Volume 15, Issue 14

open access Global reach, higher impact

◂ Last issue Next issue ▸ Archive Cover PDF

Volume 15 (14); 2025

Research Papers

Enhanced neoangiogenesis and balance of the immune response mediated by the Wilms' tumor suppressor WT1 favor repair after myocardial infarction
Nicole Wagner, Ana Vukolic, Delphine Baudouy, Sophie Pagnotta, Jean-Francois Michiels, Kay-Dietrich Wagner
Theranostics 2025; 15(14): 6593-6614. doi:10.7150/thno.104329
Full text PDF PubMed PMC

Direct delivery of MRI contrast through skull vessel/marrow pathways into the brain guided by microCT
Li Liu, Martin J. MacKinnon, Tatjana Atanasijevic, Stephen Dodd, Nadia Bouraoud, Danielle Donahue, Harikrishna Rallapalli, Alan P. Koretsky
Theranostics 2025; 15(14): 6615-6627. doi:10.7150/thno.117250
Full text PDF PubMed PMC

Gut microbiota depletion accelerates hematoma resolution and neurological recovery after intracerebral hemorrhage via p-coumaric acid-promoted Treg differentiation
Yonghe Zheng, Yin Li, Xuchao He, Yuhan Zhu, Shiyu Xu, Yirong Feng, Yirui Kuang, Huaijun Chen, Linfeng Fan, Huaping Huang, Libin Hu, Xian Yu, Jianan Wu, Lingji Jin, Junwen Hu, Xiongjie Fu, Hanhai Zeng, Shenglong Cao, Lin Wang
Theranostics 2025; 15(14): 6628-6650. doi:10.7150/thno.113764
Full text PDF PubMed PMC

A FRET-based off-on AIE nanoprobe enables instant and stain-free detection of hypoxic niches in tumor sections
Chen Wang, Jun Shen, Muredili Muhetaer, Shenwu Zhang, Jin Sun, Zhonggui He, Yuequan Wang, Cong Luo
Theranostics 2025; 15(14): 6651-6664. doi:10.7150/thno.113038
Full text PDF PubMed PMC

Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy
Yuqing Wang, Chuxing Chai, Wangxing Lin, Juanmei Cao, Zhuoxia Li, Yifan Jin, Yiting Xu, Jianyu Zhang, Yong Qu, Jinshan Zhan, Tianqi Zhao, Yufan Chen, Meng Gao, Changzheng Huang, Min Li
Theranostics 2025; 15(14): 6665-6685. doi:10.7150/thno.111635
Full text PDF PubMed PMC

Repurposing methimazole to promote coronary collateral circulation through MAPK1-mediated macrophage polarization via ferroptosis
Ling-ping Zhu, Wei He, Ke-chuan Lin, Dan Wang, Lin-lin Wang, Shuai Li, Mei-lian Yao, Jing Chen, Mei-fang Chen, Guo-gang Zhang, Chuan-chang Li, Ling-ping Zhu, Yong-ping Bai
Theranostics 2025; 15(14): 6686-6701. doi:10.7150/thno.111606
Full text PDF PubMed PMC

NGR-modified nanovesicles target ALKBH5 to inhibit ovarian cancer growth and metastasis
Cheng Du, DaLu Wang, Boquan Zhang, Yasong Zhao, Zheng He
Theranostics 2025; 15(14): 6702-6718. doi:10.7150/thno.107766
Full text PDF PubMed PMC

OTUD1 inhibits osteoclast differentiation and osteoclastic bone loss through deubiquitinating and stabilizing PRDX1
Xiaoyu Sun, Tong Wu, Shuhong Chen, Zheyu Zhao, Ruiwei Jia, Jun Ma, Lei Yin, Xingbei Pan, Yifan Ping, Yixin Mao, Lulu Ma, Yilin Ma, Wu Luo, Shengbin Huang, Guang Liang
Theranostics 2025; 15(14): 6719-6736. doi:10.7150/thno.111360
Full text PDF PubMed PMC

MTX2 facilitates PKM2 tetramerization to promote cardiac glucose metabolism and protects the heart against ischemia/reperfusion injury
Yueyang Li, Yu Li, Yang Li, Yufan Jiang, Miao Wang, Mingyi Wang, Jie Liu, Mingrui Ma, Xiaofeng Zhai, Li Yi, Tao Chen, Zhenyu Xiong, Yundai Chen
Theranostics 2025; 15(14): 6737-6752. doi:10.7150/thno.110162
Full text PDF PubMed PMC

RAB7 protects against ischemic heart failure via promoting non-canonical TUFM mitophagy pathway
Yuling Sun, Wei Wang, Mingyan Li, Wen Guan, Zhimin Gao, Luping Wang, Guanlan Lou, Ao Shen, Jiangbin Wu, Xiyong Yu, Panxia Wang, Xiaoqian Wu
Theranostics 2025; 15(14): 6753-6767. doi:10.7150/thno.104124
Full text PDF PubMed PMC

X-ray stimulates NQO1-dependent cascade reactions to induce strong immunogenicity for MRI-guided cancer radio-chemodynamic-immunotherapy
Li He, Jiao-Jiao Ma, Yi-Qun Wu, Chen-Guang Wang, Tong Lan, Lu Su, Lin Zhu, Shi-Wen Huang, Kai Deng, Yong-Chang Wei
Theranostics 2025; 15(14): 6768-6788. doi:10.7150/thno.110573
Full text PDF PubMed PMC

Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers
Cao Dai Phung, Trinh T.T. Tran, Brendon Zhi Jie Yeo, Rebecca Carissa Prajogo, Evelyn Saudjana, Eric Yew Meng Yeo, Chang Gao, Phuong H.D. Nguyen, Migara Kavishka Jayasinghe, Xuan T.T. Dang, Celest Phang Lixuan, Trinh Mai Nguyen, Boya Peng, Anh Hong Le, Tram T.T Nguyen, Gloria Mei En Chan, Yuin-Han Loh, Boon Cher Goh, Wai Leong Tam, Glenn Kunnath Bonney, Dahai Luo, Minh T.N. Le
Theranostics 2025; 15(14): 6818-6838. doi:10.7150/thno.105519
Full text PDF PubMed PMC

Divergent splicing factor SRSF1 signaling promotes inflammation post-CME: the SRSF1/ENPP3 axis acts via inhibition of BRD4 O-GlcNAcylation to enhance NF-κB activation and accelerate heart failure
Chen-Kai Hu, Lei He, Wan-Zhong Huang, Yuan Huang, Ri-Xin Dai, Chen Chang, Jun-Xiong Qiu, Qiang Wu, Qiang Su
Theranostics 2025; 15(14): 6839-6856. doi:10.7150/thno.115402
Full text PDF PubMed PMC

Bioinspired nano-micron hydrogel microspheres for periodontitis therapy through synergistic multi-targeted remodeling of microenvironment
Siqi Zhou, Yuxin Zhang, Liwen Zheng, Chang Liu, Jiajun Chen, Yaxian Liu, Shidian Ran, Tong-Chuan He, Mengqin Gu, Si Wu, Fugui Zhang, Hongmei Zhang
Theranostics 2025; 15(14): 6857-6881. doi:10.7150/thno.112782
Full text PDF PubMed PMC

Bioactive metal-protein matrix for promoting MRSA infection wound therapy through bioenergy-induced angiogenesis
Sihua Li, Junping Ma, Liuyang Zhang, Xiaoyan Qu, Long Zhang, Qian Huang, Bo Lei
Theranostics 2025; 15(14): 6882-6900. doi:10.7150/thno.112678
Full text PDF PubMed PMC

Blocking TRPM4 alleviates pancreatic acinar cell damage via an NMDA receptor-dependent pathway in acute pancreatitis
Yifan Ren, Qing Cui, Wuming Liu, Hangcheng Liu, Tao Wang, Hongwei Lu, Yi Lv, Rongqian Wu
Theranostics 2025; 15(14): 6901-6918. doi:10.7150/thno.116520
Full text PDF PubMed PMC

X-ray-responsive dissolving microneedles mediate STING pathway activation to potentiate cutaneous melanoma radio-immunotherapy
Wen Hu, Xiaohong Hong, Xinyu Zhang, Hongfan Chen, Xin Wen, Feng Lin, Jingwen Liu, Chenfenglin Yang, Binglin Cheng, Hanrui Zhu, Moting Zhang, Ruzhen Chen, Tingting Peng, Xinran Tang
Theranostics 2025; 15(14): 6919-6937. doi:10.7150/thno.110841
Full text PDF PubMed PMC

Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes
Manju Shrestha, Tiep Tien Nguyen, Rabyya Kausar, Dinesh Chaudhary, Ines Ferdiana Puspitasari, Hu-Lin Jiang, Hyung-Sik Kim, Simmyung Yook, Jee-Heon Jeong
Theranostics 2025; 15(14): 6938-6956. doi:10.7150/thno.107659
Full text PDF PubMed PMC

Tailorable bimetallic nanozyme mitigates intervertebral disc degeneration by inhibiting oxidative stress and inflammageing
Anran Zhang, Haiyang Gao, Xianglong Chen, Pengzhi Shi, Zhangrong Cheng, Yuhang Chen, Wang Wu, Wenbo Wu, Cao Yang, Yukun Zhang
Theranostics 2025; 15(14): 6957-6982. doi:10.7150/thno.108592
Full text PDF PubMed PMC

Single-cell transcriptomics of vascularized human brain organoids decipher lineage-specific stress adaptation in fetal hypoxia-reoxygenation injury
Simeng Yi, Min Huang, Chunmei Xian, Xi Kong, Shigang Yin, Jianhua Peng, Yong Zhang, Xiuju Du, Yong Jiang, Bingqing Xie, Huangfan Xie
Theranostics 2025; 15(14): 7001-7024. doi:10.7150/thno.117001
Full text PDF PubMed PMC

A subset of evolutionarily conserved centriolar satellite core components is crucial for sperm flagellum biogenesis
Bingbing Wu, Chenghong Long, Jiayi Liu, Xiaoming Huang, Shuang Ma, Yanjie Ma, Liying Wang, Yiran Jiang, Bo Yang, Chunxiu Gong, Li Yuan, Yong Zhang, Zhen Li, Wei Li
Theranostics 2025; 15(14): 7025-7044. doi:10.7150/thno.117118
Full text PDF PubMed PMC

Endothelium-specific sensing of mechanical signals drives epidermal aging through coordinating retinoid metabolism
Xia Wu, Jiangming Zhong, Jingwei Jiang, Yi Zou, Dehuan Wang, Ziyan Chen, Mengyue Wang, Xinyu Shen, Zeming Li, Yang Xiao, Yuyan Yi, Fangqi Tang, Xiaoyu Long, Weiming Qiu, Qu Tang, Xiao Xiang, Xun Zhou, Mingxing Lei, Peng Shu, Qiang Zhou
Theranostics 2025; 15(14): 7045-7063. doi:10.7150/thno.112299
Full text PDF PubMed PMC

MiR-125a-5p in extracellular vesicles of neural stem cells acts as a crosstalk signal modulating neuroinflammatory microenvironment to alleviate cerebral ischemia-reperfusion injury
Qingyue Liu, Heran Ma, Jing Liao, Zihan Zhu, Hongyuan Chen, Dong Sun, Longkun Wang, Lu Lu, Xiaowei Chen, Xinke Zhang, Fengshan Wang
Theranostics 2025; 15(14): 7064-7089. doi:10.7150/thno.115993
Full text PDF PubMed PMC

FAK signaling suppression by OCT4-ITGA6 mediates the effectively removal of residual pluripotent stem cells and enhances application safety
Wenpeng Song, Jian Wang, Shixin Gong, Xiaoyan Wang, Junji Xu, Ruiqing Wu, Zongmin Jiang, Huiyuan Zhang, Lida Wu, Yilong Wang, Yingying Su, Hao Wang, Yuchun Gu
Theranostics 2025; 15(14): 7127-7153. doi:10.7150/thno.111198
Full text PDF PubMed PMC

Artesunate-mycophenolate Mofetil Dimer Micelles Alleviate Allogeneic Skin Graft Rejection by Inhibiting the TLR-4 Pathway in Macrophages
Wentao Zhao, Zhentao Yang, Hong Tang, Jintao Zheng, Zhi Liang, Ruiqi Sun, Ning Wang, Rong Su, Hangxiang Wang, Yiting Qiao, Shusen Zheng, Penghong Song, Haiyang Xie
Theranostics 2025; 15(14): 7154-7175. doi:10.7150/thno.108173
Full text PDF PubMed PMC

Transdermal microneedle integrating a biomimetic self-enhancing Fenton reaction nano-reactor for alleviating rheumatoid arthritis by inflammatory microenvironment remodeling
Ying Gao, Xuejun Chen, Lin Liu, Jingya Xiu, Yufei Wen, Chunrong Yang, Degong Yang, Fen Yao
Theranostics 2025; 15(14): 7180-7196. doi:10.7150/thno.114855
Full text PDF PubMed PMC

Autophagy inhibitor-sensitized artificially activated neutrophils against hepatocellular carcinoma
Caixia Yang, Huang Yang, Zhengwei Mao, Weilin Wang, Yuan Ding
Theranostics 2025; 15(14): 7197-7218. doi:10.7150/thno.106404
Full text PDF PubMed PMC

Reviews

Optical theranostics in ischemic heart disease: from molecular insights to clinical translation
Yangjie Xiao, Jing Zhang, Lu Sun, Ke Wang, Yan Chen, Qiaojin Zheng, Ying Li
Theranostics 2025; 15(14): 6789-6817. doi:10.7150/thno.114307
Full text PDF PubMed PMC

Immuno-oncological interactions between meningeal lymphatics and glioblastoma: from mechanisms to therapies
Nan Wen, Xiao Xiao, Huangjie Lu, Qingyuan Chen, Genghong He, Zhiyuan Qian, Jianfeng Zeng, Li Xiao
Theranostics 2025; 15(14): 6983-7000. doi:10.7150/thno.111972
Full text PDF PubMed PMC

Overcoming barriers in glioblastoma: The potential of CAR T cell immunotherapy
Muhammad Ijaz, Qingqin Tan, Yuqian Yan, Daoming Zhang, Qi Chen, Yinghe Zhang, Yanyang Tu, Bing Guo
Theranostics 2025; 15(14): 7090-7126. doi:10.7150/thno.114257
Full text PDF PubMed PMC

Errata

Melatonin enhances sorafenib-induced cytotoxicity in FLT3-ITD acute myeloid leukemia cells by redox modification: Erratum
Tian Tian, Jiajun Li, Yizhuo Li, Yun-Xin Lu, Yan-Lai Tang, Hua Wang, Fufu Zheng, Dingbo Shi, Qian Long, Miao Chen, Guillermo Garcia-Manero, Yumin Hu, Lijun Qin, Wuguo Deng
Theranostics 2025; 15(14): 7176-7177. doi:10.7150/thno.118171
Full text PDF PubMed PMC

STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma: Erratum
Huakan Zhao, Guifang Yan, Lu Zheng, Yu Zhou, Halei Sheng, Lei Wu, Qi Zhang, Juan Lei, Jiangang Zhang, Rong Xin, Lu Jiang, Xiao Zhang, Yu Chen, Jingchun Wang, Yanquan Xu, Dingshan Li, Yongsheng Li
Theranostics 2025; 15(14): 7178-7179. doi:10.7150/thno.119395
Full text PDF PubMed PMC