Theranostics 2016; 6(13):2367-2379. doi:10.7150/thno.15829

Research Paper

Photo-decomposable Organic Nanoparticles for Combined Tumor Optical Imaging and Multiple Phototherapies

Wenjun Miao1,2, Hyungjun Kim1, Vipul Gujrati1, Jin Yong Kim3, Hyeongsu Jon1, Yonghyun Lee1, Minsuk Choi1, Jinjoo Kim1, Soyoung Lee1, Dong Yun Lee3, Sukmo Kang1, Sangyong Jon 1,3✉

1. KAIST Institute for the BioCentury, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.
2. School of Pharmaceutical Science, Nanjing Tech University, Nanjing, 211816, China.
3. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Citation:
Miao W, Kim H, Gujrati V, Kim JY, Jon H, Lee Y, Choi M, Kim J, Lee S, Lee DY, Kang S, Jon S. Photo-decomposable Organic Nanoparticles for Combined Tumor Optical Imaging and Multiple Phototherapies. Theranostics 2016; 6(13):2367-2379. doi:10.7150/thno.15829. Available from http://www.thno.org/v06p2367.htm

File import instruction

Abstract

Combination of photodynamic therapy (PDT) with photothermal therapy (PTT) has achieved significantly improved therapeutic efficacy compared to a single phototherapy modality. However, most nanomaterials used for combined PDT/PTT are made of non-biodegradable materials (e.g., gold nanorods, carbon nanotubes, and graphenes) and may remain intact in the body for long time, raising concerns over their potential long-term toxicity. Here we report a new combined PDT/PTT nanomedicine, designated SP3NPs, that exhibit photo-decomposable, photodynamic and photothermal properties. SP3NPs were prepared by self-assembly of PEGylated cypate, comprising FDA-approved PEG and an ICG derivative. We confirmed the ability of SP3NPs to generate both singlet oxygen for a photodynamic effect and heat for photothermal therapy in response to NIR laser irradiation in vitro. Also, the unique ability of SP3NPs to undergo irreversible decomposition upon NIR laser irradiation was demonstrated. Further our experimental results demonstrated that SP3NPs strongly accumulated in tumor tissue owing to their highly PEGylated surface and relatively small size (~60 nm), offering subsequent imaging-guided combined PDT/PTT treatment that resulted in tumor eradication and prolonged survival of mice. Taken together, our SP3NPs described here may represent a novel and facile approach for next-generation theranostics with great promise for translation into clinical practice in the future.

Keywords: nanomedicine · indocyanine green · photodynamic therapy · photothermal therapy · theranostics.