Theranostics 2015; 5(12):1402-1418. doi:10.7150/thno.13099 This issue Cite

Research Paper

Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics

Hyun Su Min1*, Dong Gil You1,2*, Sejin Son1, Sangmin Jeon1,2, Jae Hyung Park2, Seulki Lee3, Ick Chan Kwon1,4, Kwangmeyung Kim1✉

1. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 6, Seongbuk-gu, Seoul 136-791, South Korea
2. School of chemical engineering, Sungkyunkwan University, Suwon 440-746, South Korea
3. The Russell H. Morgan Department of Radiology and Radiological Science, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
4. KU-KIST School, Korea University, 1 Anam-dong, Seongbuk-gu, Seoul 136-701, South Korea
* Hyun Su Min and Dong Gil You are co-first authors.

Citation:
Min HS, You DG, Son S, Jeon S, Park JH, Lee S, Kwon IC, Kim K. Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics. Theranostics 2015; 5(12):1402-1418. doi:10.7150/thno.13099. https://www.thno.org/v05p1402.htm
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Abstract

Graphic abstract

Theranostic nanoparticles hold great promise for simultaneous diagnosis of diseases, targeted drug delivery with minimal toxicity, and monitoring of therapeutic efficacy. However, one of the current challenges in developing theranostic nanoparticles is enhancing the tumor-specific targeting of both imaging probes and anticancer agents. Herein, we report the development of tumor-homing echogenic glycol chitosan-based nanoparticles (Echo-CNPs) that concurrently execute cancer-targeted ultrasound (US) imaging and US-triggered drug delivery. To construct this novel Echo-CNPs, an anticancer drug and bioinert perfluoropentane (PFP), a US gas precursor, were simultaneously encapsulated into glycol chitosan nanoparticles using the oil in water (O/W) emulsion method. The resulting Echo-CNPs had a nano-sized particle structure, composing of hydrophobic anticancer drug/PFP inner cores and a hydrophilic glycol chitosan polymer outer shell. The Echo-CNPs had a favorable hydrodynamic size of 432 nm, which is entirely different from the micro-sized core-empty conventional microbubbles (1-10 μm). Furthermore, Echo-CNPs showed the prolonged echogenicity via the sustained microbubble formation process of liquid-phase PFP at the body temperature and they also presented a US-triggered drug release profile through the external US irradiation. Interestingly, Echo-CNPs exhibited significantly increased tumor-homing ability with lower non-specific uptake by other tissues in tumor-bearing mice through the nanoparticle's enhanced permeation and retention (EPR) effect. Conclusively, theranostic Echo-CNPs are highly useful for simultaneous cancer-targeting US imaging and US-triggered delivery in cancer theranostics.

Keywords: theranostic nanoparticle, echogenicity, ultrasound imaging, ultrasound contrast agent, tumor targeting, drug delivery.


Citation styles

APA
Min, H.S., You, D.G., Son, S., Jeon, S., Park, J.H., Lee, S., Kwon, I.C., Kim, K. (2015). Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics. Theranostics, 5(12), 1402-1418. https://doi.org/10.7150/thno.13099.

ACS
Min, H.S.; You, D.G.; Son, S.; Jeon, S.; Park, J.H.; Lee, S.; Kwon, I.C.; Kim, K. Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics. Theranostics 2015, 5 (12), 1402-1418. DOI: 10.7150/thno.13099.

NLM
Min HS, You DG, Son S, Jeon S, Park JH, Lee S, Kwon IC, Kim K. Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics. Theranostics 2015; 5(12):1402-1418. doi:10.7150/thno.13099. https://www.thno.org/v05p1402.htm

CSE
Min HS, You DG, Son S, Jeon S, Park JH, Lee S, Kwon IC, Kim K. 2015. Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics. Theranostics. 5(12):1402-1418.

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