Polyacrylamide-Based Biocompatible Nanoplatform Enhances the Tumor Uptake, PET/fluorescence Imaging and Anticancer Activity of a Chlorophyll Analog

Gupta, Anurag; Wang, Shouyan; Marko, Aimee; Joshi, Penny; Ethirajan, Manivannan; Chen, Yihui; Yao, Rutao; Sajjad, Munawwar; Kopelman, Raoul; Pandey, Ravindra K.

doi:10.7150/thno.8478

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Nanotheranostics 2024; 8(3): 380-400. [Abstract] [Full text] [PDF]

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Theranostics 2014; 4(6):614-628. doi:10.7150/thno.8478 This issue Cite

Research Paper

Polyacrylamide-Based Biocompatible Nanoplatform Enhances the Tumor Uptake, PET/fluorescence Imaging and Anticancer Activity of a Chlorophyll Analog

Anurag Gupta¹, Shouyan Wang², Aimee Marko¹, Penny Joshi¹, Manivannan Ethirajan¹, Yihui Chen¹, Rutao Yao³, Munawwar Sajjad³, Raoul Kopelman², Ravindra K. Pandey^{1 ✉}

1. PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA;
2. Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA;
3. Department of Nuclear Medicine, State University of New York, Buffalo, NY 14032, USA.

Citation:

Gupta A, Wang S, Marko A, Joshi P, Ethirajan M, Chen Y, Yao R, Sajjad M, Kopelman R, Pandey RK. Polyacrylamide-Based Biocompatible Nanoplatform Enhances the Tumor Uptake, PET/fluorescence Imaging and Anticancer Activity of a Chlorophyll Analog. Theranostics 2014; 4(6):614-628. doi:10.7150/thno.8478. https://www.thno.org/v04p0614.htm

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Abstract

In this report we demonstrate the outstanding advantages of multifunctional nanoplatforms for cancer-imaging and therapy. The non-toxic polyacrylamide (PAA) nanoparticles (size:18-25 nm) formulation drastically changed the pharmacokinetic profile of the ¹²⁴I- labeled chlorophyll-a derivative (formulated in 10% ethanol in PBS) with a remarkable enhancement in tumor uptake, and significantly reduced uptake in spleen and liver. Among the various nanoformulations investigated, the ¹²⁴I- labeled photosensitizer (dose: 0.6142 MBq), and the cyanine dye-nanoparticles (CD-NP) conjugate (dose 0.3 μmol/kg) in combination showed great potential for tumor imaging (PET/NIR fluorescence) in BALB/c mice bearing Colon26 tumors. Compared to free non-labeled photosensitizer, the corresponding PAA nanoformulation under similar treatment parameters showed a remarkable enhancement in long-term tumor cure by PDT (photodynamic therapy) and provides an opportunity to develop a single nanoplatform for tumor-imaging (PET/fluorescence) and phototherapy, a practical “See and Treat” approach.

Keywords: Nanoparticles, photodynamic therapy, Positron Imaging Tomography, Reactive Oxygen species.

Citation styles

APA

Gupta, A., Wang, S., Marko, A., Joshi, P., Ethirajan, M., Chen, Y., Yao, R., Sajjad, M., Kopelman, R., Pandey, R.K. (2014). Polyacrylamide-Based Biocompatible Nanoplatform Enhances the Tumor Uptake, PET/fluorescence Imaging and Anticancer Activity of a Chlorophyll Analog. Theranostics, 4(6), 614-628. https://doi.org/10.7150/thno.8478.

ACS

Gupta, A.; Wang, S.; Marko, A.; Joshi, P.; Ethirajan, M.; Chen, Y.; Yao, R.; Sajjad, M.; Kopelman, R.; Pandey, R.K. Polyacrylamide-Based Biocompatible Nanoplatform Enhances the Tumor Uptake, PET/fluorescence Imaging and Anticancer Activity of a Chlorophyll Analog. Theranostics 2014, 4 (6), 614-628. DOI: 10.7150/thno.8478.

NLM

CSE

Gupta A, Wang S, Marko A, Joshi P, Ethirajan M, Chen Y, Yao R, Sajjad M, Kopelman R, Pandey RK. 2014. Polyacrylamide-Based Biocompatible Nanoplatform Enhances the Tumor Uptake, PET/fluorescence Imaging and Anticancer Activity of a Chlorophyll Analog. Theranostics. 4(6):614-628.

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