Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes

Besser, Rachel R.; Ishahak, Matthew; Mayo, Vera; Carbonero, Daniel; Claure, Isabella; Agarwal, Ashutosh

doi:10.7150/thno.19441

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Theranostics 2018; 8(1):124-140. doi:10.7150/thno.19441 This issue Cite

Research Paper

Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes

Rachel R. Besser¹, Matthew Ishahak¹, Vera Mayo¹, Daniel Carbonero¹, Isabella Claure¹, Ashutosh Agarwal^1,2,3✉

1. Department of Biomedical Engineering, University of Miami;
2. Department of Pathology & Laboratory Medicine, University of Miami;
3. DJTMF Biomedical Nanotechnology Institute, University of Miami.

Citation:

Besser RR, Ishahak M, Mayo V, Carbonero D, Claure I, Agarwal A. Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes. Theranostics 2018; 8(1):124-140. doi:10.7150/thno.19441. https://www.thno.org/v08p0124.htm

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Abstract

Through the use of stem cell-derived cardiac myocytes, tissue-engineered human myocardial constructs are poised for modeling normal and diseased physiology of the heart, as well as discovery of novel drugs and therapeutic targets in a human relevant manner. This review highlights the recent bioengineering efforts to recapitulate microenvironmental cues to further the maturation state of newly differentiated cardiac myocytes. These techniques include long-term culture, co-culture, exposure to mechanical stimuli, 3D culture, cell-matrix interactions, and electrical stimulation. Each of these methods has produced various degrees of maturation; however, a standardized measure for cardiomyocyte maturation is not yet widely accepted by the scientific community.

Keywords: Stem cells, Cardiac Myocytes, Differentiation, Maturation, Tissue Engineering.

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APA

Besser, R.R., Ishahak, M., Mayo, V., Carbonero, D., Claure, I., Agarwal, A. (2018). Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes. Theranostics, 8(1), 124-140. https://doi.org/10.7150/thno.19441.

ACS

Besser, R.R.; Ishahak, M.; Mayo, V.; Carbonero, D.; Claure, I.; Agarwal, A. Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes. Theranostics 2018, 8 (1), 124-140. DOI: 10.7150/thno.19441.

NLM

CSE

Besser RR, Ishahak M, Mayo V, Carbonero D, Claure I, Agarwal A. 2018. Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes. Theranostics. 8(1):124-140.

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