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Volume 16 (14); 2026

Research Papers

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YOD1 drives acute kidney injury by deubiquitinating Bax and promoting apoptosis in tubular epithelial cells Ying Zhao, Shijie Fan, Yu Fang, Qingqing Zhao, Qian Zhou, Zheng Xu, Hong Zhu, Guang Liang Theranostics 2026; 16(14): 7765-7779. doi:10.7150/thno.132208 Full text PDF

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The role of an ultrasound-responsive injectable piezoelectric hydrogel in promoting nerve regeneration and alleviating neuropathic pain Zhaoyang Guo, Weiqian Jiang, Wentao Zhang, Zhongju Liu, Hang Zhou, Hang Liu, Lin Wang, Jiahao Zhang, Xinliang Peng, Xingyu Yang, Maohui Li, Hanchao Liang, Zhongyuan He, Rui Deng, Yongjun Dang, Wei Fu, Keyu Wei, Chao Xie, Zhong-Liang Deng, Youliang Ren, Lei Chu Theranostics 2026; 16(14): 7780-7805. doi:10.7150/thno.131276 Full text PDF

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PSMA-targeting hybrid molecule PSMA-914 for preoperative imaging and intraoperative fluorescence-guidance: A first-in-human experience Ann-Christin Eder, Mohamed A. Omrane, Jessica Matthias, Sven Stadlbauer, Mareike Roscher, Kerstin Michalski, ƒ, Martin A. Schick, Christoph-Ferdinand Wielenberg, Peter Bronsert, Christian Gratzke, Martin Freitag, Klaus Kopka, Matthias Eder, Philipp T. Meyer, Cordula A. Jilg, ‡, Juri Ruf, †, ‡ Theranostics 2026; 16(14): 7926-7936. doi:10.7150/thno.129889 Full text PDF

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Quantitative MRI Pharmacokinetic Modeling and MALDI Mass Spectrometry Imaging Biodistribution of a pH Mapping MRI Contrast Agent Zinia Mohanta, Caitlin M. Tressler, Sadakatali Gori, Aruna Singh, Julia Stabinska, Shaowei Bo, Sana Karbalaei, Sophie Sall, Assaf Gilad, Hernando Lopez Bertoni, Eric Gale, Kristine Glunde, Michael T. McMahon Theranostics 2026; 16(14): 7937-7957. doi:10.7150/thno.128499 Full text PDF

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Targeting microglial MyD88 reprograms injury-activated microglia and promotes spinal cord repair via TGF-β signaling and biomimetic nanodelivery Jintao Liu, Beibei Yu, Wanjun Cao, Jilu Liu, Yundi Gao, Honghui Mao, Xiaochuan Gao, Lingli Guo, Shengyou Li, Qiao Huang, Mingze Qin, Fang Kuang, Jinghui Huang Theranostics 2026; 16(14): 8017-8035. doi:10.7150/thno.136733 Full text PDF

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Endothelial epigenetic senescence driven microglial activation mediates cardio-retinal neuroinflammation in heart failure Mengdan Wang, Shuo Zhang, Tursunjan Aziz, Shiyao Zhang, Xiao Wu, Gang Li, Yan Wang Theranostics 2026; 16(14): 8055-8076. doi:10.7150/thno.136220 Full text PDF

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An engineered ferritin nanocage co-delivery system for targeted hair cells protection and hearing loss attenuation Junying Zhang, Zhiwei Zheng, Jiaru Zhang, Xinyuan Ma, Zihao Li, Hongyan Lin, Guohui Nie, Minmin Liang, Hui Ding, Yingzi He Theranostics 2026; 16(14): 8104-8116. doi:10.7150/thno.131600 Full text PDF

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Trop2-targeted PET/CT imaging with 68Ga-MY6349 improves diagnostic accuracy and influences clinical management in breast cancer Lingyu Yu, Liang Zhao, Ru Zeng, Yonghui Su, Zhenyu Wu, Shan Yu, Yin Li, Hao Fu, Wei Guo, Yining Sun, Hannan Gao, Long Sun, Hua Wu, Feng Ye, Fan Wang, Haojun Chen Theranostics 2026; 16(14): 8117-8128. doi:10.7150/thno.136704 Full text PDF

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A miniaturized-tumor culture platform for developing anti-tumor immunotherapies Yangyang Feng, Ling Li, Josh Haipeng Lei, Yuzhong Peng, Lijian Wang, Heng Sun, Dongyang Tang, Xinyu Guo, Xiangpeng Chu, Yunfeng Qiao, Kai Miao, Wen-Li Zhu, Chon-Wa Lam, Kin-Iong Chan, Wai-Kuok Chu, Shi-Xian Yao, Wei-Jian Hou, Xiaoling Xu, Zheng Chen, Chu-Xia Deng Theranostics 2026; 16(14): 8129-8150. doi:10.7150/thno.132113 Full text PDF

Reviews

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Illumination of Targeting Nanotherapeutics with Precision Eyes: From Optical to Radio-nanotheranostics Maharajan Sivasubramanian, Yao-Chen Chuang, Chia-Hui Chu, Yu Hsia, Li-Jie Lin, Leu-Wei Lo Theranostics 2026; 16(14): 7806-7868. doi:10.7150/thno.130824 Full text PDF

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Recent advances in targeting cyanine dyes: hierarchical targeting mechanisms and theranostic integration for multi-disease precision therapy Shuai Zhang, Yang Xu, Yu Wang, Zelin Chen, Yang Wang, Quanying Liu, Tantan Wang, Yali Dai, Chunmeng Shi Theranostics 2026; 16(14): 7869-7896. doi:10.7150/thno.132719 Full text PDF

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Magnetic hyperthermia as an intracellular immunomodulatory technology: From heat transduction to tumor immune reprogramming Bin Yan, Lijun Dai, Hugang Li, Kexin Yuan, Huimin Yao, Lidan Chang, Haibin Peng, Xing-Jie Liang, Xiaoli Liu Theranostics 2026; 16(14): 7897-7925. doi:10.7150/thno.130650 Full text PDF

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Ligand-modified multifunctional liposome-based targeted delivery platform: a multimodal cancer combination therapy strategy Xuehong Zhang, Yingjie Jiang, Xing Duan, Fuchun Li, Xiaozhuo Chen, Aikepaer Aikedai, Wanting Pan, Liangjie Ren, Yufei Su, Chengqi Li, Zhaoshuo Gao, Shengcai Liao, Qiang Zhang, Zhenyu Zhu, Kaipei Luo, Yingji Wang Theranostics 2026; 16(14): 7958-7984. doi:10.7150/thno.136152 Full text PDF

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The challenges and strategies for navigating in vivo barriers to therapeutic bacterial delivery Haoda Yu, Jieyu Liu, Shuxin Zhang, Bing Wang, Kui Luo, Xian Jiang Theranostics 2026; 16(14): 7985-8016. doi:10.7150/thno.137940 Full text PDF

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Emerging trends in bone marrow organoid research: From hematopoietic microenvironment reconstruction to translational and regenerative theranostic applications Heebin Park, Jaemin Jeong Theranostics 2026; 16(14): 8036-8054. doi:10.7150/thno.137874 Full text PDF

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Decoding autophagy in neuro-tumor crosstalk: from underlying mechanisms to translational opportunities Huifang Cheng, Hongyao Li, Peiyan Liu, Xin Jin, Yi Qu, Bo Liu, Aizhuo Li Theranostics 2026; 16(14): 8077-8103. doi:10.7150/thno.134896 Full text PDF

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