Theranostics 2019; 9(17):4893-4908. doi:10.7150/thno.36037 This issue Cite

Review

CD36 tango in cancer: signaling pathways and functions

Jingchun Wang, Yongsheng Li

Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University, Chongqing 400037, China.

Citation:
Wang J, Li Y. CD36 tango in cancer: signaling pathways and functions. Theranostics 2019; 9(17):4893-4908. doi:10.7150/thno.36037. https://www.thno.org/v09p4893.htm
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Abstract

Graphic abstract

CD36, a scavenger receptor expressed in multiple cell types, mediates lipid uptake, immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a transmembrane glycoprotein that contains several posttranslational modification sites and binds to diverse ligands, including apoptotic cells, thrombospondin-1 (TSP-1), and fatty acids (FAs). Beyond fueling tumor metastasis and therapy resistance by enhancing lipid uptake and FA oxidation, CD36 attenuates angiogenesis by binding to TSP-1 and thereby inducing apoptosis or blocking the vascular endothelial growth factor receptor 2 pathway in tumor microvascular endothelial cells. Moreover, CD36-driven lipid metabolic reprogramming and functions in tumor-associated immune cells lead to tumor immune tolerance and cancer development. Notable advances have been made in demonstrating the regulatory networks that govern distinct physiological properties of CD36, and this has identified targeting CD36 as a potential strategy for cancer treatment. Here, we provide an overview on the structure, regulation, ligands, functions, and clinical trials of CD36 in cancer.

Keywords: CD36, cancer treatment, biomarker, lipid metabolism, tumor-associated immune cell


Citation styles

APA
Wang, J., Li, Y. (2019). CD36 tango in cancer: signaling pathways and functions. Theranostics, 9(17), 4893-4908. https://doi.org/10.7150/thno.36037.

ACS
Wang, J.; Li, Y. CD36 tango in cancer: signaling pathways and functions. Theranostics 2019, 9 (17), 4893-4908. DOI: 10.7150/thno.36037.

NLM
Wang J, Li Y. CD36 tango in cancer: signaling pathways and functions. Theranostics 2019; 9(17):4893-4908. doi:10.7150/thno.36037. https://www.thno.org/v09p4893.htm

CSE
Wang J, Li Y. 2019. CD36 tango in cancer: signaling pathways and functions. Theranostics. 9(17):4893-4908.

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