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Volume 15 (16); 2025

Research Papers

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Synergistic tumor microenvironment modulation enabled by a nanozyme-boosted biomimetic macrophage-derived nanovesicle for highly efficient antitumor therapy
Yue Su, Haibin Wu, Ke Duan, Jiahao Xie, Weitao Huang, Xiaozhou Mou, Xiangming Ye, Yeyu Shen, Ting Li, Junjia He, Luoqin Fu, Yin Wang, Liping Wen, Qiong Bian, Mingang Zhu, Xiangmin Tong
Theranostics 2025; 15(16): 7925-7939. doi:10.7150/thno.114467
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Targeting the self-amplifying loop between ATF6 and SNAI1 to inhibit epithelial‒mesenchymal transition in fibrotic lesions
Tong Wu, Yan Liu, Jiyuan Ma, Lingshan Lu, Liang Wang, Mengmei He, Zhuang Hao, Xiaomin Liu, Luning Zhang, Chao Zhao, Mengzhang Tao, Chao Zheng, Jian Zhou
Theranostics 2025; 15(16): 7940-7955. doi:10.7150/thno.109442
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O-GlcNAcylation-dependent liquid-liquid phase separation regulates the nuclear translocation of YAP to exacerbate vascular neointimal hyperplasia
Ping Weng, Yilin Wen, Zhiyi Yuan, Limei Ma, Liming Yang, Chengju Li, Wanping Zhang, Chao Yu
Theranostics 2025; 15(16): 7956-7972. doi:10.7150/thno.113303
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Reduction-responsive RNAi nanoplatform for enhanced cancer sonoimmunotherapy via dual inhibition of mitophagy and Nrf2 pathways
Junyue Fang, Rui Xu, Yuan Cao, Zixuan Zhao, Weifan Li, Li Lin, Jingyi Hou, Xiaoding Xu, Phei Er Saw
Theranostics 2025; 15(16): 7973-7989. doi:10.7150/thno.112649
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Pharmacological and genetic inhibition of ARG2 in CXCR2Hi myeloid-derived suppressor cells combats sepsis-induced lymphopenia
Qiuyue Long, Shixu Song, Jiwei Li, Jialing Gan, Shuoqi Yang, Boyu Li, Hongli Ye, Binghan Zheng, Fangfang Wu, Zhichen Yu, Jing Wu, Linyu Ding, Mingzheng Jiang, Xiaoyi Hu, Zhancheng Gao, Yali Zheng
Theranostics 2025; 15(16): 7990-8011. doi:10.7150/thno.112339
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Disturbance of cytoskeleton induced by ligustilide promotes hepatic stellate cell senescence and ameliorates liver fibrosis
Jiaorong Qu, Jianan Li, Le Wang, Yufei Li, Yinqiang Zhang, Jingtao Li, Zixuan Huo, Junsong Han, Runping Liu, Guifang Fan, Yinhao Zhang, Xiaoyong Xue, Xiaojiaoyang Li
Theranostics 2025; 15(16): 8049-8067. doi:10.7150/thno.108869
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Co-delivery of targeted hypoallergens and resiquimod powders using silk fibroin microneedles for effective allergen-specific immunotherapy
Zhen Wang, Xiaolei Lu, Lingzhi Wu, Xin Jiang, Wei Wang, Yahua Wang
Theranostics 2025; 15(16): 8096-8116. doi:10.7150/thno.114152
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Overactivation of EGFR signaling in skeletal stem/progenitor cells promotes bone formation and repair
Yuxiang Hu, Yangyang Chen, Xiaoyao Peng, Haitao Li, Guosilang Zuo, Hao Xu, Fashuai Wu, Yi Wang, Zengwu Shao, Yulong Wei
Theranostics 2025; 15(16): 8117-8136. doi:10.7150/thno.115406
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Point-of-care mass spectrometry metabolomic analysis enabling intraoperative brain tumor diagnosis
Junhan Wu, Xinqi Fang, Haoyue Zhang, Hao Xu, Peter Jih Cheng Wong, Ying Mao, Wenpeng Zhang, Zheng Ouyang, Wei Hua
Theranostics 2025; 15(16): 8137-8149. doi:10.7150/thno.113336
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Targeting complement C3 with Tanshinone I decreases microglia-mediated synaptic engulfment to exert antidepressant effects
Huaqing Lai, Pinglong Fan, Pengxiang Zhang, Meng Zhang, Xinmu Li, Boyu Kuang, Run Zhou, Wenfei Wang, Hong Jiang, Zhenzhen Wang, Naihong Chen
Theranostics 2025; 15(16): 8150-8175. doi:10.7150/thno.115587
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An unrecognized mechanism of self-protection in degenerating neurons mediated by astrocytic YAP through Wnts/β-catenin/EAAT2 signaling in C9orf72-poly-GA mice
Dongmei Li, Yan Wei, Rui Yang, Xuan Luo, Yanzhu Liu, Weiqiao Zhao, Hui Yang, Yumin Wu, Ying Wang, Zhihui Huang
Theranostics 2025; 15(16): 8176-8201. doi:10.7150/thno.113599
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Comprehensive exome profiling identifies ARHGEF12 mutation as a driver in gastric cancer with ovarian metastasis
Mingda Zhang, Guoyu Chen, Xiaolin Lin, Yingwen Zhang, Longyu Shi, Shanshan Li, Yanxin Li, Xiuying Xiao, Haizhong Feng
Theranostics 2025; 15(16): 8202-8221. doi:10.7150/thno.113382
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A pyroptosis proportion tunable nano-modulator for cancer immunotherapy
Zhuang Chen, Zuo Yang, Zhiping Rao, Yi Luo, Weijing Liu, Chaoqiang Qiao, Qian Jia, Peng Yang, Ruili Zhang, Zhongliang Wang
Theranostics 2025; 15(16): 8320-8336. doi:10.7150/thno.112209
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CREPT promotes LUAD progression by enhancing the CDK9 and RNAPII assembly to promote ERK-driven gene transcription
Mengdi Li, Yuting Lin, Jiayu Wang, He Yang, Danhui Ma, Ye Tian, Yi Wang, Liu Yang, Umar Farooq, Yinyin Wang, Fangli Ren, Jian Sheng, Guoqing Zhang, Liang Chen, Jun Li, Xiangnan Li, Zhijie Chang
Theranostics 2025; 15(16): 8337-8359. doi:10.7150/thno.115572
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PTEN-mediated senescence of lung epithelial cells drives ventilator-induced pulmonary fibrosis
Mengyu Li, Yu Wang, Zhiqiang Hu, Shiqian Huang, Pu Chen, Lin Chen, Jing Wu, Zhouyang Wu, Shanglong Yao, Yiyi Yang
Theranostics 2025; 15(16): 8360-8376. doi:10.7150/thno.117523
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Engineered nanovesicle platform simultaneously triggers YAP-dependent ferroptosis and reprograms T-cell immunity through miR-150-3p codelivery in melanoma microenvironment
Jiemin Wang, Zhenguo Zhao, Haopeng Yang, Ruixuan Wang, Shu Wang, Jiale Yu, Yujia Wang, Ruihua Liu, Yani Chen, Yueshi Liu, Kesong Shi, Pengyong Han, Miao Liu, Jing Miao, Xiaoyang Li, Xiangnan Li, Haiquan Yu
Theranostics 2025; 15(16): 8377-8403. doi:10.7150/thno.115860
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Intermittent fasting reprograms the brain proteome to prevent synaptic degeneration and cognitive impairment in vascular dementia
Nishat I. Tabassum, Sharmelee Selvaraji, Yibo Fan, Vernise JT. Lim, Xiangru Cheng, Xiangyuan Peng, Aayushi Arora, Vismitha Rajeev, Julian Ratcliffe, Chad J. Johnson, Keshava K. Datta, Rohan Lowe, Mansour Ebrahimi, Quynh Nhu Dinh, T Michael De Silva, Christopher G. Sobey, Peiyan Wong, Eddie Feng-Ju Weng, Dong-Gyu Jo, Christopher P. Chen, Mitchell K.P. Lai, Thiruma V. Arumugam
Theranostics 2025; 15(16): 8429-8450. doi:10.7150/thno.119422
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All-in-one Biocomputing Nanoagents with Multilayered Transformable Architecture based on DNA Interfaces
Vladimir R. Cherkasov, Elizaveta N. Mochalova, Andrey V. Babenyshev, Maxim P. Nikitin
Theranostics 2025; 15(16): 8451-8472. doi:10.7150/thno.113059
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Chitosan activates NLRP3 inflammasome and cGAS-STING to suppress cancer progression through hexokinase 2 dissociation and mitochondrial dysfunction
Lu Li, Liting You, Zhenfei Bi, Ziqi Zhang, Binwu Ying, Min Luo, Xiawei Wei
Theranostics 2025; 15(16): 8473-8487. doi:10.7150/thno.112009
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PTEN restoration and CXCR2 depletion synergistically enhance the effect of enzalutamide and inhibit bone metastatic CRPC
Jiyuan Chen, Luyao Gong, Simeng Cao, Guanshan Song, Yeheng Peng, Yuanyuan Wang, Yan-Ru Lou, Teemu J. Murtola, Yao Wu, Ganjun Yu, Yuan Gao
Theranostics 2025; 15(16): 8488-8508. doi:10.7150/thno.114534
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Injectable hydrogels based on mussel-inspired nanocomposite microspheres for non-compressible intra-abdominal hemorrhage control
Tao Liu, Peng Ma, Fengya Jing, Yinghua Tao, Jinfang Lu, Dandan Wei, Liuxin Yang, Feiling Feng, Yonghua Li, Hongbin Yuan, Tianzhu Zhang
Theranostics 2025; 15(16): 8509-8530. doi:10.7150/thno.118901
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FBLN7 KO attenuates age-related cardiac fibrosis by promoting TGFBR3/ALK1/Smad1 signaling and inhibiting the profibrotic phenotypes of cardiac fibroblasts
Xuehui Zheng, Guoqing Yao, Huaitao Yu, Binghui Kong, Yuan Zhao, Yang Hu, Xiangping Ma, Jinghan Hai, Panpan Xu, Yun Ti, Peili Bu
Theranostics 2025; 15(16): 8531-8552. doi:10.7150/thno.116477
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Biosynthetic gas vesicles as a novel ultrasound contrast agent for diagnosing and treating myocardial infarction
Zihang Wang, Maierhaba Yibulayin, Kezhi Yu, Tingting Liu, Lina Guan, Baihetiya Tayier, Lingjie Yang, Shangke Chen, Yuming Mu, Fei Yan
Theranostics 2025; 15(16): 8553-8568. doi:10.7150/thno.118543
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Nanodelivery of Y-27632 by RGD-modified liposome enhances radioimmunotherapy of hepatocellular carcinoma via tumor microenvironment matrix stiffness reprogramming
Yang Shen, Zihui Zheng, Xinyao Hu, Zhuolin Zhou, Yangtao Xu, Siyu Wang, Shuhong Yu, Xiaoqin He, Ximing Xu
Theranostics 2025; 15(16): 8569-8586. doi:10.7150/thno.114892
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Single-cell RNA sequencing reveals that myeloid S100A8/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overload
Wei-Jia Yu, Wen-Xi Jiang, Shu-Jing Liu, Hui-Hua Li, Qiu-Yue Lin
Theranostics 2025; 15(16): 8587-8608. doi:10.7150/thno.118369
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Systemic inflammation-induced adipose tissue remodeling drives psoriasis exacerbation in obesity through epigenetic and immunometabolic dysregulation
Jinsun Jang, Mijoo Ahn, Jiyeong Jeong, Eun-Hui Lee, Ok-Hee Kim, Seul-A Joo, Seung Eun Baek, Han-Joo Maeng, Yun Hak Kim, In-Sun Hong, Byung-Chul Oh, Ik Soo Kim, Hee Joo Kim, YunJae Jung
Theranostics 2025; 15(16): 8639-8657. doi:10.7150/thno.116796
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Fe-flavonoid nanozyme as dual modulator of oxidative stress and autophagy for acute kidney injury repair
Ranran Luo, Zhongsheng Xu, Chenxi Zhang, Zening Zhang, Pengchen Ren, Xiaojing He, Jingjing Zhang, Yun Liu
Theranostics 2025; 15(16): 8658-8674. doi:10.7150/thno.111874
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Reviews

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Imaging hypoxia for head and neck cancer: current status, challenges, and prospects
Wenhui Huang, Nemin Li, Sheng Zhu, Yuze Zhang, Xinyang Song, Bin Zhang, Hao Yan, Jie Tian, Kun Wang, Shuixing Zhang
Theranostics 2025; 15(16): 8012-8030. doi:10.7150/thno.112781
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On the dilemma of using single EV analysis for liquid biopsy: the challenge of low abundance of tumor EVs in blood
Meruyert Imanbekova, Mohul Sharma, Sebastian Wachsmann-Hogiu
Theranostics 2025; 15(16): 8031-8048. doi:10.7150/thno.115131
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Mucus-derived biomaterial dressings: a novel approach to accelerate wound healing
Xuanqi Peng, Ziyi Wang, Leo Wang, Weiliang Hou
Theranostics 2025; 15(16): 8068-8095. doi:10.7150/thno.115988
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Inhibitory leukocyte immunoglobulin-like receptors, subfamily B (LILRBs) in human diseases: structure, roles, mechanisms, and clinical applications
Yuxiu Zhang, Yuanyuan Xu, Qihui Wu, Xiaodan Fu, Yimin Li, Anqi Li
Theranostics 2025; 15(16): 8222-8258. doi:10.7150/thno.116951
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Engineered upconversion nanoparticles for breast cancer theranostics
Shijing Wang, Lei Zhang, Minghao Wang, Xiumei Yin, Xinyao Dong, Xingyu Wu, Weijie Li, Wen Xu, Xiaoyun Mao
Theranostics 2025; 15(16): 8259-8319. doi:10.7150/thno.116153
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Epitranscriptomic mechanisms and implications of RNA m5C modification in cancer
Zhonghao Mao, Yan Tian, Lisha Wu, Yu Zhang
Theranostics 2025; 15(16): 8404-8428. doi:10.7150/thno.112332
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Synergistic integration of extracellular vesicles and metal-organic frameworks: unlocking new opportunities in disease diagnosis and therapy
Peiye Xu, Jiaxuan He, Ting Xu, Weijie Wang, Baihui Wu, Rongbing Chen, Hanbing Wang, Qinsi Yang, Wei Wu, Da Sun
Theranostics 2025; 15(16): 8609-8638. doi:10.7150/thno.113474
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The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment
Hanzhe Shi, Mingming Xiao, Yangyi Li, Xiyu Liu, Jintong Na, Chen Liang, Jie Hua, Qingcai Meng, Miaoyan Wei, Wei Wang, Jin Xu, Xianjun Yu, Si Shi
Theranostics 2025; 15(16): 8675-8703. doi:10.7150/thno.112633
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Erratum

Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect in vivo
Liping Zhong, Wei Shi, Lu Gan, Xiuli Liu, Yu Huo, Pan Wu, Zhikun Zhang, Tao Wu, Hongmei Peng, Yong Huang, Yongxiang Zhao, Yulin Yuan, Zhiming Deng, Hongliang Tang
Theranostics 2025; 15(16): 8704-8705. doi:10.7150/thno.117883
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