Volume 16, Issue 2

open access Global reach, higher impact

Volume 16 (2); 2026

Research Papers

Artesunate nanoliposome-hydrogel: a dual-modal therapy for post-surgical melanoma
Hongmei Chen, Zhongke Wang, Ying Huang, Aodi Li, Xinlei Xiong, Yifan Pu, Ling Guo
Theranostics 2026; 16(2): 580-598. doi:10.7150/thno.120793
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ROS-responsive graphene-hyaluronic acid nanomedicine for targeted therapy in renal ischemia/reperfusion injury
Seungjun Lee, Sang Heon Suh, Seong Kwon Ma, Junghyun Kim, Sehyeon Park, Soo Wan Kim, Jae Young Lee
Theranostics 2026; 16(2): 618-636. doi:10.7150/thno.120560
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Enhancing cancer susceptibility to disulfidptosis by inducing cell cycle arrest and impairing DNA repair
Jing Lin, Xueli Yang, Cizhong Jiang, Xiaoguang Liu, Jiejun Shi
Theranostics 2026; 16(2): 637-650. doi:10.7150/thno.122956
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Tumor mRNA-lipid nanoparticles via chimeric nanobody-lipid co-assembly
Chuandong Zhu, Jing Wang, Md. Mofizur Rahman, Yun Zhang, Lixue Wang, Yuan Wan
Theranostics 2026; 16(2): 651-667. doi:10.7150/thno.123633
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Piezo1 induces Wnt7b⁺ astrocytes transformation to modulate glial scar stiffness and neuro-regeneration after stroke
Shengju Wu, Wenjie Hao, Qian Suo, Qijie Lu, Ze Liu, Yang Qianbo Yao, Rubing Shi, Khan Haroon, Yuewei Chen, Xinfa Shao, Qinqin Wang, Chen Li, Qun Xu, Wanlu Li, Yaohui Tang, Guo-Yuan Yang, Zhijun Zhang
Theranostics 2026; 16(2): 668-688. doi:10.7150/thno.120838
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CCL5 promotes angiotensin II-induced cardiac remodeling through regulation of platelet-driven M2 macrophage polarization
Silin Lv, Mingxuan Zhou, Tiegang Li, Zifan Zeng, Zheng Yan, Yufang Hou, Liu Yang, Fang Zhang, Wenyi Zhao, Yixin Zhou, Min Yang
Theranostics 2026; 16(2): 689-711. doi:10.7150/thno.112163
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Tumor microenvironment-triggered aggregation of semiconducting polymer nanochangers for self-programable theranostics of orthotopic glioma
Zheming Song, Li Li, Anni Zhu, Danling Cheng, Yuyun Zhong, Zhiming Zheng, Cong Song, Jingchao Li, Zhong Guo
Theranostics 2026; 16(2): 794-809. doi:10.7150/thno.123074
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Downregulation of PCYT2 by increased portal pressure safeguards liver regeneration after partial hepatectomy
Guangyin Pu, Yayue Song, Qiushi Li, Jinjie Duan, Guangyan Wang, Wenjing Xiu, Jingwen Xu, Xiaoyu Zhao, Wenhui Dong, Tingting Lan, Rong Ai, Jingyi Zhang, Weiyan Sun, Deling Kong, Yi Zhu, Xu Zhang, Yang Liu, Chunjiong Wang
Theranostics 2026; 16(2): 810-829. doi:10.7150/thno.118755
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Reactive oxygen species/hypoxia dual-responsive polymers combined with melatonin inhibited PANoptosis of retinal ganglion cells for acute glaucoma treatment
Shuhan Meng, Weizhou Fang, Yukun Wu, Zhaohua Xia, Tiansheng Chou, Yang Xia, Lexi Ding, Xuezhi Zhou, Xiaobo Xia
Theranostics 2026; 16(2): 830-851. doi:10.7150/thno.112836
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Sequential release of bioactive factors from functionalized metal-organic framework hydrogel enhances interfacial osseointegration of 3D-printed titanium alloy porous scaffolds
Zhenjia Che, Xiao Sheng, Yanglin Wu, Binghao Lin, Kaihang Song, Qiyun Chen, Aopan Chen, Lingxuan Deng, Jing Chen, Ming Cai
Theranostics 2026; 16(2): 852-875. doi:10.7150/thno.120711
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Nuclear deformation acts as a mechanical switch to drive breast cancer cell migration in a confined microenvironment
Meng Wang, Xiaodie Li, Boyang Li, Hanyu Guo, Zihan Zhao, Xiyue Sun, Wei Yan, Yubo Tan, Jinyi Liu, Yungchang Chen, Shun Li, Tingting Li, Xiaozhen Dai, Xiang Qin, Yiyao Liu
Theranostics 2026; 16(2): 898-914. doi:10.7150/thno.119211
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rTMS-induced motor cortex activation drives neural network tissueoid mediated spinal motor neural pathway reconstruction
Jing Xu, Yue Yang, Zhen Chen, Jia-Lin Liu, Xiang-Yu Liu, Ming-Yu Lv, Yu-Jian Lin, Jia-Wei Sun, Xiang Zeng, Yuan-Huan Ma, Ge Li, Yi-Nan Guo, Shang-Bin Yang, Miao Tian, Yu Cheng, Rui Liu, Ling Zhang, Xing Li, Xiang Zhou, Yuan-Shan Zeng, Ying Ding, Bi-Qin Lai
Theranostics 2026; 16(2): 915-935. doi:10.7150/thno.117789
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Neural stem cell-loaded biohybrid hydrogel improves cochlear implants by electrode-neural coupling and neural regeneration
Menghui Liao, Xin Zhou, Hao Wei, Yanru Qi, Pan Feng, Xin Gao, Yangnan Hu, Yuyang Qiu, Yusong Wang, Hongbo Yang, Zhonghong Zhang, Zhongze Gu, Renjie Chai
Theranostics 2026; 16(2): 936-951. doi:10.7150/thno.120515
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Cell-free secretome of CD56^brightCD16^bright directly reprogrammed NK cells enhances wound healing via CCL3/4/5-CCR5 signaling
Jae Yun Kim, Han-Seop Kim, Binna Seol, Ji Eun Choi, Ji-Young Lee, Yee Sook Cho
Theranostics 2026; 16(2): 952-969. doi:10.7150/thno.120219
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Longitudinal in vivo (R)-[¹⁸F]FBFP PET imaging for preclinical evaluation of cerebral sigma-1 receptor after ischemic stroke
Jingfei Yang, Luoxia Liu, Huimin Zhou, Chuanzhi Huang, Dongdong Wang, Ziqiang Wang, Yifan Shi, Shuang Song, Xiaoyun Deng, Yuankai Zhu, Jun Zhao, Zhouping Tang, Hongmei Jia, Xiaohua Zhu
Theranostics 2026; 16(2): 970-985. doi:10.7150/thno.117418
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Single-cell RNA sequence analysis reveals USP32 as a therapeutic target to mitigate PD-L1-driven colorectal tumorigenesis in vitro and in vivo
Girish Birappa, Haribalan Perumalsamy, Seok-Ho Hong, D. A. Ayush Gowda, Arun Pandian Chandrasekaran, Janardhan Keshav Karapurkar, Sripriya Rajkumar, Sri Renukadevi Balusamy, Aparna Jayachandran, Kwang-Hyun Baek, Junwon Lee, Viswanathaiah Matam, Woo Jin Kim, Kye-Seong Kim, Suresh Ramakrishna, Bharathi Suresh
Theranostics 2026; 16(2): 986-1005. doi:10.7150/thno.117900
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A novel mouse cell line model reveals the tumor intrinsic and immune characteristics of EGFR-mutant lung cancer
Yueren Yan, Jun Shang, Chunnan Liu, Yuting Chen, Yufang Bao, Yue Zhao, Fanfan Fan, Yifu Sun, Yudi Zhou, Yuke Wu, Yongbo Wang, Han Han, Haiquan Chen, Yunjian Pan
Theranostics 2026; 16(2): 1006-1022. doi:10.7150/thno.118234
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Accelerated cartilage regeneration via chondrocyte metabolic reprogramming using nano-steroid-conjugated mesenchymal stem cells in osteoarthritis
Jong Yeong Lee, Jun Young Park, In Ah Kwon, Su Hyun Lim, Ki Bum Kim, Jun-Young Park, Youn Joo Kang, Sang-Hyun Kim, Dongwoo Khang, Jin Kyeong Choi
Theranostics 2026; 16(2): 1023-1044. doi:10.7150/thno.120765
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Lachnospira eligens attenuates epileptogenesis via gut-brain axis regulation of blood-brain barrier integrity and neuroinflammation
Huifeng Li, Ruili Niu, Wenzhen He, Huanling Lai, Shangnan Zou, Qihang Zou, Yue Gui, Tengyue Zhang, Guoyun Feng, Yue Xing, Dehai Gou, Xiaofeng Yang
Theranostics 2026; 16(2): 1045-1062. doi:10.7150/thno.116959
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Aggregation-induced emission of DNA fluorescence as a novel pan-marker of cell death, senescence and sepsis in vitro and in vivo
Yiling Hu, Xiaoyan Wang, Ke Lu, Chonin Cheang, Yichen Liu, Yaru Zhu, Liming Xie, Moxin Li, Qingqing Zhou, Wenshan Yan, Ying Hou, Hongjie Zhang, Weiming Zheng, Changhuo Xu, Xiuping Chen, Han-Ming Shen, Zhen-Ju Huang, Yi-Hao Chen, Yi Zhou, Pei-Lin Cai, Hao Zhong, Lu Liu, Xi-Ping Wu, Xingxing Liu, Xiaolin Li, Ning Zeng, Yehuda G. Assaraf, Tzu-Ming Liu
Theranostics 2026; 16(2): 1063-1081. doi:10.7150/thno.122009
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Reviews

The efficacy of oligonucleotide-based gene therapeutics in gene silencing
Christina Patra, Zain Hussein, Veronika D. Ace, Elena V. Misnik, Daria S. Rybalko, Adeliia A. Salimova, Daria S. Ereshko, Mikhail V. Dubovichenko, Moustapha A.Y. Nour, Valeriia S. Drozd, Dmitry M. Kolpashchikov
Theranostics 2026; 16(2): 599-616. doi:10.7150/thno.121775
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Endocrine nanozymology: Nanozyme applications in diabetes, obesity, and hormonal disorders
Huilun Lu, Zizhong Liu, Ya-chao Wang, Eudald Casals, Felicia A Hanzu, Manuel Morales-Ruiz, Muling Zeng, Gregori Casals
Theranostics 2026; 16(2): 712-735. doi:10.7150/thno.122577
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Integrative bioengineering strategies for endometrial regeneration: From biomaterials and stem cells to organoids and organ-on-a-chip technologies
Soo-Rim Kim, Hwa-Yong Lee
Theranostics 2026; 16(2): 736-775. doi:10.7150/thno.123298
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Neuro-lymphaphotonics opens new horizons of the future technologies for the therapy of brain diseases
Shaojun Liu, Oxana Semyachkina-Glushkovskaya, Tingting Yu, Egor Ilukov, Edik Rafailov, Sergey Sokolovski, Jürgen Kurths, Dan Zhu
Theranostics 2026; 16(2): 776-793. doi:10.7150/thno.120374
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AI and organoid platforms for brain-targeted theranostics
Rui Ye, Yupei Zhang, Wan Xu, Li Lai, Zhongwei Zhang, Yan Chen, Shugang Qin
Theranostics 2026; 16(2): 876-897. doi:10.7150/thno.123243
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