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Volume 16 (1); 2026

Research Papers

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Affibody-based optical imaging probe for noninvasive detection of liver fibrosis
Raana Kashfi Sadabad, Paul Stephen Marinec, Lawrence Lechuga, Robert Thompson, Ran Cheng, Ashmita Saigal, Irodiel Vinales, Salomon Martinez, Allan Eduardo Solis, Emily Melody Tso Newman, Una Goncin, Christopher Novotny, Corey Miller, Chih-Liang Chin
Theranostics 2026; 16(1): 1-16. doi:10.7150/thno.117262
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Development of a nanoparticle-based immunotherapy targeting CD137 for nasopharyngeal carcinoma treatment
Kang Yi Lee, Heng Sun, Yu Mei, Emily Nickles, Clemence Wei Xia Lai, Sashigala Ponnalagu, Mukul Prasad, Haiyan Liu, Herbert Schwarz
Theranostics 2026; 16(1): 17-36. doi:10.7150/thno.116136
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Antibody-induced internalization and degradation of PLA2R amplifies CD4+ T cell activation
Yuning Liu, Yinyin Li, Hui Zhou, Jieli Yu, Pei Deng, Weiwei Xu, Bingqian Pan, Lei Zhang, Hong Zhou, Jing Zhang, Xiaohan Liu, Min Shi, Xianchi Dong, Bei Tong, Enguang Bi, Nannan Guo, Yu Hu
Theranostics 2026; 16(1): 37-57. doi:10.7150/thno.123035
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Multifunctional macrophage mimetic nanoplatform modulates vascular and epithelial double gut barriers to alleviate ulcerative colitis
Weijian Cheng, Yixi Zhu, Miaoxizi Luo, Xiao Wang, Quanlong Chen, Siyao Li, Jing Xian, Meng Xiao, Licheng Liu, Yuanyuan Wang, Chaomei Fu, Ruibing Wang, Qian Cheng, Jinming Zhang
Theranostics 2026; 16(1): 58-76. doi:10.7150/thno.118236
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Inflammation Cascade-Directed Therapy by Biomimetic Polydopamine Nanosystem for Long-Term Management of Ischemic Stroke
Yuyi Zheng, Xiaojie Chen, Qi Zhang, Ziwei Xu, Yixuan Gan, Jing Zhou, Wenlu Li, Yi Wang, Zhong Chen, Di Wu
Theranostics 2026; 16(1): 77-98. doi:10.7150/thno.118196
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Targeting the ARL4C/RAP1/PI3K-Akt-mTOR signaling loop promotes ARL4C ubiquitination and reverses oxaliplatin resistance in colorectal cancer
Yang Wang, Zewen Chang, Ziquan Sun, Lu Wang, Jingtao Li, Guodong Li, Yuliuming Wang, Jinning Zhang, Lianjie Ai, Zhongxu Zhang, Jiaojiao Dong, Ming Liu
Theranostics 2026; 16(1): 99-122. doi:10.7150/thno.117590
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Quantitatively controlled and measured-traumatic brain injury impairs adult neurogenesis and alters neuropathological signatures in mice
Sungwook Yang, Suhyun Kim, Uiyeol Park, Hyeonjoo Im, Hyesun Cho, Kyung Eun Lee, Junsang Yoo, Seung Jae Hyeon, Se Jeong Lee, Im Joo Rhyu, Junghee Lee, Ann C. McKee, Eui-Sung Yoon, Hoon Ryu
Theranostics 2026; 16(1): 193-219. doi:10.7150/thno.114693
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A convective transport-enhanced multi-organoid device for therapeutic modeling of the liver-pancreas axis in obesity
Jisu Kim, Jungho Bae, Baofang Cui, Seung-Woo Cho, Kisuk Yang
Theranostics 2026; 16(1): 220-238. doi:10.7150/thno.114415
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PTBP1-mediated inhibition of circular RNA SCMH1 biogenesis impairs brain recovery after ischemic stroke
Ying Bai, Bing Han, Yi Zhang, Liying Wen, Chang Liu, Yu Wang, Jiafang Cui, Bingjing Zheng, Ningbo Cai, Lian Xu, Ling Shen, Yuan Zhang, Honghong Yao
Theranostics 2026; 16(1): 239-253. doi:10.7150/thno.114179
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Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy
Yishuang Li, Zhihong Zhou, Yonghui Lv, Haoneng Hu, Ming Chen, Kunjian Lei, Chuandong Gong, Junzhe Liu, Lufei Yang, Linzhen Huang, Wenji Liu, Jinying Li, Minhua Ye, Xingen Zhu, Kai Huang
Theranostics 2026; 16(1): 254-271. doi:10.7150/thno.114005
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Enhancer-mediated NR2F2 recruitment activates BGN to promote tumor growth and shape tumor microenvironment in papillary thyroid cancer
Mei Tao, Xianhui Ruan, Jialong Yu, Qiman Dong, Wei Luo, Wei Zhang, Mengran Tian, Xiukun Hou, Linfei Hu, Jingzhu Zhao, Dapeng Li, Jie Hao, Songfeng Wei, Xiangqian Zheng, Ming Gao
Theranostics 2026; 16(1): 298-324. doi:10.7150/thno.113712
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Dissolvable microneedles loaded with denosumab alleviate knee osteoarthritis in rodent and canine models by inhibiting macrophage senescence
Chaochang Ming, Duohang Bi, Hongtao Tian, Weijian Liu, Haitao Li, Yuxiang Hu, Zhenyu Song, Dongdong Xu, Hao Xu, Hongyan Li, Shenghui Lan, Weihua Xu, Wei Chen, Qiong Li, Jiawei Feng, Qianqian Cao, Xiaoyang Wang, Panlong Fan, Jintao Zhu, Wei Yu, Chaoge Ming, Zhipeng Dai, Yijing Liu, Wei Tong
Theranostics 2026; 16(1): 325-344. doi:10.7150/thno.116970
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Pathologically responsive ZnSrMo-LDH/Cu nanozymes with cascade antioxidant and angiogenic functions for myocardial ischemia-reperfusion treatment
Jian Xu, Susu Zhang, Yu Yang, Xingwei Wei, Yunteng Fang, Zhilin Wang, Linwen Lan, Jiayi Shen, Enqian Liu, Wuming Hu, Tingting Hu, Chaojie Yu, Ruizheng Liang, Lingchun Lyu
Theranostics 2026; 16(1): 398-416. doi:10.7150/thno.118420
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The talin1-p53 axis inhibits osteocyte senescence to promote bone mass and mediate skeletal adaptation to mechanical stimulation
Jianmei Huang, Lei Qin, Yishu Wang, Qinnan Yan, Haonan Yang, Haojin Chen, Mingyue Wu, Weihong Yi, Jiaming Yang, Sixiong Lin, Weiyuan Gong, Peijun Zhang, Shuangshuang He, Xinzhou Zhang, Guozhi Xiao
Theranostics 2026; 16(1): 465-482. doi:10.7150/thno.123532
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Biomimetic core-shell GelMA microspheres co-delivering ANXA1, NGF, and fibronectin enable phase-matched immunomodulation and neurorepair after spinal cord injury
Youjun Liu, Chunping Hu, Siyuan He, Renfeng Liu, Yuqi Zhao, Yuhao Wang, Hailiang Xu, Hui Li, Yanming Ma, Botao Lu, Yixiang Ai, Cheng Ju, Weidong Wu, Yifan Wang, Dageng Huang, Dingjun Hao, Zhiyuan Wang, Baorong He, Lei Zhu
Theranostics 2026; 16(1): 483-515. doi:10.7150/thno.120426
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Reviews

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Neutrophil-based delivery platforms: from natural mechanisms to engineered therapeutics
Yinggang Li, Xue Zhang, Yunkun Li, Ling Sun, Na Hu, Su Lui, Zhenyu Duan, Qiyong Gong, Kui Luo
Theranostics 2026; 16(1): 123-155. doi:10.7150/thno.117363
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Advancements in CRISPR-based therapies for ocular pathologies: from disease mechanisms to intervention strategies
Qinghua Li, Qingdong Bao, Sihan Zhao, Fan Wu, Yang Li, Kaiyuan Wang, Wenlong Li, Hua Gao
Theranostics 2026; 16(1): 156-192. doi:10.7150/thno.117085
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The application of nanotechnology in regulating mitochondrial function in tumor microenvironment for cancer therapy
Dazhong Wang, Meng Yuan, Ji Liu, Ming Zhao, Ting Fang
Theranostics 2026; 16(1): 272-297. doi:10.7150/thno.121956
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FGF19 in Solid Tumors: Molecular Mechanisms, Metabolic Reprogramming, and Emerging Therapeutic Opportunities
Jiayi Xu, Peng Sun, Wenjing Zhu, Xinlin Liu, Leina Ma
Theranostics 2026; 16(1): 345-397. doi:10.7150/thno.121601
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State-of-the-art boron clusters for boron neutron-capture therapy
Weiyao Wang, Enze Zhang, Jiaojiao Shan, Min Zhang, Renwei Cai, Runze Li, Lulian Pang, Baosheng Li, Dejin Zang
Theranostics 2026; 16(1): 417-464. doi:10.7150/thno.123376
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Recent advances and challenges in hydrogel-based delivery of immunomodulatory strategies for diabetic wound healing
Longyu Du, Chuanlu Lin, Haifeng Hu, Yanzhi Zhao, Jiewen Liao, Fawwaz Al-Smadi, Bobin Mi, Yiqiang Hu, Guohui Liu
Theranostics 2026; 16(1): 516-544. doi:10.7150/thno.117949
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Engineering exosomes for targeted neurodegenerative therapy: innovations in biogenesis, drug loading, and clinical translation
Qinqin Huang, Shile Wang, Zeming Liu, Lang Rao, Ke Cheng, Xiaobo Mao
Theranostics 2026; 16(1): 545-579. doi:10.7150/thno.117143
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