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Volume 15 (14); 2025
Research Papers
Enhanced neoangiogenesis and balance of the immune response mediated by the Wilms' tumor suppressor WT1 favor repair after myocardial infarction Nicole Wagner, Ana Vukolic, Delphine Baudouy, Sophie Pagnotta, Jean-Francois Michiels, Kay-Dietrich Wagner
Theranostics 2025; 15(14): 6593-6614. doi:10.7150/thno.104329
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Direct delivery of MRI contrast through skull vessel/marrow pathways into the brain guided by microCT Li Liu, Martin J. MacKinnon, Tatjana Atanasijevic, Stephen Dodd, Nadia Bouraoud, Danielle Donahue, Harikrishna Rallapalli, Alan P. Koretsky
Theranostics 2025; 15(14): 6615-6627. doi:10.7150/thno.117250
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Gut microbiota depletion accelerates hematoma resolution and neurological recovery after intracerebral hemorrhage via p-coumaric acid-promoted Treg differentiation Yonghe Zheng, Yin Li, Xuchao He, Yuhan Zhu, Shiyu Xu, Yirong Feng, Yirui Kuang, Huaijun Chen, Linfeng Fan, Huaping Huang, Libin Hu, Xian Yu, Jianan Wu, Lingji Jin, Junwen Hu, Xiongjie Fu, Hanhai Zeng, Shenglong Cao, Lin Wang
Theranostics 2025; 15(14): 6628-6650. doi:10.7150/thno.113764
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A FRET-based off-on AIE nanoprobe enables instant and stain-free detection of hypoxic niches in tumor sections Chen Wang, Jun Shen, Muredili Muhetaer, Shenwu Zhang, Jin Sun, Zhonggui He, Yuequan Wang, Cong Luo
Theranostics 2025; 15(14): 6651-6664. doi:10.7150/thno.113038
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Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy Yuqing Wang, Chuxing Chai, Wangxing Lin, Juanmei Cao, Zhuoxia Li, Yifan Jin, Yiting Xu, Jianyu Zhang, Yong Qu, Jinshan Zhan, Tianqi Zhao, Yufan Chen, Meng Gao, Changzheng Huang, Min Li
Theranostics 2025; 15(14): 6665-6685. doi:10.7150/thno.111635
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Repurposing methimazole to promote coronary collateral circulation through MAPK1-mediated macrophage polarization via ferroptosis Ling-ping Zhu, Wei He, Ke-chuan Lin, Dan Wang, Lin-lin Wang, Shuai Li, Mei-lian Yao, Jing Chen, Mei-fang Chen, Guo-gang Zhang, Chuan-chang Li, Ling-ping Zhu, Yong-ping Bai
Theranostics 2025; 15(14): 6686-6701. doi:10.7150/thno.111606
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NGR-modified nanovesicles target ALKBH5 to inhibit ovarian cancer growth and metastasis Cheng Du, DaLu Wang, Boquan Zhang, Yasong Zhao, Zheng He
Theranostics 2025; 15(14): 6702-6718. doi:10.7150/thno.107766
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OTUD1 inhibits osteoclast differentiation and osteoclastic bone loss through deubiquitinating and stabilizing PRDX1 Xiaoyu Sun, Tong Wu, Shuhong Chen, Zheyu Zhao, Ruiwei Jia, Jun Ma, Lei Yin, Xingbei Pan, Yifan Ping, Yixin Mao, Lulu Ma, Yilin Ma, Wu Luo, Shengbin Huang, Guang Liang
Theranostics 2025; 15(14): 6719-6736. doi:10.7150/thno.111360
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MTX2 facilitates PKM2 tetramerization to promote cardiac glucose metabolism and protects the heart against ischemia/reperfusion injury Yueyang Li, Yu Li, Yang Li, Yufan Jiang, Miao Wang, Mingyi Wang, Jie Liu, Mingrui Ma, Xiaofeng Zhai, Li Yi, Tao Chen, Zhenyu Xiong, Yundai Chen
Theranostics 2025; 15(14): 6737-6752. doi:10.7150/thno.110162
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RAB7 protects against ischemic heart failure via promoting non-canonical TUFM mitophagy pathway Yuling Sun, Wei Wang, Mingyan Li, Wen Guan, Zhimin Gao, Luping Wang, Guanlan Lou, Ao Shen, Jiangbin Wu, Xiyong Yu, Panxia Wang, Xiaoqian Wu
Theranostics 2025; 15(14): 6753-6767. doi:10.7150/thno.104124
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X-ray stimulates NQO1-dependent cascade reactions to induce strong immunogenicity for MRI-guided cancer radio-chemodynamic-immunotherapy Li He, Jiao-Jiao Ma, Yi-Qun Wu, Chen-Guang Wang, Tong Lan, Lu Su, Lin Zhu, Shi-Wen Huang, Kai Deng, Yong-Chang Wei
Theranostics 2025; 15(14): 6768-6788. doi:10.7150/thno.110573
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Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers Cao Dai Phung, Trinh T.T. Tran, Brendon Zhi Jie Yeo, Rebecca Carissa Prajogo, Evelyn Saudjana, Eric Yew Meng Yeo, Chang Gao, Phuong H.D. Nguyen, Migara Kavishka Jayasinghe, Xuan T.T. Dang, Celest Phang Lixuan, Trinh Mai Nguyen, Boya Peng, Anh Hong Le, Tram T.T Nguyen, Gloria Mei En Chan, Yuin-Han Loh, Boon Cher Goh, Wai Leong Tam, Glenn Kunnath Bonney, Dahai Luo, Minh T.N. Le
Theranostics 2025; 15(14): 6818-6838. doi:10.7150/thno.105519
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Divergent splicing factor SRSF1 signaling promotes inflammation post-CME: the SRSF1/ENPP3 axis acts via inhibition of BRD4 O-GlcNAcylation to enhance NF-κB activation and accelerate heart failure Chen-Kai Hu, Lei He, Wan-Zhong Huang, Yuan Huang, Ri-Xin Dai, Chen Chang, Jun-Xiong Qiu, Qiang Wu, Qiang Su
Theranostics 2025; 15(14): 6839-6856. doi:10.7150/thno.115402
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Bioinspired nano-micron hydrogel microspheres for periodontitis therapy through synergistic multi-targeted remodeling of microenvironment Siqi Zhou, Yuxin Zhang, Liwen Zheng, Chang Liu, Jiajun Chen, Yaxian Liu, Shidian Ran, Tong-Chuan He, Mengqin Gu, Si Wu, Fugui Zhang, Hongmei Zhang
Theranostics 2025; 15(14): 6857-6881. doi:10.7150/thno.112782
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Bioactive metal-protein matrix for promoting MRSA infection wound therapy through bioenergy-induced angiogenesis Sihua Li, Junping Ma, Liuyang Zhang, Xiaoyan Qu, Long Zhang, Qian Huang, Bo Lei
Theranostics 2025; 15(14): 6882-6900. doi:10.7150/thno.112678
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Blocking TRPM4 alleviates pancreatic acinar cell damage via an NMDA receptor-dependent pathway in acute pancreatitis Yifan Ren, Qing Cui, Wuming Liu, Hangcheng Liu, Tao Wang, Hongwei Lu, Yi Lv, Rongqian Wu
Theranostics 2025; 15(14): 6901-6918. doi:10.7150/thno.116520
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X-ray-responsive dissolving microneedles mediate STING pathway activation to potentiate cutaneous melanoma radio-immunotherapy Wen Hu, Xiaohong Hong, Xinyu Zhang, Hongfan Chen, Xin Wen, Feng Lin, Jingwen Liu, Chenfenglin Yang, Binglin Cheng, Hanrui Zhu, Moting Zhang, Ruzhen Chen, Tingting Peng, Xinran Tang
Theranostics 2025; 15(14): 6919-6937. doi:10.7150/thno.110841
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Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes Manju Shrestha, Tiep Tien Nguyen, Rabyya Kausar, Dinesh Chaudhary, Ines Ferdiana Puspitasari, Hu-Lin Jiang, Hyung-Sik Kim, Simmyung Yook, Jee-Heon Jeong
Theranostics 2025; 15(14): 6938-6956. doi:10.7150/thno.107659
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Tailorable bimetallic nanozyme mitigates intervertebral disc degeneration by inhibiting oxidative stress and inflammageing Anran Zhang, Haiyang Gao, Xianglong Chen, Pengzhi Shi, Zhangrong Cheng, Yuhang Chen, Wang Wu, Wenbo Wu, Cao Yang, Yukun Zhang
Theranostics 2025; 15(14): 6957-6982. doi:10.7150/thno.108592
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Single-cell transcriptomics of vascularized human brain organoids decipher lineage-specific stress adaptation in fetal hypoxia-reoxygenation injury Simeng Yi, Min Huang, Chunmei Xian, Xi Kong, Shigang Yin, Jianhua Peng, Yong Zhang, Xiuju Du, Yong Jiang, Bingqing Xie, Huangfan Xie
Theranostics 2025; 15(14): 7001-7024. doi:10.7150/thno.117001
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A subset of evolutionarily conserved centriolar satellite core components is crucial for sperm flagellum biogenesis Bingbing Wu, Chenghong Long, Jiayi Liu, Xiaoming Huang, Shuang Ma, Yanjie Ma, Liying Wang, Yiran Jiang, Bo Yang, Chunxiu Gong, Li Yuan, Yong Zhang, Zhen Li, Wei Li
Theranostics 2025; 15(14): 7025-7044. doi:10.7150/thno.117118
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Endothelium-specific sensing of mechanical signals drives epidermal aging through coordinating retinoid metabolism Xia Wu, Jiangming Zhong, Jingwei Jiang, Yi Zou, Dehuan Wang, Ziyan Chen, Mengyue Wang, Xinyu Shen, Zeming Li, Yang Xiao, Yuyan Yi, Fangqi Tang, Xiaoyu Long, Weiming Qiu, Qu Tang, Xiao Xiang, Xun Zhou, Mingxing Lei, Peng Shu, Qiang Zhou
Theranostics 2025; 15(14): 7045-7063. doi:10.7150/thno.112299
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MiR-125a-5p in extracellular vesicles of neural stem cells acts as a crosstalk signal modulating neuroinflammatory microenvironment to alleviate cerebral ischemia-reperfusion injury Qingyue Liu, Heran Ma, Jing Liao, Zihan Zhu, Hongyuan Chen, Dong Sun, Longkun Wang, Lu Lu, Xiaowei Chen, Xinke Zhang, Fengshan Wang
Theranostics 2025; 15(14): 7064-7089. doi:10.7150/thno.115993
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FAK signaling suppression by OCT4-ITGA6 mediates the effectively removal of residual pluripotent stem cells and enhances application safety Wenpeng Song, Jian Wang, Shixin Gong, Xiaoyan Wang, Junji Xu, Ruiqing Wu, Zongmin Jiang, Huiyuan Zhang, Lida Wu, Yilong Wang, Yingying Su, Hao Wang, Yuchun Gu
Theranostics 2025; 15(14): 7127-7153. doi:10.7150/thno.111198
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Artesunate-mycophenolate Mofetil Dimer Micelles Alleviate Allogeneic Skin Graft Rejection by Inhibiting the TLR-4 Pathway in Macrophages Wentao Zhao, Zhentao Yang, Hong Tang, Jintao Zheng, Zhi Liang, Ruiqi Sun, Ning Wang, Rong Su, Hangxiang Wang, Yiting Qiao, Shusen Zheng, Penghong Song, Haiyang Xie
Theranostics 2025; 15(14): 7154-7175. doi:10.7150/thno.108173
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Transdermal microneedle integrating a biomimetic self-enhancing Fenton reaction nano-reactor for alleviating rheumatoid arthritis by inflammatory microenvironment remodeling Ying Gao, Xuejun Chen, Lin Liu, Jingya Xiu, Yufei Wen, Chunrong Yang, Degong Yang, Fen Yao
Theranostics 2025; 15(14): 7180-7196. doi:10.7150/thno.114855
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Autophagy inhibitor-sensitized artificially activated neutrophils against hepatocellular carcinoma Caixia Yang, Huang Yang, Zhengwei Mao, Weilin Wang, Yuan Ding
Theranostics 2025; 15(14): 7197-7218. doi:10.7150/thno.106404
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Reviews
Optical theranostics in ischemic heart disease: from molecular insights to clinical translation Yangjie Xiao, Jing Zhang, Lu Sun, Ke Wang, Yan Chen, Qiaojin Zheng, Ying Li
Theranostics 2025; 15(14): 6789-6817. doi:10.7150/thno.114307
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Immuno-oncological interactions between meningeal lymphatics and glioblastoma: from mechanisms to therapies Nan Wen, Xiao Xiao, Huangjie Lu, Qingyuan Chen, Genghong He, Zhiyuan Qian, Jianfeng Zeng, Li Xiao
Theranostics 2025; 15(14): 6983-7000. doi:10.7150/thno.111972
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Overcoming barriers in glioblastoma: The potential of CAR T cell immunotherapy Muhammad Ijaz, Qingqin Tan, Yuqian Yan, Daoming Zhang, Qi Chen, Yinghe Zhang, Yanyang Tu, Bing Guo
Theranostics 2025; 15(14): 7090-7126. doi:10.7150/thno.114257
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Errata
Melatonin enhances sorafenib-induced cytotoxicity in FLT3-ITD acute myeloid leukemia cells by redox modification: Erratum Tian Tian, Jiajun Li, Yizhuo Li, Yun-Xin Lu, Yan-Lai Tang, Hua Wang, Fufu Zheng, Dingbo Shi, Qian Long, Miao Chen, Guillermo Garcia-Manero, Yumin Hu, Lijun Qin, Wuguo Deng
Theranostics 2025; 15(14): 7176-7177. doi:10.7150/thno.118171
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STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma: Erratum Huakan Zhao, Guifang Yan, Lu Zheng, Yu Zhou, Halei Sheng, Lei Wu, Qi Zhang, Juan Lei, Jiangang Zhang, Rong Xin, Lu Jiang, Xiao Zhang, Yu Chen, Jingchun Wang, Yanquan Xu, Dingshan Li, Yongsheng Li
Theranostics 2025; 15(14): 7178-7179. doi:10.7150/thno.119395
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