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Volume 16 (3); 2026
Research Papers
Engineered nanoconjugates for simultaneous detection and degradation of stroke-associated microthrombi Audrey Picot, Charlène Jacqmarcq, Célia Seillier, Sara Martinez de Lizarrondo, Maxime Gauberti, Ankita Talukdar, Igor Khalin, Clarisse Mouriaux, Pierre Mangin, Didier Goux, Peter Schmidt, Denis Vivien, Thomas Bonnard
Theranostics 2026; 16(3): 1082-1102. doi:10.7150/thno.119705
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Deep learning identifies TP-41 for methylglyoxal scavenging in Alzheimer's treatment Aron Park, Seong-Min Hong, Yeeun Lee, Jungeun Lee, Seunggyu Jeon, Seung-Yong Seo, Jinhyuk Lee, Seon-Hyeok Kim, Eun Ji Ko, Hae Ran Lee, Sang Heon Jung, Munhyung Bae, Min Cheol Kang, Myoung Gyu Park, Seungyoon Nam, Sun Yeou Kim
Theranostics 2026; 16(3): 1103-1122. doi:10.7150/thno.111550
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High-sensitivity spin-exchange relaxation-free (SERF) magnetometry combined with magnetic-responsive iron oxide nanoparticles for real-time monitoring of malignant tumor therapy Wenbo Wang, Gaorui Zhang, Baosheng Wang, Dawei Zhou, Ning Ding, Ziyuan Huang, Shiqiang Zheng, Qichao Cheng, Mingchuan Yu, Min Xiang, Yuguo Chen, Jiazhi Duan, Dexin Yu
Theranostics 2026; 16(3): 1123-1142. doi:10.7150/thno.117893
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Prognostic implications of [¹⁸F]FDG PET and metabolic changes in patients with advanced metastatic neuroendocrine tumors undergoing rechallenge PRRT: final results from a multicenter 10-year survival WARMTH study Giulia Santo, Margarida Rodrigues, Diana Paez, Olga Morozova, Levent Kabasakal, Kalevi Kairemo, Chiara Maria Grana, Richard P. Baum, Gianpaolo di Santo, Irene J. Virgolini
Theranostics 2026; 16(3): 1227-1237. doi:10.7150/thno.123273
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Mertk promotes early microglial-mediated synaptic engulfment in Alzheimer's disease Yifan Wu, Yuanteng Fan, Shisan Bao, Yinghao Song, Ruizhu Wang, Jiaxuan Wu, Xuan Liu, Jingwen Jin, Lingchen Kong, Baohua Hou, Peiyu Liang, Taoxiang Chen, Wanhong Liu, Biwen Peng, Fanggang He, Ying Zhou, Jian Xu, Yun Chen, Song Han, Jun Yin, Xiaohua He
Theranostics 2026; 16(3): 1238-1261. doi:10.7150/thno.116797
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“Electron transport chain interference” strategy of amplified bacterial ferroptosis and defect-engineered nanozyme for diabetic wound healing Yanlan Xie, Huan Wang, Yalan Wang, Jiajie Liu, Jinming Tong, Tao Wu, Li Yin, Chuan Zhang, Long Zhao, Yuan Yong
Theranostics 2026; 16(3): 1262-1280. doi:10.7150/thno.121636
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Precision targeting of FDX1-mediated cuproptosis by a ROS-responsive hydrogel for myocardial ischemia-reperfusion injury treatment Jiayi Hu, Xiaoyi Bao, Meihua Ting, Yecheng Tao, Ran Li, Guosheng Fu, Fuyu Qiu, Jing Zhao, Wenbin Zhang
Theranostics 2026; 16(3): 1281-1294. doi:10.7150/thno.120455
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Targeting NDUFS8 in basal forebrain ameliorates cognitive decline related to chronic cerebral hypoperfusion Yang Qu, Xiaoting Xu, Xuqiao Wang, Jinan Yang, Liye Zhang, Tao Wang, Xin Tang, Wei Cheng, Jing Li, Jing Ma, Yan Wu, Wentao Xu, Qin Wang, Lu Zeng, Xiaobin An, Dongyang Wang, Meijie Chen, Guitian Cong, Yonghui Wu, Bin Sun, Jing Ai
Theranostics 2026; 16(3): 1328-1349. doi:10.7150/thno.117635
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Synergistic chemodynamic and metabolic reprogramming-based cancer therapy by CuO@HA nanozymes with oxygen vacancy Weiwei Wang, Yuxuan Cai, Zhongxing Wang, Haoyang Song, Tangbin Hu, Ying Jia, Maoxiao Feng, Juyoung Yoon, Qiongzheng Hu, Yunshan Wang
Theranostics 2026; 16(3): 1374-1385. doi:10.7150/thno.119806
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Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation Lushuang Mao, Zhao-fu Liao, Dong Tang, Yumin Qiu, Min Yang, Yanshang Li, Yituan Xie, Weimin Feng, Ze-jun Zheng, Xiao-meng Liu, Jing-ru Ye, Shui-hong Lu, Xin-bin Tang, Ming Shi, Yun-fei Qu, Heng Li, Zhu-guo Wu, Shun Xu, Xinguang Liu, Junjun Ding, Jian-jun Xie, Jun Tao, Xing-dong Xiong
Theranostics 2026; 16(3): 1386-1409. doi:10.7150/thno.119709
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PINK1/Parkin promotes liver regeneration via Sigma-1 ubiquitination to inhibit ER-Mitochondrial calcium transfer Jian Xu, Yuechen Wang, Weizhe Zhong, Haoran Hu, Ye Zhang, Yiyun Gao, Ping Wang, Zhuqing Rao, Haoming Zhou, Xuehao Wang
Theranostics 2026; 16(3): 1410-1431. doi:10.7150/thno.115726
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Limitation-circumventing and strength-capitalizing hydrogel potentiates durable antitumor immunity and robust abscopal effect in radiotherapy Haijun Li, Xianzhou Huang, Jin Yang, Liping Bai, Meiling Shen, Yaqin Zhao, Changyang Gong, Yanjie You, Qinjie Wu
Theranostics 2026; 16(3): 1432-1444. doi:10.7150/thno.118974
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A temporally functional composite hydrogel scaffold for cranial defect repair via sequential modulation of angiogenesis and osteogenesis Zongqiang Lv, Bo Sun, Rong Li, Bowen Zhao, Hongxiang Wang, Ning Luo, Xin Ding, Xuan Tang, Chunlin Wang, Long Bai, Jiacan Su, Juxiang Chen
Theranostics 2026; 16(3): 1445-1465. doi:10.7150/thno.119835
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Spatially selective clearance of inflammation-mediated reactive oxygen species in injured kidney cells Maowei Xie, Xin Fu, Yufei Lan, Yuping Zhang, Haixin Li, Yan Su, Kun Zhou, Ying Zhang, Xuejing Ding, Jian He, Zhilei Mao
Theranostics 2026; 16(3): 1466-1481. doi:10.7150/thno.112905
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Engineering and evaluation of precision-glycosylated clickable albumin nanoplatform for targeting the tumor microenvironment Ji Yong Park, Jinyeong Choi, Jeongbin Park, Jin Sil Kim, Young Chan Ann, Hyewon Chung, Jisu Park, Jiyoon Kim, Seung Hyeok Seok, Hongyoon Choi, Hyung-Jun Im, Yun-Sang Lee
Theranostics 2026; 16(3): 1482-1503. doi:10.7150/thno.123973
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Systemic targeting of aberrant neovascular tufts using trehalose-dendrimer nanocarriers for the treatment of proliferative retinopathies Anu Rani, Shivantika Bisen, Rishi Sharma, Aqib Iqbal Dar, Anamika Sharma, Anubhav Dhull, Nina Palmer, Kenneth John Goody, Nikhlesh K Singh, Anjali Sharma
Theranostics 2026; 16(3): 1504-1527. doi:10.7150/thno.120357
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Targeted Accumulation of Reactive Acrolein via Nanoparticle-embedded Reverse Temperature Hydrogel for Bladder Cancer Treatment Yingying Xu, Qinglong Du, Zhongwei Zhao, Shuai Fu, Aijing Zhang, Jianguo Zheng, Chengyang Zhao, Yuxiang Meng, Hanru Liu, Zongyao Lv, Xin Qin, Huimin Geng, Nengwang Yu
Theranostics 2026; 16(3): 1528-1544. doi:10.7150/thno.119307
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Nanosensitizer for enhanced radiotherapy via tumor microenvironment reshaping and ROS amplification Junchao Qian, Yijun Lu, Dandan Wang, Shichuan Zhong, Xiao Liu, Xin Lai, Ziwen Wei, Guangyu Ju, Jinying Yang, Zimeng Wang, Kaiwei Wang, Yue Li, Hongcang Gu, Jian You, Shuanghu Yuan
Theranostics 2026; 16(3): 1577-1593. doi:10.7150/thno.112311
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CD45⁺ hybrid circulating cells may reflect tumor-immune interactions and serve as transcriptomic indicators of metastatic potential in prostate cancer Baek Gil Kim, Yeonsue Jang, Min Gyu Kim, Dongwook Song, Jungchan Jung, Jihee Jung, Ayoung Yoo, Jongsoo Lee, Nam Hoon Cho, Hyeong Jung Woo, Woon-Hae Kim, Hyun Young Shin, Minseok S. Kim, Hyun Ho Han, Jae Young Joung
Theranostics 2026; 16(3): 1594-1612. doi:10.7150/thno.122226
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MIF-expressing tumor cells mediate immunotherapeutic resistance in esophageal squamous cell carcinoma Jing Song, Xiaomei Song, Yue Xie, Hong Guo, Yupeng Cun
Theranostics 2026; 16(3): 1613-1629. doi:10.7150/thno.118269
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Reviews
Short-chain fatty acids in the tumor microenvironment: from molecular mechanisms to cancer therapy Yan Xiang, Ao Du, Zhen Wang, Hongyuan Pan, Kefei Yuan
Theranostics 2026; 16(3): 1143-1163. doi:10.7150/thno.119304
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Advances in the engineering of living probiotics for cancer immunotherapy Sibtain Muhammad, Menglong Li, Qingyun Jia, Muhammad Ijaz, Shiqi Liang, Wenjun Zeng, Dongxiang Chen, Yinghe Zhang, Xuelian Du, Wencong Song, Bing Guo
Theranostics 2026; 16(3): 1164-1226. doi:10.7150/thno.125301
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Design of prodrugs with reactive oxygen species as activators and their application in tumor therapy Jiaqi Xing, Wenjuan Lu, Yubing Zhang, Chen Yang, Jikai Yang, Jing Shi, Yanfeng Wang
Theranostics 2026; 16(3): 1295-1327. doi:10.7150/thno.121977
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Metal homeostasis as a therapeutic lever: advancing metalloimmunology to remodel the tumor microenvironment and enhance cancer immunotherapy Xin Chen, Qi Wang, Hongxia Zhang, Ye Wang, Haiying Zhu
Theranostics 2026; 16(3): 1350-1373. doi:10.7150/thno.121988
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Nanomedicine for targeting cancer-associated fibroblasts in cancer therapy Zi-Yi Chen, Han-Zhe Liu, Zheng-Jun Shang, Guo-Feng Luo, Xian-Zheng Zhang
Theranostics 2026; 16(3): 1545-1576. doi:10.7150/thno.120283
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