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Volume 15 (17); 2025
Research Papers
Molecular and functional MRI enables detection of cardiac fibrosis and evaluation of treatment response after chordin-like 1 gene therapy in myocardial infarction Konstantina Amoiradaki, Mateusz Tomczyk, Xiaoying Wang, Gastão Cruz, Carlos Velasco, Lorena Zentilin, Francesca Bortolotti, Claudia Prieto, René M. Botnar, Mauro Giacca, Alkystis Phinikaridou
Theranostics 2025; 15(17): 8706-8718. doi:10.7150/thno.114459
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RIPK3 promotes ASIC1a-mediated fibroblast-like synoviocyte migration and invasion via malate shuttle-driven mitochondrial respiration in rheumatoid arthritis Weirong Hu, Ke Wang, Yalu Dong, Yucai Xu, Jing Xing, Jianzhong Zhu, Jie Ding, Yingjie Zhao, Yayun Xu, Yuanzhi Cheng, Xiaoqing Peng, Renpeng Zhou, Wei Hu, Feihu Chen
Theranostics 2025; 15(17): 8719-8737. doi:10.7150/thno.113974
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Aptamer-based drug delivery for targeted therapy of imatinib-resistant gastrointestinal stromal tumor Tao Pan, Ming Wang, Linxi Yang, Yihan Zheng, Yuanding Liu, Yu Xiao, Xudong Qiu, Yanying Shen, Mahan Dawuren, Zhiqiang Ren, Keying Liu, Yang Sun, Lin Tu, Hui Cao, Weihong Tan
Theranostics 2025; 15(17): 8738-8756. doi:10.7150/thno.115496
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Injectable SF-platform orchestrates GPX4-targeted ferroptosis-autophagy-immunogenic circuit for overcoming oxidative resistance in triple-negative breast cancer Hui Yuan, Xiongwu Li, Muhua Yu, Youde Cao, Lingcheng Wu, Suyujie Shi, Yaying Yang, Kexiao Yu, Bing Liang
Theranostics 2025; 15(17): 8757-8778. doi:10.7150/thno.116013
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Self-Assembling Hydrogels of Naproxen-Conjugated Peptides for Osteoarthritis Treatment Lulu Yang, Liang Shao, Puhua Hao, Jiaqi Song, Caiting Meng, Bin Zhu, Hongwen Yu, Wanglin Duan, Xiaohua Fang, Guanying Li, Shichang Liu
Theranostics 2025; 15(17): 8779-8794. doi:10.7150/thno.114781
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Autophagy-driven lipid regulation by an herbal decoction alleviates cardiac lipotoxicity in severe acute pancreatitis Yue Yang, Qian Hu, Hongxin Kang, Long Xie, Yue Hu, Juan Li, Xianlin Zhao, Lv Zhu, Wenfu Tang, Jingping Liu, Christopher J. Lyon, Meihua Wan
Theranostics 2025; 15(17): 8822-8839. doi:10.7150/thno.117243
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Long-lasting microbubble-enhanced super-resolution ultrasound imaging unveils lymphatic activity in lymph node Jingyi Yin, Feihong Dong, Xiangui Zhang, Yuan Peng, Pengting Min, Jiabin Zhang, Shu Wang, Jing Fang, Jue Zhang
Theranostics 2025; 15(17): 8857-8872. doi:10.7150/thno.117971
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Targeting CB1R Rewires Ca2+-Dependent Mitophagy to Promote Nerve Regeneration Ningning Wang, Weizhen Li, Tuo Yang, Baolong Li, Chuikai Meng, Xiongyao Zhou, Jialu Sun, Kaiming Yu, Shusen Cui, Rangjuan Cao
Theranostics 2025; 15(17): 8873-8896. doi:10.7150/thno.119712
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Nociceptive Neurons Promote Myeloid-Derived Suppressor Cell Mobilization to Alleviate Post-Stroke Neuroinflammation Lingxin Cai, Jiayin Zhou, Xinran Cao, Huaping Huang, Qin Xie, Haifeng Chu, Gao Chen, Lulu Jin, Zhengwei Mao, Feng Yan
Theranostics 2025; 15(17): 8897-8915. doi:10.7150/thno.119474
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Modulating Macrophage Polarization for Severe Acute Pancreatitis Therapy via Cisplatin-like Prussian Blue Nanozymes Ling Wu, Rui Cai, Yuhang Li, Shuqi Liao, Yinghui Song, Yufeng Li, Jishan Li, Donghong Yu, Zhong Cao, Sulai Liu
Theranostics 2025; 15(17): 8916-8934. doi:10.7150/thno.113523
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Saikosaponin D Mitigates Radioresistance in Triple-Negative Breast Cancer by Inducing MRE11 De-Lactylation via HIF1α/HDAC5 Pathway Jingyi Li, Liang Feng, Lei Zhang, Weiguo Zhang, Yanting Zhang, Xiaoqin Liu, Qianqian Cai, Weiming Zhao, Gang Huang, Changlian Lu
Theranostics 2025; 15(17): 8935-8951. doi:10.7150/thno.113517
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Role of MiR-204 in controlling metabolic functions of the subretinal microglia Yan Chen, Sarah E Bounds, Neloy Kundu, James Regun Karmoker, Yin Liu, Dongin Kim, Jiyang Cai
Theranostics 2025; 15(17): 8952-8963. doi:10.7150/thno.111807
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ApoE deficiency protects from mRNA vaccine-induced mitochondrial dysfunction at the injection site under metabolic stress Sun-Hee Cho, Byeongkwon Choi, Jisun Lee, Yu-Sun Lee, Mi-Ock Baek, You-Jeung Lee, Chae-Ok Gil, Min-Kyung Choi, Sana Abdul Khaliq, Syeda Maham, Jae-Kyung Hyun, Gahyun Roh, Huijeong Choi, Sowon Lee, Seo-Hyeon Bae, Seonghyun Lee, Hyo-Jung Park, Jae-Hun Ahn, Na-Young Lee, Byeong-Cheol Kang, Young Kyo Seo, Byung-Kwan Lim, Jae-Hwan Nam, Mina Rho, Mee-Sup Yoon
Theranostics 2025; 15(17): 8964-8984. doi:10.7150/thno.119545
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Extracellular vehicles-mediated Twsit1 transferred from tumor cells to brain induces depressive-like behaviors via neuronal morphogenesis Ruo-Si Zou, Jin-Gang He, Yang Zhao, Bing Zhou, Si-Long Deng, Jian-Guo Chen, Fang Wang
Theranostics 2025; 15(17): 8985-9000. doi:10.7150/thno.112238
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Pilot experience of [161Tb]Tb-PSMA-617 RLT in mCRPC patients after conventional PSMA RLT within a prospective registry Florian Rosar, Caroline Burgard, Christine Petrescu, Arne Blickle, Mark Bartholomä, Stephan Maus, Moritz B. Bastian, Tilman Speicher, Andrea Schaefer-Schuler, Samer Ezziddin
Theranostics 2025; 15(17): 9019-9028. doi:10.7150/thno.115831
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The first abdominal aortic aneurysm organoid model replicates complex microenvironment for in vitro disease study Jiaxuan Feng, Mingjie Rong, Yudong Sun, Guanglang Zhu, Guangkuo Wang, Jiping Liu, Chen Wang, Jian Zhang, Xiaochen Ma, Junyi Yan, Yaojie Wang, Youjin Li, Yu Ning, Chunhui Cai, Xinxin Han
Theranostics 2025; 15(17): 9029-9046. doi:10.7150/thno.118193
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Designer amphiphilic helical peptide-decorated nanomicelles enable simultaneous inflammation control and triple-destruction of bacteria for treating bacterial pneumonia and sepsis Sixia Liu, Rui Wang, Lian Li, Xiaohuan Wang, Jiameng Gong, Xingzu Liu, Zichen Song, Liya Sun, Xiali Liu, Wen Ning, Yuanlin Song, Shan-Yu Fung, Hong Yang
Theranostics 2025; 15(17): 9047-9072. doi:10.7150/thno.110538
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Dopamine D2 receptor modulating mPFC-BLA circuit contributes to chronic sleep deprivation-induced memory impairment in mice Jiaxuan Yang, Jiahui Sun, Zili Liu, Xia Tang, Yunyun Hu, Weida Shen, Yicheng Xie, Yue Jin, Haifeng Li, Xuekun Li, Yanjun Jiang, Matthew Tak Vai Chan, William Ka Kei Wu, Zhigang Liu, Xiaodong Liu, Yaoqin Hu, Jinpiao Zhu, Daqing Ma
Theranostics 2025; 15(17): 9073-9090. doi:10.7150/thno.114797
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The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma Rongrong Liu, Xinyan Li, Jiayi Xu, Liangwen Yan, Kailing Hu, Mengjiao Shi, Yinggang Zhang, Yaping Zhao, Yudan Fan, Gang Wang, Ying Guo, Yetong Feng, Pengfei Liu
Theranostics 2025; 15(17): 9091-9113. doi:10.7150/thno.115661
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Macrophage-derived KIF13B interacts with USP9X to attenuate abdominal aortic aneurysm development by potentiating TFEB stability Jingxuan Chen, Yitong Xu, Huahui Yu, Yiran Liu, Guolin Miao, Yufei Han, Liwen Zheng, Zeyu Cai, Zihao Zhou, Jinxuan Chen, Sijing Shi, Pingping Lai, Wenxi Zhang, Lianxin Zhang, Si Mei, Yinqi Zhao, Ling Zhang, Wei Huang, Yuhui Wang, Dongyu Zhao, Wei Kong, Yanwen Qin, Erdan Dong, Xunde Xian
Theranostics 2025; 15(17): 9114-9130. doi:10.7150/thno.118958
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Nanotuner targeting mitochondrial redox and iron homeostasis imbalance for the treatment of acute liver injury Minghao Li, Qiwei Yang, Jie Gao, Xudong Liu, Jihua Shi, Wenzhi Guo, Yi Zhang, Qiwen Yu, Xinzhi Sun, Shuijun Zhang
Theranostics 2025; 15(17): 9131-9158. doi:10.7150/thno.119357
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A strategy targeting ferroptosis for mitochondrial reprogramming and intervertebral disc degeneration therapy Tianyi Wu, Yun Teng, Dawei Song, Yuqi Yang, Huaishuang Shen, Xiao Sun, Rui Chen, Leyu Zhao, Xianggu Zhong, Qi Yan, Junjie Niu, Jun Ge, Liang Cheng, Jun Zou
Theranostics 2025; 15(17): 9159-9178. doi:10.7150/thno.117725
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In situ reprogramming of fibroblasts into antigen-presenting pseudo-dendritic cells via IFN-β-engineered protoplast-derived exosomes delivered by microneedle arrays to enhance adaptive immunity Yue Yin, Shijie Zhao, Wei Li, Yuan Cui, Thanh Loc Nguyen, Ge Gao
Theranostics 2025; 15(17): 9179-9199. doi:10.7150/thno.115080
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Neutrophil extracellular traps induce endothelial damage and exacerbate vasospasm in traumatic brain injury Jinchao Wang, Lei Li, Jianye Xu, Dilmurat Gheyret, Kaiji Li, Xu Zhang, Haoran Jia, Ye Tian, Xiao Liu, Shenghui Li, Guili Yang, Yalong Gao, Ruilong Peng, Huajie Liu, Bin Liu, Jianfeng Zhuang, Cong Wang, Xin Chen, Yafan Liu, Bo Chen, Chuan Huang, Yuhan Li, Xin Chen, Jianning Zhang, Shu Zhang
Theranostics 2025; 15(17): 9221-9239. doi:10.7150/thno.115746
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Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress Bo Hyun Yoon, Jinho Kim, Sandip Sengupta, Chan-Jung Park, Minjoo Ko, Ji Hee Kang, Young Tag Ko, Yeji Kim, Seung Min Lim, Yoonhee Bae, MooYoung Choi, Yunyeong Jang, Ho Jeong Kwon, Hyo Jin Son, Hee Jin Kim, Taebo Sim, Keun-A Chang, Myung-Shik Lee
Theranostics 2025; 15(17): 9240-9260. doi:10.7150/thno.118409
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RBMS1-mediates the biogenesis of circNFIB promotes perineural invasion of pancreatic ductal adenocarcinoma via the L1CAM/MAPK pathway Zhuo Wu, Zhou Fang, Liangtang Zeng, Dingwen Zhang, Yu Zhou, Rufu Chen
Theranostics 2025; 15(17): 9261-9278. doi:10.7150/thno.112753
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Reprogramming the aging ovarian microenvironment via mitochondrial sharing and structural remodeling Chia-Jung Li, Li-Te Lin, Pei-Hsuan Lin, Jim Jinn-Chyuan Sheu, Zhi-Hong Wen, Kuan-Hao Tsui
Theranostics 2025; 15(17): 9279-9293. doi:10.7150/thno.119957
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Tumor-responsive cuproptosis nanoinducer realizing efficient PANoptosis for enhanced cancer immunotherapy Kaiqing Yun, Xiaohong Yu, Shuang Liang, Qingling Wang, Ziyi Zhang, Yue Han, Yueyang Zhao, Yuxuan Peng, Lang Rao, Yong Cui, Zhaohui Wang
Theranostics 2025; 15(17): 9294-9305. doi:10.7150/thno.115275
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Dimeric CCK2R radiotheranostic tracers synergize with mTOR inhibition for enhanced tumor therapy Linjie Bian, Zheyi Wang, Panli Li, Simin He, Jianping Zhang, Xiaoping Xu, Xiangwei Wang, Shaoli Song
Theranostics 2025; 15(17): 9306-9325. doi:10.7150/thno.117021
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Triple-targeting nanosystems with synergistic effects on iron Trojan horse, fluoroquinolone antibiotics, and photodynamic therapy specifically kill intracellular MRSA Kuiyu Meng, Liwen Yuan, Lulu Feng, Yaoyao Zhang, Hao Wu, Jie Zhang, Mubbashar Abbas, Wei Qu, Dongmei Chen, Shuyu Xie
Theranostics 2025; 15(17): 9326-9343. doi:10.7150/thno.109374
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Natural killer cell-specific chimeric antigen receptor enhances CAR NK cell functions and anti-tumor activity Changqing Pan, You Zhai, Zhongliang Cui, Yiyun Yin, Menghui Xu, Di Wang, Yishuo Sun, Jiazheng Zhang, Chen Wang, Ziwei Li, Mingchen Yu, Zhongfang Shi, Guanzhang Li, Tao Jiang, Wei Zhang
Theranostics 2025; 15(17): 9344-9358. doi:10.7150/thno.120909
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Reviews
Liquid Metal Gallium Pharmaceuticals Dawei Wang, Wei Xu, Yuxin Liu, Luying Chen, Ting He, Hong Tan, Shuting He, Jie Zhu, Caiting Wang, Zhongyang Yu, Chong Li, Weidong Pan, Wei Rao, Jing Liu
Theranostics 2025; 15(17): 8795-8821. doi:10.7150/thno.116184
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Modulation of Stem Cell Survival and Engraftment: Implications for Stem Cell-Based Therapy Qingwen Xu, Chaochao Zhang, Xinyu Liu, Yuyao Sun, Bowei Li, Sihui Nian, Yan Wang, Chenggong Yu
Theranostics 2025; 15(17): 8840-8856. doi:10.7150/thno.120805
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Imaging Brown Adipose Tissue: Current State and Future Perspective Junhao Li, Li Wang, Shiyao Wu, Guifen Yang, Long Jiang Zhang
Theranostics 2025; 15(17): 9001-9018. doi:10.7150/thno.111643
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Erratum
An electroporation strategy to synthesize the membrane-coated nanoparticles for enhanced anti-inflammation therapy in bone infection: Erratum Miusi Shi, Kailun Shen, Bin Yang, Peng Zhang, Kangle Lv, Haoning Qi, Yunxiao Wang, Mei Li, Quan Yuan, Yufeng Zhang
Theranostics 2025; 15(17): 9200. doi:10.7150/thno.121003
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