Theranostics 2018; 8(1):124-140. doi:10.7150/thno.19441 This issue Cite

Research Paper

Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes

Rachel R. Besser1, Matthew Ishahak1, Vera Mayo1, Daniel Carbonero1, Isabella Claure1, Ashutosh Agarwal1,2,3✉

1. Department of Biomedical Engineering, University of Miami;
2. Department of Pathology & Laboratory Medicine, University of Miami;
3. DJTMF Biomedical Nanotechnology Institute, University of Miami.

Citation:
Besser RR, Ishahak M, Mayo V, Carbonero D, Claure I, Agarwal A. Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes. Theranostics 2018; 8(1):124-140. doi:10.7150/thno.19441. https://www.thno.org/v08p0124.htm
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Abstract

Graphic abstract

Through the use of stem cell-derived cardiac myocytes, tissue-engineered human myocardial constructs are poised for modeling normal and diseased physiology of the heart, as well as discovery of novel drugs and therapeutic targets in a human relevant manner. This review highlights the recent bioengineering efforts to recapitulate microenvironmental cues to further the maturation state of newly differentiated cardiac myocytes. These techniques include long-term culture, co-culture, exposure to mechanical stimuli, 3D culture, cell-matrix interactions, and electrical stimulation. Each of these methods has produced various degrees of maturation; however, a standardized measure for cardiomyocyte maturation is not yet widely accepted by the scientific community.

Keywords: Stem cells, Cardiac Myocytes, Differentiation, Maturation, Tissue Engineering.


Citation styles

APA
Besser, R.R., Ishahak, M., Mayo, V., Carbonero, D., Claure, I., Agarwal, A. (2018). Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes. Theranostics, 8(1), 124-140. https://doi.org/10.7150/thno.19441.

ACS
Besser, R.R.; Ishahak, M.; Mayo, V.; Carbonero, D.; Claure, I.; Agarwal, A. Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes. Theranostics 2018, 8 (1), 124-140. DOI: 10.7150/thno.19441.

NLM
Besser RR, Ishahak M, Mayo V, Carbonero D, Claure I, Agarwal A. Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes. Theranostics 2018; 8(1):124-140. doi:10.7150/thno.19441. https://www.thno.org/v08p0124.htm

CSE
Besser RR, Ishahak M, Mayo V, Carbonero D, Claure I, Agarwal A. 2018. Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes. Theranostics. 8(1):124-140.

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