Theranostics 2014; 4(3):240-255. doi:10.7150/thno.6914


Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers

Lian Jin1,*, Xin Zeng2,*, Ming Liu1, Yan Deng1,3, Nongyue He1,3✉

1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
2. Nanjing Maternal and Child Health Medical Institute, Nanjing Maternal and Child Health Hospital Affiliated of Nanjing Medical University, Nanjing 210029, China
3. Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province, Hunan Key Laboratory of Green Packaging and Biomedical Nanotechnology, Hunan University of Technology, Zhuzhou 412007, China
* These two authors contribute to this paper equally.

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Jin L, Zeng X, Liu M, Deng Y, He N. Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers. Theranostics 2014; 4(3):240-255. doi:10.7150/thno.6914. Available from

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Gene transfer methods are promising in the field of gene therapy. Current methods for gene transfer include three major groups: viral, physical and chemical methods. This review mainly summarizes development of several types of chemical methods for gene transfer in vitro and in vivo by means of nano-carriers like; calcium phosphates, lipids, and cationic polymers including chitosan, polyethylenimine, polyamidoamine dendrimers, and poly(lactide-co-glycolide). This review also briefly introduces applications of these chemical methods for gene delivery.

Keywords: Non-viral, Gene delivery, Vectors, Chemical Methods.