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Volume 16 (5); 2026
Research Papers
Targeted nanoparticles for placenta-specific drug delivery in pregnant rhesus macaques Jenna K. Schmidt, Ann M. Mitzey, Logan T. Keding, Sarah A. Shaw, Lewis Renshall, Frances Beards, Mona H. Al-Mugotir, Heather A. Simmons, Puja Basu, Michele L. Schotzko, Emily Ren, Thaddeus G. Golos, Lynda K. Harris
Theranostics 2026; 16(5): 2118-2135. doi:10.7150/thno.115081
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Nanoparticle retention enables non-invasive detection of metastases by magnetic particle imaging in murine breast cancer models Preethi Korangath, Hayden Carlton, Toby Sanders, Olivia C Sehl, Suqi Ke, Abdul Rahman Mohtasebzadeh, Lyndsey Werhane, Cordula Grüttner, Chen Hu, Kathleen Gabrielson, Patrick W Goodwill, Robert Ivkov
Theranostics 2026; 16(5): 2136-2155. doi:10.7150/thno.122259
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Focused ultrasound-enhanced nose-to-brain delivery of a therapeutic antibody in a large-animal model Siaka Fadera, Cristian Antonio Wieczorek Villas Boas, Yimei Yue, Zhaoning Gu, Jinyun Yuan, Debolina De, Buck E. Rogers, Arash Nazeri, Hong Chen
Theranostics 2026; 16(5): 2156-2169. doi:10.7150/thno.124354
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Single-cell and spatial transcriptomics reveal P4HA2-mediated radiotherapy resistance mechanisms in breast cancer Huimin Li, Junzhi Liu, Yuheng Jiao, Fengyu Xu, Shurui Wang, Qiang Tang
Theranostics 2026; 16(5): 2192-2220. doi:10.7150/thno.121257
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LPC-engineered liposomes activate transcytosis for paclitaxel brain delivery and potentiation of TTFields/TMZ via TALECT regimen in glioblastoma Qi Zhan, Kaikai Yi, Shixue Yang, Biao Hong, Dongyuan Su, Jixing Zhao, Qixue Wang, Xiaoteng Cui, Yanping Huang, Yaqing Ding, Chunchao Cheng, Jiasheng Ju, Chunsheng Kang
Theranostics 2026; 16(5): 2249-2268. doi:10.7150/thno.122658
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Macrophage Nrf1/NFE2L1-Foxo1 axis controls liver fibrosis by modulation of mitochondrial reprogramming Yuanbang Lin, Xiyun Bian, Yao Yao, Jingman Xu, Yingli Cao, Qiong Wu, Wen Ning, Lian Li, Mingwei Sheng, Fengmei Wang
Theranostics 2026; 16(5): 2269-2283. doi:10.7150/thno.112337
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Clearance of amyloid plaque via focused ultrasonication in a mouse model of Alzheimer's disease Songmin Lee, Jeungeun Kum, Kyeonghwan Kim, Tae Young Park, HeeEun Ko, Duk L. Na, Suk Yun Kang, Hyungmin Kim, YoungSoo Kim, Jaeho Kim
Theranostics 2026; 16(5): 2310-2323. doi:10.7150/thno.122123
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DeepLuAd: Semantic-guided virtual histopathology of lung adenocarcinoma via stimulated Raman scattering Liyang Ma, Yuheng Guo, Min Du, Yongjun Cai, Yingjie He, Qingjun Meng, Zhijie Liu, Yichuan Lan, Ming Li, Minbiao Ji, Lin Qi
Theranostics 2026; 16(5): 2324-2341. doi:10.7150/thno.125443
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Lipid nanoparticle-formulated DNA acts as a potent immune modulator for cancer immunotherapy through interferon signaling pathways Chen-Yi Chiang, Ming-Shu Hsieh, Mei-Yu Chen, Yu-Wen Tsai, Chang-Ling Lin, Chia-Wei Hsu, Guann-Yi Yu, Ming-Hsi Huang, Shih-Jen Liu, Hsin-Wei Chen
Theranostics 2026; 16(5): 2342-2356. doi:10.7150/thno.121364
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Hollow RuO2 nanozymes sensitized by carbon dot sonosensitizers for sonodynamic/chemodynamic-activated immunotherapy Ming Cao, Yanwei Liu, Zhenlin Zhang, Jinming Cai, Dengyu Pan, Bijiang Geng, Yunsheng Cheng
Theranostics 2026; 16(5): 2357-2371. doi:10.7150/thno.125880
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Verteporfin-loaded hydrogel targeting YAP-mediated MDSCs recruitment for the treatment of residual tumors after incomplete radiofrequency ablation Jiawen Chen, Junfeng Liu, Xiaoting Zhang, Xi Li, Jinming Fan, Shengchao Zhao, Junbin Liu, Bin Zhou, Ke Zhang
Theranostics 2026; 16(5): 2372-2387. doi:10.7150/thno.119377
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Neuronal mitochondrial disaggregase CLPB ameliorates Huntington's disease pathology in mice Hyeonho Kim, Gaeun Hyun, Seunghye Kim, Changmo Yu, Young-gi Hong, Jihyeon Yu, Sangsu Bae, Hyun-Woo Rhee, Jaewon Ko, Ji Won Um
Theranostics 2026; 16(5): 2388-2404. doi:10.7150/thno.122651
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Channel-specific differential effects of bacterial mechanosensitive channels for ultrasound neuromodulation in precision sonogenetics Xin Li, Chenguang Zheng, Yutao Tian, Dong Ming
Theranostics 2026; 16(5): 2447-2465. doi:10.7150/thno.119770
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Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction Ming-Rui Zhai, Jie Pan, Zhen-Huan Wu, Yu-Ying He, Kai-Run Zhang, Long Ren, Yu-Rong Wang, Yi-Bing Li, Jun Gao, Lei Xiao, Yue-Hua Liu
Theranostics 2026; 16(5): 2466-2487. doi:10.7150/thno.122944
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Synaptotagmin-7 drives stress-induced cardiomyocyte necroptosis via the p53-Bak-mPTP axis Jialei Li, Shuang Wang, Yu Han, Jinhong Liu, Yuhan Li, Jingyu Zhang, Liping Guo, Yue Jin, Jiasong Chang, Ting Liu, Lan Zhou, Siqi Liu, Guangzhao Yang, Shengxiao Zhang, Jimin Cao, Jie Na, Teng Sun
Theranostics 2026; 16(5): 2517-2537. doi:10.7150/thno.119528
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Development of New IL-1R Antagonists with Improved Anti-inflammatory Efficacy Mooseok Kang, Ae-Ree Lee, Hyeji Jung, Gyubin Jang, Byeongchan Kim, Sung-Hyun Yoon, Je-Wook Yu, Jaewon Ko, Ji Won Um, Iksoo Chang
Theranostics 2026; 16(5): 2561-2575. doi:10.7150/thno.120259
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Endothelial KSR2 regulated by genetic variation protects against atherosclerosis through AMPKα1 stabilization Ming Liu, Xiangrui Fu, Hui Zhang, Jinyu pan, Qiufeng Jia, Chengrui Zhang, Fengshuang An
Theranostics 2026; 16(5): 2598-2626. doi:10.7150/thno.122864
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Microglial TIA1-mediated stress granules promote neuroinflammation and aggravate neuron loss in mice after ischemic stroke by IGF2 signaling Yiming Qian, Hong Yu, Jianhong Dong, Jinyuan Liu, Jiaqi Han, Tianwen Zheng, Wei Zhang, Lipei Wang, Zhihui Huang, Ying Wang
Theranostics 2026; 16(5): 2627-2648. doi:10.7150/thno.122008
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Reviews
Searching for a HIV-1 Cure Chen Zhang, Bharat N. Chaudhary, Mohammad Uzair Ali, Mary G. Heser, Swara S. Patel, Xiaoqing Du, Soumya S. Dey, R. Lee Mosley, Sudipta Panja, Howard E. Gendelman
Theranostics 2026; 16(5): 2170-2191. doi:10.7150/thno.124358
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Hydrogel adhesives for upper gastrointestinal wound healing Lianjun Ma, Fangming Gu, Jiaqian Hu, Xin Wang, Ying-Wei Yang
Theranostics 2026; 16(5): 2221-2248. doi:10.7150/thno.124843
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Role of central and peripheral serotonin in liver physiology and diseases Arnauld Belmer, Carmelo Luci, Philippe Gual
Theranostics 2026; 16(5): 2284-2309. doi:10.7150/thno.126199
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Cuproptosis-triggering nanomedicine boosts antitumor immunotherapy Maoshan Wang, Chunyu Shi, Zhenbo Shu, Zhongmin Li
Theranostics 2026; 16(5): 2405-2446. doi:10.7150/thno.123080
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Functional material probes and advanced technologies in organ-on-a-chip characterization Yanan Wang, Xiao Chang, Shiwen Deng, Shihuan Tang, Peng Chen
Theranostics 2026; 16(5): 2488-2516. doi:10.7150/thno.122552
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Modulating CD8⁺ T cell immunity through exercise: mechanistic insights and implications for precision immunotherapy Xinyuan Zhao, Xu Chen, Pei Lin, Yunfan Lin, Weiyao Feng, Meiyan Zou, Nina Li, Li Cui
Theranostics 2026; 16(5): 2539-2558. doi:10.7150/thno.126053
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RNA Modifications in T cell Immunity: Mechanisms, Disease Relevance, and Therapeutic Potential Xinyuan Zhao, Meiyan Zou, Weiyao Feng, Nina Li, Xu Chen, Pei Lin, Zihao Zhou, Yunfan Lin, Li Cui
Theranostics 2026; 16(5): 2576-2597. doi:10.7150/thno.124482
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Errata
Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties: Erratum Hongchuan Wang, Na Mu, Yaqi He, Xiaoguang Zhang, Jie Lei, Cao Yang, Liang Ma, Yong Gao
Theranostics 2026; 16(5): 2538. doi:10.7150/thno.119205
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Albumin-seeking dyes with adjustable assemblies in situ enable programmable imaging windows and targeting tumor imaging: Erratum Yijing Du, Jiajun Xu, Tianyang Han, Zijian Jiang, Yuewei Zhang, Jia Li, Xiaoyuan Chen, Shoujun Zhu
Theranostics 2026; 16(5): 2559-2560. doi:10.7150/thno.126837
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