Theranostics 2013; 3(3):167-180. doi:10.7150/thno.5716
Analytical and Theranostic Applications of Gold Nanoparticles and Multifunctional Nanocomposites
1. Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS), Russian Federation;
2. Saratov State University, Russian Federation;
3. Ulyanovsk State University, Russian Federation.
Khlebtsov N, Bogatyrev V, Dykman L, Khlebtsov B, Staroverov S, Shirokov A, Matora L, Khanadeev V, Pylaev T, Tsyganova N, Terentyuk G. Analytical and Theranostic Applications of Gold Nanoparticles and Multifunctional Nanocomposites. Theranostics 2013; 3(3):167-180. doi:10.7150/thno.5716. Available from http://www.thno.org/v03p0167.htm
Gold nanoparticles (GNPs) and GNP-based multifunctional nanocomposites are the subject of intensive studies and biomedical applications. This minireview summarizes our recent efforts in analytical and theranostic applications of engineered GNPs and nanocomposites by using plasmonic properties of GNPs and various optical techniques. Specifically, we consider analytical biosensing; visualization and bioimaging of bacterial, mammalian, and plant cells; photodynamic treatment of pathogenic bacteria; and photothermal therapy of xenografted tumors. In addition to recently published reports, we discuss new data on dot immunoassay diagnostics of mycobacteria, multiplexed immunoelectron microscopy analysis of Azospirillum brasilense, materno-embryonic transfer of GNPs in pregnant rats, and combined photodynamic and photothermal treatment of rat xenografted tumors with gold nanorods covered by a mesoporous silica shell doped with hematoporphyrin.
Keywords: Gold nanoparticles, multifunctional nanocomposites, immunoassay, DNA detection, cell bioimaging, mycobacteria, Azospirillum brasilense, photodynamic and photothermal therapy, placental barrier, materno-embryonic transfer of gold nanoparticles.