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Volume 16 (4); 2026

Research Papers

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Intra-arterial peptide receptor radionuclide therapy (IA-PRRT) in patients with SSTR-expressing neuroendocrine neoplasms: short- and long-term safety and efficacy for up to 13 years
Jingjing Zhang, Birger Mensel, Richard P. Baum
Theranostics 2026; 16(4): 1658-1670. doi:10.7150/thno.112012
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An integrated ultrasound-guided focused ultrasound system enables spatiotemporal control of thermal gene activation in engineered immune cells
Jeungyoon Lee, Melissa Cadena, Myeongsoo Kim, Seoyoon Song, Ali Zamat, Gabriel A. Kwong, Stanislav Y. Emelianov
Theranostics 2026; 16(4): 1671-1680. doi:10.7150/thno.118405
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Mitochondria-specific targeting of noncanonical EGR1 ntmRNA-coordinated mitophagy receptor BNIP3 homodimerization disrupts mitochondrial metabolism and suppresses hepatocellular carcinoma growth in vitro and in vivo
Yan Li, Lei Zhou, Mengmeng Liu, Hui Li, Ying Meng, Xue Wen, Yijing Zhao, Shanshan Liu, Zi Yan, Changhao Fu, Shan Zong, Wei Li, Andrew R. Hoffman, Jiuwei Cui, Ji-Fan Hu
Theranostics 2026; 16(4): 1681-1700. doi:10.7150/thno.117745
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Impairment of mitochondrial quality control exacerbates diabetes-related atrial fibrillation by cGAS-STING signaling pathway and cardiomyocyte-macrophage crosstalk
Shan Meng, Jinfeng Duan, Jikai Zhao, Zijun Zhou, Boxuan Sun, Yinli Xu, Tao Huang, Tao Hong, Xin Chen, Tong Su, Liming Yu, Huishan Wang
Theranostics 2026; 16(4): 1701-1719. doi:10.7150/thno.124140
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An organolutetium nanosensitizer synergizes with PARP inhibition to unleash STING-mediated immunity for low-dose radioimmunotherapy
Bingchun Zeng, Kai Ling, Qingpeng Yuan, Zeyang Chen, Guangrong Zhang, Wenyue Kang, Xuanjun Zheng, Chuanghong Liao, Youqing Mai, Zhongjie Huang, Ruibin Huang, Tiantian Zhai, Hongyan Jiang
Theranostics 2026; 16(4): 1720-1739. doi:10.7150/thno.124034
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Targeting CPS1 attenuates lung cancer metastasis by regulating EMT through an epigenetic mechanism
Yi Ding, Yuying Tian, Mengjuan Li, Yunyun Fu, Tingting Wang, Xiaoyao Du, Mingming Wang, Lele Dong, Fei Gao, Bei Liu, Yunhan Lu, Chenfei Zhang, Lin Mao, Jinhua Jiang, Lei Li, Lujian Liao, Kun Li
Theranostics 2026; 16(4): 1740-1761. doi:10.7150/thno.123679
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A novel TM4SF4-targeting therapeutic antibody candidate with antitumor activity by blocking IGF1R and CD44 signaling and downregulating PD-L1 and B7-H4
Rae-Kwon Kim, Chang-Kyu Heo, Mun Ju Choi, Yeon-jee Kahm, Min Kyu Kim, Minyong Lee, Ji Yoon Lee, Hwangseo Park, Uhee Jung, Byung-Chul Shin, Bum-Jin Kim, Sung-Chul Kim, Eun-Wie Cho, Chun Jeih Ryu, In-Gyu Kim
Theranostics 2026; 16(4): 1762-1781. doi:10.7150/thno.113347
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Lactylation-driven NSUN2-mediated RNA m5C modification promotes perineural invasion in pancreatic cancer
Tianhao Huang, Chonghui Hu, Huimou Chen, Honghui Jiang, Tingting Li, Qing Tian, Rihua He, Yuan Yuan, Yong Jiang, Yu Zhou, Qing Lin, Zhihua Li, Mingming Xiao, Xuebiao Wei, Rufu Chen, Shangyou Zheng
Theranostics 2026; 16(4): 1782-1803. doi:10.7150/thno.122294
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Emergence of a barium metal-organic framework for mitigating off-target effects of alpha radionuclide therapy
Long Qiu, Jie Lyu, Yuqi Guo, Shilong Shi, Xijian Chen, Junshan Geng, Qian Xiao, Jiali Liao, Yuanyou Yang, Jinsong Zhang, Ning Liu, Feize Li
Theranostics 2026; 16(4): 1804-1817. doi:10.7150/thno.121316
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Glutathione-depleting photosensitizers for tumor-specific imaging and pyroptosis-driven photodynamic therapy
Hui Yang, Yifei Yang, Zhengyumeng Zhu, Pei Chen, Jucai Gao, Yajun Lin, Qiang Wang, Fang Hu
Theranostics 2026; 16(4): 1818-1832. doi:10.7150/thno.124154
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Long-acting management of diabetes and associated complications using an injectable thermosensitive hydrogel incorporating IgG-conjugated GLP-1RA
Hancheng Wang, Zhiyong Chen, Siyi Gu, Yaoben Wang, Yang Wang, Caiyun Gao, Jiayue Shi, Jiandong Ding, Qinghua Wang, Lin Yu
Theranostics 2026; 16(4): 1833-1854. doi:10.7150/thno.120844
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Pharmacologically inherited carbon dots from Salvia miltiorrhiza with potent antioxidant activity and multi-pathway modulation for myocardial ischemia-reperfusion injury therapy
Kai Zhang, Zhenyuan Wang, Letong Zhang, Hao Wu, Jing Liu, Mingzhen Zhang, Zhichao Deng, Ruina Liu
Theranostics 2026; 16(4): 1855-1876. doi:10.7150/thno.123141
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CD146+ pericyte-like lung cancer brain metastatic stem cells promote tumor angiogenesis through dual regulatory effects on the VEGF/VEGFR axis
Wenwen Liu, Wenzhe Duan, Shengkai Xia, Ye Liu, Huiying Chu, Kun Liang, Shaobo Fang, Manqing Lin, Song Wei, Xin You, Qiuping Hu, Jingwei Qi, Qi Wang
Theranostics 2026; 16(4): 1905-1924. doi:10.7150/thno.122241
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Self-boosting targeted anticancer therapy via cancer cell self-reprogramming with GGT-targeting oxidative stress nanoamplifiers
Sujin Kim, Suyeon Lee, Manseok Yang, Seungwon Jung, Nanhee Song, Nuri Kim, Hanui Jo, Seunga Lee, Chaihong Nah, Seong-Cheol Park, Dongwon Lee
Theranostics 2026; 16(4): 1925-1940. doi:10.7150/thno.120954
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ROS-responsive cellular vesicles with ferroptosis-targeting siACMSD delivery for acute kidney injury therapy
Yunjing Zhang, Qing Deng, Yangtao Xu, Wei Wu, Tian Wu, Jia Huang, Yugang Hu, Weiqiang Lin, Ximing Xu, Jicheng Wu
Theranostics 2026; 16(4): 1941-1958. doi:10.7150/thno.119667
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MAP3K3 Contributes to Myocardial Ischemia/Reperfusion Injury by Promoting Myeloid Cell Diapedesis through TAL1/JAM-A Pathway
Shiyu Hu, Jian Zhang, Jingpu Wang, Chenguang Li, Yiwen Wang, Jiayu Liang, Rong Huang, Ji'e Yang, Yang Gao, Yanan Qu, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Feng Zhang, Junbo Ge
Theranostics 2026; 16(4): 1959-1974. doi:10.7150/thno.122130
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Tissue-type Differences in Focused Ultrasound and Microbubble-mediated Drug Delivery to the Brain Exist at Vessel Level
Alessandro De Maio, Fa-Hsuan Lin, Bojana Stefanovic, Meaghan A. O'Reilly
Theranostics 2026; 16(4): 1975-1996. doi:10.7150/thno.117691
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Reviews

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Translational molecular imaging and drug development in multiple sclerosis
Daniel Tay, Hazem Ahmed, Alyaa Dawoud, Mohamed Salam, Luca Gobbi, Uwe Grether, Martin R. Edelmann, Matthias B. Wittwer, Ludovic Collin, Kenneth Atz, James Keaney, Maude Giroud, Alexia Rossi, Antonio Giulio Gennari, Gennaro Pagano, Neil John Parrot, Muhamed Barakovic, Axel Rominger, Catherine Gebhard, Simon M. Ametamey, Amit M. Saindane, Steven H. Liang, Achi Haider
Theranostics 2026; 16(4): 1630-1657. doi:10.7150/thno.119559
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Programmable molecular microscopy: CRISPR/Cas fluorescent probes revolutionizing spatiotemporal genomic imaging
Xing-Yu Zhong, Yu-Xuan Yang, Yi-Fan Xiong, Gui-Chen Ye, Xi Gong, Ming-Liang Zhong, Hao-Dong He, Shao-Gang Wang, Qi-Dong Xia
Theranostics 2026; 16(4): 1877-1904. doi:10.7150/thno.125565
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