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Volume 15 (15); 2025

Research Papers

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Phosphoserine aminotransferase 1 promotes serine synthesis pathway and cardiac repair after myocardial infarction
Ajit Magadum, Vandana Mallaredy, Rajika Roy, Darukeshwara Joladarashi, Charan Thej, Zhongjian Cheng, Maria Cimini, May Truongcao, Adam Chatoff, Claudia V Crispim, Vagner O C Rigaud, Carolina Gonzalez, Cindy Benedict, Celio X.C. Santos, Nathaniel W. Snyder, Mohsin Khan, Ajay M. Shah, Walter J. Koch, Raj Kishore
Theranostics 2025; 15(15): 7219-7241. doi:10.7150/thno.112077
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Single-cell RNA sequencing uncovers intestinal immune alterations and cellular diversity from chronic fluoride exposure in mice
Jinge Xin, Yu Chen, Yongmei Huang, Ning Sun, Weiqi Peng, Chunxiao Lai, Ruanruan Yang, Wenqing Chen, Lixiao Duan, Dandan Wang, Yuhao He, Yang Bai, Xueqin Ni, Hesong Wang
Theranostics 2025; 15(15): 7242-7269. doi:10.7150/thno.116567
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Liver-targeted degradation of BRD4 reverses hepatic fibrosis and enhances metabolism in murine models
Shengjie Yuan, Ayesha Nisar, Chuanjie Chen, Xin Dong, Yongzhang Pan, Meiting Zi, Qiong Wang, Sawar Khan, Yaxun Guo, Xuan Zhang, Yonghan He
Theranostics 2025; 15(15): 7270-7290. doi:10.7150/thno.113852
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Tea plant-inspired nanoassembled supraparticles alleviate colitis and associated mental disorders via microbiota-gut-brain interactions
Qinling Liu, Yunxiang He, Qingxin Fan, Yue Wu, Jiawen Li, Siqi Deng, Qiuping Xie, Yueling Zhao, Junling Guo, Xiao Du
Theranostics 2025; 15(15): 7291-7307. doi:10.7150/thno.113573
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Disrupted macrophage metabolic adaptation and function drive senescence-induced decline in vertebrate regeneration
Audrey Barthelaix, Claudia Terraza-Aguirre, Yalén Del Río-Jay, Candice Bohaud, Jérémy Salvador, Marie Morille, Miguel Godinho Ferreira, Christian Jorgensen, Farida Djouad
Theranostics 2025; 15(15): 7308-7326. doi:10.7150/thno.111352
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Neutrophil extracellular traps aggravate neuronal apoptosis and neuroinflammation via neddylation after traumatic brain injury
Xu Zhang, Jianye Xu, Yonggang Fan, Guihong Shi, Bo Chen, Anni Wang, Yanlin Zhu, Lei Li, Haoran Jia, Dilmurat Gheyret, Jinchao Wang, Yiyao Cao, Shenghui Li, Xin Chen, Jianning Zhang, Shu Zhang
Theranostics 2025; 15(15): 7327-7345. doi:10.7150/thno.111512
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Unraveling α-synuclein and amylin co-aggregation: pathological insights and biomarker development for Parkinson's disease
Yuhang Zhou, Minchao Lai, Bowen Shu, Benguo Wang, Dian Wang, Haoran Liu, Baowan Li, Jianhe Guo, Dongjie Hu, Mingyuan Li, Cheng Zhu, Muzhi Kang, Zhong Alan Li, Renzhi Wang, Yongjuan Zhao, Rocky S. Tuan, Keying Guo, Chenzhong Li, Cheng Jiang
Theranostics 2025; 15(15): 7409-7424. doi:10.7150/thno.112396
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A strain-programmed lignin-based Janus patch for rapid healing of postoperative rectal wounds
Yi Yu, Jiaxin Pan, Jianbo Zhang, Zhengdong Zhang, Chenghao Qiu, Yiming Xiang, Yizhou Zhu, Zhanjun Wu, Peng Yu, Tong Li, Lei Tan
Theranostics 2025; 15(15): 7425-7439. doi:10.7150/thno.115444
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AI-powered 3D pathology protocol enhances enteric nervous system visualization and quantification for clinical diagnostics
Young Hyun Yun, Kee Young Chung, Yunjoo Lee, Tae Sik Sung, Dayoung Ko, Seung-Bum Ryoo, Hyun-Young Kim, Kyu Joo Park, Jong Pil Im, Byeong Gwan Kim, Joo Sung Kim, Seong-Joon Koh, Hyung Jin Choi
Theranostics 2025; 15(15): 7440-7453. doi:10.7150/thno.112024
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GD2-mediated impairment of macrophage phagocytosis drives pulmonary metastasis in osteosarcoma
Yunfei He, Peng Yang, Peng Ding, Zeng Zhang, Jichuan Wu, Chunjie Wang, Guanghui Hou, Jun Ge, Quan Zhou, Zhuorun Song, Huilin Yang, Tao Liu, Shunyi Lu
Theranostics 2025; 15(15): 7454-7466. doi:10.7150/thno.113887
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Mn3O4 nanozyme-based anti-inflammatory therapy modulates microglial phenotype by downregulating TLR4/NOX2 expression and further alleviates Alzheimer's disease pathology
Jun Xie, Kai Cao, Luman Liu, Liding Zhang, Ying Yang, Hui Gong, Haiming Luo
Theranostics 2025; 15(15): 7467-7488. doi:10.7150/thno.112213
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Comparison of targeting two antigens (GPA33 versus HER2) for 225Ac-pretargeted alpha-radioimmunotherapy of colorectal cancer
Sara S. Rinne, Daniela Burnes Vargas, Brett A. Vaughn, Sumudu Katugampola, Brian W. Miller, Darren R. Veach, Blesida Punzalan, Elisa de Stanchina, Rona Yaeger, Ileana C. Miranda, Hong Xu, Hongfen Guo, Jazmin Schwartz, Edward K. Fung, Roger W. Howell, Steven M. Larson, Nai-Kong V. Cheung, Sarah M. Cheal
Theranostics 2025; 15(15): 7489-7500. doi:10.7150/thno.116062
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Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy
Stuart Prince, Miro Viitala, Riikka Sjöroos, Ábris Á. Bendes, Jenna H. Rannikko, Daniel A. Patten, Ilaria di Benedetto, Rita Turpin, Arno Ylitalo, Laura Tyni, Carlos R. Figueiredo, Pia Boström, Ilkka Koskivuo, Tiina A. Salminen, Shishir Shetty, Maija Hollmén
Theranostics 2025; 15(15): 7501-7527. doi:10.7150/thno.110544
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The LRP4/YAP axis drives the radiation-tolerant persister (RTP) cell state in breast cancer
Violaine Forissier, Julien Wicinski, Martin Castagné, Guillaume Pinna, Shuheng Lin, Anaïs Grandon, Caroline Bonnet, Manon Macario, Remy Castellano, Simon Valdenaire, Julien Darréon, Agnès Tallet, Christophe Ginestier, Emmanuelle Charafe-Jauffret
Theranostics 2025; 15(15): 7528-7544. doi:10.7150/thno.101393
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Lung cancer diagnosis through extracellular vesicle analysis using label-free surface-enhanced Raman spectroscopy coupled with machine learning
Hai-Sha Liu, Kai-Wen Ye, Jun Liu, Jin-Kuang Jiang, Ying-Fang Jian, Dong-Mei Chen, Chao Kang, Li Qiu, Ya-Juan Liu
Theranostics 2025; 15(15): 7545-7566. doi:10.7150/thno.110178
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Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability
Pingping Hu, Mengmeng Liu, Tongtong Wu, Yiping Zhang, Chenyuan Liu, Langtao Wang, Wanping Zhang, Yumei Que, Jiali You, Weimin Yu, Xiaoyong Tong
Theranostics 2025; 15(15): 7567-7583. doi:10.7150/thno.112041
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Extracellular vesicle-mediated spinal cord-brain crosstalk induces hippocampal neurogenesis impairment and cognitive deficits post-spinal cord injury
Tian Qin, Yiming Qin, Yuxin Jin, Xiangyu Liang, Yi Sun, Baozhi Liu, Hongbin Lu, Chengjun Li, Jianzhong Hu, Liyuan Jiang
Theranostics 2025; 15(15): 7584-7606. doi:10.7150/thno.110560
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Metabolic Targeting of Oxidative Phosphorylation Enhances Chemosensitivity in Triple-Negative Breast Cancer via a Synergistic Nanomedicine
Xiaoding Shen, Hao Cai, Yihan Wang, Maodi Xie, Yunkun Li, Dayi Pan, Jing Jing, Qiyong Gong, Kui Luo
Theranostics 2025; 15(15): 7607-7626. doi:10.7150/thno.116250
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Phase-specific and laser-modulated polydopamine-chlorella-curdlan hydrogels: pioneering a melanoma integrative therapy
Zhenzhen Yan, Tinglin Zhang, Yuxiang Wang, Chao Ji, Heru Wang, Yicheng Ma, Jingzhu Li, Yixin Wu, Zhi Liu, Jingnan Xun, Xiaowan Fang, Yongjun Zheng, Shizhao Ji, Shichu Xiao, Jie Gao
Theranostics 2025; 15(15): 7627-7652. doi:10.7150/thno.113417
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Multi-dimensional data-driven computational drug repurposing strategy for screening novel neuroprotective agents in ischemic stroke
Qingqi Meng, Qing Liu, Yan Mi, Libin Xu, Feng Wang, Danyang Mu, Yueyang Liu, Yuxin Yang, Yongye Huang, Dakuo He, Yue Hou
Theranostics 2025; 15(15): 7653-7676. doi:10.7150/thno.112608
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NIR-II light-driven in situ nanovaccine for cancer immunotherapy via lymph node migration-mediated accumulation
Yucheng Huang, Miao Su, Weihuan Lin, Peirong Zhang, Hengliang Hou, Fanjun Zeng, Luyu Huang, Qiaxuan Li, Jialong Deng, Shengbo Liu, Hongrui Qiu, Xiaoqing Yuan, Li Peng, Bin Xu, Haiyu Zhou
Theranostics 2025; 15(15): 7677-7692. doi:10.7150/thno.114347
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Gut microbiota-derived formate exacerbates pulmonary metastasis in cancer
Ray Putra Prajnamitra, Chaw Yee Beh, Wen-Hung Tang, Shu-Chian Ruan, Yuan-Yuan Cheng, Pei-Teng Kuo, Yu-Wen Tien, Patrick Ching-Ho Hsieh
Theranostics 2025; 15(15): 7693-7708. doi:10.7150/thno.108873
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Tumor Exosomal HIF2A Induce Peritumoral M2 Macrophages Accumulation to Facilitate Intestinal Invasion in Colorectal Cancer
Dan Wang, Qingyang Lei, Li Yang, Yachang Huo, Weina Yu, Shasha Liu, Yangfei Duan, Shumin Feng, Zhen Li, Jinbo Liu, Zhenqiang Sun, Weitang Yuan, Lihua Liu, Bin Zhang, Yi Zhang
Theranostics 2025; 15(15): 7709-7725. doi:10.7150/thno.113190
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Tetrahydromagnolol induces autophagic cell death by targeting the m6A reader protein YTHDF2 and enhances the efficacy of anti-PD-1 immunotherapy in pancreatic cancer cells
Guohua Li, Qibiao Wu, Yiping Mou, Yunhao Qiao, Lijun Jin, Qian Shi, Ruonan Zhang, Jie Li, Yitian Sun, Aili Zhang, Haiyang Jiang, Zijing Yang, Zhiyu Zhu, Mengmeng Ma, Xiaoyu Sun, Xinbing Sui
Theranostics 2025; 15(15): 7726-7746. doi:10.7150/thno.112612
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Engineered RAP-anchored copper-escorting liposomes for FDX1-targeted cuproptosis in glioblastoma therapy‌
Meng-Meng Liu, Ling-Xiao Zhao, Zhi-Qiang Gong, Yi-Jiang He, Xue Jiang, Wei Luo, Xin Yu, Zhan-You Wang
Theranostics 2025; 15(15): 7802-7819. doi:10.7150/thno.115723
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Targeting granulosa cells with engineered DFO nanoparticles for the treatment of chemotherapy-induced premature ovarian failure
Tuo Zhang, Zhiyi Sheng, Jixian Zhang, Heng Zhang, Yan Zhang, Yunpeng Du, Xiangxin Liu, Zhu Hu, Qiyuan Luo, Guoqiang Xu, Yuan Gao, Meina He, Tengxiang Chen
Theranostics 2025; 15(15): 7820-7840. doi:10.7150/thno.115416
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Reviews

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Artemisiae Annuae Herba: from anti-malarial legacy to emerging anti-cancer potential
Jing Sun, Junzi Xufeng, Zejing Qiu, Quan Gao, Zhiyu Zhu, Jun He, Shegan Gao, Xinbing Sui
Theranostics 2025; 15(15): 7346-7377. doi:10.7150/thno.115414
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Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to intervention
Hancheng Wu, Jing Li, Ruilin Yao, Jing Liu, Lili Su, Wenjie You
Theranostics 2025; 15(15): 7378-7408. doi:10.7150/thno.113727
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Smart Nanoarchitectures for Precision RNA Delivery: Harnessing Endogenous and Exogenous Stimuli in Cancer Treatment
Jintao Hao, Yue Li, Lu Huang, Nannan Qi, Yanan Sun, Chaoxing He, Shaokun Yang, Zhiyun Niu, Xianrong Qi, Bai Xiang
Theranostics 2025; 15(15): 7747-7778. doi:10.7150/thno.112492
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Harnessing mRNA for heart health: a new era in cardiovascular treatment
Fengli Peng, Zhimei Qiu, Zimu Wang, Fuhai Li, Fating Zhou, Shuai Yuan, Jinsong Yuan, Yan Wang, Yongchao Zhao, Chaofu Li, Bei Shi
Theranostics 2025; 15(15): 7779-7801. doi:10.7150/thno.111503
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Zinc-based Nanomaterials in Cancer Therapy: Mechanisms, Applications, and Future Directions
Sen Mu, Hongyu Yang, Siqi Wang, Aiyang Tong, Rui Ding, Jiaxin Wang, Dongkai Wang, Ji Li
Theranostics 2025; 15(15): 7841-7871. doi:10.7150/thno.117773
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Mesoporous nanomaterial-based smart nanoplatforms for precise therapies of ulcerative colitis: Strategies and challenges
Zihong Xie, Jun Wu, Jin Xie, Hongxin Chen, Xinmin Wang, Junfeng Huang, Baode Shen, Hao Song, Lina Fu, Pengfei Yue
Theranostics 2025; 15(15): 7872-7901. doi:10.7150/thno.109268
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New insights into acute ischemic stroke from the perspective of spatial omics
Xinpeng Deng, Mingyue Zhao, Enhao Zhang, Liangzhe Wei, Xiang Gao, Dong Zhang, Yi Huang
Theranostics 2025; 15(15): 7902-7924. doi:10.7150/thno.113396
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