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Theranostics 2022; 12(3):1459-1485. doi:10.7150/thno.66676 This issue Cite
Review
Activated molecular probes for enzyme recognition and detection
MOE key laboratory for analytical science of food safety and biology Institution, College of Chemistry, Fuzhou University, Fuzhou 350108, China
Citation:
Yuan M, Wu Y, Zhao C, Chen Z, Su L, Yang H, Song J. Activated molecular probes for enzyme recognition and detection. Theranostics 2022; 12(3):1459-1485. doi:10.7150/thno.66676. https://www.thno.org/v12p1459.htm
Other stylesAbstract
Exploring and understanding the interaction of changes in the activities of various enzymes, such as proteases, phosphatases, and oxidoreductases with tumor invasion, proliferation, and metastasis is of great significance for early cancer diagnosis. To detect the activity of tumor-related enzymes, various molecular probes have been developed with different imaging methods, including optical imaging, photoacoustic imaging (PAI), magnetic resonance imaging, positron emission tomography, and so on. In this review, we first describe the biological functions of various enzymes and the selectively recognized chemical linkers or groups. Subsequently, we systematically summarize the design mechanism of imaging probes and different imaging methods. Finally, we explore the challenges and development prospects in the field of enzyme activity detection. This comprehensive review will provide more insight into the design and development of enzyme activated molecular probes.
Keywords: enzyme, biosensor, molecular probe, photoacoustic imaging, fluorescence imaging (FLI)
Citation styles
APA
Yuan, M., Wu, Y., Zhao, C., Chen, Z., Su, L., Yang, H., Song, J. (2022). Activated molecular probes for enzyme recognition and detection. Theranostics, 12(3), 1459-1485. https://doi.org/10.7150/thno.66676.
ACS
Yuan, M.; Wu, Y.; Zhao, C.; Chen, Z.; Su, L.; Yang, H.; Song, J. Activated molecular probes for enzyme recognition and detection. Theranostics 2022, 12 (3), 1459-1485. DOI: 10.7150/thno.66676.
NLM
Yuan M, Wu Y, Zhao C, Chen Z, Su L, Yang H, Song J. Activated molecular probes for enzyme recognition and detection. Theranostics 2022; 12(3):1459-1485. doi:10.7150/thno.66676. https://www.thno.org/v12p1459.htm
CSE
Yuan M, Wu Y, Zhao C, Chen Z, Su L, Yang H, Song J. 2022. Activated molecular probes for enzyme recognition and detection. Theranostics. 12(3):1459-1485.
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