Yijia Dong, Yaqing Zhang, Junrong Wu, Yujun Yang, Yanli Zhang, Zhenjun Zhu, Rabiya Noor, Jawad Hussain, Longquan Shao, Yi Xing
Theranostics 2026; 16(12): 7029-7066. doi:10.7150/thno.133095
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Erratum
SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells: Erratum Yang Xuan, Huogang Wang, Mingo MH Yung, Fushun Chen, Wai-Sun Chan, Yau-Sang Chan, Stephen KW Tsui, Hextan YS Ngan, Karen KL Chan, David W Chan
Theranostics 2026; 16(12): 6691. doi:10.7150/thno.134905
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