Theranostics
13.3
Impact Factor
Global reach, higher impact
Volume 15 (18); 2025
Research Papers
Quantitative MALDI imaging of aspirin metabolites in mouse models of triple-negative breast cancer
Tae-Hun Hahm, Dalton R. Brown, Caitlin M. Tressler, Thao Tran, Alice Ly, Arvind P. Pathak, Michael T. McMahon, Kristine Glunde
Theranostics 2025; 15(18): 9359-9374. doi:10.7150/thno.116819
Full text
PDF
Trimmed N-glycans define aggressive gastric cancer and predict clinical outcomes
Dylan Ferreira, Beatriz Marinho-Santos, Marta Relvas-Santos, Bernardo Orr, Andreia Brandão, Luís Pedro Afonso, Lúcio Lara Santos, José Alexandre Ferreira
Theranostics 2025; 15(18): 9375-9398. doi:10.7150/thno.111670
Full text
PDF
Dual-parameter tomographic imaging of attenuation and backscattering coefficients for quantitative evaluation of immune cell-mediated cytotoxicity in tumor spheroids
Seokgyu Han, Ingyoung Kim, Baekcheon Seong, Woovin Kim, Hongseong Kim, Sein Kim, Chulmin Joo, Sungsu Park
Theranostics 2025; 15(18): 9399-9414. doi:10.7150/thno.118722
Full text
PDF
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy
Ping Xu, Wen Zhou, Shida Wang, Linjiao Wang, Yu Bai, Shan Xing, Wenda Xue, Meng Li, Jun Shi, Haoxin Wu
Theranostics 2025; 15(18): 9415-9446. doi:10.7150/thno.112661
Full text
PDF
Transcriptomic Profiling of the Tumor Immune Microenvironment Reveals Prognostic Markers in mCRPC Patients Treated with LuPSMA Therapy
Analena Handke, Leonor Lopes, Claudia Kesch, Christopher Darr, Elai Davicioni, Kuangyu Shi, Tugce Telli, Wolfgang P. Fendler, Ken Herrmann, Katharina Lückerath, Boris Hadaschik, Robert Seifert
Theranostics 2025; 15(18): 9447-9458. doi:10.7150/thno.113614
Full text
PDF
Single-cell RNA sequencing reveals endothelial cell heterogeneity and Sox18-mediated EndMT in abdominal aortic aneurysm
Xianxian Wu, Xuanyu Liu, Yuanzhi Cheng, Yuhan Zhang, Dou Shi, Yang Shi, Xing Liu, Jianghao Feng, Anxiong Long, Wei Hu, Zhiwei Yang
Theranostics 2025; 15(18): 9486-9507. doi:10.7150/thno.110254
Full text
PDF
Luminal Stem-like Cells in High-Risk/Locally Advanced Prostate Cancer Promote Resistance to Hormonal Therapy
Guyu Tang, Jing Liu, Xiaomei Gao, Kai Yuan, Minfeng Chen, Long Wang, Lin Qi, Yi Cai
Theranostics 2025; 15(18): 9558-9579. doi:10.7150/thno.112496
Full text
PDF
Macrophage-TREM2 promotes cardiac repair by restricting the infiltration of CD8+ T cells via CXCL16-CXCR6 axis after myocardial infarction
Linlin Zhang, Sheng Wang, Yu Ding, Tao Zheng, Jie Sheng, Yanshan Chen, Zhiyue Wang, Ximei Dai, Canbiao Wang, Long Ma, Jing Pan, Yunming Zhang, Longjiang Zhang
Theranostics 2025; 15(18): 9580-9600. doi:10.7150/thno.118014
Full text
PDF
GPX1-driven selenium nanoplatform reprograms MAMs-mediated organelle crosstalk to reverse inflammatory adipose expansion in thyroid eye disease
Yao Tan, Feng Zhang, Jiamin Cao, Lemeng Feng, Bingyu Xie, Limo Gao, Xiangdong Chen, Zuyun Yan, Wei Xiong
Theranostics 2025; 15(18): 9601-9622. doi:10.7150/thno.117582
Full text
PDF
ASIC1a Induces Excessive Mitophagy and PANoptosis of Chondrocyte by the Inhibition of SIRT3 Mitochondrial Translocation
Zhuoyan Zai, Xuewen Qian, Yayun Xu, Huifang Lv, Mengjia Hao, Yueming Tao, Lixin Rui, Xiaoyue Zhang, Xiaoqing Peng, Yihao Zhang, Feihu Chen
Theranostics 2025; 15(18): 9623-9642. doi:10.7150/thno.116712
Full text
PDF
Engineering a spleen-selective mRNA-LNPs vaccine by decoupling the inflammation from cellular immunity-mediated cancer immunotherapy
Xiaoke Gao, Meng Zhang, Shiyang Du, Lixia Ma, Xiaohan Yao, Boao Xie, Jiajia Wan, Yuqiao Sheng, Bo Qin, Wenjing Deng, Ningjing Lei, Wentao Mo, Ming Wang, Zhijun Sun, Zhihai Qin, Fazhan Wang
Theranostics 2025; 15(18): 9643-9662. doi:10.7150/thno.118976
Full text
PDF
Machine learning-enhanced confocal Raman imaging enables label-free diagnosis and spatial metabolic profiling of isoniazid-induced hepatotoxicity
Shimei Wang, Xiaoren Wang, Xudong Cui, Xiaotong Xie, Zhu Zhu, Tomii Ayaka, Renxing Song, Liping Zhou, Jin Sun, Li Zhang, Ruisheng Ge, Lei Yu, Yang Li
Theranostics 2025; 15(18): 9663-9677. doi:10.7150/thno.119785
Full text
PDF
Single-shot multiparametric MRI for separating T2 effects from dynamic glucose-enhanced contrast
Junxian Jin, Haizhen Ding, Zhekai Chen, Yuan Huang, Hongmin Chen, Zhong Chen, Lin Chen
Theranostics 2025; 15(18): 9678-9694. doi:10.7150/thno.116483
Full text
PDF
Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression
Lin Zhu, Xin Diao, Chenrui Yuan, Chun Man Lawrence Lau, Jianing Wang, Wenlong Wu, Ali Mobasheri, Xavier Houard, Chunyi Wen, Zongwei Cai
Theranostics 2025; 15(18): 9729-9741. doi:10.7150/thno.117788
Full text
PDF
Ultrasound spatiotemporally enables prolonged therapeutic mRNA translation in engineered bacteria for enhanced cancer immunotherapy
Zhaoyou Liu, Lantian Wang, Jieyuan An, Tian Zhou, Mengying Wei, Guodong Yang, Pengying Wu, Lijun Yuan
Theranostics 2025; 15(18): 9742-9756. doi:10.7150/thno.120342
Full text
PDF
Biofilm-disrupting heterojunction microneedles: dual ROS amplification and glucose deprivation for accelerated diabetic wound healing
Wenjie You, Feng Xiao, Zichao Cai, Jiaxin Zhao, Zhengyao Zhang, Weikang Hu, Yun Chen, Kwang Leong Choy, Zijian Wang
Theranostics 2025; 15(18): 9757-9774. doi:10.7150/thno.120787
Full text
PDF
Enhancing glymphatic transport through angiotensin II type 2 receptor activation promotes neurological recovery after traumatic brain injury
Xiaoyu Zhang, Bin Sun, Wenzhong Li, Tianyi Liu, Wenchen Li, Bo Chen, Chuan He, Qin Liu, Shoujun Zhu, Haifeng Wang
Theranostics 2025; 15(18): 9775-9792. doi:10.7150/thno.117743
Full text
PDF
Endothelial cell-derived SDF-1α elicits stemness traits of glioblastoma via dual-regulation of GLI1
Ye Yuan, Xudong Liu, Liwen Kuang, Shixue Yang, Lihong Wang, Jiao Wang, Sen Wei, Zexuan Yan, Qinghua Ma, Juan Lei, Yu Zhou, Yu Chen, Jiongming Chen, Tao Luo, Kaidi Yang, Mengsi Zhang, Yongsheng Li
Theranostics 2025; 15(18): 9819-9837. doi:10.7150/thno.108843
Full text
PDF
Naturally derived hydrogel with antioxidant, angiogenesis and photothermal effect to accelerate infected diabetic wound healing and reduce scar formation
Mengyu Yang, Pengyuan Liu, Pei Cheng, Chenghao Li, Jingmei Liu, Haifeng Sun, Fangxia Guan, Minghao Yao
Theranostics 2025; 15(18): 9838-9861. doi:10.7150/thno.117179
Full text
PDF
Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1/ATP axis to accelerate wound healing
Yujie Xiao, Zhijun Shi, Yixuan Yuan, Danna Yao, Rongqin Feng, Yue Zhang, Deli Zhao, Hao Zhang, Panpan Sun, Yang Liu, Yan Li, Xuefeng Shen, Zhantong Wang, Dahai Hu, Hao Guan, Hongtao Wang
Theranostics 2025; 15(18): 9862-9884. doi:10.7150/thno.118364
Full text
PDF
Kazald1 attenuates chondrocyte fibrosis to potentiate hyaline cartilage regeneration by interfering with the pro-fibrotic TGF-β signaling
Yue Zhu, Haoyang Liu, Yuting Zhang, Danning Zheng, Yaning Li, Jialin Chen, Jiake Xu, Wei Zhang
Theranostics 2025; 15(18): 9885-9910. doi:10.7150/thno.113604
Full text
PDF
Chemo-RaST with bortezomib inhibits multiple myeloma relapse
Anchal Ghai, Alexander Zheleznyak, Christopher Egbulefu, Nicole Blasi, Kvar Black, Rui Tang, Matthew L Cooper, Kiran Vij, Ravi Vij, John DiPersio, Monica Shokeen, Samuel Achilefu
Theranostics 2025; 15(18): 9911-9921. doi:10.7150/thno.111508
Full text
PDF
Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC
Shengnan Lv, Jian Zhang, Xinyu Peng, Huan Liu, Tongjia Chu, Ziyu Liu, Kehang Duan, Jianxiong Guo, Jie Wang, Yan Liu, Feng Wei
Theranostics 2025; 15(18): 9922-9943. doi:10.7150/thno.117202
Full text
PDF
EZH2-mediated H3K27me3 links microbial inosine loss to depression: a gut-brain epigenetic switch
Sen Zhu, Xuan Li, Ying Yu, Xiaoyi Han, Fang Yang, Mengxi Lu, Gaole Dai, Liang Guo, Dan Xu
Theranostics 2025; 15(18): 9969-9986. doi:10.7150/thno.120824
Full text
PDF
ROS-targeting heterojunction-integrated GelMA microneedles for photo-responsive antioxidative action and accelerated diabetic wound healing
Jinlan Tang, Weijun Liu, Zhengyao Zhang, Ye Yang, Wenwen Cheng, Xiaoyu Wang, Zesheng Chen, Zijian Wang, Weikang Hu
Theranostics 2025; 15(18): 9987-10006. doi:10.7150/thno.120879
Full text
PDF
Reviews
Dissecting Tertiary Lymphoid Structures in Cancer: Maturation, Localization and Density
Guang-Liang Su, Meng-Jie Zhang, Hao Li, Zhi-Jun Sun
Theranostics 2025; 15(18): 9459-9485. doi:10.7150/thno.113940
Full text
PDF
Advances and challenges in decellularized adipose tissue based composite hydrogels for adipose tissue regeneration: a review over the last fifteen years
Lu Cui, Tian-Jie Lyu, Bin Fu, Yubo Wang, Qing Qu, Fanglin Wang, Rui Guo, Jun Fan
Theranostics 2025; 15(18): 9508-9532. doi:10.7150/thno.120300
Full text
PDF
Synthetic reprogramming of tumor cell fate for modulating radiotherapy-induced dynamic responses: perspectives on radiosensitizing and immunoregulatory effects
Wei Zhou, Lulu Wang, Hui Zhang, Yongzhong Wu, Menghuan Li, Zhong Luo
Theranostics 2025; 15(18): 9533-9557. doi:10.7150/thno.119822
Full text
PDF
Hot-spot empowered gold nanoparticles for theranostics in breast cancer
Meng Tian, Shiqi Hu, Wen Sun, Ying Hu, Xingyi Ma
Theranostics 2025; 15(18): 9695-9728. doi:10.7150/thno.119678
Full text
PDF
The pathophysiology of mixed Alzheimer's disease and vascular dementia
Mutaz Sarhan, Christian Wohlfeld, Ariel Perry-Mills, Jeffrey Meyers, James Fadel, E. Angela Murphy, Leonardo Bonilha, Daping Fan
Theranostics 2025; 15(18): 9793-9818. doi:10.7150/thno.118737
Full text
PDF
GM-CSF+ Th: a central player in autoimmunity
Sha-Sha Fan, Xuan Xu, Yu-Bin Luo, Xiang-Yu Meng, Yi Liu
Theranostics 2025; 15(18): 9944-9968. doi:10.7150/thno.121766
Full text
PDF