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Volume 15 (18); 2025
Research Papers
Quantitative MALDI imaging of aspirin metabolites in mouse models of triple-negative breast cancer Tae-Hun Hahm, Dalton R. Brown, Caitlin M. Tressler, Thao Tran, Alice Ly, Arvind P. Pathak, Michael T. McMahon, Kristine Glunde
Theranostics 2025; 15(18): 9359-9374. doi:10.7150/thno.116819
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Trimmed N-glycans define aggressive gastric cancer and predict clinical outcomes Dylan Ferreira, Beatriz Marinho-Santos, Marta Relvas-Santos, Bernardo Orr, Andreia Brandão, Luís Pedro Afonso, Lúcio Lara Santos, José Alexandre Ferreira
Theranostics 2025; 15(18): 9375-9398. doi:10.7150/thno.111670
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Dual-parameter tomographic imaging of attenuation and backscattering coefficients for quantitative evaluation of immune cell-mediated cytotoxicity in tumor spheroids Seokgyu Han, Ingyoung Kim, Baekcheon Seong, Woovin Kim, Hongseong Kim, Sein Kim, Chulmin Joo, Sungsu Park
Theranostics 2025; 15(18): 9399-9414. doi:10.7150/thno.118722
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Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy Ping Xu, Wen Zhou, Shida Wang, Linjiao Wang, Yu Bai, Shan Xing, Wenda Xue, Meng Li, Jun Shi, Haoxin Wu
Theranostics 2025; 15(18): 9415-9446. doi:10.7150/thno.112661
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Transcriptomic Profiling of the Tumor Immune Microenvironment Reveals Prognostic Markers in mCRPC Patients Treated with LuPSMA Therapy Analena Handke, Leonor Lopes, Claudia Kesch, Christopher Darr, Elai Davicioni, Kuangyu Shi, Tugce Telli, Wolfgang P. Fendler, Ken Herrmann, Katharina Lückerath, Boris Hadaschik, Robert Seifert
Theranostics 2025; 15(18): 9447-9458. doi:10.7150/thno.113614
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Single-cell RNA sequencing reveals endothelial cell heterogeneity and Sox18-mediated EndMT in abdominal aortic aneurysm Xianxian Wu, Xuanyu Liu, Yuanzhi Cheng, Yuhan Zhang, Dou Shi, Yang Shi, Xing Liu, Jianghao Feng, Anxiong Long, Wei Hu, Zhiwei Yang
Theranostics 2025; 15(18): 9486-9507. doi:10.7150/thno.110254
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Luminal Stem-like Cells in High-Risk/Locally Advanced Prostate Cancer Promote Resistance to Hormonal Therapy Guyu Tang, Jing Liu, Xiaomei Gao, Kai Yuan, Minfeng Chen, Long Wang, Lin Qi, Yi Cai
Theranostics 2025; 15(18): 9558-9579. doi:10.7150/thno.112496
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Macrophage-TREM2 promotes cardiac repair by restricting the infiltration of CD8+ T cells via CXCL16-CXCR6 axis after myocardial infarction Linlin Zhang, Sheng Wang, Yu Ding, Tao Zheng, Jie Sheng, Yanshan Chen, Zhiyue Wang, Ximei Dai, Canbiao Wang, Long Ma, Jing Pan, Yunming Zhang, Longjiang Zhang
Theranostics 2025; 15(18): 9580-9600. doi:10.7150/thno.118014
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GPX1-driven selenium nanoplatform reprograms MAMs-mediated organelle crosstalk to reverse inflammatory adipose expansion in thyroid eye disease Yao Tan, Feng Zhang, Jiamin Cao, Lemeng Feng, Bingyu Xie, Limo Gao, Xiangdong Chen, Zuyun Yan, Wei Xiong
Theranostics 2025; 15(18): 9601-9622. doi:10.7150/thno.117582
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ASIC1a Induces Excessive Mitophagy and PANoptosis of Chondrocyte by the Inhibition of SIRT3 Mitochondrial Translocation Zhuoyan Zai, Xuewen Qian, Yayun Xu, Huifang Lv, Mengjia Hao, Yueming Tao, Lixin Rui, Xiaoyue Zhang, Xiaoqing Peng, Yihao Zhang, Feihu Chen
Theranostics 2025; 15(18): 9623-9642. doi:10.7150/thno.116712
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Engineering a spleen-selective mRNA-LNPs vaccine by decoupling the inflammation from cellular immunity-mediated cancer immunotherapy Xiaoke Gao, Meng Zhang, Shiyang Du, Lixia Ma, Xiaohan Yao, Boao Xie, Jiajia Wan, Yuqiao Sheng, Bo Qin, Wenjing Deng, Ningjing Lei, Wentao Mo, Ming Wang, Zhijun Sun, Zhihai Qin, Fazhan Wang
Theranostics 2025; 15(18): 9643-9662. doi:10.7150/thno.118976
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Machine learning-enhanced confocal Raman imaging enables label-free diagnosis and spatial metabolic profiling of isoniazid-induced hepatotoxicity Shimei Wang, Xiaoren Wang, Xudong Cui, Xiaotong Xie, Zhu Zhu, Tomii Ayaka, Renxing Song, Liping Zhou, Jin Sun, Li Zhang, Ruisheng Ge, Lei Yu, Yang Li
Theranostics 2025; 15(18): 9663-9677. doi:10.7150/thno.119785
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Single-shot multiparametric MRI for separating T2 effects from dynamic glucose-enhanced contrast Junxian Jin, Haizhen Ding, Zhekai Chen, Yuan Huang, Hongmin Chen, Zhong Chen, Lin Chen
Theranostics 2025; 15(18): 9678-9694. doi:10.7150/thno.116483
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Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression Lin Zhu, Xin Diao, Chenrui Yuan, Chun Man Lawrence Lau, Jianing Wang, Wenlong Wu, Ali Mobasheri, Xavier Houard, Chunyi Wen, Zongwei Cai
Theranostics 2025; 15(18): 9729-9741. doi:10.7150/thno.117788
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Ultrasound spatiotemporally enables prolonged therapeutic mRNA translation in engineered bacteria for enhanced cancer immunotherapy Zhaoyou Liu, Lantian Wang, Jieyuan An, Tian Zhou, Mengying Wei, Guodong Yang, Pengying Wu, Lijun Yuan
Theranostics 2025; 15(18): 9742-9756. doi:10.7150/thno.120342
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Biofilm-disrupting heterojunction microneedles: dual ROS amplification and glucose deprivation for accelerated diabetic wound healing Wenjie You, Feng Xiao, Zichao Cai, Jiaxin Zhao, Zhengyao Zhang, Weikang Hu, Yun Chen, Kwang Leong Choy, Zijian Wang
Theranostics 2025; 15(18): 9757-9774. doi:10.7150/thno.120787
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Enhancing glymphatic transport through angiotensin II type 2 receptor activation promotes neurological recovery after traumatic brain injury Xiaoyu Zhang, Bin Sun, Wenzhong Li, Tianyi Liu, Wenchen Li, Bo Chen, Chuan He, Qin Liu, Shoujun Zhu, Haifeng Wang
Theranostics 2025; 15(18): 9775-9792. doi:10.7150/thno.117743
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Endothelial cell-derived SDF-1α elicits stemness traits of glioblastoma via dual-regulation of GLI1 Ye Yuan, Xudong Liu, Liwen Kuang, Shixue Yang, Lihong Wang, Jiao Wang, Sen Wei, Zexuan Yan, Qinghua Ma, Juan Lei, Yu Zhou, Yu Chen, Jiongming Chen, Tao Luo, Kaidi Yang, Mengsi Zhang, Yongsheng Li
Theranostics 2025; 15(18): 9819-9837. doi:10.7150/thno.108843
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Naturally derived hydrogel with antioxidant, angiogenesis and photothermal effect to accelerate infected diabetic wound healing and reduce scar formation Mengyu Yang, Pengyuan Liu, Pei Cheng, Chenghao Li, Jingmei Liu, Haifeng Sun, Fangxia Guan, Minghao Yao
Theranostics 2025; 15(18): 9838-9861. doi:10.7150/thno.117179
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Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1/ATP axis to accelerate wound healing Yujie Xiao, Zhijun Shi, Yixuan Yuan, Danna Yao, Rongqin Feng, Yue Zhang, Deli Zhao, Hao Zhang, Panpan Sun, Yang Liu, Yan Li, Xuefeng Shen, Zhantong Wang, Dahai Hu, Hao Guan, Hongtao Wang
Theranostics 2025; 15(18): 9862-9884. doi:10.7150/thno.118364
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Kazald1 attenuates chondrocyte fibrosis to potentiate hyaline cartilage regeneration by interfering with the pro-fibrotic TGF-β signaling Yue Zhu, Haoyang Liu, Yuting Zhang, Danning Zheng, Yaning Li, Jialin Chen, Jiake Xu, Wei Zhang
Theranostics 2025; 15(18): 9885-9910. doi:10.7150/thno.113604
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Chemo-RaST with bortezomib inhibits multiple myeloma relapse Anchal Ghai, Alexander Zheleznyak, Christopher Egbulefu, Nicole Blasi, Kvar Black, Rui Tang, Matthew L Cooper, Kiran Vij, Ravi Vij, John DiPersio, Monica Shokeen, Samuel Achilefu
Theranostics 2025; 15(18): 9911-9921. doi:10.7150/thno.111508
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Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC Shengnan Lv, Jian Zhang, Xinyu Peng, Huan Liu, Tongjia Chu, Ziyu Liu, Kehang Duan, Jianxiong Guo, Jie Wang, Yan Liu, Feng Wei
Theranostics 2025; 15(18): 9922-9943. doi:10.7150/thno.117202
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EZH2-mediated H3K27me3 links microbial inosine loss to depression: a gut-brain epigenetic switch Sen Zhu, Xuan Li, Ying Yu, Xiaoyi Han, Fang Yang, Mengxi Lu, Gaole Dai, Liang Guo, Dan Xu
Theranostics 2025; 15(18): 9969-9986. doi:10.7150/thno.120824
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ROS-targeting heterojunction-integrated GelMA microneedles for photo-responsive antioxidative action and accelerated diabetic wound healing Jinlan Tang, Weijun Liu, Zhengyao Zhang, Ye Yang, Wenwen Cheng, Xiaoyu Wang, Zesheng Chen, Zijian Wang, Weikang Hu
Theranostics 2025; 15(18): 9987-10006. doi:10.7150/thno.120879
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Bone remodeling stimulated by Wnt-mediated mitophagy regulated extracellular vesicles in subchondral bone contributes to osteoarthritis development Yuyuan Gu, Qirong Zhou, Shihao Sheng, Huijian Yang, Dan Huang, Qin Zhang, Hao Zhang, Zijian Cao, Yuanwei Zhang, Zuhao Li, Yingying Jiang, Xiao Chen, Yingying Jing, Chenglong Wang, Hongbo Tan, Ke Xu, Jiacan Su
Theranostics 2025; 15(18): 10007-10027. doi:10.7150/thno.111724
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Ultrasound flow imaging for assessing cerebrovascular changes following focused-ultrasound blood-brain barrier opening Sua Bae, Stephen A. Lee, Seongyeon Kim, Fotios Tsitsos, Yangpei Liu, Elisa E. Konofagou
Theranostics 2025; 15(18): 10028-10044. doi:10.7150/thno.98098
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MR molecular imaging for monitoring and predicting tumor responses to immunotherapy Victoria E. A. Laney, Walter Zhao, Inga M. Hwang, Emma Hampson, Juan Dong, Ryan C. Hall, Kristin Weber-Bonk, Xueer Yuan, Elizabeth Delaney, Hannah Gilmore, Ruth Keri, Jordan Winter, Li Lily Wang, Zheng-Rong Lu
Theranostics 2025; 15(18): 10045-10063. doi:10.7150/thno.106481
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Deep brain stimulation-induced normalization of hippocampal synchrony in a transgenic rat model of Alzheimer's disease Andrea Trevisiol, Tina Beckett, Monica Bell Vila, Mary Hill, Joanne McLaurin, Bojana Stefanovic
Theranostics 2025; 15(18): 10064-10075. doi:10.7150/thno.110292
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Reviews
Dissecting Tertiary Lymphoid Structures in Cancer: Maturation, Localization and Density Guang-Liang Su, Meng-Jie Zhang, Hao Li, Zhi-Jun Sun
Theranostics 2025; 15(18): 9459-9485. doi:10.7150/thno.113940
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Advances and challenges in decellularized adipose tissue based composite hydrogels for adipose tissue regeneration: a review over the last fifteen years Lu Cui, Tian-Jie Lyu, Bin Fu, Yubo Wang, Qing Qu, Fanglin Wang, Rui Guo, Jun Fan
Theranostics 2025; 15(18): 9508-9532. doi:10.7150/thno.120300
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Synthetic reprogramming of tumor cell fate for modulating radiotherapy-induced dynamic responses: perspectives on radiosensitizing and immunoregulatory effects Wei Zhou, Lulu Wang, Hui Zhang, Yongzhong Wu, Menghuan Li, Zhong Luo
Theranostics 2025; 15(18): 9533-9557. doi:10.7150/thno.119822
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Hot-spot empowered gold nanoparticles for theranostics in breast cancer Meng Tian, Shiqi Hu, Wen Sun, Ying Hu, Xingyi Ma
Theranostics 2025; 15(18): 9695-9728. doi:10.7150/thno.119678
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The pathophysiology of mixed Alzheimer's disease and vascular dementia Mutaz Sarhan, Christian Wohlfeld, Ariel Perry-Mills, Jeffrey Meyers, James Fadel, E. Angela Murphy, Leonardo Bonilha, Daping Fan
Theranostics 2025; 15(18): 9793-9818. doi:10.7150/thno.118737
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GM-CSF+ Th: a central player in autoimmunity Sha-Sha Fan, Xuan Xu, Yu-Bin Luo, Xiang-Yu Meng, Yi Liu
Theranostics 2025; 15(18): 9944-9968. doi:10.7150/thno.121766
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