Theranostics 2016; 6(4):485-500. doi:10.7150/thno.13411 This issue
1. Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, PR China.
2. The Materials Science and Engineering Program, Dept of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, 45221, USA.
3. Institute of Biomedical Engineering, Shanghai University, Shanghai 200444, P. R. China.
In this study, a multimodal therapeutic system was shown to be much more lethal in cancer cell killing compared to a single means of nano therapy, be it photothermal or photodynamic. Hollow magnetic nanospheres (HMNSs) were designed and synthesized for the synergistic effects of both magneto-mechanical and photothermal cancer therapy. By these combined stimuli, the cancer cells were structurally and physically destroyed with the morphological characteristics distinctively different from those by other therapeutics. HMNSs were also coated with the silica shells and conjugated with carboxylated graphene quantum dots (GQDs) as a core-shell composite: HMNS/SiO2/GQDs. The composite was further loaded with an anticancer drug doxorubicin (DOX) and stabilized with liposomes. The multimodal system was able to kill cancer cells with four different therapeutic mechanisms in a synergetic and multilateral fashion, namely, the magnetic field-mediated mechanical stimulation, photothermal damage, photodynamic toxicity, and chemotherapy. The unique nanocomposites with combined mechanical, chemo, and physical effects will provide an alternative strategy for highly improved cancer therapy efficiency.
Keywords: Drug-loaded magnetic nanocomposites, graphene quantum dots, magnetic field-mediated mechanical stimulation, near-infrared laser, cancer therapy.