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Volume 15 (13); 2025
Research Papers
Transcriptomic profiling of granuloma in patients with cardiac sarcoidosis Praveen Gajawada, Stefan Günther, Andreas Rolf, Jamal Nabhanizadeh, Rajkumar Savai, Yeong-Hoon Choi, Manfred Richter
Theranostics 2025; 15(13): 6044-6057. doi:10.7150/thno.109211
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IFN-I-mediated neutropoiesis bias drives neutrophil priming and inflammatory comorbidities Yuman Li, Yiming Chen, Chenyu Deng, Yuting Niu, Yue Yang, Shiyu Sun, Zhewen Hu, Yan Wei, Mingming Xu, Ying Huang, Thomas Van Dyke, Xuliang Deng
Theranostics 2025; 15(13): 6058-6081. doi:10.7150/thno.110859
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Toll-like receptor 2 deficiency exacerbates corneal angiogenesis in injury by impairing regulatory T cells Jung Hwa Ko, Hyun Ju Lee, Hyeon Ji Kim, Jin Suk Ryu, Yoo Rim Choi, Chang Ho Yoon, Hyun Beom Song, Donghyun Kim, Ryang Hwa Lee, Joo Youn Oh
Theranostics 2025; 15(13): 6082-6099. doi:10.7150/thno.110322
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First-in-human PET imaging and evaluation of melanin-targeted [18F]DMPY2 in malignant melanoma patients Yi Yang, Ming Zhou, Shuang Zhao, Tingting Long, Na Chen, Xingming Wang, Yulai Li, Xiaozhen Chen, Junchen Chen, Xinqiong Huang, Dengming Chen, Juan Su, Shuo Hu, Xiang Chen
Theranostics 2025; 15(13): 6100-6110. doi:10.7150/thno.109243
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Orthogonal upconversion supramolecular microneedles promote endogenous ferroptosis in keloids Wenchang Lv, Yue Zhang, Yiping Wu, Hongbo Chen
Theranostics 2025; 15(13): 6184-6202. doi:10.7150/thno.108289
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Programmatically activated DNA hydrogel microcapsules for precision therapy in inflammatory bowel disease Peifen Lu, Hongxiu Yuan, Gang Wang, Yixi Dong, Runyu Zhao, Jia Man, Jianwei Jiao, Zhaoyin Wang, Jin Jiao
Theranostics 2025; 15(13): 6203-6220. doi:10.7150/thno.111583
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Mannosylated neutrophil vesicles targeting macrophages alleviate liver inflammation by delivering CRISPR/Cas9 RNPs Dongqing Wu, Hang Shu, Mengmeng Zhang, Xiaoli Wei, Jingjing Ji, Haiyuan Shen, Hejiao Zhang, Linxi Xie, Liangliang Zhou, Lei Yang, Jiali Jiang, Chen Chen, Shanfei Tian, Xinru Zhang, Xu Long, Xiaoyan He, Hua Wang
Theranostics 2025; 15(13): 6221-6235. doi:10.7150/thno.107791
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BCAA catabolism targeted therapy for heart failure with preserved ejection fraction Meng Wang, Zhao Liu, Shuxun Ren, Jinyun Zhu, Norihiko Morisawa, Geok Lin Chua, Xuewen Zhang, Yun Ka Wong, Liping Su, Ming Xiang Wong, Jieping Yang, Marc Titze Jens, Zhaoping Li, Haipeng Sun, Yibin Wang, Christoph D. Raul, Sanjiv J. Shah, Chen Gao, Yunxia Liu
Theranostics 2025; 15(13): 6257-6273. doi:10.7150/thno.105894
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GPA33-pretargeted radioimmunotherapy with mono- and bivalent DOTA-based Lu-177-labeled radiohaptens in a mouse orthotopic liver xenograft model of metastatic human colorectal cancer Alexandre B. Le Roux, Edward K. Fung, Sang Gyu Lee, Sebastien Monette, Hong Xu, Hong-Fen Guo, Guangbin Yang, Ouathek Ouerfelli, Achim Jungbluth, Heiko Schöder, Steven M. Larson, Nai-Kong V. Cheung, Sarah M. Cheal, Darren R. Veach
Theranostics 2025; 15(13): 6274-6289. doi:10.7150/thno.107209
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KLK8/HGF/Met signaling pathway mediates diabetes-associated hippocampal neuroinflammation in male mice Dan-Hong Xu, Xiao-Yong Zhang, Shi-Yu Liu, Juan Wei, Jun-Hui Zhan, Jian-Kui Du, Yu-Jian Liu, Xiao-Yan Zhu
Theranostics 2025; 15(13): 6290-6312. doi:10.7150/thno.109513
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Regulation of heart regeneration by LSD1 through suppressing CEND1 Huahua Liu, Jinling Dong, Shuang Liu, Yuru Luo, Yuan Fang, Hongyu Su, Weihao Xue, Rui Zhou, Wenjun Huang, Baochang Lai, Ying Xiong, Shuangshuang Wang, Lingli Liang, Zhen Wang, Donghong Zhang, Lianpin Wu, Yanmin Zhang, Bin Zhou, John Y-J Shyy, Zuyi Yuan, Yidong Wang
Theranostics 2025; 15(13): 6313-6328. doi:10.7150/thno.110297
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Boosting mRNA cancer vaccine efficacy via targeting Irg1 on macrophages in lymph nodes Wenwen Wei, Xiao Yang, Yeshan Chen, Mengjie Che, Ying Ye, Yue Deng, Mengyao Su, Yajie Sun, Jingshu Meng, Yan Hu, Jiacheng Wang, Yijun Wang, Zishan Feng, Zhiyuan Zhou, Yan Li, Qian Li, Zhanjie Zhang, Bian Wu, Haibo Zhang, You Qin, Lu Wen, Chao Wan, Kunyu Yang
Theranostics 2025; 15(13): 6329-6346. doi:10.7150/thno.110305
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An AIM2 inflammasome biomimetic mineralization inhibitor for vascular dementia therapy Yueqi Zhang, Lixian Jiang, Rongrong Wu, Wei Gao, Xiaojie Zhang, Lan Liu, Yaxuan Zhang, Jin Lu, Yuanyi Zheng, Xiaojun Cai, Jianliang Fu
Theranostics 2025; 15(13): 6347-6368. doi:10.7150/thno.110389
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SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy Xinyu Wang, Gaowei Hu, Yupeng Shao, Zhongwei Dong, Lina Liu, Yixuan Wang, Yaxi Xie, Nuoya Yu, Caixia Zhu, Fang Wei, Yuping Jia, Yuyan Wang, Qiliang Cai
Theranostics 2025; 15(13): 6369-6386. doi:10.7150/thno.111256
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Large-scale super-resolution optoacoustic imaging facilitated by FeNP/ICG-loaded coreless polyelectrolyte microcapsules Daniil Nozdriukhin, Shuxin Lyu, Daniel Razansky, Xosé Luís Deán-Ben
Theranostics 2025; 15(13): 6412-6427. doi:10.7150/thno.112050
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Development of a Janus nanofibrous patch with antibacterial and anti-oxidative properties for urethral regeneration Wang Wang, Zesheng Chen, Ruoyu Li, Zhijun Zhou, Guanyi Wang, Xinjun Su, Weikang Hu, Zijian Wang, Xingyuan Xiao, Bing Li
Theranostics 2025; 15(13): 6428-6443. doi:10.7150/thno.112435
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Association of integrated biomarkers and progression-free survival prediction in patients with gastroenteropancreatic neuroendocrine tumors undergoing [177Lu]Lu-DOTA-TATE therapy Felix L. Herr, Christian Dascalescu, Ricarda Ebner, Moritz L. Schnitzer, Matthias P. Fabritius, Christine Schmid-Tannwald, Mathias J. Zacherl, Vera Wenter, Lena M. Unterrainer, Matthias Brendel, Adrien Holzgreve, Rudolf A. Werner, Christoph J. Auernhammer, Christine Spitzweg, Thomas Knösel, Tanja Burkard, Jens Ricke, Maurice M. Heimer, Gabriel T. Sheikh, Clemens C. Cyran
Theranostics 2025; 15(13): 6444-6453. doi:10.7150/thno.112588
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Mechanotransduction-enhanced bioconstructs fabricated using a bioink comprising collagen and omega-3 fatty acids for gingival tissue regeneration GaEun Heo, Hoon Noh, Dogeon Yoon, SooJung Chae, Hanjun Hwangbo, Ji Hye Park, Won Hee Lim, WonJin Kim, GeunHyung Kim
Theranostics 2025; 15(13): 6476-6496. doi:10.7150/thno.114503
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Limitations of the radiotheranostic concept in neuroendocrine tumors due to lineage-dependent somatostatin receptor expression on hematopoietic stem and progenitor cells Nghia Nguyen, Yu Min, Jennifer Rivière, Mark van der Garde, Sukhen Ghosh, Laura M. Bartos, Matthias Brendel, Florian Bassermann, Ali Azhdarinia, Wolfgang A. Weber, Katharina S. Götze, Susanne Kossatz
Theranostics 2025; 15(13): 6497-6515. doi:10.7150/thno.113354
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Loss of SLC25A20 in Pancreatic Adenocarcinoma Reversed the Tumor-Promoting Effects of a High-Fat Diet Sang Myung Woo, Ho Lee, Joon Hee Kang, Mingyu Kang, Wonyoung Choi, Sung Hoon Sim, Jung Won Chun, Nayoung Han, Kyung-Hee Kim, Woojin Ham, Woosol Hong, Chaeyoung Kim, Jeong Hwan Park, Dawool Han, Jong In Yook, Woo Jin Lee, Soo-Youl Kim
Theranostics 2025; 15(13): 6516-6533. doi:10.7150/thno.114912
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Precision treatment of ventilator-induced lung injury through alveolar epithelial cell targeted lipid nanoparticle delivery Ning Ding, Hui Xiao, Huiqing Li, Zengzhen Zhang, Junke Ge
Theranostics 2025; 15(13): 6534-6552. doi:10.7150/thno.111200
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Bioinspired exosome-SiO2 nanohybrid therapeutic for rheumatoid arthritis treatment Qicui Zhu, Ruofei Chen, Xueting Wu, Yuanyuan Zhou, Zexin Wang, Huaixuan Zhang, Haofang Zhu, Lingyun Sun, Zongwen Shuai
Theranostics 2025; 15(13): 6553-6571. doi:10.7150/thno.108296
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Activatable biomimetic probe with aggregation-induced emission characteristics for non-invasive monitoring of allograft rejection Mengdan Ding, Fang He, Shuangze Han, Wuqi Zhou, Tian Huang, Nan Cui, Yuanting Quan, Wenqu Li, Wenyuan Wang, Tang Gao, Mingxing Xie, Li Zhang
Theranostics 2025; 15(13): 6572-6592. doi:10.7150/thno.110866
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Reviews
Challenges and opportunities for the diverse substrates of SPOP E3 ubiquitin ligase in cancer Xiaojuan Yang, Jiang Zhu, Xue Tao, Fengwei Gao, Yunshi Cai, Yinghao Lv, Sinan Xie, Kunlin Xie, Tian Lan, Junhong Han, Hong Wu
Theranostics 2025; 15(13): 6111-6145. doi:10.7150/thno.113356
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Antioxidant nanozymes: current status and future perspectives in spinal cord injury treatments Yanming Ma, Jingxin Pan, Cheng Ju, Xiaojun Yu, Yingguang Wang, Ruoyu Li, Huimin Hu, Xiaodong Wang, Dingjun Hao
Theranostics 2025; 15(13): 6146-6183. doi:10.7150/thno.114836
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Piezo-catalytic immunotherapy: mechanisms and feasibility in cancer treatment Zhiguang Chen, Liang Sang, Donglin Bian, Yanjun Liu, Zhiqun Bai
Theranostics 2025; 15(13): 6236-6252. doi:10.7150/thno.114676
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Extrachromosomal circular DNA drives dynamic genome plasticity: emerging roles in disease progression and clinical potential Bin Shi, Ping Yang, Huaijin Qiao, Daojiang Yu, Shuyu Zhang
Theranostics 2025; 15(13): 6387-6411. doi:10.7150/thno.111765
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Breaking the premetastatic niche barrier: the role of endothelial cells and therapeutic strategies Yingshuai Fang, Wenming Cui, Yabing Yang, Xinhao Zhang, Mengyao Tian, Zhiyuan Xie, Ying Guo, Weitang Yuan, Zhen Li, Shuaixi Yang
Theranostics 2025; 15(13): 6454-6475. doi:10.7150/thno.113665
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Errata
miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury: Erratum Jing Shi, Yihua Bei, Xiangqing Kong, Xiaojun Liu, Zhiyong Lei, Tianzhao Xu, Hui Wang, Qinkao Xuan, Ping Chen, Jiahong Xu, Lin Che, Hui Liu, Jiuchang Zhong, Joost PG Sluijter, Xinli Li, Anthony Rosenzweig, Junjie Xiao
Theranostics 2025; 15(13): 6253-6254. doi:10.7150/thno.115473
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Oxygen carrier in core-shell fibers synthesized by coaxial electrospinning enhances Schwann cell survival and nerve regeneration: Erratum Teng Ma, Yafeng Yang, Xin Quan, Lei Lu, Bing Xia, Jianbo Gao, Fengyu Qi, Shengyou Li, Laihe Zhao, Liangwei Mei, Yi Zheng, Yanbing Shen, Zhuojing Luo, Yan Jin, Jinghui Huang
Theranostics 2025; 15(13): 6255-6256. doi:10.7150/thno.113747
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